P V Giannoudis

Summary

Publications

  1. ncbi request reprint Can we accelerate fracture healing? A critical analysis of the literature
    Peter Giannoudis
    Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Injury 38:S81-9. 2007
  2. doi request reprint Surgical techniques-How do I do it? Open reduction and internal fixation of posterior wall fractures of the acetabulum
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Injury 39:1113-8. 2008
  3. ncbi request reprint Principles of fixation of osteoporotic fractures
    P V Giannoudis
    Academic Department of Trauma and Orthopaedic Surgery, University of Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    J Bone Joint Surg Br 88:1272-8. 2006
  4. ncbi request reprint Fracture healing in osteoporotic fractures: is it really different? A basic science perspective
    Peter Giannoudis
    Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, UK
    Injury 38:S90-9. 2007
  5. ncbi request reprint Fracture healing: a harmony of optimal biology and optimal fixation?
    Peter V Giannoudis
    Academic Dept of Trauma and Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK
    Injury 38:S1-2. 2007
  6. pmc Compartment syndrome following lower limb arthroplasty: a review
    Nikolaos G Lasanianos
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Leeds, UK
    Open Orthop J 5:181-92. 2011
  7. pmc Do nonsteroidal anti-inflammatory drugs affect bone healing? A critical analysis
    Ippokratis Pountos
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds LS1 3EX, UK
    ScientificWorldJournal 2012:606404. 2012
  8. pmc Effects of antithrombotic drugs fondaparinux and tinzaparin on in vitro proliferation and osteogenic and chondrogenic differentiation of bone-derived mesenchymal stem cells
    Argiris Papathanasopoulos
    LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
    J Orthop Res 29:1327-35. 2011
  9. doi request reprint A cohort study on the incidence and outcome of pulmonary embolism in trauma and orthopedic patients
    Suribabu Gudipati
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Clarendon Wing Level A, Great George Street, LS1 3EX Leeds, West Yorkshire, UK
    BMC Med 12:39. 2014
  10. pmc Spinal metastasis in thyroid cancer
    Sami Ramadan
    Department of Medicine, University College London Medical School, London, UK
    Head Neck Oncol 4:39. 2012

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. ncbi request reprint Can we accelerate fracture healing? A critical analysis of the literature
    Peter Giannoudis
    Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Injury 38:S81-9. 2007
    ..In addition, the available evidence lacks phase III, level I studies. Until such studies become available, the results should be interpreted with caution...
  2. doi request reprint Surgical techniques-How do I do it? Open reduction and internal fixation of posterior wall fractures of the acetabulum
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Injury 39:1113-8. 2008
    ....
  3. ncbi request reprint Principles of fixation of osteoporotic fractures
    P V Giannoudis
    Academic Department of Trauma and Orthopaedic Surgery, University of Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    J Bone Joint Surg Br 88:1272-8. 2006
    ..This review highlights the current aspects of management of these fractures and focuses on advances in implant design and surgical technique...
  4. ncbi request reprint Fracture healing in osteoporotic fractures: is it really different? A basic science perspective
    Peter Giannoudis
    Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, UK
    Injury 38:S90-9. 2007
    ..However, the mechanics of this influence of osteoporosis on fracture healing have not yet been clarified and clinical evidence is still lacking...
  5. ncbi request reprint Fracture healing: a harmony of optimal biology and optimal fixation?
    Peter V Giannoudis
    Academic Dept of Trauma and Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK
    Injury 38:S1-2. 2007
  6. pmc Compartment syndrome following lower limb arthroplasty: a review
    Nikolaos G Lasanianos
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Leeds, UK
    Open Orthop J 5:181-92. 2011
    ..In this study we present the current evidence with regard to incidence and causation of compartment syndrome after lower limb joint arthroplasty and make recommendations on how to avoid the development of this devastating complication...
  7. pmc Do nonsteroidal anti-inflammatory drugs affect bone healing? A critical analysis
    Ippokratis Pountos
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds LS1 3EX, UK
    ScientificWorldJournal 2012:606404. 2012
    ..In the absence of robust clinical or scientific evidence, clinicians should treat NSAIDs as a risk factor for bone healing impairment, and their administration should be avoided in high-risk patients...
  8. pmc Effects of antithrombotic drugs fondaparinux and tinzaparin on in vitro proliferation and osteogenic and chondrogenic differentiation of bone-derived mesenchymal stem cells
    Argiris Papathanasopoulos
    LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
    J Orthop Res 29:1327-35. 2011
    ..Whilst MSC proliferation, but not differentiation, is negatively affected by TZP, there was no evidence for adverse effects of FDP in this in vitro model system which argues well for its use in the orthopedic setting...
