Nicholas Stone

Summary

Affiliation: Gloucestershire Royal Hospital

Publications

  1. doi request reprint Advanced transmission Raman spectroscopy: a promising tool for breast disease diagnosis
    Nicholas Stone
    Biophotonics Research Unit, Gloucestershire Royal Hospital, Gloucester, United Kingdom
    Cancer Res 68:4424-30. 2008
  2. ncbi request reprint Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus
    Catherine Kendall
    Cranfield Postgraduate Medical School, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    J Pathol 200:602-9. 2003
  3. ncbi request reprint The use of Raman spectroscopy to provide an estimation of the gross biochemistry associated with urological pathologies
    Nicholas Stone
    Biophotonics Research Group, Pullman Court, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    Anal Bioanal Chem 387:1657-68. 2007
  4. ncbi request reprint Subsurface probing of calcifications with spatially offset Raman spectroscopy (SORS): future possibilities for the diagnosis of breast cancer
    Nicholas Stone
    Biophotonics Research Group, Gloucestershire Royal Hospital, Great Western Road, Gloucester, UKGL1 3NN
    Analyst 132:899-905. 2007
  5. pmc New relationships between breast microcalcifications and cancer
    R Baker
    Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, GL1 3NN, UK
    Br J Cancer 103:1034-9. 2010
  6. pmc Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus
    G Shetty
    Biophotonics Research Group, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    Br J Cancer 94:1460-4. 2006
  7. pmc The future of medical diagnostics: review paper
    Waseem K Jerjes
    Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
    Head Neck Oncol 3:38. 2011
  8. pmc At the frontiers of surgery: review
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 3:7. 2011
  9. pmc Head & neck optical diagnostics: vision of the future of surgery
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 1:25. 2009
  10. ncbi request reprint Standardizing dosimetry in esophageal PDT: an argument for use of centering devices and removal of misleading units
    Nicholas Stone
    Cranfield Postgraduate Medical School, Gloucestershire Royal Hospital, Great Western Road, Gloucester, Gloucestershire, GL1 3NN, England
    Technol Cancer Res Treat 2:333-8. 2003

Collaborators

  • Pavel Matousek
  • C A Kendall
  • Hugh Barr
  • Martin Isabelle
  • Jaspreet Babrah
  • Kaustuv Das
  • P Moayyedi
  • Geeta Shetty
  • Jenny Smith
  • Karen Faulds
  • Michael Towrie
  • Duncan Graham
  • K Geboes
  • Michael G Sowa
  • Jonathan Horsnell
  • Tahwinder Upile
  • Joanne Hutchings
  • Waseem K Jerjes
  • Christian S Betz
  • Anil K D'Cruz
  • Rebecca Richards-Kortum
  • Herbert Stepp
  • Ann Sandison
  • Zhongping Chen
  • Lina Bolotine
  • Katarina Svanberg
  • Herbert Wolfsen
  • Malini Olivo
  • Merrill A Biel
  • Andreas Leunig
  • Lin Ping Choo-Smith
  • Kristian Berg
  • Arjun G Yodh
  • Alexander J MacRobert
  • Dominic J Robinson
  • Colin Hopper
  • Irving Bigio
  • Adel K El-Naggar
  • Vanderlei Bagnato
  • I Bing Tan
  • Brian C Wilson
  • Gordon McKenzie
  • Ann Gillenwater
  • Gavin Rhys Lloyd
  • Khee C Soo
  • Justus F Ilgner
  • Charles A Mosse
  • Robert van Veen
  • Brian J Wong
  • Henricus J Sterenborg
  • Max J Witjes
  • Sheila Fisher
  • Marleen M Kerssens
  • R Baker
  • Neil Shepherd
  • Keith Rogers
  • Janelle Maria Reyes-Goddard
  • Jacob Filik
  • Rebecca Baker
  • Anthony William Parker
  • Maria Consuelo Hart Prieto
  • Michael Thomas
  • Linda E Orr
  • Keith McCarthy
  • Simon Rose
  • Jonathan Christie-Brown
  • Holger Sudhoff
  • Zaid Hamdoon
  • Jennifer Rosen
  • Arjen Amelink
  • K D Rogers
  • N Shepherd
  • Khee Chee Soo
  • Waseem Jerjes
  • Brian J F Wong
  • Max J H Witjes
  • Brian Smith
  • Charles Alexander Mosse
  • Henricus J C M Sterenborg
  • Kate Louise Ronayne
  • Mark Wright
  • Alistair William Ritchie

