Greg Gibson

Summary

Publications

  1. pmc Geographical genomics of human leukocyte gene expression variation in southern Morocco
    Youssef Idaghdour
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    Nat Genet 42:62-7. 2010
  2. doi Decanalization and the origin of complex disease
    Greg Gibson
    School of Integrative Biology, Goddard Building, St Lucia Campus, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Rev Genet 10:134-40. 2009
  3. pmc Nucleotide variation in the Egfr locus of Drosophila melanogaster
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27513 7614, USA
    Genetics 167:1199-212. 2004
  4. pmc Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, 27695 7614, USA
    Genetics 169:2115-25. 2005
  5. pmc Genomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 181:1065-76. 2009
  6. pmc The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 187:1171-84. 2011
  7. pmc Genetic and nongenetic variation revealed for the principal components of human gene expression
    Anita Goldinger
    University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland 4102, Australia
    Genetics 195:1117-28. 2013
  8. pmc Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Genet 6:44. 2005
  9. pmc Detection and replication of epistasis influencing transcription in humans
    Gibran Hemani
    1 Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia 2 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4072, Australia
    Nature 508:249-53. 2014
  10. pmc Association of orthodenticle with natural variation for early embryonic patterning in Drosophila melanogaster
    Lisa M Goering
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    J Exp Zool B Mol Dev Evol 312:841-54. 2009

