Organochlorine pollutants [corrected] in California sea lions revisitedBurney J Le Boeuf
Department of Biology and Institute of Marine Sciences, University of California, Santa Cruz, CA 95064, USA
BMC Ecol 2:11. 2002
..Top trophic level predators, like sea birds and marine mammals, bioaccumulate these lipophilic compounds, reflecting their presence in the environment...
- Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans
Jeremy N Moore
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Arch Environ Contam Toxicol 57:416-25. 2009
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Cell bioassays for detection of aryl hydrocarbon (AhR) and estrogen receptor (ER) mediated activity in environmental samplesJ P Giesy
Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Mar Pollut Bull 45:3-16. 2002
..The bioassay approach is an efficient (fast and cost effective) screening system to identify the samples of interest and to provide basic information for further analysis and risk evaluation...
- Examination of reproductive endpoints in goldfish (Carassius auratus) exposed in situ to municipal sewage treatment plant effluent discharges in Michigan, USA
John P Giesy
Department of Zoology, National Food Safety and Toxicology Center, Institute of Environmental Toxicology, East Lansing, Michigan, USA
Environ Toxicol Chem 22:2416-31. 2003
..The results indicate that the risk for estrogen agonist exposure below these mid-Michigan WWTPs is small...
- Global distribution of perfluorooctane sulfonate in wildlife
J P Giesy
Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Sci Technol 35:1339-42. 2001
..Currently available data indicate that the concentrations of PFOS in wildlife are less than those required to cause adverse effects in laboratory animals...
- Effects of nonylphenol ethoxylate exposure on reproductive output and bioindicators of environmental estrogen exposure in fathead minnows Pimephales promelas
K M Nichols
Department of Fisheries and Wildlife, Michigan State University, East Lansing 48824, USA
Environ Toxicol Chem 20:510-22. 2001
..Similarly, plasma T concentrations did not exhibit a concentration-dependent response to NPEOs...
- Polychlorinated naphthalenes, -biphenyls, -dibenzo-p-dioxins, and -dibenzofurans in double-crested cormorants and herring gulls from Michigan waters of the Great Lakes
K Kannan
National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 35:441-7. 2001
..PCB congener 126 (3,3',4,4',5-PeCB) accounted for 57-72% of the total TEQs in double-crested cormorant and herring gull eggs...
- Identification and quantitation method for nonylphenol and lower oligomer nonylphenol ethoxylates in fish tissues
S A Snyder
Department of Zoology and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Toxicol Chem 20:1870-3. 2001
..Nonylphenol ethoxylates were not detected in the carp collected at Lake Mead...
- Identification and quantitation of nonylphenol ethoxylates and nonylphenol in fish tissues from Michigan
T L Keith
Department of Zoology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824-1311, USA
Environ Sci Technol 35:10-3. 2001
..NPE1 was detectable in some samples but at concentrations less than the method detection limit (16.8 ng/g). Concentrations of NPE2 and NPE3 in all samples were less than their respective MDLs of 18.2 and 20.6 ng/g...
- Organochlorine insecticides, polychlorinated biphenyls, and metals in water, sediment, and green frogs from southwestern Michigan
C D Gillilland
Department of Zoology and National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA
Chemosphere 44:327-39. 2001
..Significance of study. This study provides information on the incidence of deformities in green frog populations in southwestern Michigan and offers background data on chemical residues in green frogs and their environment...
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents in tissue samples from three species in the Denver, Colorado, USA, metropolitan area
K K Coady
Department of Zoology, National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Toxicol Chem 20:2433-42. 2001
....
- Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF7) cell line
V J Kramer
Pesticide Research Center and Department of Fisheries and Wildlife, Institute of Environmental Toxicology, Michigan State University, East Lansing 48824 1222, USA
Toxicol Appl Pharmacol 144:363-76. 1997
..0009 nM E2 and weak anti-estrogenicity in the presence of 0.1 and 1 nM E2. Human metabolites of PCBs were not estrogenic in MCF7 cells...
- In vitro response of fish and mammalian cells to complex mixtures of polychlorinated naphthalenes, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons
D L Villeneuve
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, 218 C, East Lansing, MI 48824, USA
Aquat Toxicol 54:125-41. 2001
....
