William H Gmeiner

Summary

Publications

  1. pmc The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs
    William H Gmeiner
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nucleic Acids 2011:631372. 2011
  2. pmc Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    J Neurooncol 116:447-54. 2014

Detail Information

Publications3

  1. pmc The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs
    William H Gmeiner
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nucleic Acids 2011:631372. 2011
    ..These effects are inherent in the DNA duplex and do not require formation of the Top1:DNA complex. These results provide a biophysical rationale for the inhibition of Top1-mediated DNA religation by nucleotide analog substitution...
  2. pmc Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors
    William H Gmeiner
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    J Neurooncol 116:447-54. 2014
    ..F10 displays strong efficacy for GBM treatment with minimal toxicity upon i.c. administration establishing F10 as a promising drug-candidate for treating GBM in human patients. ..