Christos C Zouboulis

Summary

Country: Germany

Publications

  1. ncbi request reprint Isotretinoin revisited: pluripotent effects on human sebaceous gland cells
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 126:2154-6. 2006
  2. doi request reprint Treating acne with antibiotic-resistant bacterial colonization
    Thrasivoulos Tzellos
    Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany
    Expert Opin Pharmacother 12:1233-47. 2011
  3. doi request reprint [Pathophysiology of acne. What is confirmed?]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau Roßlau
    Hautarzt 64:235-40. 2013
  4. doi request reprint Hormonal therapy of intrinsic aging
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Rejuvenation Res 15:302-12. 2012
  5. doi request reprint Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
  6. doi request reprint Human skin stem cells and the ageing process
    Christos C Zouboulis
    Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Exp Gerontol 43:986-97. 2008
  7. ncbi request reprint Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Cutis 84:223-9. 2009
  8. doi request reprint [Acne vulgaris. The role of hormones]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847 Dessau Rosslau
    Hautarzt 61:107-8, 110-4. 2010
  9. doi request reprint The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Arch Dermatol Res 300:397-413. 2008
  10. ncbi request reprint Sexual hormones in human skin
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Horm Metab Res 39:85-95. 2007

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Isotretinoin revisited: pluripotent effects on human sebaceous gland cells
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 126:2154-6. 2006
    ..These events were specific to sebocytes, as isotretinoin failed to induce apoptosis in keratinocytes. Isotretinoin-induced apoptosis was shown to be an RAR-independent mechanism...
  2. doi request reprint Treating acne with antibiotic-resistant bacterial colonization
    Thrasivoulos Tzellos
    Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany
    Expert Opin Pharmacother 12:1233-47. 2011
    ..Antibiotics have been the primary treatment against P. acnes for more than 40 years. However, a gradual increase in the prevalence of antibiotic-resistant strains of P. acnes has been observed...
  3. doi request reprint [Pathophysiology of acne. What is confirmed?]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau Roßlau
    Hautarzt 64:235-40. 2013
    ..Proinflammatory lipids, chemokines and cytokines overtake the role of mediators for the further development of acne lesions. Bacterial antigens can potentate the inflammatory phenomena...
  4. doi request reprint Hormonal therapy of intrinsic aging
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Rejuvenation Res 15:302-12. 2012
    ..Vitamin D substitution and antioxidant treatment may also be beneficial. Replacement therapy with androgens, GH, IGF-I, progesterone, melatonin, cortisol, and thyroid hormones still remains controversial...
  5. doi request reprint Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
    ..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland...
  6. doi request reprint Human skin stem cells and the ageing process
    Christos C Zouboulis
    Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Exp Gerontol 43:986-97. 2008
    ..In addition, they provide in vitro models to study epidermal lineage selection and its role in the ageing process...
  7. ncbi request reprint Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Cutis 84:223-9. 2009
    ....
  8. doi request reprint [Acne vulgaris. The role of hormones]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847 Dessau Rosslau
    Hautarzt 61:107-8, 110-4. 2010
    ..Hormone-like active lipids, hormones in diet and neuropeptides may also play a role in the development of acne lesions. The target of antiandrogen treatment of the skin is mainly the sebaceous gland and the primary effect is sebostasis...
  9. doi request reprint The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Arch Dermatol Res 300:397-413. 2008
    ..This article summarizes the data of newest research of sebostasis, seborrhoea and acne made possible through the development of human and animal sebocyte culture models...
  10. ncbi request reprint Sexual hormones in human skin
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Horm Metab Res 39:85-95. 2007
    ..However, they reliably reduce acne. Cyproterone acetate and spironolactone are similarly effective as anti-androgens in reducing hirsutism, although there is wide variability in individual responses...
  11. doi request reprint Clinical aspects and molecular diagnostics of skin aging
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Clin Dermatol 29:3-14. 2011
    ..Understanding the molecular mechanisms of aging may open new strategies to deal with the various diseases accompanying high age, including cancer...
  12. doi request reprint Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Br J Dermatol 165:269-76. 2011
    ..On the other hand, fatty acid delta-6 desaturase-2 (FADS2) catalyses the conversion of LA to AA...