- Interaction of tributyltin with 3,3',4,4',5-pentachlorobiphenyl-induced ethoxyresorufin O-deethylase activity in rat hepatoma cells
K Kannan
National Food Safety and Toxicology Center, Department of Zoology, Michigan State University, East Lansing 48824, USA
J Toxicol Environ Health A 55:373-84. 1998
..Potentiation of EROD activity and cytotoxicity as a consequence of coexposure to PCB-126 and TBT is of considerable toxicological significance, given their coaccumulation in a variety of marine organisms...
- Effects of waterborne exposure to 4-nonylphenol on plasma sex steroid and vitellogenin concentrations in sexually mature male carp (Cyprinus carpio)
D L Villeneuve
Department of Zoology, Michigan State University, East Lansing 48824, USA
Chemosphere 47:15-28. 2002
..Furthermore, they provide information regarding the concentrations and variability of E2, T, and VTG in the plasma of sexually mature male carp, which may aid in design and interpretation of future studies...
- Bioconcentration of nonylphenol in fathead minnows (Pimephales promelas)
S A Snyder
Department of Zoology, Institute of Environmental Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824 1311, USA
Chemosphere 44:1697-702. 2001
..Mass spectrometry was used for verification of peak assignments. Bioconcentration factors (BCFs) ranged from 245 to 380...
- Accumulation of perfluorooctane sulfonate in marine mammals
K Kannan
National Food Safety and Toxicology Center, Department of Zoology, Institute of Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 35:1593-8. 2001
..The occurrence of PFOS in marine mammals from the Arctic waters suggests widespread global distribution of PFOS including remote locations...
- Polychlorinated naphthalenes, biphenyls, dibenzo-p-dioxins, and dibenzofurans as well as polycyclic aromatic hydrocarbons and alkylphenols in sediment from the Detroit and Rouge Rivers, Michigan, USA
K Kannan
National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA
Environ Toxicol Chem 20:1878-89. 2001
..Analysis of data from selected locations suggested that PCNs contributed a greater proportion of the dioxin-like activity than PCBs and PCDDs/PCDFs contributed...
- Perfluorooctane sulfonate in fish-eating water birds including bald eagles and albatrosses
K Kannan
Department of Zoology, Institute of Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Sci Technol 35:3065-70. 2001
..Occurrence of PFOS in birds from remote marine locations suggests widespread distribution of PFOS and related fluorochemicals in the environment...
- Accumulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin by rainbow trout (Onchorhynchus mykiss) at environmentally relevant dietary concentrations
P D Jones
National Food Safety and Toxicology Center, Institute of Environmental Toxicology and Department of Zoology, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 20:344-50. 2001
..This model will allow more refined risk assessments by predicting TCDD concentrations in sensitive tissues such as developing eggs...
- Nonylphenol and nonylphenol ethoxylates in fish, sediment, and water from the Kalamazoo River, Michigan
K Kannan
Department of Zoology, 213 National Food Safety and Toxicology Center, and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Arch Environ Contam Toxicol 44:77-82. 2003
..4 ng NP/g wet weight, just above the detection limit of 3.3 ng/g. Three of 36 sediments and 1 of 24 water samples contained detectable concentrations of NP or NPE(1). NPE(2), NPE(3), and NPEC were not detected in water samples...
- Morphological effects of Bisphenol-A on the early life stages of medaka (Oryzias latipes)
S D Pastva
Department of Fisheries and Wildlife, Institute of Environmental Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA
Chemosphere 45:535-41. 2001
..By day 9, SI scores were not statistically different among treatments. BPA caused transient embryonic deformities in medaka at environmentally relevant concentrations...
- Identification and quantification of estrogen receptor agonists in wastewater effluents
S A Snyder
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824 1311, USA
Environ Sci Technol 35:3620-5. 2001
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- Perfluorooctane sulfonate in oysters, Crassostrea virginica, from the Gulf of Mexico and the Chesapeake Bay, USA
K Kannan
National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Arch Environ Contam Toxicol 42:313-8. 2002
..This study provides baseline data for future monitoring programs to examine long-term trends in concentrations of PFOS...
- Hematology and serum chemistries of nestling bald eagles (Haliaeetus leucocephalus) in the lower peninsula of MI, USA
W W Bowerman
Department of Fisheries and Wildlife, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824 1222, USA
Chemosphere 41:1575-9. 2000
..We caution that arrangements for rapid analysis be done in advance of sample collection...
- Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens
A L Blankenship
National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, East Lansing, MI, USA
Comp Biochem Physiol C Toxicol Pharmacol 136:47-62. 2003
....