  9. doi request reprint A cohort study on the incidence and outcome of pulmonary embolism in trauma and orthopedic patients
    Suribabu Gudipati
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Clarendon Wing Level A, Great George Street, LS1 3EX Leeds, West Yorkshire, UK
    BMC Med 12:39. 2014
    ....
  10. pmc Spinal metastasis in thyroid cancer
    Sami Ramadan
    Department of Medicine, University College London Medical School, London, UK
    Head Neck Oncol 4:39. 2012
    ..Firstly we sought to analyse the proposed management options in the literature. Then, secondly, we endeavoured to make recommendations that might improve the prognosis of patients with spinal metastasis from thyroid carcinomas...
  11. pmc Analysis of the compatibility of dental implant systems in fibula free flap reconstruction
    Ramin Carbiner
    Head and Neck Centre, University College London Hospitals, London, UK
    Head Neck Oncol 4:37. 2012
    ..This study reached a conclusion that the width of fibula is sufficient for placement of most frequently used dental implants for oral rehabilitation after mandibular reconstructive procedures...
  12. pmc Central and peripheral venous lines-associated blood stream infections in the critically ill surgical patients
    Mohamed Ali Ugas
    Department of Surgery, Al Yarmouk University College, Baghdad, Iraq
    Ann Surg Innov Res 6:8. 2012
    ..Our current understanding is still limited; the studies we have identified do point us towards some tentative understanding that the CVC/PICC performance remains inconclusive...
  13. doi request reprint Acetabular fractures with marginal impaction: mid-term results
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    Bone Joint J 95:230-8. 2013
    ..Elevation of the articular impaction leads to joint preservation with satisfactory overall medium-term functional results, but secondary collapse is likely to occur in some patients...
  14. pmc "Internal fixation of proximal humeral fractures using the Polarus intramedullary nail: our institutional experience and review of the literature"
    Peter V Giannoudis
    Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Clarendon Wing Level A, Great George Street, LS1 3EX, Leeds, UK
    J Orthop Surg Res 7:39. 2012
    ....
  15. doi request reprint Subtrochanteric fracture non-unions with implant failure managed with the "Diamond" concept
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK
    Injury 44:S76-81. 2013
    ..Subtrochanteric femoral non-unions in the setting of failed metalwork pose a challenging clinical problem. This study assessed the clinical outcome of patients treated according to the principles of the "Diamond" concept...
  16. pmc Spinal metastasis in head and neck cancer
    Gregory M Trilling
    Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Head Neck Oncol 4:36. 2012
    ..This study aims to conduct a systematic review of the evidence available on management of spinal metastasis from head and neck cancer and to use such evidence to draw up guiding principles in the management of the distant spread...
  17. pmc The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence
    Rozalia Dimitriou
    Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, Leeds LS1 3EX, UK
    BMC Med 10:81. 2012
    ....
  18. pmc Challenges and barriers to improving care of the musculoskeletal patient of the future - a debate article and global perspective
    Hangama C Fayaz
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Patient Saf Surg 5:23. 2011
    ..abstract:..
  19. pmc MRI efficacy in diagnosing internal lesions of the knee: a retrospective analysis
    Vassilios S Nikolaou
    Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals, School of Medicine, University of Leeds, UK
    J Trauma Manag Outcomes 2:4. 2008
    ..The diagnostic performance of the initial clinical examination was also calculated for the meniscal and cruciate ligament injuries...
  20. pmc Comparison of migration behavior between single and dual lag screw implants for intertrochanteric fracture fixation
    George K Kouvidis
    Department of Orthopaedic Surgery and Traumatology, University of Crete, Heraklion, Greece
    J Orthop Surg Res 4:16. 2009
    ..abstract:..
  21. pmc Genetic predisposition to fracture non-union: a case control study of a preliminary single nucleotide polymorphisms analysis of the BMP pathway
    Rozalia Dimitriou
    Academic Unit of Trauma and Orthopaedic Surgery, LIMM Section Musculoskeletal Disease, Clarendon Wing, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds LS1 3EX, UK
    BMC Musculoskelet Disord 12:44. 2011
    ..This pilot study aimed to address this issue by performing a preliminary SNP analysis of specific genes known to regulate fracture healing...
