K Ghosh

Summary

Publications

  1. ncbi request reprint Von Willebrand factor 1 and factor 2 alleles (intron 40) are suitable markers for carrier detection in von Willebrand disease families in the Indian population
    Sucheta Trasi
    Institute of Immunohematology ICMR, KEM Hospital Campus, Parel, Mumbai, India
    Acta Haematol 115:64-7. 2006
  2. pmc Hydroxyurea could be a good clinically relevant iron chelator
    Khushnooma Italia
    Hematogenetics Department, National Institute of Immunohaematology, I C M R, Mumbai, Maharashtra, India
    PLoS ONE 8:e82928. 2013
  3. pmc Antiplatelet antibodies in cases of Glanzmann's thrombasthenia with and without a history of multiple platelet transfusion
    Kanjaksha Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Indian J Hum Genet 15:23-7. 2009
  4. ncbi request reprint Genetic heterogeneity in a large cohort of Indian type 3 von Willebrand disease patients
    Priyanka Kasatkar
    Department of Haemostasis and Thrombosis, National Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    PLoS ONE 9:e92575. 2014
  5. pmc Coagulation disorders seen through the window of molecular biology
    Kanjaksha Ghosh
    Institute of Immunohematology, 13 Floor, KEM Hospital Campus, Parel, Mumbai 400 012, India
    Indian J Hum Genet 13:81-7. 2007
  6. pmc A homozygous female hemophilia A
    Preethi S Nair
    Department of Thrombosis Haemostasis, National Institute of Immunohaematology, KEM Hospital Campus, Parel, Mumbai, Maharashtra, India
    Indian J Hum Genet 18:134-6. 2012
  7. pmc Recollections of J.B.S. Haldane, with special reference to Human Genetics in India
    Krishna R Dronamraju
    Foundation for Genetic Research and Visiting Professor, University of Paris, Houston, TX, USA
    Indian J Hum Genet 18:3-8. 2012
  8. ncbi request reprint Chimeric fusion karyotypes in childhood B-cell acute lymphoblastic leukemia
    Lily S Kerketta
    Department of Cytogenetics, National Institute of Immunohematology, KEM Hoapital, Parel, Mumbai, India
    Indian Pediatr 51:152-3. 2014
  9. doi request reprint FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India
    Kanjaksha Ghosh
    Indian Council of Medical Research, National Institute of Immunohaematology, 13th Floor NMS building, KEM Hospital Campus, Parel, Mumbai, 400 012, India
    Ann Hematol 91:1703-12. 2012
  10. doi request reprint Bone health in persons with haemophilia: a review
    Kanjaksha Ghosh
    National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Eur J Haematol 89:95-102. 2012

Collaborators

Detail Information

Publications175 found, 100 shown here

  1. ncbi request reprint Von Willebrand factor 1 and factor 2 alleles (intron 40) are suitable markers for carrier detection in von Willebrand disease families in the Indian population
    Sucheta Trasi
    Institute of Immunohematology ICMR, KEM Hospital Campus, Parel, Mumbai, India
    Acta Haematol 115:64-7. 2006
    ..The high heterozygosity of the two vWF intron 40 VNTR markers and the simplicity of the technique without much cost being involved suggest the practical feasibility of this technique in developing countries like India...
  2. pmc Hydroxyurea could be a good clinically relevant iron chelator
    Khushnooma Italia
    Hematogenetics Department, National Institute of Immunohaematology, I C M R, Mumbai, Maharashtra, India
    PLoS ONE 8:e82928. 2013
    ..Thus hydroxyurea proves its role in reducing iron from iron overloaded mice. The iron chelating effect of these drugs can also be increased if given in combination. ..
  3. pmc Antiplatelet antibodies in cases of Glanzmann's thrombasthenia with and without a history of multiple platelet transfusion
    Kanjaksha Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Indian J Hum Genet 15:23-7. 2009
    ..We conclude that GT patients who have not received transfusions may develop antiplatelet antibodies to the missing/abnormal receptor. Whether this is due to a molecular mimicry or due to some other mechanism needs to be explored...
  4. ncbi request reprint Genetic heterogeneity in a large cohort of Indian type 3 von Willebrand disease patients
    Priyanka Kasatkar
    Department of Haemostasis and Thrombosis, National Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    PLoS ONE 9:e92575. 2014
    ..The study is aimed at unravelling the molecular pathology in a large series of VWD patients from India using an effective strategy...
  5. pmc Coagulation disorders seen through the window of molecular biology
    Kanjaksha Ghosh
    Institute of Immunohematology, 13 Floor, KEM Hospital Campus, Parel, Mumbai 400 012, India
    Indian J Hum Genet 13:81-7. 2007
    ..This overview presents several examples which show how we have enriched our understanding about the varied clinical phenotypes of different coagulation disorders...