Detail Information

Publications36

  1. doi request reprint Advanced transmission Raman spectroscopy: a promising tool for breast disease diagnosis
    Nicholas Stone
    Biophotonics Research Unit, Gloucestershire Royal Hospital, Gloucester, United Kingdom
    Cancer Res 68:4424-30. 2008
    ..7 cm within a breast phantom made up of porcine tissues. The technique has shown significant potential for probing human breasts to provide complementary data in the early diagnosis of breast cancer...
  2. ncbi request reprint Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus
    Catherine Kendall
    Cranfield Postgraduate Medical School, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    J Pathol 200:602-9. 2003
    ..76). Raman spectroscopy appears to provide a highly sensitive and specific technique for the identification and classification of neoplasia in Barrett's oesophagus...
  3. ncbi request reprint The use of Raman spectroscopy to provide an estimation of the gross biochemistry associated with urological pathologies
    Nicholas Stone
    Biophotonics Research Group, Pullman Court, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    Anal Bioanal Chem 387:1657-68. 2007
    ..In this way we can achieve a better understanding of disease processes such as carcinogenesis. This could have major implications in the future of the diagnosis of disease within the bladder and the prostate gland...
  4. ncbi request reprint Subsurface probing of calcifications with spatially offset Raman spectroscopy (SORS): future possibilities for the diagnosis of breast cancer
    Nicholas Stone
    Biophotonics Research Group, Gloucestershire Royal Hospital, Great Western Road, Gloucester, UKGL1 3NN
    Analyst 132:899-905. 2007
    ..Non-invasive elucidation of calcification composition, and hence type, associated with benign or malignant lesions, could eliminate the requirement for biopsy in many patients...
  5. pmc New relationships between breast microcalcifications and cancer
    R Baker
    Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, GL1 3NN, UK
    Br J Cancer 103:1034-9. 2010
    ..This study explores the hypothesis that breast calcification composition is directly related to the local tissue pathological state...
  6. pmc Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus
    G Shetty
    Biophotonics Research Group, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK
    Br J Cancer 94:1460-4. 2006
    ..There is potential for in vivo application for real-time endoscopic optical diagnosis...
  7. pmc The future of medical diagnostics: review paper
    Waseem K Jerjes
    Head and Neck Optical Diagnostics Society Council, International Society of Minimally Invasive Diagnostics, University College London, London, UK
    Head Neck Oncol 3:38. 2011
    ..The meeting included 2 sections: oral communication sessions running in parallel to the IPA programme and poster presentation sessions combined with the IPA and EPPM posters sessions...
  8. pmc At the frontiers of surgery: review
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 3:7. 2011
    ..We review the salient advances in the field and propose further directions of investigation...
  9. pmc Head & neck optical diagnostics: vision of the future of surgery
    Tahwinder Upile
    The Head and Neck Optical Diagnostics Society Council, Head and Neck Centre, University College Hospital, 250 Euston Road, London, NW1 2PG, UK
    Head Neck Oncol 1:25. 2009
    ..We are fortunate that this is indeed a possibility and may fundamentally change current clinical and surgical practice to improve our patients' lives...
  10. ncbi request reprint Standardizing dosimetry in esophageal PDT: an argument for use of centering devices and removal of misleading units
    Nicholas Stone
    Cranfield Postgraduate Medical School, Gloucestershire Royal Hospital, Great Western Road, Gloucester, Gloucestershire, GL1 3NN, England
    Technol Cancer Res Treat 2:333-8. 2003
