Seyed H Ghaffari

Summary

Publications

  1. ncbi Silibinin induces apoptosis and inhibits proliferation of estrogen receptor (ER)-negative breast carcinoma cells through suppression of nuclear factor kappa B activation
    Meysam Yousefi
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Arch Iran Med 17:366-71. 2014
  2. ncbi Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription
    Seyed H Ghaffari
    Department of Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Hematology 17:198-206. 2012
  3. pmc Cytogenetic and FMS-like tyrosine kinase 3 mutation analyses in acute promyelocytic leukemia patients
    Marjan Yaghmaie
    Dept of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modarres University, P O BOX 14115 111, Tehran
    Iran Biomed J 16:10-7. 2012
  4. ncbi Alteration in miRNA gene expression pattern in acute promyelocytic leukemia cell induced by arsenic trioxide: a possible mechanism to explain arsenic multi-target action
    Seyed H Ghaffari
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Tumour Biol 33:157-72. 2012
  5. ncbi Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP,
    Majid Momeny
    Hematology, Oncology and Bone Marrow Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Med Oncol 27:833-42. 2010
  6. ncbi BIBR 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for APL
    Davood Bashash
    Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Iran
    Anticancer Agents Med Chem 13:1115-25. 2013
  7. ncbi Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide
    Meysam Yousefi
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Neurochem Int 63:809-17. 2013
  8. ncbi Autocrine human growth hormone increases sensitivity of mammary carcinoma cell to arsenic trioxide-induced apoptosis
    Ali Zekri
    Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Mol Cell Endocrinol 377:84-92. 2013
  9. ncbi Multitargeting and antimetastatic potentials of silibinin in human HepG-2 and PLC/PRF/5 hepatoma cells
    Reza Ghasemi
    Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Nutr Cancer 65:590-9. 2013
  10. ncbi Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells
    Davood Bashash
    Department of Hematology, Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Leuk Lymphoma 54:561-8. 2013

Collaborators

  • Kamran Alimoghaddam
  • Shahriar Nafissi
  • Farhad Zaker
  • Bagher Larijani
  • Reza Shirkoohi
  • Ardeshir Ghavamzadeh
  • Meysam Yousefi
  • Ali Zekri
  • Majid Momeny
  • Saeed Hassani
  • Davood Bashash
  • Mohsen Malehmir
  • Reza Ghasemi
  • Marjan Yaghmaie
  • Ali Khaleghian
  • Samad Ghanizadeh-Vesali
  • Shahin Ahmadian
  • Majid Zaki Dizaji
  • Rahim Amini
  • Gholamreza Toogeh
  • Mehdi Yousefi
  • Majid Zakidizaji
  • Saeed Pirouzpanah
  • Kebria Hezave
  • Azam Zaghal
  • Rohellah Mirzaee
  • Majid Mojarrad
  • Masoumeh Rostami
  • Hajar Mardani
  • Rooholah Mirzaee
  • Elham Hosseini
  • Maryam Kazerani
  • Masomeh Rostami
  • Vahid Haghpanah
  • Vahid Lesan
  • Ramin Heshmat
  • Bahram M Soltani
  • Mehrdad Behmanesh
  • Marjan Hajhashemi
  • Mozaffar Aznab
  • Khadijeh Adabi
  • Mina Hajifaraj Tabrizi
  • Hossein Mozdarani
  • Mohammad Hussein Modarressi
  • Razieh Yazdanparast
  • Shirin Ferdowsi
  • Fatemeh Naadali
  • Safiyeh Aghazadeh
  • Yassan Abdolazimi
  • Mohammad A Shokrgozar
  • Amir H Emami
  • Maryam Rahimi-Balaei
  • Ahmad R Dehpour
  • Habibeh Ghadimi
  • Seyed Asadollah Mousavi
  • Rezvan Esmaeili
  • Babak Bahar
  • Mohammad R Nooridaloii
  • Mohammad Jahani
  • Mohammad R Khorramizadeh
  • Isa Bibordi
  • Masoud Irvani
  • Ardashir Ghavamzadeh
  • Zahra Jahanshiri
  • Mir S Yekaninejad