  6. pmc A homozygous female hemophilia A
    Preethi S Nair
    Department of Thrombosis Haemostasis, National Institute of Immunohaematology, KEM Hospital Campus, Parel, Mumbai, Maharashtra, India
    Indian J Hum Genet 18:134-6. 2012
    ..Hemophilia A (HA), being an X-linked recessive disorder, females are rarely affected, although they can be carriers...
  7. pmc Recollections of J.B.S. Haldane, with special reference to Human Genetics in India
    Krishna R Dronamraju
    Foundation for Genetic Research and Visiting Professor, University of Paris, Houston, TX, USA
    Indian J Hum Genet 18:3-8. 2012
    ..Population genetic research on Y-linkage in man, inbreeding, color blindness and other aspects are described...
  8. ncbi request reprint Chimeric fusion karyotypes in childhood B-cell acute lymphoblastic leukemia
    Lily S Kerketta
    Department of Cytogenetics, National Institute of Immunohematology, KEM Hoapital, Parel, Mumbai, India
    Indian Pediatr 51:152-3. 2014
    ..The chromosomal aberration frequency in B-ALL and T-ALL was 79% and 71%, respectively. TEL/AML1 translocation was detected in 28% of patients. ..
  9. doi request reprint FLT3 and NPM1 mutations in a cohort of AML patients and detection of a novel mutation in tyrosine kinase domain of FLT3 gene from Western India
    Kanjaksha Ghosh
    Indian Council of Medical Research, National Institute of Immunohaematology, 13th Floor NMS building, KEM Hospital Campus, Parel, Mumbai, 400 012, India
    Ann Hematol 91:1703-12. 2012
    ..These patients also tended to have significantly lower expression of CD34 antigen on flowcytometry. Distinct prognostic subclasses of adult AML patients were identified based on the presence of NPM1 and FLT3 mutations...
  10. doi request reprint Bone health in persons with haemophilia: a review
    Kanjaksha Ghosh
    National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Eur J Haematol 89:95-102. 2012
    ..This review summarises the prevalence, plausible mechanisms and management options of this important morbidity in PWH...
  11. doi request reprint Hemostasis research in India: past, present, and future
    Kanjaksha Ghosh
    National Institute of Immunohaematology, KEM Hospital Campus, Mumbai, India
    Clin Appl Thromb Hemost 18:128-33. 2012
    ....
  12. doi request reprint Epidemiology, diagnosis, and management of von Willebrand disease in India
    Kanjaksha Ghosh
    National Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Semin Thromb Hemost 37:595-601. 2011
    ..This is likely to tilt the ratios of different VWD types, and VWD is likely to emerge as the most common of all coagulation disorders in the near future...
  13. ncbi request reprint Blood coagulation in falciparum malaria--a review
    Kanjaksha Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai 400 012, India
    Parasitol Res 102:571-6. 2008
    ..Thus, in severe falciparum malaria, there is activation of blood coagulation system along with thrombocytopaenia, even before widespread DIC and coagulation failure occur...
  14. ncbi request reprint Flowcytometric evidence of platelet activation in patients on aspirin following myocardial infarction
    K Ghosh
    Institute of Immunohaematology ICMR, 13th Floor, New Building, K E M Hospital, Parel, Mumbai 400012, Maharashtra
    Natl Med J India 19:73-4. 2006
    ..However, there are no quick and easy methods to assess the efficacy of the antiplatelet activity of aspirin...
  15. ncbi request reprint Implications of human genome and modern cell biology research in management of cardiovascular diseases
    Kanjaksha Ghosh
    Institute of Immunohaematology, KEM Hospital, Parel, Mumbai
    Indian Heart J 57:270-3. 2005
  16. ncbi request reprint Thrombophilia: hereditary and acquired in cardiovascular disease
    A Khare
    Institute of Immunohaematology I C M R, 13th Floor, New Building, KEM Hospital, Parel, Mumbai 400 012, India
    Haematologia (Budap) 32:293-311. 2002
  17. ncbi request reprint Use of a new enzyme-linked immunosorbent assay for the detection of type 2N von Willebrand disease and its prevalence in an Indian population
    Kanjaksha Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital Campus, Parel, Mumbai, India
    Blood Coagul Fibrinolysis 17:7-11. 2006
    ..The simple ELISA technique described here should be available in all routine laboratories in developing countries...
  18. ncbi request reprint Co-existence of Bernard Soulier syndrome and factor XI deficiency in a family: a unified pathology?