    ..A requirement for centering devices and standard units of Joules per cm(2) of treatment area are indicated...
  11. ncbi request reprint Depth profiling of calcifications in breast tissue using picosecond Kerr-gated Raman spectroscopy
    Rebecca Baker
    Biophotonics Research Group, Gloucestershire Royal Hospital, Great Western Road, Gloucester, UK
    Analyst 132:48-53. 2007
    ..This presents great potential for the use of Raman spectroscopy as an adjunct to mammography in the early diagnosis of breast cancer...
  12. doi request reprint Rapid endoscopic identification and destruction of degenerating Barrett's mucosal neoplasia
    Hugh Barr
    Leadon House Gloucestershire Royal hospital, Gloucester GL1 3NN, UK
    Surgeon 9:119-23. 2011
    ..Following endoscopic resection of 95 patients, the mean survival for intramucosal adenocarcinoma and high-grade dysplasia was 40.6 and 60.8 months respectively...
  13. pmc Endoscopic screening and surveillance for Barrett's esophagus--clinical implications
    Hugh Barr
    Cranfield Postgraduate Medical School, Gloucestershire, Gloucestershire Royal Hospital, Gloucester, United Kingdom
    MedGenMed 8:88. 2006
    ..The detection of dysplasia requires increased surveillance and usually intervention either endoscopically or with surgery...
  14. ncbi request reprint Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue
    Maria Consuelo Hart Prieto
    Gloucestershire Royal Hospital, Biophotonics Research Group, Pullman Court, Great Western Road, Gloucester GL 1 3NN, United Kingdom
    J Biomed Opt 10:44006. 2005
    ....
  15. doi request reprint Raman spectroscopy--a potential new method for the intra-operative assessment of axillary lymph nodes
    Jonathan D Horsnell
    Department of Biophotonics Research, Gloucestershire Hospitals NHS Foundation Trust, Gloucester Royal Hospital, Leadon House, Gt Western Road, Gloucester GL1 3NN, UK
    Surgeon 10:123-7. 2012
    ..Using Raman spectroscopy in this way could allow lymph node assessment within a time-frame suitable for intra-operative use...
  16. doi request reprint Evaluation of Raman probe for oesophageal cancer diagnostics
    Catherine Kendall
    Biophotonics Research Group, Leadon House, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, GL1 3NN, UK
    Analyst 135:3038-41. 2010
    ..This technique could facilitate improved targeting of excisional biopsy with associated clinical benefits...
  17. doi request reprint The potential for histological screening using a combination of rapid Raman mapping and principal component analysis
    Joanne Hutchings
    Biophotonics Research Group, Gloucester Royal Hospital, Great Western Road, Gloucester, UK
    J Biophotonics 2:91-103. 2009
    ..This demonstrates that low signal to noise spectral maps are sufficient for the identification of histologically relevant biochemistry using principal component analysis as long as the spectral dataset is large enough...
  18. doi request reprint Vibrational spectroscopy: a clinical tool for cancer diagnostics
    Catherine Kendall
    Biophotonics Research Unit, Leadon House, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK GL1 3NN
    Analyst 134:1029-45. 2009
    ..Clinical requirements are increasingly met by technological developments which show promise to become a clinical reality. This review summarises recent advances in vibrational spectroscopy and their impact on the diagnosis of cancer...
  19. doi request reprint Towards a safe non-invasive method for evaluating the carbonate substitution levels of hydroxyapatite (HAP) in micro-calcifications found in breast tissue
    Marleen M Kerssens
    Biophotonics Research Unit, Gloucestershire Royal Hospital, Great Western Road, Gloucester, Gloucestershire GL1 3NN, UK
    Analyst 135:3156-61. 2010
    ..whether benign or invasive or in situ carcinoma, the new findings provide a major step forward towards establishing a new capability for diagnosing benign and malignant lesions in breast tissue in a safe and non-invasive manner in vivo...