  22. pmc Bone regeneration: current concepts and future directions
    Rozalia Dimitriou
    Department of Trauma and Orthopaedics, Academic Unit, Clarendon Wing, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    BMC Med 9:66. 2011
    ....
  23. pmc Pregnancy-related pelvic girdle pain: an update
    Nikolaos K Kanakaris
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds Teaching Hospitals NHS Trust, Leeds, UK
    BMC Med 9:15. 2011
    ..Ongoing research is desirable to establish clear management strategies that are based on the pathophysiologic mechanisms responsible for the escalation of the syndrome's symptoms to a fraction of the population of pregnant women...
  24. doi request reprint Damage control orthopaedics: lessons learned
    Peter V Giannoudis
    Academic Dept of Trauma and Orthopaedics, Leeds General Infirmary, Leeds, UK
    Injury 40:S47-52. 2009
    ..Although DCO has been proven a useful surgical strategy for efficiently managing patients with multiple trauma, further work is required to establish fully its indications, results and cost implications...
  25. ncbi request reprint Biological enhancement of bone healing with Bone Morphogenetic Protein-7 at the clinical setting of pelvic girdle non-unions
    Peter V Giannoudis
    Academic Dept of Trauma and Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK
    Injury 38:S43-8. 2007
    ..The implantation of BMP-7 in pelvic reconstruction procedures adds another alternative to the treatment methods of contemporary orthopaedics...
  26. doi request reprint Factors determining quality of life and level of sporting activity after internal fixation of an isolated acetabular fracture
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine University of Leeds, Leeds General Infirmary, Leeds, UK
    J Bone Joint Surg Br 91:1354-9. 2009
    ..Of all the parameters analysed, the Matta radiological follow-up criteria were the single best predictor for resumption of sporting activity and frequency of participation...
  27. ncbi request reprint Two-level reconstruction of comminuted posterior-wall fractures of the acetabulum
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Clarendon Wing, Floor A, Great George Street, Leeds General Infirmary, Leeds LS1 3EX, UK
    J Bone Joint Surg Br 89:503-9. 2007
    ..However, poor results may occur in patients over the age of 55 years...
  28. ncbi request reprint Incidence and outcome of whiplash injury after multiple trauma
    Peter V Giannoudis
    Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, United Kingdom
    Spine (Phila Pa 1976) 32:776-81. 2007
    ..A retrospective study of 101 consecutive polytrauma patients with regard to whiplash injury...
  29. doi request reprint Surgical techniques: how I do it? The Reamer/Irrigator/Aspirator (RIA) system
    P V Giannoudis
    Department of Trauma and Orthopaedics, Academic Unit, Clarendon Wing, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
    Injury 40:1231-6. 2009
    ..We present our current approach to the use of the RIA system, including the preoperative planning, the details of the operative procedure, the pitfalls and the potential complications that could be encountered...
  30. ncbi request reprint Accelerated bone healing and excessive callus formation in patients with femoral fracture and head injury
    P V Giannoudis
    Academic Department Orthopaedic Trauma Surgery, Leeds University, Chancellor Wing, St James s University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK
    Injury 37:S18-24. 2006
    ..462, 95% CI 0.312 to 0.602, p<0.0001, LAT: mean difference 0.289, 95% CI 0.142 to 0.436, p<0.001) with the head injured patients having more florid callus compared to the control group...
  31. ncbi request reprint Pelvic and acetabular surgery within Europe: the need for the co-ordination of treatment concepts
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Clarendon Wing, Floor A, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, United Kingdom
    Injury 38:410-5. 2007
    ..In this article we examine the current problems affecting the provision of a high quality pelvic and acetabular service and analyse the needs for the co-ordination of treatment concepts within the European Landscape...
  32. pmc The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, Leeds General Infirmary, Clarendon Wing, Level A, Great George Street, Leeds LS1 3EX, UK
    Clin Orthop Relat Res 467:3239-48. 2009
    ..BMP-7 as a bone-stimulating agent combined with conventional autograft resulted in a nonunion healing rate of 100% in these 45 patients...
  33. ncbi request reprint A minimally-invasive technique for the treatment of pyogenic sacroiliitis
    P V Giannoudis
    Department of Trauma and Orthopaedics, St James s University Hospital, Beckett Street, Leeds, UK
    J Bone Joint Surg Br 89:112-4. 2007
    ..A percutaneous technique is described, using the principles of sacroiliac screw insertion commonly used for pelvic reconstruction surgery. After successful evacuation of the infected joint, fusion was observed in our patient...