Collaborators

Detail Information

Publications47

  1. pmc Geographical genomics of human leukocyte gene expression variation in southern Morocco
    Youssef Idaghdour
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    Nat Genet 42:62-7. 2010
    ..No evidence of large-effect trans-acting mediators of the pervasive environmental influence was found; instead, genetic and environmental factors acted in a largely additive manner...
  2. doi Decanalization and the origin of complex disease
    Greg Gibson
    School of Integrative Biology, Goddard Building, St Lucia Campus, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Rev Genet 10:134-40. 2009
    ..The rapid evolution of the human genome combined with marked environmental and cultural perturbation in the past two generations might lead to the uncovering of cryptic genetic variation that is a major source of disease susceptibility...
  3. pmc Nucleotide variation in the Egfr locus of Drosophila melanogaster
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27513 7614, USA
    Genetics 167:1199-212. 2004
    ..The effect of sample size on inference of the roles of population structure, uneven recombination, and weak selection in patterning nucleotide variation in the locus is discussed...
  4. pmc Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, 27695 7614, USA
    Genetics 169:2115-25. 2005
    ..These results are discussed both within the framework of future association-mapping studies and within the context of the evolutionary dynamics of alleles in populations...
  5. pmc Genomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 181:1065-76. 2009
    ....
  6. pmc The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 187:1171-84. 2011
    ..We discuss these results in the light of possible attractor states of gene expression and how this would affect interpretation of covariation between transcriptional profiles and other phenotypes...
  7. pmc Genetic and nongenetic variation revealed for the principal components of human gene expression
    Anita Goldinger
    University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, Queensland 4102, Australia
    Genetics 195:1117-28. 2013
    ..Therefore, this study highlights the danger of eliminating biologically relevant data when employing PC correction in gene expression data. ..
  8. pmc Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Genet 6:44. 2005
    ..This re-evaluation utilized different genetic testcrosses to generate heterozygous individuals with a variety of genetic backgrounds as well as sampling of new alleles from Kenyan stocks...
  9. pmc Detection and replication of epistasis influencing transcription in humans
    Gibran Hemani
    1 Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia 2 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4072, Australia
    Nature 508:249-53. 2014
    ..This study presents the first evidence, to our knowledge, for many instances of segregating common polymorphisms interacting to influence human traits. ..
  10. pmc Association of orthodenticle with natural variation for early embryonic patterning in Drosophila melanogaster
    Lisa M Goering
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    J Exp Zool B Mol Dev Evol 312:841-54. 2009
    ....
  11. pmc Mixture modeling of transcript abundance classes in natural populations
    Wen Ping Hsieh
    Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genome Biol 8:R98. 2007
    ..Here, we explore the distributions of cis-acting and trans-acting factors and their relative contributions to expression of transcripts that exhibit two or more classes of abundance among individuals within populations...
  12. pmc A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs
    Youssef Idaghdour
    North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 4:e1000052. 2008
    ....
  13. pmc Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 173:1417-31. 2006
    ..These results provide an entry point into the genetics of wing shape and are discussed within the framework of the dissection of complex phenotypes...
  14. pmc Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data
    Joseph E Powell
    University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    PLoS Genet 9:e1003502. 2013
    ..Consistent with the genetic architecture of common diseases, gene expression is predominantly additive, but a minority of transcripts display non-additive effects...
  15. ncbi Impact of population structure on genetic diversity of a potential vaccine target in the canine hookworm (Ancylostoma caninum)
    Jennifer M Moser
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    J Parasitol 93:796-805. 2007
    ..3-kilobase stretch of sequence. Evidence for gene flow among geographically distinct samples suggests that the mobility of hosts of A. caninum is an important contributing factor to the population structure of the parasite...
  16. doi The environmental contribution to gene expression profiles
    Greg Gibson
    School of Integrative Biology, The University of Queensland, Goddard Building, St Lucia Campus, Brisbane, Queensland 4072, Australia
    Nat Rev Genet 9:575-81. 2008
    ..Incorporating estimates of genetic relationships into study designs will facilitate genomic analysis of environmental plasticity by aiding the identification of major regulatory loci in natural populations...
  17. pmc Comparison of regional gene expression differences in the brains of the domestic dog and human
    Erin Kennerly
    Department of Genetics, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA
    Hum Genomics 1:435-43. 2004
    ..This study lays the foundation for detailed analysis of the population structure of transcriptional variation as it relates to cognitive and neurological phenotypes in the domestic dog...
  18. pmc Association between nucleotide variation in Egfr and wing shape in Drosophila melanogaster
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 167:1187-98. 2004
    ..However, these features severely limit the ability of linkage disequilibrium mapping in Drosophila to resolve quantitative effects to single nucleotides...
  19. ncbi Population genomics: finding the variants of mass disruption
    Greg Gibson
    Department of Genetics, North Carolina State University, Raleigh, NC 27695 76214, USA
    Curr Biol 13:R901-3. 2003
  20. pmc Extensive sex-specific nonadditivity of gene expression in Drosophila melanogaster
    Greg Gibson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 167:1791-9. 2004
    ..Strikingly, while 25% of all genes differ between the two parents, 33% differ between both F1's and the parents, averaged across sexes. However, only 5% of genes show overdominance, suggesting that heterosis for expression is rare...
  21. ncbi Use of regression methods to identify motifs that modulate germline transcription in Drosophila melanogaster
    Emily Honeycutt
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695 7566, USA
    Genet Res 83:177-88. 2004
    ..In our case, this grouping of motifs suggests binding sites for cooperating factors in sex-specific expression, as well as a way of combining smaller motifs into larger binding sites...
  22. ncbi Human genetics: the hidden text of genome-wide associations
    Greg Gibson
    Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, North Carolina 27695 7614, USA
    Curr Biol 17:R929-32. 2007
    ..Several challenges lie ahead, including translation of the findings into practical public health outcomes, and integrating genetic analysis with broader biological understanding...
  23. ncbi Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster
