Association of antipsychotics with mortality among elderly patients with dementiaSudeep S Gill
Am J Geriatr Psychiatry 15:983-4; author reply 984-5. 2007
- The value of positron emission tomography in the clinical evaluation of dementia
Sudeep S Gill
Kunin Lunenfeld Applied Research Unit, Baycrest Center for Geriatric Care, Toronto, Canada
J Am Geriatr Soc 51:258-64. 2003
..In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. Suggestions for future research in this area are offered...
Cholinesterase inhibitors and adverse pulmonary events in older people with chronic obstructive pulmonary disease and concomitant dementia: a population-based, cohort studyAnne Stephenson
Women s College Research Institute, Women s College Hospital, Toronto, ON, Canada
Drugs Aging 29:213-23. 2012
..Cholinesterase inhibitors (ChEIs) are a mainstay treatment for individuals with dementia. ChEIs may worsen airflow obstruction because of their pro-cholinergic properties...
- Antipsychotic drugs and the risk of hyperglycemia in older adults without diabetes: a population-based observational study
Lorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 19:1026-33. 2011
..To determine whether current antipsychotic use among older persons without diabetes is associated with a higher risk of hospital visits for hyperglycemia, as previous studies in this population have yielded conflicting results...
- Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study
Sudeep S Gill
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Arch Intern Med 169:867-73. 2009
..These drugs can provoke symptomatic bradycardia and syncope, which may lead to permanent pacemaker insertion. Drug-induced syncope may also precipitate fall-related injuries, including hip fracture...
- A population-based study of cholinesterase inhibitor use for dementia
Nathan Herrmann
Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
J Am Geriatr Soc 55:1517-23. 2007
....
- Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study
Janine R Hutson
Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Drugs Aging 29:205-11. 2012
..Donepezil is metabolized by the cytochrome P450 isozyme 3A4 (CYP3A4). Clarithromycin is a potent inhibitor of CYP3A4, and patients taking both of these drugs may be at increased risk of cardiac adverse events...
- Effects of cholinesterase inhibitors on postoperative outcomes of older adults with dementia undergoing hip fracture surgery
Dallas P Seitz
Kunin Lunenfeld Applied Research Unit, Baycrest Center, Toronto, Ontario, Canada
Am J Geriatr Psychiatry 19:803-13. 2011
..We evaluated the effects of ChEIs on the postoperative outcomes of older adults who underwent hip fracture surgery...
- New thyroxine treatment in older adults beginning lithium therapy: implications for clinical practice
Kenneth I Shulman
Dept of Psychiatry and the Institute for Clinical Evaluative Sciences, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
Am J Geriatr Psychiatry 13:299-304. 2005
....
- Antipsychotic drugs and hyperglycemia in older patients with diabetes
Lorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Arch Intern Med 169:1282-9. 2009
..Evidence suggests that there is an association between antipsychotic drugs and new-onset diabetes, but little is known about the risk of hyperglycemia among persons with preexisting diabetes...
Initiation of benzodiazepines in the elderly after hospitalizationChaim M Bell
Department of Medicine, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
J Gen Intern Med 22:1024-9. 2007
..To estimate the rate of new chronic benzodiazepine use after hospitalization in older adults not previously prescribed with benzodiazepines...
- Exploring variation in rates of polypharmacy across long term care homes
Susan E Bronskill
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
J Am Med Dir Assoc 13:309.e15-21. 2012
..We quantified the scope of this practice by exploring variation in the use of nine or more drug therapies across LTC homes...
- Association between tamsulosin and serious ophthalmic adverse events in older men following cataract surgery
Chaim M Bell
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
JAMA 301:1991-6. 2009
..No studies have documented whether use of tamsulosin or other alpha-blocker drug therapies affect the risk of serious postoperative adverse events...
- Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study
Anne Stephenson
Department of Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
Arch Intern Med 171:914-20. 2011
..The systemic anticholinergic effects of IAC therapy have not been extensively studied. This study sought to determine the risk of acute urinary retention (AUR) in seniors with COPD using IACs...
- Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study
Sudeep S Gill
Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada
BMJ 330:445. 2005
..To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics...
- Nursing home profit status and quality of care: is there any evidence of an association?
Michael P Hillmer
University of Toronto, Toronto, Ontario, Canada
Med Care Res Rev 62:139-66. 2005
..For-profit nursing homes appear to provide lower quality of care in many important areas of process and outcome...
- Representation of patients with dementia in clinical trials of donepezil
Sudeep S Gill
Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario
Can J Clin Pharmacol 11:e274-85. 2004
..To evaluate the representation of frail older adults in randomized controlled trials (RCTs), and to assess consequences of under representation by analyzing drug discontinuation rates...
- Haunted manuscripts: ghost authorship in the medical literature
Stephanie Ngai
Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada
Account Res 12:103-14. 2005
..Other approaches have been taken by the United Kingdom and Denmark. A solution is necessary, as the relationship between authorship and accountability must be maintained...
- Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review
Philip E Lee
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1
BMJ 329:75. 2004
..To review the role of oral atypical antipsychotic drugs in the management of the behavioural and psychological symptoms of dementia (BPSD)...
- Management of overactive bladder
Sudeep S Gill
N Engl J Med 350:2213. 2004
- A prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs
Sudeep S Gill
Institute for Clinical Evaluative Sciences, Toronto, Ontario
Arch Intern Med 165:808-13. 2005
..We present a new example of the prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs used to manage urinary incontinence...
- Antipsychotic therapy and short-term serious events in older adults with dementia
Paula A Rochon
Department of Medicine, University of Toronto, Canada
Arch Intern Med 168:1090-6. 2008
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- Delusions and hallucinations in Alzheimer disease
Sudeep S Gill
Arch Neurol 63:627; author reply 627. 2006
- Atypical antipsychotic drugs, dementia, and risk of death
Sudeep S Gill
JAMA 295:495-6; author reply 496-7. 2006
- Antipsychotic medications and drug-induced movement disorders other than parkinsonism: a population-based cohort study in older adults
Philip E Lee
Division of Geriatric Medicine, Providence Health Care, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
J Am Geriatr Soc 53:1374-9. 2005
..To study the relationship between initiating therapy with an antipsychotic medication and a subsequent new diagnosis of a drug-induced movement disorder other than parkinsonism in older adults with dementia...
- Antipsychotic drug use and mortality in older adults with dementia
Sudeep S Gill
Queen s University, Kingston, Ontario, Canada
Ann Intern Med 146:775-86. 2007
..Antipsychotic drugs are widely used to manage behavioral and psychological symptoms in dementia despite concerns about their safety...