  34. ncbi request reprint Fat embolism: the reaming controversy
    Peter V Giannoudis
    Department Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK
    Injury 37:S50-8. 2006
    ..Additional studies are required to determine whether a subgroup of trauma patients is adversely affected by intramedullary reaming, thus necessitating other fixation techniques...
  35. ncbi request reprint Safety and efficacy of vena cava filters in trauma patients
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, United Kingdom
    Injury 38:7-18. 2007
    ..In this study, we review all the available data on IVC filter placement in trauma patients and we discuss the potential complications of IVC filters in order to understand better the risk/benefit ratio of their use...
  36. doi request reprint Severe and multiple trauma in older patients; incidence and mortality
    P V Giannoudis
    Academic Department Orthopaedic Trauma Surgery, Leeds University, Great George Street, Leeds, West Yorkshire LS1 3EX, UK
    Injury 40:362-7. 2009
    ..To examine the differences between severely injured older patients (aged over 65 years) compared with similarly injured younger adults in terms of incidence, inpatient mortality and factors predicting outcome...
  37. doi request reprint Growth factor release following femoral nailing
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Bone 42:751-7. 2008
    ..The osteogenic effect of reaming could be secondary not only to grafting debris but also to the increased liberation of these molecules...
  38. doi request reprint Is the lateral sacral fluoroscopic view essential for accurate percutaneous sacroiliac screw insertion? An experimental study
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Injury 39:875-80. 2008
    ..001), with sufficient data to support percutaneous screw fixation using inlet, outlet and lateral views rather than only inlet and outlet acquisition images...
  39. ncbi request reprint Fracture healing: the diamond concept
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK
    Injury 38:S3-6. 2007
    ..The traditional discussed triangular concept therefore should be reconsidered and be accepted as the 'diamond concept'...
  40. pmc Femoral nailing-related coagulopathy determined by first-hit magnitude: an animal study
    Peter V Giannoudis
    Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Room 194, A Floor, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Clin Orthop Relat Res 466:473-80. 2008
    ..The magnitude of the injury appears equally important as the type of subsequent surgery and should be considered in planning for fracture fixation in patients at high risk for complications...
  41. ncbi request reprint Prevalence of pelvic fractures, associated injuries, and mortality: the United Kingdom perspective
    Peter V Giannoudis
    Department of Orthopaedics and Trauma, Leeds General Infirmary, Leeds, United Kingdom
    J Trauma 63:875-83. 2007
    ....
  42. ncbi request reprint Quantification and characterisation of endothelial injury after trauma
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, Leeds Teaching Hospitals, University of Leeds, UK
    Injury 38:1373-81. 2007
    ..This review article assesses the existing evidence on the biomarkers of endothelial injury and their potential utility as quantification parameters of endothelial dysfunction in trauma patients...
  43. doi request reprint Biological considerations of mesenchymal stem cells and endothelial progenitor cells
    Argiris Papathanasopoulos
    Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK
    Injury 39:S21-32. 2008
    ..This paper examines the biological properties of these cells, the animal trials that have been performed so far and highlights their therapeutic potential in the treatment of musculoskeletal and cardiovascular diseases...
  44. ncbi request reprint The genetic predisposition to adverse outcome after trauma
    P V Giannoudis
    Department of Trauma and Orthopaedics, Clarendon Wing, Floor A, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    J Bone Joint Surg Br 89:1273-9. 2007
    ....
  45. doi request reprint The diamond concept--open questions
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK
    Injury 39:S5-8. 2008
    ..In this article, important issues which continue to remain obscured are discussed...
  46. doi request reprint Long-term quality of life in trauma patients following the full spectrum of tibial injury (fasciotomy, closed fracture, grade IIIB/IIIC open fracture and amputation)
    Peter V Giannoudis
    Academic Department Orthopaedic Trauma Surgery, Leeds University, Leeds General Infirmary University Hospital, Great George Street, Leeds, West Yorkshire LS1 3EX, UK
    Injury 40:213-9. 2009
    ..To measure long-term functional outcome and health-related quality of life following tibial fracture in association with the full spectrum of soft tissue injury...