    K Ghosh
    Institute of Immunohematology I C M R, 13th Floor, K E M Hospital Campus, Parel, Mumbai 400 012, India
    Platelets 16:85-9. 2005
    ..This is the first case of coinheritance of BSS and factor XI deficiency reported in the English literature...
  19. ncbi request reprint Non haematological effects of iron deficiency - a perspective
    Kanjaksha Ghosh
    Institute of Immunohaematology, KEM Hospital Campus, Parel, Mumbai 400 012, India
    Indian J Med Sci 60:30-7. 2006
    ....
  20. ncbi request reprint Haematuria and urolithiasis in patients with haemophilia
    Kanjaksha Ghosh
    Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital Campus, Parel, Mumbai, India
    Eur J Haematol 70:410-2. 2003
    ..01). In developing countries, severe and moderately severe haemophiliacs may be at a higher risk of urolithiasis because of prolonged recumbency necessitated by recurrent joint bleeds and inadequate replacement therapy...
  21. ncbi request reprint Management of haemophilia and its complications in developing countries
    K Ghosh
    Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Clin Lab Haematol 26:243-51. 2004
    ..The present review broadly describes the management of various aspects of severe haemophilia in developing countries...
  22. ncbi request reprint Intracranial haemorrhage in severe haemophilia: prevalence and outcome in a developing country
    K Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital Campus, Parel, Mumbia, India
    Haemophilia 11:459-62. 2005
    ..8%) similar to that of the western countries and almost no morbidity. Surgery was not required in any of these patients except in one elderly patient with HIV infection on antiretroviral therapy...
  23. ncbi request reprint Pathogenesis of anemia in malaria: a concise review
    Kanjaksha Ghosh
    Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital Campus, Parel, Mumbai 400 012, India
    Parasitol Res 101:1463-9. 2007
    ..Cooperation between chronic malarial infection and infection with E-B virus infection in producing Burkitt's lymphoma is well known. In this review, the fascinating and multifaceted pathophysiolgoy of malarial anemia has been discussed...
  24. doi request reprint Frequency of partial D in Western India
    S Kulkarni
    Institute of Immunohaematology ICMR, 13th Floor, New Multistoreyed Building, KEM Hospital Campus, Parel, Mumbai, India
    Transfus Med 18:91-6. 2008
    ..4 and 76.6% of partial D by partial D kit and M-PCR, respectively. The incidence of partial D in West India was found to be at least 0.15% when tested with partial D kit. DFR partial D was found to be predominant in the present study...
  25. ncbi request reprint Development of inhibitors in patients with haemophilia from India
    K Ghosh
    Institute of Immunohaematology, KEM Hospital Parel, Mumbai, India
    Haemophilia 7:273-8. 2001
    ..The overall prevalence of inhibitors was thus 8.2%, which is similar to the reports from western countries, prior to the introduction of highly purified factor concentrate therapy...
  26. ncbi request reprint Role of epsilon amino caproic acid in the management of haemophilic patients with inhibitors
    K Ghosh
    Comprehensive Hemophilia Care Centre, Hemostasis Unit, Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Haemophilia 10:58-62. 2004
    ..This will lead to substantial financial savings in countries where up to 35% of severe haemophilia A patients develop inhibitors...
  27. ncbi request reprint Systemic capillary leak syndrome preceding plasma cell leukaemia
    K Ghosh
    Institute of Immunohaematology Indian Council of Medical Research, KEM Hospital Campus, Parel, Mumbai, India
    Acta Haematol 106:118-21. 2001
    ..His disease relapsed without recurrence of the capillary leak. He died 15 months after PBSCT and 20 months after the diagnosis of plasma cell leukaemia...
  28. ncbi request reprint False-positive serological tests in acute malaria
    K Ghosh
    Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital MS Building, Parel, Mumbai 400012, India
    Br J Biomed Sci 58:20-3. 2001
    ..In tropical countries such as India, where malaria is endemic, results of serological tests should be interpreted with caution in a patient with pyrexia of unknown origin (PUO)...
  29. doi request reprint Spontaneous resolution of severe aplastic anemia following thymic hemorrhage
    Kanjaksha Ghosh
    Institute of Immunohaematology, KEM Hospital, Mumbai, India
    Acta Haematol 119:69-72. 2008
    ..These cases show possible ways to manipulate the thymus gland as a management strategy for this disease...
  30. ncbi request reprint Successful pregnancy outcome in women with bad obstetric history and recurrent fetal loss due to thrombophilia: effect of unfractionated heparin and low-molecular weight heparin
    Kanjaksha Ghosh
    Deptartment of Haemostasis, Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Clin Appl Thromb Hemost 14:174-9. 2008
    ..None of the patients in either group had to interrupt the therapy for any adverse treatment-related complications...
