William H Gmeiner

Summary

Publications

  1. doi request reprint Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, United States Comprehensive Cancer Center at Wake Forest University, Wake Forest School of Medicine, Winston Salem, NC 27157, United States Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, NC 27157, United States Electronic address
    Leuk Res 39:229-35. 2015
  2. pmc The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs
    William H Gmeiner
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nucleic Acids 2011:631372. 2011
  3. pmc Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    J Neurooncol 116:447-54. 2014
  4. pmc Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity
    Jamie Jennings-Gee
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Exp Hematol 41:180-188.e4. 2013
  5. pmc Site-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells
    Christopher H Stuart
    Department of Cancer Biology, Department of Molecular Medicine and Translation Science, Wake Forest School of Medicine, and Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States
    Bioconjug Chem 25:406-13. 2014
  6. pmc The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells
    Timothy S Pardee
    Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston Salem, NC Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC
    Oncotarget 5:4170-9. 2014
  7. doi request reprint The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina Comprehensive Cancer Center, Wake Forest School of Medicine, Winston Salem, North Carolina
    Prostate 75:360-9. 2015
  8. pmc Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA
    Supratim Ghosh
    a Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Biomol Struct Dyn 31:1301-10. 2013
  9. pmc Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity
    Timothy S Pardee
    Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Blood 119:3561-70. 2012
  10. pmc Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity
    Supratim Ghosh
    Program in Molecular Genetics, Wake Forest School of Medicine, Winston Salem, NC, USA Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nanomedicine 10:451-61. 2014

Collaborators

Detail Information

Publications11

  1. doi request reprint Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, United States Comprehensive Cancer Center at Wake Forest University, Wake Forest School of Medicine, Winston Salem, NC 27157, United States Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, NC 27157, United States Electronic address
    Leuk Res 39:229-35. 2015
    ....
  2. pmc The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs
    William H Gmeiner
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nucleic Acids 2011:631372. 2011
    ..These effects are inherent in the DNA duplex and do not require formation of the Top1:DNA complex. These results provide a biophysical rationale for the inhibition of Top1-mediated DNA religation by nucleotide analog substitution...
  3. pmc Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    J Neurooncol 116:447-54. 2014
    ..F10 displays strong efficacy for GBM treatment with minimal toxicity upon i.c. administration establishing F10 as a promising drug-candidate for treating GBM in human patients. ..
  4. pmc Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity
    Jamie Jennings-Gee
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Exp Hematol 41:180-188.e4. 2013
    ..Top1CC form in cells upon re-entry into S-phase, resulting in DNA double-strand breaks, and initiating apoptotic signaling that can be either muted or enhanced by Jnk-signaling depending on cell type...
  5. pmc Site-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells
    Christopher H Stuart
    Department of Cancer Biology, Department of Molecular Medicine and Translation Science, Wake Forest School of Medicine, and Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States
    Bioconjug Chem 25:406-13. 2014
    ..The dual conjugate, DCH-FA, can be used for safer and more effective chemotherapy with Dox and this conjugation strategy can be expanded to include additional anticancer drugs. ..
  6. pmc The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells
    Timothy S Pardee
    Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston Salem, NC Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC
    Oncotarget 5:4170-9. 2014
    ..Consistent with this decreased uptake, F10 treatment did not alter the ability of human hematopoietic stem cells to engraft in immunodeficient mice. ..
  7. doi request reprint The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina Comprehensive Cancer Center, Wake Forest School of Medicine, Winston Salem, North Carolina
    Prostate 75:360-9. 2015
    ..The effects of exogenous Zn(2+) or Zn(2+) chelation for enhancing F10 cytotoxicity are investigated as is the role of Omi/HtrA2, a serine protease that promotes apoptosis in response to cellular stress...
  8. pmc Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA
    Supratim Ghosh
    a Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Biomol Struct Dyn 31:1301-10. 2013
    ..g. Zn(2+):3'FdU) indicating that this new structural motif may be therapeutically useful for PCa treatment. An animated interactive 3D complement (I3DC) is available in Proteopedia at http://proteopedia.org/w/Journal:JBSD:32. ..
  9. pmc Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity
    Timothy S Pardee
    Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Blood 119:3561-70. 2012
    ..In summary, FdUMP[10] was highly efficacious and better tolerated than standard therapies...
  10. pmc Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity
    Supratim Ghosh
    Program in Molecular Genetics, Wake Forest School of Medicine, Winston Salem, NC, USA Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nanomedicine 10:451-61. 2014
    ..Our results demonstrate that PDN have properties useful for therapeutic applications, including cancer treatment...