  13. doi request reprint [The sebaceous gland]
    C C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Germany
    Hautarzt 61:467-8, 4704, 476-7. 2010
    ..Atopic dermatitis, seborrheic dermatitis, psoriasis and acne vulgaris are some of the disease on which pathogenesis and severity sebaceous lipids may or are surely involved...
  14. ncbi request reprint HLA-independent antibacterial host response toward Th1 immunity mediated by IL-12: a new concept for the pathogenesis of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology and Immunology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 126:1444-7. 2006
    ..The authors provide evidence for an antibacterial host response toward T-helper type 1 immunity mediated by IL-12 in patients with ABD, which is HLA independent...
  15. ncbi request reprint [Epidemiology and clinical manifestations of Adamantiades-Behçet disease in Germany -- current pathogenetic concepts and therapeutic possibilities]
    Andreas Altenburg
    Clinic for Dermatology, Venerology and Allergology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin
    J Dtsch Dermatol Ges 4:49-64; quiz 65-6. 2006
  16. ncbi request reprint Aging of human sebocytes in vitro induced by exposure to a defined hormone environment
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dermatology 213:262-3. 2006
  17. ncbi request reprint Longterm visual prognosis of patients with ocular Adamantiades-Behçet's disease treated with interferon-alpha-2a
    Lothar Krause
    Department of Ophthalmology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Rheumatol 35:896-903. 2008
    ..Interferon-alpha (IFN-alpha) has proven to be effective in mucocutaneous ABD and has been reported to improve ocular lesions. We examined the longterm effects of IFN-alpha-2a in a case series of 45 patients with ocular involvement...
  18. doi request reprint Ocular involvement in Adamantiades-Behçet's disease in Berlin, Germany
    Lothar Krause
    Department of Ophthalmology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 247:661-6. 2009
    ..Berlin is the city with the highest number of non-native German inhabitants, and its multi-ethnic character renders it uniquely appropriate for epidemiological studies on ABD...
  19. pmc Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing?
    Evgenia Makrantonaki
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    PLoS ONE 7:e50393. 2012
    ..Furthermore, our data give evidence that skin could be used as a good alternative to understand ageing of different tissues such as CNS...
  20. ncbi request reprint Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake
    Jana Stecová
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, D 14195, Berlin, Germany
    Pharm Res 24:991-1000. 2007
    ..To improve skin penetration of the poorly absorbed drug, we intended to identify the active moiety and to load it to particulate carrier systems...
  21. doi request reprint Interplay of IGF-I and 17beta-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Exp Gerontol 43:939-46. 2008
    ..In conclusion, IGF-I is a key regulator of human skin aging and declining IGF-I levels with age may play a significant role in the reduction of skin surface lipids and thickness...
  22. ncbi request reprint Differentiation and apoptosis in human immortalized sebocytes
    ANNA WROBEL
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 120:175-81. 2003
    ..The latter result fits well with the currently reported inability of normal skin cells to undergo apoptosis after treatment with retinoids, in contrast to their malignant counterparts...
  23. ncbi request reprint Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous pemphigoid sera by ELISA
    Vassiliki Bekou
    Department of Dermatology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Invest Dermatol 124:732-40. 2005
    ..Thus, the established LN5 ELISA holds great promise as a novel diagnostic and prognostic parameter for MMP...
  24. ncbi request reprint Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands
    Theodosios Alestas
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    J Mol Med (Berl) 84:75-87. 2006
    ..In conclusion, human sebocytes possess the enzyme machinery for functional leukotriene and prostaglandin pathways. A comprehensive link between inflammation and sebaceous lipid synthesis is provided...
  25. doi request reprint KdPT, a tripeptide derivative of alpha-melanocyte-stimulating hormone, suppresses IL-1 beta-mediated cytokine expression and signaling in human sebocytes
    Arianna Mastrofrancesco
    Department of Dermatology, University of Munster, Munster, Germany
    J Immunol 185:1903-11. 2010
    ..Our data demonstrate a promising anti-inflammatory potential of KdPT and point toward novel future directions in the treatment of acne-as well as of various other IL-1-mediated inflammatory diseases-with this small molecule...