  31. ncbi request reprint Acute myelomonocytic leukaemia with pseudo-Chediak-Higashi inclusions in leukaemic blasts report of an unusual case
    K Ghosh
    Department of Haematology, Sultan Qaboos University, Muscat, Sultanate of Oman
    Haematologia (Budap) 30:229-34. 2000
    ..We report here on a patient with acute myeloid leukaemia showing pseudo-Chediak-Higashi inclusions in leukaemic blasts with unusual ultrastructural morphology...
  32. ncbi request reprint Common human leucocyte antigen haplotypes in Indians--its implications in finding unrelated compatible bone marrow donors
    K Ghosh
    HLA Department, Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Mumbai, India
    Transfus Med 12:43-8. 2002
    ..It is hoped that this will give the busy clinician an idea whether a search for prospective unrelated stem cell donor for an Indian patient is likely to succeed or not...
  33. doi request reprint Mycobacterium tuberculosis infection precipitates SLE in patients from endemic areas
    Kanjaksha Ghosh
    Department of Immunology and Autoimmunedisorders, National Institute of Immunohaematology ICMR, 13 Th Fl KEM Hospital Campus, Parel, Mumbai, 400 012, India
    Rheumatol Int 29:1047-50. 2009
    ..This study suggests a role of prior tuberculosis in precipitating SLE in genetically predisposed patients...
  34. ncbi request reprint Evolution of prenatal diagnostic techniques from phenotypic diagnosis to gene arrays: its likely impact on prenatal diagnosis of hemophilia
    Kanjaksha Ghosh
    Department of Haemostasis, Institute of Immunohaematology, KEM Hospital Campus, Parel, Mumbai 400 012, India
    Clin Appl Thromb Hemost 15:277-82. 2009
    ....
  35. ncbi request reprint Low cost autologous peripheral blood stem cell transplantation performed in a municipal hospital for a patient with plasma cell leukaemia
    K Ghosh
    Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital Campus, Parel, Mumbai, India
    Clin Lab Haematol 24:187-90. 2002
    ..The patient remained in remission for 7 months, after which he relapsed and was treated with chemotherapy and electron beam radiation to the skin...
  36. ncbi request reprint Development of anti-VWF antibody in a patient with severe haemophilia A following the development of high-grade non-Hodgkin's lymphoma
    K Ghosh
    Institute of Immunohaematology ICMR, Parel, Mumbai, India
    Clin Lab Haematol 24:191-3. 2002
    ..The present case shows that antibody to VWF should be considered as a possible reason for an increased factor VIII requirement in such patients...
  37. ncbi request reprint Correlation of thromboelastographic patterns with clinical presentation and rationale for use of antifibrinolytics in severe haemophilia patients
    K Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai 400012, India
    Haemophilia 13:734-9. 2007
    ....
  38. doi request reprint Immune response to FVIII in hemophilia A: an overview of risk factors
    Kanjaksha Ghosh
    National Institute of Immunohaematology, 13th Fl, KEM Hospital, Parel, Mumbai 400012, India
    Clin Rev Allergy Immunol 37:58-66. 2009
    ..The modifiable risk factors for inhibitor formation may provide the key to predict and perhaps prevent the formation of inhibitors in hemophilia patients...
  39. doi request reprint Tuberculosis and female reproductive health
    K Ghosh
    National Institute of Immunohaematology, 13th flr, KEM Hospital, Mumbai, India
    J Postgrad Med 57:307-13. 2011
    ..Hence, doctors need to be properly trained to become "Tuberculosis Minded"...
  40. ncbi request reprint Venous thromboembolism in young patients from western India: a study
    K Ghosh
    Institute of Immunohaematology (Indian Council of Medical Research) KEM Hospital Campus, Parel, Mumbai, India
    Clin Appl Thromb Hemost 7:158-65. 2001
    ..8% of the patients had homozygosity for the MTHFR C677T polymorphism...
  41. ncbi request reprint Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP
    Y S Mehta
    Institute of Immunohaematology ICMR, K E M Hospital Campus, Parel, Mumbai, India
    Platelets 11:94-8. 2000
    ..On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids...
  42. doi request reprint Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India
    U Shankarkumar
    National Institute of Immunohaematology, ICMR, KEM Hospital, Parel, Mumbai, India
    Int J Immunogenet 37:199-204. 2010
    ..Our results indicate clearly that there are HLA class II alleles involved in the susceptibility to and protection from HIV-1 infection in our study group and further they vary in different ethnic groups reported in literature...