  47. ncbi request reprint Management of long-bone non-unions
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, UK
    Injury 38:S1-2. 2007
  48. pmc The role of plating in the operative treatment of severe open tibial fractures: a systematic review
    Peter V Giannoudis
    Professor of Trauma and Orthopaedic Surgery School of Medicine, University of Leeds, Leeds, UK
    Int Orthop 33:19-26. 2009
    ..Plate fixation for the treatment of open tibial fractures can be considered under specific conditions which need to be elicited and clarified with future well-designed and conducted clinical trials...
  49. ncbi request reprint Internal fixation of traumatic diastasis of pubic symphysis: is plate removal essential?
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK
    Arch Orthop Trauma Surg 128:325-31. 2008
    ..Both functional outcome and long term physiological effects of plate retention have not been clearly addressed and no specific indications regarding implant removal have been proposed in the literature...
  50. ncbi request reprint Interaction of bone morphogenetic proteins with cells of the osteoclast lineage: review of the existing evidence
    P V Giannoudis
    Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK
    Osteoporos Int 18:1565-81. 2007
    ..The present review evaluates the existing scientific evidence of this supplementary role of the BMPs, and summarises its clinical implications...
  51. ncbi request reprint Principles of internal fixation and selection of implants for periprosthetic femoral fractures
    Peter V Giannoudis
    Department of Trauma and Orthopaedic Surgery, Academic Unit, School of Medicine, University of Leeds, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds, United Kingdom
    Injury 38:669-87. 2007
    ..The current study reviews the existing literature on internal fixation of femoral periprosthetic fractures...
  52. ncbi request reprint The impact of lower leg compartment syndrome on health related quality of life
    P V Giannoudis
    Level 5, C S B, Department of Orthopaedics and Trauma, University of Leeds, St James s Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 33:117-21. 2002
    ..This study has demonstrated that compartment syndrome may be associated with long-term impact on health related quality of life...
  53. ncbi request reprint Clinical applications of BMP-7: the UK perspective
    Peter V Giannoudis
    Academic Department of Orthopadic and Trauma Surgery, School of Medicine, University of Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S47-50. 2005
    ..The role of BMP's as a bone stimulating agent is safe, well established and could be considered as a power adjunct in the surgeon's armamentarium for the treatment of these challenging clinical conditions...
  54. ncbi request reprint Bone substitutes: an update
    Peter V Giannoudis
    Academic Department of Orthopaedics and Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S20-7. 2005
    ..We present here an overview of bone grafts and graft substitutes available for clinical applications...
  55. ncbi request reprint Methicillin-resistant Staphylococcus aureus in trauma and orthopaedic practice
    P V Giannoudis
    St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    J Bone Joint Surg Br 87:749-54. 2005
  56. ncbi request reprint Current concepts of the inflammatory response after major trauma: an update
    P V Giannoudis
    Department of Trauma and Orthopaedic Surgery, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 34:397-404. 2003
    ..This review article highlights the current concepts of post-traumatic immunological changes and their impact in the management of trauma patients...
  57. ncbi request reprint Double-crush syndrome after acetabular fractures. A sign of poor prognosis
    P V Giannoudis
    Department of Trauma and Orthopaedics, St James s University Hospital, Leeds, England, UK
    J Bone Joint Surg Br 87:401-7. 2005
    ..In the remaining 11 with foot-drop at presentation, including all nine with the double-crush lesion, there was no improvement in function at a mean follow-up of 4.3 years...
  58. doi request reprint Masquelet technique for the treatment of bone defects: tips-tricks and future directions
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedic Surgery, Leeds NIHR Biomedical Research Unit, Clarendon Wing, Floor A, Great George Street, Leeds General Infirmary, Leeds LS1 3EX, UK
    Injury 42:591-8. 2011
    ....
  59. ncbi request reprint Knee dislocation with ipsilateral femoral shaft fracture: a report of five cases
    Peter V Giannoudis
    Department of Trauma and Orthopaedic Surgery, St James s University Hospital, Leeds, United Kingdom
    J Orthop Trauma 19:205-10. 2005
    ..Four of the 5 dislocations underwent a secondary ligament reconstruction. At the 2-year follow up, the mean Knee Society Score was 133 (range 99-170)...
  60. doi request reprint The surgical treatment of anterior column and anterior wall acetabular fractures: short- to medium-term outcome
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    J Bone Joint Surg Br 93:970-4. 2011
    ..Complications of minor to moderate severity were seen in six of the 30 cases (20%) and none of the patients underwent secondary surgery or replacement of the hip...
  61. ncbi request reprint Damage control orthopaedics in unstable pelvic ring injuries
    P V Giannoudis
    Departments of Trauma and Orthopaedic Surgery, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
    Injury 35:671-7. 2004
    ....