- Global biomonitoring of perfluorinated organics
J P Giesy
National Food Safety and Toxicology Center, Department of Zoology, Michigan State University, East Lansing 48824, USA
ScientificWorldJournal 1:627-9. 2001
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- Specific binding of hydroxylated polychlorinated biphenyl metabolites and other substances to bovine calf uterine estrogen receptor: structure-binding relationships
V J Kramer
Fisheries and Wildlife Department, Michigan State University, East Lansing, USA
Sci Total Environ 233:141-61. 1999
..The QSBR model predicted the ER binding log (IC50) to within one log unit...
- Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole
L A Verbrugge
Department of Fisheries and Wildlife, Pesticide Research Center and Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824-1222, USA
Comp Biochem Physiol C Toxicol Pharmacol 130:67-83. 2001
..Variations in responses among avian species indicate that CYP1A proteins and substrate specificities should be characterized for each species used in PHAH biomonitoring programs...
- Environmental fate and bioavailability of Agent Orange and its associated dioxin during the Vietnam War
Alvin L Young
Institute for Science and Public Policy, The University of Oklahoma, Norman, Oklahoma, USA
Environ Sci Pollut Res Int 11:359-70. 2004
..This paper is intended to help investigators understand better the fate and transport of herbicides and TCDD from spray missions, particularly in performing epidemiological studies...
- Effects of bisphenol A on energy balance and accumulation in brown adipose tissue in rats
A A Nunez
Department of Psychology, Michigan State University, East Lansing 48824 1117, USA
Chemosphere 42:917-22. 2001
..There was a preferential concentration of BPA in brown adipose tissue. These results indicate that BPA can affect energy balance and that brown adipose tissue may be a primary tissue into which BPA accumulates in mammals...
- Relative potencies of individual polycyclic aromatic hydrocarbons to induce dioxinlike and estrogenic responses in three cell lines
D L Villeneuve
Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol 17:128-37. 2002
..Overall, this research contributes to the growing consensus regarding the dioxinlike potency of priority PAHs and PAH derivatives and provides some additional evidence about potentially estrogenic PAHs...
- Laboratory analyses of the potential toxicity of sediment-associated polydimethylsiloxane to benthic macroinvertebrates
K S Henry
Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Toxicol Chem 20:2611-6. 2001
..tentans only, emergence. Short-term and life-cycle exposures to concentrations of > or = 1,000 mg PDMS/kg sediment (dry wt) indicated that PDMS will not reduce survival, growth, or reproduction in H. azteca or C. tentans...
- Plasma sex steroid concentrations and gonadal aromatase activities in African clawed frogs (Xenopus laevis) from South Africa
Markus Hecker
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 23:1996-2007. 2004
..Although exposure to agricultural inputs did not affect aromatase activities, effects of atrazine or coapplied pesticides on sex steroid homeostasis cannot be excluded at this point...
- Reproductive responses of common carp (Cyprinus carpio) exposed in cages to influent of the Las Vegas Wash in Lake Mead, Nevada, from late winter to early spring
Erin M Snyder
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 38:6385-95. 2004
..Few differences among fish caged at different sites were potentially attributable to exposure to contaminants..
Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assayTannia Gracia
Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
Environ Sci Pollut Res Int 15:332-43. 2008
..After exposing H295R cells to extracts of water, the expression of four steroidogenic genes and the production of three steroid hormones were measured...
- In situ hybridization to detect spatial gene expression in medaka
A R Tompsett
Department of Zoology, Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA
Ecotoxicol Environ Saf 72:1257-64. 2009
..The ISH method developed in this study allowed tissue-specific resolution of gene expression in a whole animal model, as well as the ability to analyze cellular morphological detail in the same organism...
- Tree swallow (Tachycineta bicolor) exposure to polychlorinated biphenyls at the Kalamazoo River superfund site, Michigan, USA
Arianne M Neigh
Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 25:428-37. 2006
..Hazard quotients calculated from literature-derived toxicity reference values were below 1.0 at both the target and the reference site based on the no-observed-adverse-effect level and the lowest-observed-adverse-effect level...
- Comparison of risk assessment methodologies for exposure of mink to PCBs on the Kalamazoo River, Michigan
Stephanie D Millsap
Department of Fisheries and Wildlife, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 38:6451-9. 2004
..37 to 0.87 at KRAOC and 0.31-0.73 at FC. HQs based on PCBs in the diet ranged from 0.20 to 1.8 at KRAOC and from 0.04 to 0.35 at FC. Dietary HQs were less than 10-fold different than tissue-based HQs...