  43. ncbi request reprint Changes in platelet glycoprotein receptors after smoking--a flow cytometric study
    S Nair
    Institute of Immunohaematology, K. E. M. Hospital, Parel, Mumbai, India
    Platelets 12:20-6. 2001
    ..Therefore this study suggests that smoking-induced platelet activation may be an important contributory mechanism for acute coronary events in smokers...
  44. ncbi request reprint Platelet function tests using platelet aggregometry: need for repetition of the test for diagnosis of defective platelet function
    K Ghosh
    Institute of Immunohaematology, ICMR, KEM Hospital, Parel, Mumbai, India
    Platelets 14:351-4. 2003
    ..In north India similar group of defect in a large number of patients have been reported as isolated PF3 abnormality or thrombasthenic thrombopathy...
  45. doi request reprint Spectrum of novel mutations in the human PKLR gene in pyruvate kinase-deficient Indian patients with heterogeneous clinical phenotypes
    P Kedar
    National Institute of Immunohaematology, Indian Council of Medical Research, K E M Hospital Campus, Parel, Mumbai, India
    Clin Genet 75:157-62. 2009
    ..66%) and 992A>G (16.66%). This is the first study to correlate the clinical profile with the molecular defects causing PK deficiency from India where 10 novel mutations that produce non-spherocytic haemolytic anaemia were identified...
  46. ncbi request reprint HLA associations in P. falciparum malaria patients from Mumbai, western India
    U Shankarkumar
    HLA Deptt, Institute of Immunohaematology, K E M Hospital Campus, Mumbai 400 012, India
    Indian J Malariol 39:76-82. 2002
    ..Further, when compared to HLA associations of other world populations the present study indicates the relative importance of different HLA alleles that may vary in different populations...
  47. ncbi request reprint Molecular pathogenesis and clinical variability of beta-thalassemia syndromes among Indians
    A Nadkarni
    Institute of Immunohaematology (ICMR, 13(th) Floor, NMS Building, KEM Hospital Campus, Parel, Mumbai, India
    Am J Hematol 68:75-80. 2001
    ..7)) and the presence of the XmnI polymorphism were associated with lesser severity of the disease in Indians...
  48. ncbi request reprint Epsilon-aminocaproic acid inhibits the activity of factor VIII inhibitors in patients with severe haemophilia A in vivo and in vitro
    K Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Mumbai, India
    Acta Haematol 103:67-72. 2000
    ..The inhibitory activity of EACA on factor VIII inhibitor was equally seen with recombinant factor VIII also; hence this action cannot be explained by its antifibrinolytic activity...
  49. ncbi request reprint Hybrid cytogenetics of chronic lymphocytic leukemia and follicular cell lymphoma in a case of non-Hodgkin's lymphoma
    V Babu Rao
    Institute of Immunohematology, ICMR, KEM Hospital, Parel, Mumbai, India
    Acta Haematol 116:150-2. 2006
  50. ncbi request reprint Ophthalmic surgery in haemophilia
    F Jijina
    JC Patel Department of Haematology, KEM Hospital, Mumbai, India
    Haemophilia 7:464-7. 2001
    ..Thus, satisfactory eye surgery in patients with haemophilia is possible with a restricted amount of factor concentrates with gratifying results...
  51. ncbi request reprint Varied distribution of RhD epitopes in the Indian population
    S S Kulkarni
    Institute of Immunohaematology ICMR, K E M Hospital Campus, Parel, Mumbai, Maharashtra, India
    Natl Med J India 20:169-71. 2007
    ..As monoclonal anti-D typing reagents may not detect all RhD antigen epitopes, we studied the RhD antigen epitope heterogeneity in different population groups in India...
  52. pmc HLA-DRB1*03 and DQB1*0302 associations in a subset of patients severely affected with systemic lupus erythematosus from western India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, 13th Floor, KEM Hospital, Parel, Mumbai 400012, Maharastra, India
    Ann Rheum Dis 62:92-3. 2003
  53. ncbi request reprint Carrier detection and prenatal diagnosis in families with haemophilia
    S Shetty
    Institute of Immunohaematology ICMR, 13 Floor, New Multistoreyed Building, KEM Hospital, Parel, Mumbai 400012, Maharashtra, India
    Natl Med J India 14:81-3. 2001
    ..Over the last 6 years we performed carrier detection and antenatal diagnosis in families with patients of haemophilia A and B...
  54. ncbi request reprint Prenatal diagnosis of haemophilia: a preliminary report
    S Shetty
    Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, Maharashtra, India
    Natl Med J India 11:218-9. 1998
    ..CONCLUSION: All three polymorphic markers yielded information. This suggests that these three markers can be effectively used in the antenatal diagnosis of haemophilia A in Indian families...