  26. doi request reprint Characterization of the vitamin D endocrine system in human sebocytes in vitro
    Christina Krämer
    Department of Dermatology, The Saarland University Hospital, 66421 Homburg Saar, Germany
    J Steroid Biochem Mol Biol 113:9-16. 2009
    ..We conclude that sebaceous glands represent potential targets for therapy with vitamin D analogues or for pharmacological modulation of 1,25(OH)(2)D(3) synthesis/metabolism...
  27. ncbi request reprint Intraocular surgery under systemic interferon-alpha therapy in ocular Adamantiades-Behçet's disease
    Lothar Krause
    Department of Ophthalmology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1617-21. 2007
    ..In some cases, such as tractional retinal detachment, secondary glaucoma or secondary cataract formation, intraocular surgery is required...
  28. doi request reprint [Modern aspects of acne pathogenesis]
    Christos C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Dessau Rosslau
    J Dtsch Dermatol Ges 8:S7-14. 2010
    ..Acne is worldwide the most common skin disease...
  29. ncbi request reprint Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease
    Aylin Kalayciyan
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 127:81-9. 2007
    ..Moreover, biochanin A is likely to exhibit similar and even more profound results than nicotine...
  30. doi request reprint Anti-acne agents attenuate FGFR2 signal transduction in acne
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    J Invest Dermatol 129:1868-77. 2009
    ....
  31. ncbi request reprint Differential regulation of Toll-like receptor and CD14 pathways by retinoids and corticosteroids in human sebocytes
    Marina K Oeff
    Department of Dermatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dermatology 213:266. 2006
  32. ncbi request reprint Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Aging Cell 5:331-44. 2006
    ....
  33. ncbi request reprint A historical review of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Adv Exp Med Biol 528:7-14. 2003
  34. ncbi request reprint Update and future of systemic acne treatment
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Dermatology 206:37-53. 2003
    ....
  35. doi request reprint Propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany
    J Invest Dermatol 129:2093-6. 2009
    ..acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that P. acnes-induced lipids may represent a recruitment of allies and/or enemies of the human skin...
  36. ncbi request reprint The skin as a mirror of the aging process in the human organism--state of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)
    Evgenia Makrantonaki
    Departments of Dermatology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Exp Gerontol 42:879-86. 2007
    ..Thus, these results could be a basis for an integrated and interdisciplinary approach to the analysis of the aging process...
  37. ncbi request reprint Acne and sebaceous gland function
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    Clin Dermatol 22:360-6. 2004
    ..They should also influence peroxisome proliferator-activated receptor regulation. Isotretinoin is still the most active available drug for the treatment of severe acne...
  38. ncbi request reprint Intralesional cryosurgery enhances the involution of recalcitrant auricular keloids: a new clinical approach supported by experimental studies
    Yaron Har-Shai
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Wound Repair Regen 14:18-27. 2006
    ....
  39. doi request reprint Aging-related changes in cutaneous corticotropin-releasing hormone system reflect a defective neuroendocrine-stress response in aging
    Rana Mohsen Elewa
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Rejuvenation Res 15:366-73. 2012
    ..However, a consistent logic interaction between the different CRH system components and the aging process has, to our knowledge, never been examined before...
  40. ncbi request reprint New pharmaceutical concepts for sebaceous gland diseases: implementing today's pre-clinical data into tomorrow's daily clinical practice
    Vasiliki A Zampeli
    Department of Dermatology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Curr Pharm Biotechnol 13:1898-913. 2012
    ..This review will focus on the pathogenesis of the most common sebaceous gland diseases and their molecular pathways which may represent future pharmaceutical targets...
  41. pmc Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    Alessandro Prigione
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 6:e27352. 2011
    ..Nevertheless, we believe it will be essential to develop reprogramming protocols capable of safeguarding the integrity of the genome of aged somatic cells, before employing iPSC-based therapy for age-associated disorders...
  42. doi request reprint [Hormonal antiandrogens in acne treatment]
    Christos C Zouboulis
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Dessau Rosslau
    J Dtsch Dermatol Ges 8:S60-74. 2010
    ....
  43. doi request reprint Skin and brain age together: The role of hormones in the ageing process
    Evgenia Makrantonaki
    Department of Dermatology, Dessau Medical Center, Germany
    Exp Gerontol 45:801-13. 2010
    ....