- Exposure and effects assessment of resident mink (Mustela vison) exposed to polychlorinated dibenzofurans and other dioxin-like compounds in the Tittabawassee River basin, Midland, Michigan, USA
Matthew J Zwiernik
Department of Zoology, National Food Safety and Toxicology Center, 224 National Food Safety and Toxicology Building, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 27:2076-87. 2008
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- Effects of atrazine on metamorphosis, growth, laryngeal and gonadal development, aromatase activity, and sex steroid concentrations in Xenopus laevis
Katherine K Coady
Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, E Lansing, MI 48824, USA
Ecotoxicol Environ Saf 62:160-73. 2005
..E2-exposed female frogs had decreased gonadal aromatase activity, and E2-exposed male frogs had statistically greater plasma concentrations of E2 compared to controls...
- Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17 beta or alpha-zearalenol
T Celius
National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824 1319, USA
J Steroid Biochem Mol Biol 75:109-19. 2000
..ZR was more responsive to low levels of E(2) and alpha-ZEA than VTG, and real-time PCR was shown to be more sensitive than the ELISA. Rainbow trout ZR-gene and proteins provide a sensitive biomarker for assessing estrogenic activity...
- Effects of atrazine on CYP19 gene expression and aromatase activity in testes and on plasma sex steroid concentrations of male African clawed frogs (Xenopus laevis)
Markus Hecker
Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Toxicol Sci 86:273-80. 2005
..laevis from all treatments, and that the tested concentrations of atrazine did not interfere with steroidogenesis through an aromatase-mediated mechanism of action...
- Passerine exposure to primarily PCDFs and PCDDs in the river floodplains near Midland, Michigan, USA
Timothy B Fredricks
Department of Zoology, Michigan State University, East Lansing, MI 48824, USA
Arch Environ Contam Toxicol 58:1048-64. 2010
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- Reproductive success of passerines exposed to polychlorinated biphenyls through the terrestrial food web of the Kalamazoo River
Arianne M Neigh
Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Ecotoxicol Environ Saf 66:107-18. 2007
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- Plasma concentrations of estradiol and testosterone, gonadal aromatase activity and ultrastructure of the testis in Xenopus laevis exposed to estradiol or atrazine
Markus Hecker
Department of Zoology, Aquatic Toxicology Laboratory, 218C National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
Aquat Toxicol 72:383-96. 2005
..These results indicate that atrazine does not cause responses that are similar to those caused by exposure to E2...
- Terminology of gonadal anomalies in fish and amphibians resulting from chemical exposures
Markus Hecker
Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824-1222, USA
Rev Environ Contam Toxicol 187:103-31. 2006
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- Perfluorochemical surfactants in the environment
John P Giesy
National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Sci Technol 36:146A-152A. 2002
- The H295R system for evaluation of endocrine-disrupting effects
Tannia Gracia
Department of Zoology, 218C National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824 1311, USA
Ecotoxicol Environ Saf 65:293-305. 2006
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- In vitro assessment of potential mechanism-specific effects of polybrominated diphenyl ethers
Daniel L Villeneuve
National Food Safety and Toxicology Center, Department of Zoology and Institute for Environmental Toxicology, Michigan State University, East Lansing 48824 1311, USA
Environ Toxicol Chem 21:2431-3. 2002
..Overall, the PBDEs tested were found to be at least 200,000 times less potent than TCDD and 50,000 times less potent than E2 for inducing AhR- and ER-mediated gene expression, respectively...
- Risk assessment methodologies for exposure of great horned owls (Bubo virginianus) to PCBs on the Kalamazoo River, Michigan
Karl D Strause
Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Integr Environ Assess Manag 4:24-40. 2008
..This evaluation indicated that a multiple-lines-of-evidence approach provided the best estimate of risk...
- Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds
Tannia Gracia
Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
Toxicol Appl Pharmacol 225:142-53. 2007
..Dose-response results indicated that although two chemicals may share a common mechanism of action the concentration effects observed may be significantly different...
- Polychlorinated dibenzo-p-dioxin and dibenzofuran concentration profiles in sediments and flood-plain soils of the Tittabawassee River, Michigan
Klara Hilscherova
National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 37:468-74. 2003
..A significant correlation existed between bioassay-derived TCDD-EQs and instrumentally measured TEQs (r2 = 0.94)...