  62. pmc Trauma networks: present and future challenges
    Nikolaos K Kanakaris
    Academic Department of Trauma and Orthopaedics, Leeds General Infirmary, Clarendon Wing, Level A, Great George Street, LS13EX, Leeds, UK
    BMC Med 9:121. 2011
    ..Such an approach may reverse the disinterest attitude of many, and will gradually evolve into a cultural shift of the public, clinicians and policymakers in the fullness of time...
  63. ncbi request reprint Segmental tibial fractures: an assessment of procedures in 27 cases
    P V Giannoudis
    Departments of Trauma and Orthopaedic Surgery, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 34:756-62. 2003
    ..The risk of non-union delayed union, infection and additional procedures is high as seen in this series of patients...
  64. doi request reprint The systemic inflammatory response following femoral canal reaming using the reamer-irrigator-aspirator (RIA) device
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, School of Medicine, University of Leeds, UK
    Injury 41:S57-61. 2010
    ..In polytrauma patients, large scale studies are desirable to evaluate further the immuno-inflammatory response using the RIA reamers prior to the instrumentation of the femoral canal...
  65. ncbi request reprint Tissue regeneration. The past, the present and the future
    Peter V Giannoudis
    Department of Trauma and Orthopaedics, St James s University Hospital, School of Medicine, University of Leeds, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S2-5. 2005
    ....
  66. doi request reprint Management, complications and clinical results of femoral head fractures
    P V Giannoudis
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Injury 40:1245-51. 2009
    ....
  67. ncbi request reprint A review of the management of open fractures of the tibia and femur
    P V Giannoudis
    Department of Trauma and Orthopaedic Surgery, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    J Bone Joint Surg Br 88:281-9. 2006
  68. doi request reprint Articular step-off and risk of post-traumatic osteoarthritis. Evidence today
    P V Giannoudis
    Academic Dept of Trauma and Orthopaedics, School of Medicine, University of Leeds, UK
    Injury 41:986-95. 2010
    ..Different joints and even different areas of the same joint appear to have different tolerances for post-traumatic articular step-offs...
  69. ncbi request reprint Gene therapy in orthopaedics
    Peter V Giannoudis
    Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 37:S30-40. 2006
    ..These developments have the potential to transform many areas of musculoskeletal care, leading to treatments that are less invasive, more effective and less expensive than existing modalities...
  70. doi request reprint Autologous bone graft: when shall we add growth factors?
    Peter V Giannoudis
    Department of Trauma and Orthopedic Surgery, University of Leeds, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Foot Ankle Clin 15:597-609. 2010
    ..In this article, we consider the potential clinical scenarios for graft expansion with BMPs...
  71. doi request reprint Bone morphogenetic proteins in musculoskeletal medicine
    Peter V Giannoudis
    Academic Department of Trauma and Orthopaedics, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Injury 40:S1-3. 2009
    ....
  72. doi request reprint Autologous bone graft: when shall we add growth factors?
    Peter V Giannoudis
    Department of Trauma and Orthopedic Surgery, University of Leeds, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    Orthop Clin North Am 41:85-94; table of contents. 2010
    ..In this article, we consider the potential clinical scenarios for graft expansion with BMPs...
  73. ncbi request reprint Tricortical bone graft for primary reconstruction of comminuted distal humerus fractures
    P V Giannoudis
    Department of Trauma and Orthopaedic Surgery, St James s University Hospital, Beckett Street, Leeds, United Kingdom
    J Orthop Trauma 19:741-3. 2005
    ..Radiocapitellar contact may be essential to good elbow function in this situation, because the corticocancellous bone graft does not restore the important lateral lip of the trochlea...
  74. doi request reprint BMPs: Options, indications, and effectiveness
    Peter V Giannoudis
    From the Academic Department of Trauma and Orthopaedic Surgery, University of Leeds, Leeds, United Kingdom
    J Orthop Trauma 24:S9-16. 2010
    ..Future research should refine issues regarding the relative effectiveness of bone morphogenetic proteins, the interaction between bone morphogenetic protein subtypes, and their specific effect on various target cell populations...
  75. ncbi request reprint Application of recombinant BMP-7 on persistent upper and lower limb non-unions
    R Dimitriou
    St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:S51-9. 2005
    ..This study supports the view that the application of rhBMP-7 as a bone-stimulating agent is safe and a power adjunct to be considered in the surgeon's armamentarium for the treatment of these challenging clinical conditions...