    Gisele Passador-Gurgel
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 39:264-8. 2007
    ..Differences between populations from North Carolina and California suggest that the resistance mechanism may be an evolved response to environmental exposure...
  24. doi A gene expression signature of confinement in peripheral blood of red wolves (Canis rufus)
    Erin Kennerly
    Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695 7614, USA
    Mol Ecol 17:2782-91. 2008
    ....
  25. ncbi Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Curr Biol 13:1888-93. 2003
    ..A tendency for the rarer alleles to have more disrupted eye development suggests that mutation-selection balance is a possible mechanism contributing to maintaining cryptic variation for Egfr...
  26. ncbi Genetic variation for dorsal-ventral patterning of the Drosophila melanogaster eggshell
    Lisa M Goering
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Evol Dev 7:81-8. 2005
    ..Therefore, we conclude that the polymorphisms we have identified in Egfr do not contribute to variation in DAS, and further work is required to understand the genetic architecture of this trait...
  27. ncbi Evolution. The synthesis and evolution of a supermodel
    Greg Gibson
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Science 307:1890-1. 2005
  28. doi Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs
    Erin M Kennerly
    Department of Genetics, Gardner Hall, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    Pharmacogenet Genomics 19:911-22. 2009
    ..Exploration of the genetic mechanisms involved in drug response may provide better treatment options for epileptic patients...
  29. pmc Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia
    Elizabeth Mason
    School of Biological Sciences, University of Queensland, St Lucia, Australia
    PLoS ONE 5:e14479. 2010
    ....
  30. pmc Genotype-by-diet interactions drive metabolic phenotype variation in Drosophila melanogaster
    Laura K Reed
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 185:1009-19. 2010
    ..Changes in metabolic trait mean and variance in response to diet indicates that shifts in both population mean and variance in underlying traits could contribute to increases in complex disease...
  31. pmc Cross-species comparison of genome-wide expression patterns
    Xianghong Jasmine Zhou
    Department of Genetics, North Carolina State University, Raleigh, NC 27695 7614, USA
    Genome Biol 5:232. 2004
    ..Recent studies have used cross-species comparisons of expression profiles to annotate gene functions, to draw evolutionary inferences concerning specific biological processes and to study the global properties of expression networks...
  32. pmc Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes
    Pierre R Bushel
    National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Syst Biol 1:15. 2007
    ..The inability of clustering algorithms to incorporate biological data in the grouping process can limit proper interpretation of the data and its underlying biology...
  33. pmc Microarray analysis: genome-scale hypothesis scanning
    Greg Gibson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    PLoS Biol 1:E15. 2003
  34. ncbi The quantitative genetics of transcription
    Greg Gibson
    Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 37695 7614, USA
    Trends Genet 21:616-23. 2005
    ..The implications of these findings for genotype-phenotype mapping and modeling the evolution of transcription are discussed...
  35. ncbi Merging ecology, molecular evolution, and functional genetics
    Michael Purugganan
    Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, NC 27695 7614, USA
    Mol Ecol 12:1109-12. 2003
  36. ncbi Evolution: the plastic transcriptome
    Greg Gibson
    Department of Genetics, North Carolina State University, Raleigh, 27695 7614, USA
    Curr Biol 16:R285-7. 2006
    ....
  37. ncbi Uncovering cryptic genetic variation
    Greg Gibson
    Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Nat Rev Genet 5:681-90. 2004
    ....
  38. pmc Mixed-model reanalysis of primate data suggests tissue and species biases in oligonucleotide-based gene expression profiles
    Wen Ping Hsieh
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 165:747-57. 2003
    ..A small subset of genes that are candidates for adaptive divergence may be identified on the basis of a high ratio of interspecific to intraspecific divergence...
  39. ncbi Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila
    Rebecca M Riley
    Department of Genetics, North Carolina State University, Raleigh, NC 27695 7614, USA
    Mol Ecol 12:1315-23. 2003
    ....
  40. ncbi Enabling population and quantitative genomics
    Greg Gibson
    Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695 7614, USA
    Genet Res 80:1-6. 2002
    ..Here we discuss the set of community-wide genetic and molecular resources, including panels of specific types of inbred lines and high density resequencing and SNP detection, that will facilitate such studies...
  41. ncbi Microarrays in ecology and evolution: a preview
    Greg Gibson
    Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, NC 27695 7614, USA
    Mol Ecol 11:17-24. 2002
    ....
  42. ncbi Gene expression profiles associated with the transition to parasitism in Ancylostoma caninum larvae
    Jennifer M Moser
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Mol Biochem Parasitol 143:39-48. 2005
    ..Comparison of two strains of A. caninum from North Carolina and Maryland only identified a single gene, one of the members of the ASP family, that was differentially repressed upon serum stimulation...
  43. ncbi Greg Gibson
    Greg Gibson
    Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, North Carolina 27695 7614, USA
    Curr Biol 15:R531-2. 2005
  44. ncbi Analysis of variance of microarray data
    Julien F Ayroles
    Department of Genetics, North Carolina State University, Raleigh, NC, USA
    Methods Enzymol 411:214-33. 2006
    ..Commercial and open-source software for performing ANOVA is widely available...
  45. ncbi Unusual genetic architecture of natural variation affecting drug resistance in Drosophila melanogaster
    Roland Carrillo
    Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695 7614, USA
    Genet Res 80:205-13. 2002
    ....
  46. pmc TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres
    Jiangguo Lin
    Physics Department, North Carolina State University, Raleigh, NC 27695, USA, Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA, Electric and Computer Engineering Department, University of North Carolina at Charlotte, Charlotte, NC 28223, USA, Department of Industrial and System Engineering, North Carolina State University, Raleigh, NC 27695, USA, Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA, Division of Biophysics, Universitat Osnabruck, Barbarstrasse 11, 49076, Osnabruck, Germany and School of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ UK
    Nucleic Acids Res 42:2493-504. 2014
    ..This 'tag-team proofreading' represents a more general mechanism to ensure a specific set of proteins interact with each other on long repetitive specific DNA sequences without requiring external energy sources...
  47. ncbi Human evolution: thrifty genes and the dairy queen
    Greg Gibson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Curr Biol 17:R295-6. 2007
    ..Two new studies of genes that have experienced positive selection since the origin of pastoral agriculture help explain the incidence of lactose tolerance and diabetes, but cast considerable doubt on the popular thrifty genes hypothesis...