  44. ncbi request reprint High albumin levels restrict the kinetics of 13-cis retinoic acid uptake and intracellular isomerization to all-trans retinoic acid and inhibit its anti-proliferative effect on SZ95 sebocytes
    Miki Tsukada
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    J Invest Dermatol 119:182-5. 2002
    ..These results indicate a critical function of serum albumin as retinoid-binding protein in reducing the concentration of active retinoids and restricting their biologic effects on human sebocytes...
  45. doi request reprint Androgens and ageing of the skin
    Evgenia Makrantonaki
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Curr Opin Endocrinol Diabetes Obes 16:240-5. 2009
    ..This study reviews current advances in our understanding of the role of androgens in the initiation of skin ageing...
  46. ncbi request reprint Vitamins as hormones
    J Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Horm Metab Res 39:71-84. 2007
    ..This review summarizes existing knowledge on vitamins A and D, the major vitamin-hormones of the skin...
  47. doi request reprint Diagnostics of autoimmune bullous diseases in German dermatology departments
    Nina van Beek
    Department of Dermatology, Allergology and Venereology, University of Lubeck, Germany
    J Dtsch Dermatol Ges 10:492-9. 2012
    ..The aim of this survey was to describe currently performed diagnostic methods for bullous autoimmune diseases in German dermatology departments...
  48. ncbi request reprint William J. Cunliffe Scientific Awards. Characteristics and pathomechanisms of endogenously aged skin
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dermatology 214:352-60. 2007
    ..In conclusion, among other factors the hormone environment plays a distinct role in the generation of aged skin...
  49. ncbi request reprint Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial
    Thomas Ruzicka
    Department of Dermatology, Heinrich Heine University Hospital, Dusseldorf, Germany
    Arch Dermatol 140:1453-9. 2004
    ..To assess the efficacy and safety of oral alitretinoin (9-cis-retinoic acid), 10 mg/d, 20 mg/d, and 40 mg/d, compared with placebo control, in the treatment of chronic hand dermatitis...
  50. ncbi request reprint Extended venous thrombosis in Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Fabeckstrasse 60 62 14195 Berlin, Germany
    Eur J Dermatol 14:268-71. 2004
    ..During the 52-month follow-up single oral aphthous ulcers were occasionally observed and erythema nodosum-like lesions and skin pustules occurred at the lower extremities two weeks after a temporary discontinuation of treatment...
  51. ncbi request reprint Neuroendocrine regulation of sebocytes -- a pathogenetic link between stress and acne
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Dermatol 13:31-5. 2004
    ..By means of their autocrine, paracrine and endocrine actions, these neuroendocrine factors appear to mediate centrally and topically induced stress towards the sebaceous gland, ultimately affecting the clinical course of acne...
  52. ncbi request reprint Pathogenesis of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Adv Exp Med Biol 528:161-71. 2003
  53. ncbi request reprint Association of Mycoplasma fermentans with Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Adv Exp Med Biol 528:191-4. 2003
  54. ncbi request reprint Interferon alfa-2a in the treatment of ocular Adamantiades-Behçet's disease
    Lothar Krause
    Department of Ophthalmology, University Medical Center Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Adv Exp Med Biol 528:511-9. 2003
  55. ncbi request reprint Benediktos Adamantiades and his forgotten contributions to medicine
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    Eur J Dermatol 12:471-4. 2002
    ..Adamantiades compiled over 150 scientific papers many of which marked a new stage in his field. He died in 1962 in Athens...
  56. doi request reprint 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro
    Qiang Ju
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Exp Dermatol 20:320-5. 2011
    ..In addition and together with the results of a parallel study (J Dermatol Sci 58, 2010, 211), we provide evidence that TCDD effects on human sebocytes are mediated through the AhR signalling pathway...
  57. ncbi request reprint Psychophysiological reactivity under mental stress in atopic dermatitis
    Kristina Seiffert
    Department of Psychosomatics and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dermatology 210:286-93. 2005
    ..An association of mental stress with atopic dermatitis is widely accepted. However, no long-term evaluation of psychophysiological reactivity over the course of disease has yet been performed...
  58. ncbi request reprint Androgen action on human skin -- from basic research to clinical significance
    Christos C Zouboulis
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Exp Dermatol 13:5-10. 2004
    ..Partial effectiveness has only been achieved either by androgen depletion, inhibition of androgen metabolism or blockade of the androgen receptor...