- Risk assessment of great horned owls (Bubo virginianus) exposed to polychlorinated biphenyls and DDT along the Kalamazoo River, Michigan, USA
Karl D Strause
Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48823, USA
Environ Toxicol Chem 26:1386-98. 2007
..0, except at the LKRSS (PCB HQ = 3.1; TEQ(WHO-Avian) HQ = 1.3). Productivity and relative abundance measures indicated no population level effects in the UKRSS...
- Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production
Markus Hecker
Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
Toxicol Appl Pharmacol 217:114-24. 2006
..Based on these results, the H295R in vitro system has potential for high throughput screening to not only characterize the effects of chemicals on endocrine systems but also to prioritize chemicals for additional testing...
- Distribution of PCDDs and PCDFs in soils collected from the Denver Front Range--principal components analysis of diffuse dioxin sources
Paul D Jones
Zoology Department, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
Environ Sci Pollut Res Int 12:189-98. 2005
....
- Effects of chronic dietary exposure to environmentally relevant concentrations to 2,3,7,8-tetrachlorodibenzo-p-dioxin on survival, growth, reproduction and biochemical responses of female rainbow trout (Oncorhynchus mykiss)
John P Giesy
Department of Zoology, Michigan State University, East Lansing, MI 48824, USA
Aquat Toxicol 59:35-53. 2002
..This suggests that direct adult toxicity as well as reproductive endpoints need to be incorporated in the current risk assessment paradigm for these compounds...
- Squamous epithelial lesion of the mandibles and maxillae of wild mink (Mustela vison) naturally exposed to polychlorinated biphenyls
Kerrie J Beckett
Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 24:674-7. 2005
..Significant correlations were found between the severity of the lesion and the hepatic concentrations of total PCBs and TEQs. To our knowledge, this is the first published report of the lesion occurring in wild mink...
- Receptor-mediated in vitro bioassay for characterization of Ah-R-active compounds and activities in sediment from Korea
Hoon Yoo
National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, 218C, Aquatic Toxicology, NSFTC, East Lansing, MI 48824, USA
Chemosphere 62:1261-71. 2006
..Acid-treatment of REs samples improved quantitative biological responses of samples followed by decreases in cytotoxicity identified by MTT cell viability assays...
- Productivity of tree swallows (Tachycineta bicolor) exposed to PCBs at the Kalamazoo River superfund site
Arianne M Neigh
Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
J Toxicol Environ Health A 69:395-415. 2006
....
- Induction of cytochrome P4501A in African brown house snake (Lamprophis fuliginosus) primary hepatocytes
Markus Hecker
Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 25:496-502. 2006
..The test system offers a method for rapid screening of reptilian responsiveness to these compounds using smaller numbers of organisms than with in vivo studies, an important consideration for many declining reptile species...
- Accumulation of polychlorinated biphenyls from floodplain soils by passerine birds
Arianne M Neigh
Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 25:1503-11. 2006
..Despite the greater accumulation of PCBs at the more contaminated location, the risk of exposure to PCBs did not exceed the threshold for adverse effects at either location...
- Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine-disrupting compounds
June Woo Park
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 28:1951-62. 2009
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- Chronic effects of polychlorinated dibenzofurans on mink in laboratory and field environments
Matthew J Zwiernik
Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
Integr Environ Assess Manag 5:291-301. 2009
..Therefore, hazard cannot be accurately predicted by making comparisons to toxicity reference values derived from exposure studies conducted with PCBs or PCDDs in situations where mink are exposed to TEQ mixtures dominated by PCDFs...
- Nondestructive scat sampling in assessment of mink (Mustela vison) exposed to polychlorinated dibenzofurans (PCDFs)
Matthew J Zwiernik
Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Arch Environ Contam Toxicol 55:529-37. 2008
..Overall, concentrations of PCDFs in mink scat can be used as a rapid and inexpensive nondestructive method to predict concentrations of PCDFs in mink when certain assumptions are met...
- Binding of perfluorinated fatty acids to serum proteins
Paul D Jones
Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 22:2639-49. 2003
..Concentrations of PFOS required to saturate albumin would be in excess of 50 to 100 mg/L. Based on current environmental concentrations, it is unlikely that PFOS would cause displacement of hormones from serum proteins in wildlife...