  55. ncbi request reprint HLA B27 polymorphism in Western India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, KEM, Hospital Parel, Mumbia
    Tissue Antigens 60:98-101. 2002
    ..In addition, B*2714 was observed in a patient with ankylosing spondylitis. This association has not been previously reported in ethnic groups from India...
  56. doi request reprint The angiotensin-converting enzyme gene insertion/deletion polymorphism in Indian patients with vitiligo: a case-control study and meta-analysis
    M Patwardhan
    Department of Clinical and Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai 400012, India
    Br J Dermatol 168:1195-204. 2013
    ..Furthermore, significantly higher serum ACE levels have been demonstrated in patients with some autoimmune and autoinflammatory disorders...
  57. ncbi request reprint Spectrum of inherited bleeding disorders from Western India
    M Manisha
    Institute of Immunohematology, K E M Hospital Campus, Parel, Mumbai, India
    Haematologia (Budap) 32:39-47. 2002
    ..The study was undertaken to assess the magnitude and diversity of different bleeding disorders in Western India...
  58. ncbi request reprint First-time development of FVIII inhibitor in haemophilia patients during the postoperative period
    K Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Haemophilia 8:776-80. 2002
    ....
  59. ncbi request reprint Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22
    B R Vundinti
    Institute of Immunohaematology ICMR, 13th Floor, New Multistoryed Building, KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India
    Indian J Cancer 45:30-2. 2008
    ..The patient did not respond to therapy and follow-up of cytogenetics revealed same chromosome abnormality. Hence, this three way translocation involving X chromosome might be associated with poor prognosis...
  60. ncbi request reprint First-trimester prenatal diagnosis of pyruvate kinase deficiency in an Indian family with the pyruvate kinase-Amish mutation
    P S Kedar
    Institute of Immunohaematology, Indian Council of Medical Research, K E M Hospital Campus, Parel, Mumbai, India
    Genet Mol Res 6:470-5. 2007
    ..Prenatal diagnosis allowed the parents with a severely affected child with PK deficiency to have the reproductive choice of having the fetus tested in a subsequent pregnancy...
  61. ncbi request reprint Frequency distribution of antigens in the human platelet antigen-1 system in the western Indian population
    Bipin Kulkarni
    Institute of Immunohaematology, Indian Council of Medical Research, K E M Hospital, Parel, Mumbai, India
    Transfusion 42:317-20. 2002
    ..The molecular method of genotyping the platelet antigens is preferred to serology. It will enable future prenatal diagnosis in mothers suspected to have NAITP so that they can be managed better...
  62. ncbi request reprint Role of HLA antigens in Rh (D) alloimmunized pregnant women from Mumbai, Maharashtra, India
    U Shankar Kumar
    HLA Department, Institute of Immunohaematology, 13th Floor, New MS Building, KEM Hospital, Parel, Mumbai 400 012, India
    J Biosci 27:135-41. 2002
    ....
  63. ncbi request reprint Carrier detection and prenatal diagnosis in haemophilia in India: realities and challenges
    K Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Haemophilia 8:51-5. 2002
    ..Prenatal diagnosis and carrier detection in India therefore must be discussed in this context...
  64. ncbi request reprint Placental histomorphology in unexplained foetal loss with thrombophilia
    S Vora
    National Institute of Immunohaematology ICMR, Mumbai, India
    Indian J Med Res 129:144-9. 2009
    ..This study was carried out to examine the placenta from women with abnormal pregnancies and a history of unexplained foetal loss, and to associate with maternal thrombophilia status...
  65. doi request reprint Comparative case control study of clinical features and human leukocyte antigen susceptibility between familial and nonfamilial vitiligo
    Rachita Misri
    Department of Dermatology, Seth G S Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Indian J Dermatol Venereol Leprol 75:583-7. 2009
    ..Various studies worldwide suggest that human leukocyte antigen (HLA) region may be involved in the genetic susceptibility of vitiligo but little information is available from India...
  66. ncbi request reprint Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India
    U Shankarkumar
    Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400012, Maharashtra, India
    J Autoimmun 24:227-33. 2005
    ....
  67. doi request reprint Antiphospholipid antibodies in haemophilia patients with severe bleeding tendency: cause, consequence or a consequential cause?
    S Shetty
    National Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Haemophilia 15:1104-8. 2009
    ..Higher thrombin-generating potential in case of patients positive for beta2GP1 did not seem to have any impact on the clinical severity of haemophilia patients...