  20. doi request reprint Discrimination between benign, primary and secondary malignancies in lymph nodes from the head and neck utilising Raman spectroscopy and multivariate analysis
    Gavin Rhys Lloyd
    Biophotonics Research Group, Gloucestershire Royal Hospital, Great Western Road, Gloucester, GL1 3NN, UK
    Analyst 138:3900-8. 2013
    ..RS measures the presence of biomolecules by the inelastic scattering of light within cells and tissues. This can be performed in vivo in real-time...
  21. doi request reprint Raman spectroscopy--a new method for the intra-operative assessment of axillary lymph nodes
    Jonathan Horsnell
    Department of Biophotonics Research, Gloucestershire Hospitals NHS Foundation Trust, Gloucester Royal Hospital, Leadon House, Gloucester, Glos, UK GL1 3NN
    Analyst 135:3042-7. 2010
    ..Leave one node out cross validation achieved a sensitivity of up to 92% and a specificity of up to 100% in differentiating between normal and metastatic lymph nodes...
  22. ncbi request reprint Endoscopic screening and surveillance for Barrett's esophagus--clinical implications
    Hugh Barr
    Cranfield Postgraduate Medical School in Gloucestershire, Gloucestershire Royal Hospital, Gloucester, United Kingdom
    MedGenMed 8:66. 2006
    ..The detection of dysplasia requires increased surveillance and usually intervention either endoscopically or with surgery...
  23. doi request reprint Evaluation of linear discriminant analysis for automated Raman histological mapping of esophageal high-grade dysplasia
    Joanne Hutchings
    Gloucestershire Hospitals NHS Foundation Trust, Gloucester, Gloucestershire, GL1 3NN, UK
    J Biomed Opt 15:066015. 2010
    ....
  24. ncbi request reprint Exploiting the diagnostic potential of biomolecular fingerprinting with vibrational spectroscopy
    Catherine Kendall
    Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Leadon House, Great Western Road, Gloucester, UK
    Faraday Discuss 149:279-90; discussion 333-56. 2011
    ..Technological developments are bringing the technologies closer to the clinical reality of spectral pathology and high-throughput non-destructive measurement with high resolution...
  25. doi request reprint FTIR of touch imprint cytology: a novel tissue diagnostic technique
    Kaustuv Das
    Biophotonics Research Group, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester GL1 3NN, UK
    J Photochem Photobiol B 92:160-4. 2008
    ..There is potential for the application of the technique in sentinel lymph node biopsy diagnosis and tumour margin evaluation...
  26. ncbi request reprint Raman spectroscopy for identification of epithelial cancers
    Nicholas Stone
    Optical Diagnostics Group, Cranfield Postgraduate Medical School, Gloucestershire Royal Hospital, Great Western Road, Gloucester, UK
    Faraday Discuss 126:141-57; discussion 169-83. 2004
    ..However larger sample numbers are required for further evaluation. The discussions outline the likely work required for successful implementation of in vivo Raman detection of early malignancies...
  27. doi request reprint Correlation mapping: rapid method for identification of histological features and pathological classification in mid infrared spectroscopic images of lymph nodes
    Martin Isabelle
    Cranfield Health, Gloucestershire Hospitals NHS Foundation Trust, Biophotonics Research Group, Gloucester, GL1 3NN United Kingdom
    J Biomed Opt 15:026030. 2010
    ....
  28. ncbi request reprint Raman spectroscopy of parathyroid tissue pathology
    Kaustuv Das
    Department of Breast and Endocrine Surgery, Gloucestershire Royal Hospital, Great Western Road, Gloucester, GL1 3NN, UK
    Lasers Med Sci 21:192-7. 2006
    ..Detection sensitivity for parathyroid adenomas was 95% and hyperplasia was 93%. These preliminary results indicate that Raman spectroscopy is potentially an excellent tool to differentiate between parathyroid adenomas and hyperplasia...