- Alterations in cell membrane properties caused by perfluorinated compounds
Wen yue Hu
National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824, USA
Comp Biochem Physiol C Toxicol Pharmacol 135:77-88. 2003
..This suggests that PFOS effects membrane properties at concentrations below those associated with other adverse effects...
- Spatial and temporal trends of mercury loadings to Michigan inland lakes
Matthew J Parsons
Department of Geological Sciences, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 41:5634-40. 2007
..Local sources and pathways for mercury to inland lakes need to be more fully understood to effectively reduce Hg loading to the environment...
- Concentrations and profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans in soils from Korea
Sook Hyeon Im
National Food Safety and Toxicology Center, Department of Zoology, Michigan State University, East Lansing 48824, USA
Environ Sci Technol 36:3700-5. 2002
....
- Quantitative RT-PCR methods for evaluating toxicant-induced effects on steroidogenesis using the H295R cell line
Xiaowei Zhang
Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
Environ Sci Technol 39:2777-85. 2005
..Overall, our findings demonstrated that the present assay can facilitate the development of compound-specific response profiles, and will provide a sensitive and integrative screen for the effects of chemicals on steroidogenesis...
- Sources and distribution of polychlorinated dibenzo-p-dioxins and dibenzofurans in sediments from Masan Bay, Korea
Sook Hyeon Im
National Food Safety and Toxicology Center, Department of Zoology, Institute of Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Toxicol Chem 21:245-52. 2002
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- Polychlorinated-naphthalenes, -biphenyls, -dibenzo-p-dioxins, -dibenzofurans and p,p'-DDE in bluefin tuna, swordfish, cormorants and barn swallows from Italy
Kurunthachalam Kannan
National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824, USA
Ambio 31:207-11. 2002
..Relative contribution of PCDDs/DFs to TEQs was greater in cormorants and swallows compared to that in fishes. PCDD/DF congeners accounted for up to 80 and 45% of the total TEQs in cormorants and swallows, respectively...
- Perfluorooctanesulfonate and related fluorinated hydrocarbons in mink and river otters from the United States
Kurunthachalam Kannan
National Food Safety and Toxicology Center, Department of Zoology, Institute of Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Sci Technol 36:2566-71. 2002
..PFOS was detected in livers of all river otters collected from Washington and Oregon at concentrations ranging from 25 to 994 ng/g, wet wt...
- Effects of atrazine on fish, amphibians, and aquatic reptiles: a critical review
Keith R Solomon
Department of Environmental Biology and Centre for Toxicology, University of Guelph, Guelph, Ontario, Canada
Crit Rev Toxicol 38:721-72. 2008
..For other responses, such as immune function, stress endocrinology, parasitism, or population-level effects, there are no indications of effects or there is such a paucity of good data that definitive conclusions cannot be made...
- Nonylphenol isomers differ in estrogenic activity
Thomas G Preuss
Institute of Environmental Research, Aachen University, Germany
Environ Sci Technol 40:5147-53. 2006
..Among other applications, they should be used in the future to explain differences in estrogenic potency due to NPs as detected by various in vitro assays...
- Interference of contaminated sediment extracts and environmental pollutants with retinoid signaling
Jiri Novak
Research Centre for Environmental Chemistry and Ecotoxicology, Masaryk University, Kamenice 3, 625 00 Brno, Czech Republic
Environ Toxicol Chem 26:1591-9. 2007
..However, the effects of PAHs on the retinoic acid signaling pathways do not seem to be mediated directly by crosstalk with aryl hydrocarbon receptor...
- Comparison of fathead minnow ovary explant and H295R cell-based steroidogenesis assays for identifying endocrine-active chemicals
Daniel L Villeneuve
US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, 55804, USA
Ecotoxicol Environ Saf 68:20-32. 2007
..Overall, however, results of this study suggest that both the H295R and fathead minnow ovary explant assays have utility for identifying endocrine-active chemicals in screening-type applications...
- Concentrations of pentachlorophenol (PCP) in fish and shrimp in Jiangsu Province, China
Jiachun Ge
Freshwater Fishery Research Institute of Jiangsu Province, China, 79 Chating East Street, Nanjing 210017, China
Chemosphere 69:164-9. 2007
..Based on the allowable daily intake (ADI) set by the US National Academy of Science, current concentrations of PCP measured in aquatic products from Jiangsu Province presented minimus health risks to humans...