  68. doi request reprint Vitiligo patients from India (Mumbai) show differences in clinical, demographic and autoantibody profiles compared to patients in western countries
    V Pradhan
    Department of Autoimmune Disorders, National Institute of Immunohaematology, Indian Council of Medical Research, King Edward Memorial Hospital, Parel, Mumbai India Department of Dermatology, King Edward Memorial Hospital, Parel, Mumbai, India Department of Human Metabolism, The Medical School, University of Sheffield, Sheffield, UK Department of Dermatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
    J Eur Acad Dermatol Venereol 27:279-86. 2013
    ..Several studies have reported the clinical and demographic characteristics of Indian vitiligo patients, however, none has characterized their antibody profiles...
  69. ncbi request reprint Hemophilia B in a female
    S Shetty
    Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital, Parel, Mumbai, India
    Acta Haematol 106:115-7. 2001
    ....
  70. ncbi request reprint Hb Q(India) and its interaction with beta-thalassaemia: a study of 64 cases from India
    S Phanasgaonkar
    Institute of Immunohaematology, K E M Hospital, Parel, Mumbai, India
    Br J Biomed Sci 64:160-3. 2007
    ..Hb Q is rare and not a single homozygous case has been reported. However, Hb Q disease showed wide variation in clinical and haematological presentation in the same family...
  71. doi request reprint Five alpha globin chain variants identified during screening for haemoglobinopathies
    S Nair
    National Institute of Immunohaematology I C M R, Mumbai 400 012, India
    Eur J Clin Invest 40:226-32. 2010
    ....
  72. ncbi request reprint Combined factor VIII and IX deficiency in a family
    S Shetty
    Institute of Immunohematology (ICMR, KEM Hospital, Parel, Mumbai, India
    Clin Lab Haematol 23:201-4. 2001
    ..Thus, the combined deficiency observed was due to a chance association of two distinct genetic defects...
  73. ncbi request reprint Evaluation of markers of endothelial damage in cases of young myocardial infarction
    A Khare
    Institute of Immunohaematology ICMR, 13th Floor, New Bldg, KEM Hospital, Parel, Mumbai 400 012, India
    Atherosclerosis 180:375-80. 2005
    ..05). Thus, folic acid had a dual effect in that it reduced hyperhomocysteinemia and sE-selectin which showed a significant reduction on folate supplementation for 15 days...
  74. ncbi request reprint Novel HLA B*2714 and B*2708 allele associations in seronegative spondarthritis patients and haemophilia patients with chronic synovitis in India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, K E M Hospital, Mumbai, India
    Tissue Antigens 62:175-8. 2003
    ..We also found a significant association between haemophilia patients with chronic synovitis from India and a hitherto unidentified allele, B*2708...
  75. ncbi request reprint Maternal origin of extra marker chromosome 1Q31.1-qter and 13pter-q12.12 in a child with dysmorhic features
    V B Rao
    Institute of Immunohaematology ICMR 13th Floor, New Multistoryed Building, K E M Hospital Campus, Parel, Mumbai 12, India
    Genet Couns 16:139-43. 2005
    ..This is the first case of trisomy 1q with an extra marker chromosome which also contained chromosome 13pter-q12.12 material...
  76. ncbi request reprint Frequency distribution of human platelet antigens in the Indian population
    B Kulkarni
    Institute of Immunohaematology, KEM Hospital, Mumbai, India
    Transfus Med 15:119-24. 2005
    ..This study has established a DNA technique to diagnose cases of NAITP definitively and to treat these cases during the neonatal period, and also gives the frequency distribution of HPA in some of the Indian population...
  77. ncbi request reprint Anti-neutrophil cytoplasmic antibodies (ANCA) in malaria
    Vandana Pradhan
    Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai 400 012, India
    Indian J Malariol 39:51-9. 2002
    ..It also alerts us to the fact, whether in cases of repeated malarial infections in susceptible individuals, vasculitic disorders, which through ANCA pathways develop, could lead to renal and other complications...
  78. ncbi request reprint Evolution and selection of human leukocyte antigen alleles by Plasmodium falciparum infection
    Kanjaksha Ghosh
    National Institute of Immunohaematology, KEM Hospital, Mumbai, India
    Hum Immunol 69:856-60. 2008
    ..falciparum infection. Data might have been overwhelmed by the noise of additional selection pressure exerted by other infectious agents prevalent in endemic areas of P. falciparum malaria...
  79. doi request reprint Utility of an exon 14 BslI polymorphism for improved genetic diagnosis of hemophilia A in Indian population
    Preethi Mukundan
    National Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Prenat Diagn 28:920-2. 2008
    ....
  80. ncbi request reprint Novel mutations in factor IX gene from western India with reference to their phenotypic and haplotypic attributes
    Leera Quadros
    Department of Haemostasis and Thrombosis, National Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    J Pediatr Hematol Oncol 31:157-60. 2009
    ..Hemophilia B (HB) is an X-linked recessively inherited bleeding disorder caused by heterogeneous mutations in the factor IX gene...