  76. ncbi request reprint Open pelvic fractures: epidemiology, current concepts of management and outcome
    M R W Grotz
    Department of Trauma and Orthopaedics, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:1-13. 2005
    ..Selective faecal diversion, based on wound location, is compulsory and safe, minimising the risk of sepsis and reducing mortality rates...
  77. pmc A cost analysis of treatment of tibial fracture nonunion by bone grafting or bone morphogenetic protein-7
    Z Dahabreh
    Academic Department of Trauma and Orthopaedics, Leeds General Infirmary, Clarendon Wing, Level A, Great George Street, Leeds, LS1 3EX, UK
    Int Orthop 33:1407-14. 2009
    ..In addition to the satisfactory efficacy and safety of BMP-7 in comparison to the gold standard of ICBG, as documented in multiple studies, its cost effectiveness is advocated favourably in this analysis...
  78. doi request reprint Gustilo IIIC fractures in the lower limb: our 15-year experience
    A Soni
    Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
    J Bone Joint Surg Br 94:698-703. 2012
    ..Distal tibial fractures had an increased rate of nonunion when associated with posterior tibial artery damage, and seven patients (39%) were not able to return to their previous occupation...
  79. doi request reprint Open patellar fractures: high energy injuries with a poor outcome?
    Sanjeev Anand
    Academic Orthopaedic Department, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, United Kingdom
    Injury 39:480-4. 2008
    ..Sixteen patients with closed patellar fractures, matched for age, sex and fracture pattern, were randomly selected from our database to form the control group...
  80. doi request reprint Early palsy of the sciatic nerve due to heterotopic ossification after surgery for fracture of the posterior wall of the acetabulum
    N Manidakis
    University of Leeds, Leeds, England
    J Bone Joint Surg Br 91:253-7. 2009
    ..Prompt excision and neural release followed by irradiation and administration of indometacin resulted in a full neurological recovery and no recurrence 27 months later...
  81. ncbi request reprint Femoral fractures in children, is early interventional treatment beneficial?
    S W Sturdee
    Department of Orthopaedics and Trauma, The General Infirmary at Leeds, Great George Street, Leeds, West Yorkshire LS1 3EX, United Kingdom
    Injury 38:937-44. 2007
    ..This has benefits for the child, the family and the hospital...
  82. ncbi request reprint Early experience with linezolid for infections in orthopaedics
    P J Harwood
    Academic Department of Orthopaedic Trauma Surgery, Leeds University, UK
    Injury 37:818-26. 2006
    ..Linezolid offers an alternative to traditional treatments for resistant infections and can facilitate early discharge. Patients need to be monitored closely, particularly where long-term therapy is planned...
  83. ncbi request reprint Cruciate fracture of the distal femur: the double Hoffa fracture
    S Agarwal
    Department of Orthopaedic Surgery, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, UK
    Injury 35:828-30. 2004
  84. ncbi request reprint The management of post-traumatic osteoarthritis
    G Mouzopoulos
    Academic Department of Trauma and Orthopedics, Leeds Institute of Molecular Medicine, Leeds UK
    Minerva Med 102:41-58. 2011
    ..For the early stages, arthroscopic debridement should be considered. At late stages, corrective osteotomies or arthrodesis are strongly recommended for the young patients. In older patients arthroplasties remain the treatment of choice...
  85. ncbi request reprint The functional outcome of severe, open tibial fractures managed with early fixation and flap coverage
    S Gopal
    Department Trauma and Orthopaedics, St James s University Hospital, Leeds, England
    J Bone Joint Surg Br 86:861-7. 2004
    ..Our results compare favourably with previous outcome measurements published for both limb salvage and amputation. All patients were pleased to have retained their limbs...
  86. pmc Pelvic ring disruptions: treatment modalities and analysis of outcomes
    C Papakostidis
    Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, UK
    Int Orthop 33:329-38. 2009
    ..From the functional point of view only walking capacity was proved to be significantly better in the groups of operative treatment compared to the non-operative group...
  87. ncbi request reprint The role and efficacy of retrograding nailing for the treatment of diaphyseal and distal femoral fractures: a systematic review of the literature
    G Papadokostakis
    Department of Trauma, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 36:813-22. 2005
    ..However, in the management of diaphyseal fractures, retrograde intramedullary nailing is associated with high rates of knee pain and lower rates of fracture union...