  59. ncbi request reprint Inhibition of the androgen receptor by antisense oligonucleotides regulates the biological activity of androgens in SZ95 sebocytes
    S Fimmel
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:149-56. 2007
    ....
  60. doi request reprint [Dermatoendocrinology. Skin aging]
    E Makrantonaki
    Klinik fur Dermatologie, Venerologie und Allergologie Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Germany
    Hautarzt 61:505-10. 2010
    ....
  61. pmc Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:311-5. 2013
    ....
  62. pmc Malignant atrophic papulosis (Köhlmeier-Degos disease) - a review
    Athanasios Theodoridis
    Departments of Dermatology, Venerology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, Dessau, 06847, Germany
    Orphanet J Rare Dis 8:10. 2013
    ..is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim...
  63. doi request reprint Non-infectious ulcerating oral mucous membrane diseases
    Andreas Altenburg
    Department of Dermatology, Venerology and Allergology Immunological Center, Dessau Medical Center, Germany
    J Dtsch Dermatol Ges 7:242-57. 2009
    ....
  64. pmc Discovering the link between nutrition and skin aging
    Silke K Schagen
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center Dessau, Germany
    Dermatoendocrinol 4:298-307. 2012
    ..This review will provide an overview of the current literature "linking" nutrition with skin aging...
  65. ncbi request reprint Univariate and multivariate analyses comparing demographic, genetic, clinical, and serological risk factors for severe Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Adv Exp Med Biol 528:123-6. 2003
  66. ncbi request reprint Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis
    Christos C Zouboulis
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 19:148-50. 2010
    ..IL-6 release and neutral lipid content were also reduced under long-term zileuton treatment. In conclusion, zileuton prevents the activation of the leukotriene pathway and enhancement of lipogenesis by AA in human sebocytes in vitro...
  67. doi request reprint [S2k-guideline for therapy of acne]
    Alexander Nast
    Division of Evidence Based Medicine, Klinik fur Dermatologie, Venerologie und Allergologie, Charite Universitatsmedizin Berlin, Berlin
    J Dtsch Dermatol Ges 8:s1-59. 2010
    ..For maintenance treatment: topical retinoid or its combination with BPO. Particular attention should be paid to compliance and quality of life. Additional treatment options are discussed in the main body of the text...
  68. pmc Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 99:7148-53. 2002
    ..The findings implicate CRH in the clinical development of acne, seborrhea, androgenetic alopecia, skin aging, xerosis, and other skin disorders associated with alterations in lipid formation of sebaceous origin...
  69. ncbi request reprint Pathogenesis of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Med Microbiol Immunol 192:149-55. 2003
    ..Endothelial activation leading to a chronic local inflammation process together with platelet and serum factors enhance coagulation and thrombosis...
  70. ncbi request reprint Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands
    K Krause
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:166-70. 2007
    ..However, further investigations into the downstream effects of CRH and Uct are required to elucidate the mechanism by which these neuropeptides could establish a stress-related pathophysiological condition in the skin...
  71. ncbi request reprint The human sebocyte culture model provides new insights into development and management of seborrhoea and acne
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Dermatology 196:21-31. 1998
    ....
  72. ncbi request reprint Sebocytes are the key regulators of androgen homeostasis in human skin
    M Fritsch
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 116:793-800. 2001
    ..Sebocytes are able to synthesize testosterone from adrenal precursors and to inactivate it in order to maintain androgen homeostasis, whereas keratinocytes are responsible for androgen degradation...
  73. ncbi request reprint Chronological ageing and photoageing of the human sebaceous gland
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Clin Exp Dermatol 26:600-7. 2001
    ..Topical and systemic oestrogens offer treatment options for skin xerosis in menopausal females. A combination of isotretinoin and interferon-alpha may prevent tumour development in patients with Muir-Torre syndrome...
  74. doi request reprint Acrodermatitis enteropathica: an uncommon differential diagnosis in childhood - first description of a new sequence variant
    Anja G Jung
    Department of Dermatology, Dessau Hospital, Dessau, Germany
    J Dtsch Dermatol Ges 9:999-1002. 2011
    ..Lifelong zinc substitution is recommended. A differential diagnosis can be difficult because bacterial and fungal superinfection is common in zinc deficiency. Precise diagnosis requires testing family members for the gene...
