Roberto Gherzi

Summary

Publications

  1. ncbi request reprint A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery
    Roberto Gherzi
    Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genoa, Italy
    Mol Cell 14:571-83. 2004
  2. ncbi request reprint p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Mol Cell 20:891-903. 2005
  3. ncbi request reprint KSRP, many functions for a single protein
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Front Biosci (Landmark Ed) 16:1787-96. 2011
  4. pmc KH domains with impaired nucleic acid binding as a tool for functional analysis
    David Hollingworth
    Molecular Structure Division, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nucleic Acids Res 40:6873-86. 2012
  5. pmc Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
    Tina Ruggiero
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    BMC Mol Biol 8:28. 2007
  6. pmc The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling
    Roberto Gherzi
    Nazionale per la Ricerca sul Cancro, Genova, Italy
    PLoS Biol 5:e5. 2006
  7. doi request reprint The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew University Medical Center, PO Box 12000, Jerusalem, Israel 91120
    FASEB J 22:3458-68. 2008
  8. pmc Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay
    Chu Fang Chou
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Cell Biol 26:3695-706. 2006
  9. pmc The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
    Martin Schmidlin
    Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    EMBO J 23:4760-9. 2004
  10. ncbi request reprint The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation
    María Flor García-Mayoral
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Structure 15:485-98. 2007

Collaborators

  • Michael Karin
  • Andres Ramos
  • Georg Stoecklin
  • Irene Díaz-Moreno
  • Tally Naveh-Many
  • Tina Ruggiero
  • Michele Trabucchi
  • Paola Briata
  • Ching Yi Chen
  • David Hollingworth
  • Annamaria Bevilacqua
  • Chu Fang Chou
  • Morris Nechama
  • María Flor García-Mayoral
  • Sergio Capaccioli
  • Gianfranco Canti
  • Angelo Nicolin
  • Giorgio Corte
  • Martin Schmidlin
  • Christoph Moroni
  • Giuseppe Nicastro
  • Stephen R Martin
  • Adela M Candel
  • Michela Pasero
  • Matteo Giovarelli
  • Iddo Z Ben-Dov
  • Giovanna Maresca
  • Laura Masino
  • Laura Ghisolfi
  • Sara Franzi
  • Geoff Kelly
  • Sushmit Maitra
  • John Kappes
  • Alok Mulky
  • Wei Jye Lin
  • Pier Lorenzo Puri
  • Marco Ponassi
  • Sonia Vanina Forcales
  • Brigitte Gross
  • Sabrina A Leuenberger
  • Daniel Hess
  • Michel Mallaun
  • Min Lu
  • Brian A Hemmings
  • Michael G Rosenfeld
  • Laura Asnaghi
  • Maria Cristina Ceriani
  • Laura Papucci
  • Cristina Ilengo
  • Gary Brewer
  • Nicola Schiavone

Detail Information

Publications13

  1. ncbi request reprint A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery
    Roberto Gherzi
    Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genoa, Italy
    Mol Cell 14:571-83. 2004
    ..The ability of KHs to promote mRNA decay correlates with their ability to bind the ARE and associate with RNA-degrading enzymes. Thus, KHs promote rapid mRNA decay by recruiting degradation machinery to ARE-containing mRNAs...
  2. ncbi request reprint p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Mol Cell 20:891-903. 2005
    ..Our results uncover an unanticipated role for KSRP in establishing a biochemical link between differentiation-activated p38 signaling and turnover of myogenic mRNAs...
  3. ncbi request reprint KSRP, many functions for a single protein
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Front Biosci (Landmark Ed) 16:1787-96. 2011
    ..In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors...
  4. pmc KH domains with impaired nucleic acid binding as a tool for functional analysis
    David Hollingworth
    Molecular Structure Division, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nucleic Acids Res 40:6873-86. 2012
    ..This work defines a general molecular biology tool for the investigation of the function of individual KH domains in nucleic acid binding proteins...
  5. pmc Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
    Tina Ruggiero
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    BMC Mol Biol 8:28. 2007
    ..We have recently described that phosphatidylinositol 3-kinase/AKT (PI3K-AKT) activation induces stabilization and accumulation of the labile beta-catenin mRNA through an impairment of KSRP function...
  6. pmc The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling
    Roberto Gherzi
    Nazionale per la Ricerca sul Cancro, Genova, Italy
    PLoS Biol 5:e5. 2006
    ..We propose KSRP phosphorylation as a link between phosphatidylinositol 3-kinase-AKT signaling and beta-catenin accumulation...
  7. doi request reprint The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew University Medical Center, PO Box 12000, Jerusalem, Israel 91120
    FASEB J 22:3458-68. 2008
    ..Therefore, calcium or phosphorus depletion, as well as chronic kidney failure, regulate the interaction of KSRP and AUF1 with PTH mRNA and its half-life. Our data indicate a novel role for KSRP in PTH gene expression...
  8. pmc Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay
    Chu Fang Chou
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Cell Biol 26:3695-706. 2006
    ..These results provide a foundation for the development of novel therapeutic strategies to inhibit specific gene expression in patients with acquired or hereditary diseases...
  9. pmc The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
    Martin Schmidlin
    Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    EMBO J 23:4760-9. 2004
    ..In vivo and in vitro data support a model where PKB causes ARE-mRNA stabilization by inactivating BRF1 through binding to 14-3-3...
  10. ncbi request reprint The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation
    María Flor García-Mayoral
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Structure 15:485-98. 2007
    ..Surprisingly, we find that KH4 binds to its target AREs with lower affinity than KH3 and that KSRP's mRNA binding, and mRNA degradation activities are closely associated with a conserved structural element of KH4...
  11. ncbi request reprint Stabilization of cellular mRNAs and up-regulation of proteins by oligoribonucleotides homologous to the Bcl2 adenine-uridine rich element motif
    Annamaria Bevilacqua
    Department of Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Mol Pharmacol 71:531-8. 2007
    ....
  12. ncbi request reprint The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    Mol Cell 12:1201-11. 2003
    ..Our previous and present data support the hypothesis that a single pathway can coordinately regulate sequential transcriptional and posttranscriptional events leading to an integrated functional gene regulatory network...
  13. ncbi request reprint Bcl-2 protein is required for the adenine/uridine-rich element (ARE)-dependent degradation of its own messenger
    Annamaria Bevilacqua
    Department of Pharmacology, University of Milan, 20129 Milan, Italy
    J Biol Chem 278:23451-9. 2003
    ..We conclude that Bcl-2 is necessary to activate the degradation complex on the relevant RNA target...