- Response of larval Xenopus laevis to atrazine: assessment of growth, metamorphosis, and gonadal and laryngeal morphology
James A Carr
Department of Biological Sciences, Texas Tech University, Lubbock, Texas 79409, USA
Environ Toxicol Chem 22:396-405. 2003
..laevis. The incidence of atrazine-induced intersex animals was small (<5%) and occurred only at the greatest concentration of atrazine tested, a concentration that is rarely observed in surface waters in the United States...
- Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography-mass spectrometry and fluorescence detection
Haruhiko Nakata
Graduate School of Science and Technology, Kumamoto University, 2 39 1 Kurokami, Kumamoto 860 8555, Japan
Chemosphere 58:759-66. 2005
..Monitoring studies of QAs in sewage from WWTPs and in sediment/soil near aquaculture facilities and livestock farms will be necessary for the evaluation of the environmental distribution and risk of these compounds...
- Distribution and elimination of polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls, and p,p'-DDE in tissues of bald eagles from the Upper Peninsula of Michigan
Kurunthachalam Senthil Kumar
Graduate School of Environment and Information Sciences, Yokohama National University, Japan
Environ Sci Technol 36:2789-96. 2002
..PCDDs and PCDFs collectively accounted for, on average, 17% of the total TEQs. On the basis of the analysis of a single gall bladder with bile, biliary excretion rates of PCDDs, PCDFs, and PCBs were estimated as 0.015-0.02% per day...
- Analysis of trace organic contaminants in sediment, pore water, and water samples from Onsan Bay, Korea: instrumental analysis and in vitro gene expression assay
Chul Hwan Koh
School of Earth and Environmental Sciences, College of Natural Sciences, Seoul National University, South Korea
Environ Toxicol Chem 21:1796-803. 2002
..The combination of instrumental analysis and in vitro bioassay was useful to assess sediment quality and characterize the causative agents or potential toxic compounds present...
- Measuring and monitoring persistent organic pollutants in the context of risk assessment
Rudolf S S Wu
Department of Biology and Chemistry, Research Centre for Coastal Pollution and Conservation, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong
Mar Pollut Bull 57:236-44. 2008
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- Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China
Man Ka So
Centre for Coastal Pollution and Conservation, Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, Peoples Republic of China
Environ Sci Technol 40:2924-9. 2006
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- Contribution of known endocrine disrupting substances to the estrogenic activity in Tama River water samples from Japan using instrumental analysis and in vitro reporter gene assay
Takuma Furuichi
Graduate School of Environment and Information Sciences, Yokohama National University, 79 7 Tokiwadai, Hodogaya ku, Yokohama 240 8501, Japan
Water Res 38:4491-501. 2004
..7-9) were 0.49-0.97 and 0.29-1.12, respectively. Above results indicated that the major causal substances to the estrogenic activity in the Tama River were E1 and E2...
- Perfluorinated compounds in aquatic organisms at various trophic levels in a Great Lakes food chain
Kurunthachalam Kannan
Wadsworth Center, New York State Department of Health and Department of Environmental Health and Toxicology, School of Public Health, State University of New York at Albany, Empire State Plaza, 12201 0509, USA
Arch Environ Contam Toxicol 48:559-66. 2005
..Eggs of fish contained notable concentrations of PFOS, suggesting oviparous transfer of this compound. PFOA was found in water, but its biomagnification potential was lower than that of PFOS...
- Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells
Robert J Letcher
National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada K1A 0H3
Toxicol Appl Pharmacol 209:95-104. 2005
..Environmental exposure of fish to BPA and related diphenylalkanes, depending on the structure, may pose anti-estrogenic, and to a lesser extent estrogenic, risks to development and reproduction...
- AhR-active compounds in sediments of the Haihe and Dagu Rivers, China
Maoyong Song
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, China
Chemosphere 63:1222-30. 2006
..The concentrations of TCDD-EQs, based on the EC20 and the relative potency ranges, of SCEs ranged from 330 to 930 and 1200 to 13,900 pg TCDD-EQ g(-1) dry wt in Haihe and Dagu Rivers, respectively...
- Characterization of trace organic contaminants in marine sediment from Yeongil Bay, Korea: 2. Dioxin-like and estrogenic activities
Chul-Hwan Koh
School of Earth and Environmental Sciences (Oceanography, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea
Environ Pollut 142:48-57. 2006
..As in previous studies of Korean coastal sediment, more polar fractions (F3) generated more modest responses both in terms of magnitude and the number of samples responding...