  75. ncbi request reprint A historical review of early descriptions of Adamantiades-Behçet's disease
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    J Invest Dermatol 119:201-5. 2002
  76. pmc Medium-dose prednisolone pulse therapy in alopecia areata
    Pinelopi Efentaki
    Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Dessau, Germany
    Dermatoendocrinol 1:310-3. 2009
    ..Although the exact etiology of alopecia areata is still unknown, systemic prednisolone treatment seem to be effective in early stages but significant side effects may occur leading to discontinuation of treatment...
  77. ncbi request reprint Isotretinoin: state of the art treatment for acne vulgaris
    Ruta Ganceviciene
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    J Dtsch Dermatol Ges 8:S47-59. 2010
    ....
  78. ncbi request reprint Current developments and uses of cryosurgery in the treatment of keloids and hypertrophic scars
    Christos C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Wound Repair Regen 10:98-102. 2002
  79. ncbi request reprint The William J. Cunliffe Scientific Awards
    Christos C Zouboulis
    Department of Dermatology, Charité University of Medicine Berlin, Germany
    Dermatology 211:191-2. 2005
  80. ncbi request reprint [Severe erythrodermic psoriasis in a patient with 22q11 deletion syndrome]
    Jan C Preiss
    Medizinische Klinik I Gastroenterologie, Infektiologie, Rheumatologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin
    Med Klin (Munich) 100:275-8. 2005
    ..Erythrodermic psoriasis is a severe manifestation of psoriasis and can be triggered by several factors...
  81. ncbi request reprint Sebaceous glands and the prostaglandin pathway--key stones of an exciting mosaic
    Christos C Zouboulis
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 125:x-xi. 2005
  82. ncbi request reprint Responsiveness to androgens and effectiveness of antisense oligonucleotides against the androgen receptor on human epidermal keratinocytes is dependent on the age of the donor and the location of cell origin
    S Fimmel
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:157-65. 2007
    ..Our results demonstrate an enhanced androgen sensitivity of keratinocytes from aged individuals associated with an origin-specific type of response...
  83. ncbi request reprint Impressive skin manifestation of systemic sarcoidosis
    A M H A Janitha P Chandani
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    Int J Dermatol 41:232-6. 2002
  84. ncbi request reprint All-trans-retinoic acid and 13-cis-retinoic acid: pharmacokinetics and biological activity in different cell culture models of human keratinocytes
    M Schroeder
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:136-40. 2007
    ..On the other hand, induced keratinocyte proliferation in low seeding densities may provide an explanation for the acanthosis induced by topical retinoids in aged and steroid-damaged skin...
  85. ncbi request reprint Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Invest Dermatol 113:1011-20. 1999
    ..Thus SZ95 is an immortalized human sebaceous gland cell line that shows the morphologic, phenotypic and functional characteristics of normal human sebocytes...
  86. ncbi request reprint Clindamycin phosphate/tretinoin gel formulation in the treatment of acne vulgaris
    M Badawy Abdel-Naser
    Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg 38, 06847 Dessau, Germany
    Expert Opin Pharmacother 9:2931-7. 2008
    ..The once daily use of CTG, its rapid and dual effect and good tolerability have a positive impact on the duration of disease, patients' compliance and overall costs of therapy...
  87. ncbi request reprint Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes
    E Makrantonaki
    Laboratory of Biogerontology, Dermatopharmacology and Dermatoendocrinology, Institute of Clinical Pharmacology and Toxicology, Charite University Medicine Berlin, Berlin, Germany
    Br J Dermatol 156:428-32. 2007
    ..This contradiction led to the assumption that cofactors may be required for lipid regulation and peroxisome proliferator-activated receptor (PPAR) ligands were suggested to be adequate candidates...
  88. ncbi request reprint Ulerythema ophryogenes and keratosis pilaris in a child with monosomy 18p
    C C Zouboulis
    Department of Dermatology, University Medical Center Steglitz, Germany
    Pediatr Dermatol 11:172-5. 1994
    ..The association of chromosome 18p deletion defect and ulerythema ophryogenes may be helpful in future attempts to localize the gene defect responsible for follicular genokeratoses...