  29. doi request reprint Fourier transform infrared spectroscopic studies of T-cell lymphoma, B-cell lymphoid and myeloid leukaemia cell lines
    Jaspreet Babrah
    Biophotonics Research Group, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, UK GL1 3NN
    Analyst 134:763-8. 2009
    ..In conclusion, this paper demonstrates a potential for this technique to be used in developing a clinical tool for the detection and identification of haematological malignancies...
  30. doi request reprint Current practice in management of high-grade dysplasia in Barrett's oesophagus: the real problem
    Hugh Barr
    Biophotonics Research Unit, Cranfield Health, Gloucestershire Hospitals Foundation Trust, Great Western Road, Gloucester GL1 3NN, United Kingdom
    Photodiagnosis Photodyn Ther 5:38-41. 2008
    ..The current practice is variable and there is a requirement for randomised evidence comparing endoscopic therapy with surgical excision. This is becoming more appropriate with the development of minimally invasive oesophagectomy...
  31. ncbi request reprint Photodynamic therapy for esophageal cancer: a useful and realistic option
    Hugh Barr
    Cranfield Postgraduate Medical School, Gloucestershire Royal Hospital, Great Western Road, Gloucester, GL1 3NN, UK
    Technol Cancer Res Treat 2:65-76. 2003
    ..Photodynamic therapy is particularly useful for the eradication of field cancerous change in patients with pre-malignant Barrett's esophagus, or early tumors in patients unfit for radical therapy...
  32. doi request reprint Surface enhanced Raman scattering of herpes simplex virus in tear film
    Janelle Maria Reyes-Goddard
    Medical Physics Department, Gloucestershire Royal Hospital, Great Western Road, Gloucester, GL1 3NN, United Kingdom
    Photodiagnosis Photodyn Ther 5:42-9. 2008
    ..5+/-5.9% and 78.3+/-6.2% respectively. The results show proof of principle that SERS could potentially be used to detect the presence of herpes simplex viral particles in an aqueous solution such as the tear film...
  33. ncbi request reprint Drop coating deposition Raman spectroscopy of protein mixtures
    Jacob Filik
    Biophotonics Research, Gloucester Royal Hospital, Great Western Road, Gloucester, UK
    Analyst 132:544-50. 2007
    ..The results of this study suggest that DCDR spectroscopy could be a simple, fast, near-patient technique capable of assisting the diagnosis of ocular infection...
  34. ncbi request reprint Prospects of Deep Raman Spectroscopy for Noninvasive Detection of Conjugated Surface Enhanced Resonance Raman Scattering Nanoparticles Buried within 25 mm of Mammalian Tissue
    Nicholas Stone
    Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, GL1 3NN, Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, and Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Oxfordshire, OX11 0QX
    Anal Chem 82:3969-73. 2010
    ..This permits noninvasive measurement of Raman signatures from conjugated SERRS nanoparticles at clinically relevant concentrations through tissues of between 15 and 25 mm thick...
  35. ncbi request reprint Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy
    Pavel Matousek
    Council for the Central Laboratory of the Research Councils, Rutherford Appleton Laboratory, Central Laser Facility, Oxfordshire OX11 0QX, United Kingdom
    J Biomed Opt 12:024008. 2007
    ....
  36. ncbi request reprint Semi-parametric estimation in the compositional modeling of multicomponent systems from Raman spectroscopic data
    Michael G Sowa
    Institute for Biodiagnostics, National Research Council Canada, 435 Ellice Avenue, Winnipeg, Manitoba R3B 1Y6, Canada
    Appl Spectrosc 60:877-83. 2006
    ..Constituent concentrations estimated with such partial linear models should outperform strict parametric linear models when the user has limited information on the composition of a multi-constituent system...