- Characterization of trace organic contaminants in marine sediment from Yeongil Bay, Korea: 1. Instrumental analyses
Chul-Hwan Koh
School of Earth and Environmental Sciences (Oceanography, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea
Environ Pollut 142:39-47. 2006
..Concentrations of PCBs and PAHs were great near shipyards and industrial complexes. Vertical profiles of PAHs and APs indicated that they have been associated with sediments since the 1950s...
- Instrumental and bioanalytical measures of dioxin-like and estrogenic compounds and activities associated with sediment from the Korean coast
Chul-Hwan Koh
School of Earth and Environmental Sciences (Oceanography, College of Natural Sciences, Seoul National University, Seoul 151-742, Republic of Korea
Ecotoxicol Environ Saf 61:366-79. 2005
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- Differential accumulation of polychlorinated biphenyl congeners in the aquatic food web at the Kalamazoo River Superfund site, Michigan
Denise P Kay
ENTRIX, Inc, 4295 Okemos Road, Suite 101, Okemos, Michigan 48864, USA
Environ Sci Technol 39:5964-74. 2005
..The relative potency of the mixture of PCBs, expressed as the ratio of TEQs to total PCBs, increased with trophic position in the avian and mammalian aquatic food webs located within the former Trowbridge impoundment...
- Differential accumulation of polychlorinated biphenyl congeners in the terrestrial food web of the Kalamazoo River Superfund site, Michigan
Alan L Blankenship
ENTRIX, Inc, 4295 Okemos Road, Suite 101, Okemos, Michigan 48864, USA
Environ Sci Technol 39:5954-63. 2005
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- Spatial and temporal distribution of polycyclic aromatic hydrocarbons in sediments from Michigan inland lakes
Kurunthachalam Kannan
Wadsworth Center, New York State Department of Health, Albany, New York, USA
Environ Sci Technol 39:4700-6. 2005
..A general increase in the proportion of high-molecular-weight PAHs suggests an increase in combustion-related sources recently...
- Assessment of potential exposure to Agent Orange and its associated TCDD
Alvin L Young
Environ Sci Pollut Res Int 11:347-8. 2004
- Measurement of estrogenic activity in sediments from Haihe and Dagu River, China
Maoyong Song
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing, 100085, China
Environ Int 32:676-81. 2006
..The estrogenic activity of these chemicals were E2>E1>NP>OP>BPA...
- Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects
Ludek Blaha
RECETOX Research Centre for Environmental Chemistry and Ecotoxicology, Masaryk University, Kamenice 3, CZ62500 Brno, Czech Republic
Environ Int 32:749-57. 2006
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- Determinations of dioxinlike activity in selected mollusks from the coast of the Bohai Sea, China, using the H4IIE-luc bioassay
Maoyong Song
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
Ecotoxicol Environ Saf 67:157-62. 2007
..33% of the extracts concentrations (0.83 microL extract well(-1)). All the dilutions of sample N1 were cytotoxic to the H4IIE cells...
- Polychlorinated naphthalenes and other dioxin-like compounds in Elbe River sediments
Werner Brack
UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
Environ Toxicol Chem 27:519-28. 2008
..The contribution of PCBs was less significant (maximum, 0.2%). Thus, in Elbe River sediments, PCNs should be considered as relevant contaminants and be included in future monitoring and risk assessment programs...
- Cytotoxicity and aryl hydrocarbon receptor-mediated activity of n-heterocyclic polycyclic aromatic hydrocarbons: structure-activity relationships
Iva Sovadinova
RECETOX Research Centre for Environmental Chemistry and Ecotoxicology, Masaryk University, Kamenice 126 3, CZ62500 Brno, Czech Republic
Environ Toxicol Chem 25:1291-7. 2006
..Comparable relative toxic potencies (induction equivalency factors) for individual aza-PAHs are derived, and their use for evaluation of complex contaminated samples is discussed...
- Quantitative structure-activity relationships for the prediction of relative in vitro potencies (REPs) for chloronaphthalenes
Tomasz Puzyn
Department of Environmental Chemistry and Ecotoxicology, University of Gdansk, Faculty of Chemistry, Gdansk, Poland
J Environ Sci Health A Tox Hazard Subst Environ Eng 42:573-90. 2007
..These findings are discussed relative to the use of consensus TCDD equivalency factors' (TEFs) for use in risk assessments of CNs for regulatory purposes...