Detail Information

Publications22

  1. ncbi Silibinin induces apoptosis and inhibits proliferation of estrogen receptor (ER)-negative breast carcinoma cells through suppression of nuclear factor kappa B activation
    Meysam Yousefi
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Arch Iran Med 17:366-71. 2014
    ..The current study was designed to evaluate the restrictive effects of pharmacological doses of silibinin on SKBR3, an ErbB2-overexpressed and ER-negative human breast carcinoma cell line...
  2. ncbi Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription
    Seyed H Ghaffari
    Department of Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Hematology 17:198-206. 2012
    ..On aggregate, these issues indicate that ATO might preempt cell growth and proliferation in NB4 cells through suppression of Pin1-mediated NF-κB-dependent stimulation of telomerase and survivin...
  3. pmc Cytogenetic and FMS-like tyrosine kinase 3 mutation analyses in acute promyelocytic leukemia patients
    Marjan Yaghmaie
    Dept of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modarres University, P O BOX 14115 111, Tehran
    Iran Biomed J 16:10-7. 2012
    ..However, the prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established...
  4. ncbi Alteration in miRNA gene expression pattern in acute promyelocytic leukemia cell induced by arsenic trioxide: a possible mechanism to explain arsenic multi-target action
    Seyed H Ghaffari
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Tumour Biol 33:157-72. 2012
    ..The results of this study support the hypothesis that miRNAs may play a mediatory role in eliciting the multi-target and pleiotropic action of ATO...
  5. ncbi Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP,
    Majid Momeny
    Hematology, Oncology and Bone Marrow Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Med Oncol 27:833-42. 2010
    ....
  6. ncbi BIBR 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for APL
    Davood Bashash
    Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Iran
    Anticancer Agents Med Chem 13:1115-25. 2013
    ....
  7. ncbi Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide
    Meysam Yousefi
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Neurochem Int 63:809-17. 2013
    ..However, for successful strategies for the treatment of this heterogeneous tumor, other combinations approaches need to be considered to simultaneously target other NB cells. ..
  8. ncbi Autocrine human growth hormone increases sensitivity of mammary carcinoma cell to arsenic trioxide-induced apoptosis
    Ali Zekri
    Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Mol Cell Endocrinol 377:84-92. 2013
    ..Our study may highlight the potential application of ATO for the treatment of patients with breast cancer, especially in those who have metastatic and chemoresistant tumor phenotype possibly due to the over expression of hGH...
  9. ncbi Multitargeting and antimetastatic potentials of silibinin in human HepG-2 and PLC/PRF/5 hepatoma cells
    Reza Ghasemi
    Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Nutr Cancer 65:590-9. 2013
    ..In conclusion, our findings suggest that silibinin could potentially function as a multitargeting antimetastatic agent and might provide new insights for HCC therapy particularly for HBV-related and/or P53-mutated HCCs...
  10. ncbi Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells
    Davood Bashash
    Department of Hematology, Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Leuk Lymphoma 54:561-8. 2013
    ....
  11. ncbi Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest
    Saeed Hassani
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Ann Hematol 92:1207-20. 2013
    ....
  12. ncbi Therapeutic efficacy of silibinin on human neuroblastoma cells: Akt and NF-κB expressions may play an important role in silibinin-induced response
    Meysam Yousefi
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Neurochem Res 37:2053-63. 2012
    ..Our results suggest that suppression of SK-N-MC cell line by silibinin may be through inhibition of Akt-mediated NF-κB1...
  13. ncbi Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line
    Majid Zaki Dizaji
    Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Neurochem Res 37:370-80. 2012
    ..This study may supply insight into the design of new combination cancer therapies to cells intrinsically less sensitive to routine therapies and suggested a new combination therapy for the highly invasive human glioma treatment...
  14. ncbi Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation
    Mohsen Malehmir
    Endocrinology and Metabolism Research Center EMRC, Tehran University of Medical Sciences, Tehran, Iran
    Mol Cell Endocrinol 348:260-9. 2012
    ..Altogether, ATRA treatment could hold the aggressive behavior of thyroid carcinoma in restraint and/or potentiate the effect of chemotherapy drug ATO...
  15. ncbi Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9
    Majid Momeny
    Hematology, Oncology and Bone Marrow Transplantation Research Center, Tehran, Iran
    Anticancer Drugs 21:252-60. 2010
    ..Furthermore, silibinin might cripple the activation of gelatinase B by cramping transcriptional and enzymatic activities of cathepsin B in U87 cells...
  16. ncbi Metabolism of arsenic trioxide in acute promyelocytic leukemia cells
    Ali Khaleghian
    Institute of Biochemistry and Biophysics IBB, University of Tehran, P O Box 13145 1384, Tehran, Iran Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    J Cell Biochem 115:1729-39. 2014
    ..Production of intracellular methylated metabolites and epigenetic changes of DNA methylation during As2O3 metabolism may contribute to the therapeutic effect of As2O3 in APL...
  17. ncbi Concomitant presence of JAK2 V617F mutation and BCR-ABL translocation in a pregnant woman with polycythemia vera
    Gholamreza Toogeh
    Hematology Oncology and BMT Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Med Oncol 28:1555-8. 2011
    ..This case report suggests that in a PV pregnant woman with a concomitant presence of JAK2 V617F mutation and BCR-ABL translocation, the administration of interferon during the pregnancy could lead to a safe pregnancy and delivery...
  18. ncbi Frequency of BCR-ABL fusion transcripts in Iranian patients with chronic myeloid leukemia
    Marjan Yaghmaie
    Hematology Oncology and Bone Marrow Transplant Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Arch Iran Med 11:247-51. 2008
    ..The objective of this study was to set up a multiplex RT-PCR assay for detection and to determine the frequency of different fusion genes in 75 Iranian patients with chronic myeloid leukemia...
  19. ncbi Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation
    Majid Momeny
    Department of Medical Genetics, University of Tehran, Tehran, Iran
    Eur J Pharmacol 591:13-20. 2008
    ..In addition, cell growth and proliferation may be inhibited by silibinin through down-regulation of Hec1...
  20. ncbi Teucrium polium reversed the MCD diet-induced liver injury in rats
    Rahim Amini
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Hum Exp Toxicol 30:1303-12. 2011
    ..These results indicate that the ethyl acetate fraction of T. poium effectively reversed NASH, mainly due to its strong antioxidant and anti-inflammatory properties...
  21. ncbi Gene amplification and overexpression of Aurora-C in breast and prostate cancer cell lines
    Ali Zekri
    Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
    Oncol Res 20:241-50. 2012
    ..At DNA level, only Aurora-C showed gene amplification in breast cancer cell lines (p < 0.005). Here we provide evidence for the first time of Aurora-C overexpression and gene amplification...
  22. ncbi Monitoring of cytomegalovirus reactivation in bone marrow transplant recipients by real-time PCR
    Seyed H Ghaffari
    Oncology and BMT Research Center, Tehran University Medical Sciences, Shariati Hospital, Tehran, 11411, Iran
    Pathol Oncol Res 14:399-409. 2008
    ..The quantitative CMV PCR might be a useful tool for monitoring the CMV reactivation and guiding the efficacy of the CMV preemptive therapy in BMT recipients...