  81. ncbi request reprint Differentiation of Nijmegen breakage syndrome from Fanconi anemia
    V B Rao
    Institute of Immunohaematology ICMR, K E M Hospital Campus, Parel, Mumbai 12, India
    Genet Mol Res 6:622-6. 2007
    ..On the basis of clinical and cytogenetic evaluation, these two cases were confirmed as NBS. However, detailed molecular studies are essential for accurate diagnosis and management of this disease...
  82. ncbi request reprint MHC non -HLA gene polymorphisms in transplantation
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, K E M Hospital, Parel, Mumbai
    Indian J Pathol Microbiol 50:881-5. 2007
    ..A scenario can be envisaged where polymorphisms associated with transplant outcome are tested prior to transplantation at the same time as HLA typing...
  83. ncbi request reprint Seronegative spondarthritis and human leucocyte antigen association
    U Shankarkumar
    HLA Department, Institute of lmmunohaematology, KEM Hospital, Mumbai, Maharashtra, India
    Br J Biomed Sci 59:38-41. 2002
    ....
  84. ncbi request reprint Molecular diversity of HLA-Cw alleles in the Maratha community of Mumbai, Maharashtra, western India
    U Shankarkumar
    Institute of Immunohaematology, Indian Council of Medical Research, 13th Floor KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India
    Int J Immunogenet 32:223-7. 2005
    ..Our results will have clinical implications in related and unrelated HLA-matched bone marrow transplantation in India...
  85. ncbi request reprint Haemorrhage in upper cervical cord: an unusual manifestation in moderate haemophilia patients who ride motorbikes
    K Ghosh
    Institute of Immunohaematology, KEM Hospital Campus, Mumbai, India
    Haemophilia 7:515-6. 2001
    ..This is a very rare presentation of moderate haemophilia with serious consequences and has not to our knowledge, previously been reported in the English literature...
  86. ncbi request reprint Iron deficiency as a risk factor for first febrile seizure
    Rajwanti K Vaswani
    Department of Pediatrics, King Edward Memorial Hospital, Parel, Mumbai, India
    Indian Pediatr 47:437-9. 2010
    ..The mean serum ferritin level (microg/L) was significantly low in Cases (31.9 +/- 31.0) as compared to Controls (53.9 +/- 56.5) with P = 0.003. Iron deficiency could be a potential risk factor for febrile seizure in children...
  87. ncbi request reprint St 14 (DX S52) VNTR polymorphism in the Indian population and its application in carrier detection and prenatal diagnosis of haemophilia A families
    S Shetty
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Haematologia (Budap) 30:203-7. 2000
    ..thus indicating that this polymorphism can serve as an important marker in the carrier detection and prenatal diagnosis of haemophilia A families...
  88. ncbi request reprint Haemophilia care in India: innovations and integrations by various chapters of Haemophilia Federation of India (HFI)
    K Ghosh
    National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Haemophilia 16:61-5. 2010
    ....
  89. ncbi request reprint Implications of HLA sequence-based typing in transplantation
    U Shankarkumar
    Institute of Immunohaematology, 13th Floor, K E M Hospital, Parel, Mumbai, Maharashtra, India
    J Postgrad Med 54:41-4. 2008
    ....
  90. ncbi request reprint Fc gamma R IIIB polymorphisms: their association with clinical manifestations and autoantibodies in SLE patients from western India
    Vandana Pradhan
    Department of Autoimmune Disorders, National Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital, Parel, Mumbai, Maharashtra, India
    Int J Rheum Dis 13:138-43. 2010
    ..Fc gamma alleles may be associated with inefficient removal of apoptotic cells or antigens and hence may be associated with higher risk of SLE...
  91. ncbi request reprint Report of proceedings of the national meeting on "Guidelines for Immunophenotyping of Hematolymphoid Neoplasms by Flow Cytometry"
    Sumeet Gujral
    Department of Pathology, Tata Memorial Hospital, Mumbai, India
    Indian J Pathol Microbiol 51:161-6. 2008
    ..The first national meeting on "Guidelines for Immunophenotyping of Hematolymphoid Neoplasms by Flow Cytometry" was held on 14 March 2008 in Mumbai, India...
  92. doi request reprint Familial small supernumerary marker chromosome (sSMC) (14)(:p11-q11:) [corrected] in a child with translocation Down syndrome
    Babu Rao Vundinti
    Department of Cytogenetics, National Institute of Immunohematology ICMR K E M Hospital Campus, Parel, Mumbai, India
    Indian J Pediatr 76:1265-7. 2009
    ..The phenotypic changes were not evident, may be due to trisomy condition in the child or the sSMC contain repetitive sequences...