  89. ncbi request reprint Effect of 5alpha-dihydrotestosterone and testosterone on apoptosis in human dermal papilla cells
    A Winiarska
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Pharmacol Physiol 19:311-21. 2006
    ..These data suggest that DPC from nonbalding scalp regions do have the capacity to undergo apoptosis, but need a high androgen stimulus. The present study provides an interesting new pathogenetic approach in androgenetic alopecia...
  90. ncbi request reprint Human skin: an independent peripheral endocrine organ
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Horm Res 54:230-42. 2000
    ..Therefore, the human skin fulfils all requirements for being the largest, independent peripheral endocrine organ...
  91. ncbi request reprint Molecular mechanisms of skin aging: state of the art
    E Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute Clinical Pharmacology and Toxiology, Berlin, Berlin, Germany
    Ann N Y Acad Sci 1119:40-50. 2007
    ..Understanding the molecular mechanisms of aging may open new strategies in dealing with the various diseases accompanying aging, including cancer...
  92. ncbi request reprint Exploration of retinoid activity and the role of inflammation in acne: issues affecting future directions for acne therapy
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Eur Acad Dermatol Venereol 15:63-7. 2001
    ..Therefore, future compounds targeting acne have to inhibit pro-inflammatory lipids in sebum, and thus down-regulate acne-related inflammatory signals and reduce the LTB4-induced migration of inflammatory cells...
  93. ncbi request reprint Retinoids--which dermatological indications will benefit in the near future?
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Skin Pharmacol Appl Skin Physiol 14:303-15. 2001
    ....
  94. ncbi request reprint Influence of physiological androgen levels on wound healing and immune status in men
    S Fimmel
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Aging Male 8:166-74. 2005
    ....
  95. ncbi request reprint Cryosurgery in dermatology
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D 12 200, Berlin, Germany
    Eur J Dermatol 8:466-74. 1998
    ..Pain during and/or shortly after treatment, bulla formation and local oedema are the major, temporary adverse effects; lesional hypopigmentation and/or peripheral hyperpigmentation is the most common by occurring long-term complication...
  96. ncbi request reprint Topical all-trans retinoic acid (RA) induces an early, coordinated increase in RA-inducible skin-specific gene/psoriasin and cellular RA-binding protein II mRNA levels which precedes skin erythema
    C C Zouboulis
    Department of Dermatology, University Medical Center, Benjamin Franklin, Free University of Berlin, Germany
    Arch Dermatol Res 288:664-9. 1996
    ..We conclude, therefore, that induction of RIS-1 and CRABP II mRNA levels by topical RA in human skin are early, coordinated molecular events which precede the clinical cutaneous erythematous response to RA...
  97. ncbi request reprint Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
    Anja Thielitz
    Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Invest Dermatol 127:1042-51. 2007
    ....
  98. ncbi request reprint Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production
    Qiwei Zhang
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Dermatol 15:769-74. 2006
    ..These studies suggest that SZ95 sebocytes express functional PAF-Rs and PAF-Rs are involved in regulating the expression of inflammatory mediators, including COX-2, PGE(2) and IL-8...
  99. ncbi request reprint Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin
    Eleni Papakonstantinou
    Department of Pharmacology, School of Medicine, Aristotle University, Thessaloniki, Greece
    J Invest Dermatol 125:673-84. 2005
    ..These data indicate that MMP and TIMP of epithelial origin may be involved in acne pathogenesis, and that isotretinoin-induced reduction in MMP-9 and -13 may contribute to the therapeutic effects of the agent in acne...
  100. ncbi request reprint Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris
    Monica Ottaviani
    San Gallicano Dermatological Institute IRCCS, Rome, Italy
    J Invest Dermatol 126:2430-7. 2006
    ....
  101. ncbi request reprint LXRalpha enhances lipid synthesis in SZ95 sebocytes
    Il Hong
    College of Pharmacy and Bio MAX Institute, Seoul National University, Seoul, Korea
    J Invest Dermatol 128:1266-72. 2008
    ..Thus, we suggest that LXR ligands could provide a new class of therapeutic agents for sebaceous gland-associated disorders such as seborrhea and acne...