- The REFLO-STEMI trial comparing intracoronary adenosine, sodium nitroprusside and standard therapy for the attenuation of infarct size and microvascular obstruction during primary percutaneous coronary intervention: study protocol for a randomised control
Sheraz A Nazir
Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, LE3 9QP Leicester, UK
Trials 15:371. 2014
..However, the evidence base remains weak as the trials have had variable endpoints, differing drug doses and delivery. As such, the results regarding benefit are conflicting...
- Prevalence and extent of infarct and microvascular obstruction following different reperfusion therapies in ST-elevation myocardial infarction
Jamal N Khan
Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
J Cardiovasc Magn Reson 16:38. 2014
..We sought to characterise the prevalence and extent of microvascular injury and IS using Cardiovascular magnetic resonance (CMR), in relation to the mode of reperfusion following acute ST-Elevation Myocardial Infarction (STEMI)...
- Reperfusion therapy for STEMI: is there still a role for thrombolysis in the era of primary percutaneous coronary intervention?
Anthony H Gershlick
Leicester Cardiovascular Biomedical Research Unit, University of Leicester, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UK
Lancet 382:624-32. 2013
..We review recent trial data, and explore opportunities for optimisation of STEMI outcomes with a pharmacoinvasive approach. ..
- Zotarolimus-eluting stents in patients with native coronary artery disease: clinical and angiographic outcomes in 1,317 patients
University Hospitals of Leicester School of Medicine, Leicester, United Kingdom
Am J Cardiol 100:45M-55M. 2007
- Rescue angioplasty after failed thrombolytic therapy for acute myocardial infarction
Anthony H Gershlick
Department of Cardiology, University Hospitals of Leicester, Leicester, United Kingdom
N Engl J Med 353:2758-68. 2005
..There are few data comparing emergency percutaneous coronary intervention (rescue PCI) with conservative care in such patients, and none comparing rescue PCI with repeated thrombolysis...
- Drug eluting stents in 2005
A H Gershlick
University of Leicester School of Medicine, Glenfield General Hospital, Leicester, UK
Heart 91:iii24-31. 2005
- Treating atherosclerosis: local drug delivery from laboratory studies to clinical trials
A H Gershlick
University Hospital Leicester, Glenfield Hospital, Groby Rd, Leicester LE3 9QP, UK
Atherosclerosis 160:259-71. 2002
..Issues such as which stent, how to load the drug onto the stent and what drug to use to inhibit the unwanted pathobiological response are ongoing issues...
- Inhibition of restenosis with a paclitaxel-eluting, polymer-free coronary stent: the European evaLUation of pacliTaxel Eluting Stent (ELUTES) trial
Department of Cardiology, University Hospitals of Leicester, Glenfield Hospital, Leicester, UK
Circulation 109:487-93. 2004
..The use of a stent to deliver a drug may reduce in-stent restenosis. Paclitaxel interrupts the smooth muscle cell cycle by stabilizing microtubules, thereby arresting mitosis...
- Two-year clinical results of a polymer-free, paclitaxel-eluting stent: the ELUTES trial
Department of Cardiology, University Hospitals of Leicester, Glenfield Hospital, Leicester, United Kingdom
EuroIntervention 3:109-12. 2007
..Conclusions: Non-polymer, paclitaxel-coated stents effectively inhibited angiographic parameters of restenosis. The stent system appeared safe with no recorded late stent thrombosis...
- Human internal mammary artery organ culture model of coronary stenting: a novel investigation of smooth muscle cell response to drug-eluting stents
Clinical Sciences Department, Glenfield Hospital, Leicester LE3 9QP, UK
Clin Sci (Lond) 103:347-53. 2002
..Such an organ culture model of stented mammary artery will provide useful data in addition to that from animal or cell culture models of drug-eluting stents...
- Contemporary percutaneous coronary intervention--30 years in the making
A H Gershlick
University Hospitals of Leicester
Clin Med 8:171-2. 2008
..Many have a lot to be grateful for when we reflect on the insights and pioneering work of Andreas Gruntzig...
- Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base
Department of Cardiology, Glenfield Hospital, Leicester, United Kingdom
EuroIntervention 7:1103-10. 2012
- Retrograde approach to chronic total occlusions: can septal vessels be used more than once?
Cardiovascular Intervention Department, University Hospitals of Leicester, United Kingdom
J Invasive Cardiol 21:E234-6. 2009
..We present 2 cases where a second attempt at the retrograde approach was unsuccessful because of changes in the septal collateral, which having previously allowed passage of the balloon, failed to do so on the subsequent attempt...
- Drug eluting stents in interventional cardiology -- current evidence and emerging uses
University Hospitals of Leicester, UK
Curr Drug Targets Cardiovasc Haematol Disord 5:313-21. 2005
..This reduction is highly significant in angiographic terms and, to a lesser degree, in the prevention of clinically important restenosis requiring revascularisation, but not clearly in terms of overall mortality...
- Is there a role for provocation testing to diagnose coronary artery spasm?
Department of Cardiology, Glenfield Hospital, Groby Road, Leicester LE3 9QP, England
Int J Cardiol 102:1-7. 2005
..A more widespread use of these tests in patients with undiagnosed chest pain syndromes would not currently be recommended...
- Clopidogrel induced urticarial rash in a patient with left main stem percutaneous coronary intervention: management issues
S K Khambekar
Department of Cardiology, Glenfield Hospital, University Hospital of Leicester, Leicester, UK
Heart 90:e14. 2004
- Role of non-invasive imaging in the management of coronary artery disease: an assessment of likely change over the next 10 years. A report from the British Cardiovascular Society Working Group
A H Gershlick
Department of Cardiology, University of Leicester, Glenfield Hospital, Leicester, UK
Heart 93:423-31. 2007
- The acute management of myocardial infarction
A H Gershlick
Academic Department of Cardiology, University Hospitals Leicester, Leicester, UK
Br Med Bull 59:89-112. 2001
..Once they have arrived at point of medical contact, rapid triage, early diagnosis and the institution of therapies designed to reduce the extent of myocardial damage are paramount...
- Refractory vasospastic angina causing myocardial infarction and VF arrest requiring combined medical, electrophysiological, percutaneous and surgical intervention--a case report
Salman S Nishtar
Int J Cardiol 119:e4-7. 2007
- Percutaneous coronary intervention after fibrinolysis: a multiple meta-analyses approach according to the type of strategy
Jean Philippe Collet
Pitie Salpetriere University Hospital, Paris, France
J Am Coll Cardiol 48:1326-35. 2006