  88. ncbi request reprint Injury patterns associated with mortality following motorcycle crashes
    S Ankarath
    Department of Trauma and Orthopaedics, St James s University Hospital, Leeds, UK
    Injury 33:473-7. 2002
    ..Head injury followed by chest and abdominal trauma were found to predict a reduced survival rate. Use of helmets should continue to be compulsory. Chest and abdominal injuries should be diagnosed and treated early to reduce mortality...
  89. ncbi request reprint Spontaneous healing of a 14 cm diaphyseal cortical defect of the tibia
    A F Hinsche
    Department of Trauma and Orthopaedic Surgeon, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 34:385-8. 2003
  90. pmc Early internal fixation and soft tissue cover of severe open tibial pilon fractures
    J Conroy
    Department of Orthopaedics and Trauma, St James University Hospital, Leeds, LS9 7TF, UK
    Int Orthop 27:343-7. 2003
    ..5 was significantly better ( p<0.01) when compared with amputees from severe lower-extremity trauma. Our protocol for management resulted in a good functional outcome with low infection and amputation rates...
  91. ncbi request reprint Incidence and aetiology of anterior knee pain after intramedullary nailing of the femur and tibia
    E Katsoulis
    Department of Trauma and Orthopaedics, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    J Bone Joint Surg Br 88:576-80. 2006
  92. ncbi request reprint Prevalence and patterns of foot injuries following motorcycle trauma
    R F Jeffers
    Department of Trauma and Orthopaedic Surgery, St James s University Hospital, Leeds, United Kingdom
    J Orthop Trauma 18:87-91. 2004
    ..To determine the prevalence and patterns of foot injuries following motorcycle trauma...
  93. ncbi request reprint Percutaneous fixation of the pelvic ring: an update
    P V Giannoudis
    Department of Orthopaedic and Trauma Surgery, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    J Bone Joint Surg Br 89:145-54. 2007
    ..This paper presents an overview of the technical aspects of percutaneous surgery of the pelvis and acetabulum...
  94. doi request reprint Total elbow arthroplasty for the treatment of insufficient distal humeral fractures. A retrospective clinical study and review of the literature
    B Chalidis
    Academic Department of Trauma, and Orthopaedics, School of Medicine, University, of Leeds, Leeds, UK
    Injury 40:582-90. 2009
    ..Careful patient selection and regular follow up evaluation are mandatory for achieving an optimal result and eliminating the risks of mismanagement and early implant failure...
  95. doi request reprint Stimulation of the local femoral inflammatory response to fracture and intramedullary reaming: a preliminary study of the source of the second hit phenomenon
    J R Morley
    Academic Department of Orthopaedic and Trauma Surgery, Leeds University, The General Infirmary at Leeds, Clarendon Wing, Great George Street, Leeds LS1 3EX, UK
    J Bone Joint Surg Br 90:393-9. 2008
    ..In patients who underwent intramedullary reaming of the femoral canal a further significant local release of IL-6 was demonstrated, providing evidence that intramedullary reaming can cause a significant local inflammatory reaction...
  96. ncbi request reprint Operative treatment of displaced fractures of the acetabulum. A meta-analysis
    P V Giannoudis
    Department of Trauma and Orthopaedics, St James s University Hospital, Leeds, England, UK
    J Bone Joint Surg Br 87:2-9. 2005
    ..It is important, at operation, to obtain the most accurate reduction of the fracture which is possible, with a minimal surgical approach, as both are related to improved outcome...
  97. ncbi request reprint Distal femoral fractures: long-term outcome following stabilisation with the LISS
    A A Syed
    Department of Orthopaedics and Trauma, St James University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Injury 35:599-607. 2004
    ..However, when the LISS is used as a revision tool the results seem to be less satisfactory. The system appears to be user-friendly and no technical difficulties were encountered...
  98. ncbi request reprint Use of bio-resorbable implants for stabilisation of distal radius fractures: the United Kingdom patients' perspective
    R Mittal
    Department of Trauma and Orthopaedic Surgery, St James s University Hospital, Leeds LS9 7TF, UK
    Injury 36:333-8. 2005
    ..0001). This study sets the foundation for the implementation of prospective randomised trials to assess the efficacy of the new generation of bio-resorbable implants...
  99. ncbi request reprint Surgical priorities in damage control in polytrauma
    P V Giannoudis
    Department of Trauma and Orthopaedics, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    J Bone Joint Surg Br 85:478-83. 2003