C C Zouboulis

Summary

Country: Germany

Publications

  1. ncbi request reprint Extracorporeal photopheresis of cutaneous T-cell lymphoma is associated with reduction of peripheral CD4+ T lymphocytes
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Dermatology 196:305-8. 1998
  2. ncbi request reprint Adamantiades-Behçet's disease: interleukin-8 is increased in serum of patients with active oral and neurological manifestations and is secreted by small vessel endothelial cells
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Arch Dermatol Res 292:279-84. 2000
  3. ncbi request reprint Epidemiology of Adamantiades-Behçet's disease
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Ann Med Interne (Paris) 150:488-98. 1999
  4. ncbi request reprint Epidemiological features of Adamantiades-Behçet's disease in Germany and in Europe
    C C Zouboulis
    German Registry of Adamantiades Behçet s Disease, Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Yonsei Med J 38:411-22. 1997
  5. ncbi request reprint The human sebocyte culture model provides new insights into development and management of seborrhoea and acne
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Dermatology 196:21-31. 1998
  6. ncbi request reprint Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Invest Dermatol 113:1011-20. 1999
  7. ncbi request reprint Cryosurgery in dermatology
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D 12 200, Berlin, Germany
    Eur J Dermatol 8:466-74. 1998
  8. ncbi request reprint Inhibition of the androgen receptor by antisense oligonucleotides regulates the biological activity of androgens in SZ95 sebocytes
    S Fimmel
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:149-56. 2007
  9. ncbi request reprint Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3
    N Booken
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Leukemia 22:393-9. 2008
  10. ncbi request reprint Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands
    K Krause
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:166-70. 2007

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Extracorporeal photopheresis of cutaneous T-cell lymphoma is associated with reduction of peripheral CD4+ T lymphocytes
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Dermatology 196:305-8. 1998
    ..Extracorporeal photopheresis (ECP) has been successfully introduced for the treatment of cutaneous T-cell lymphoma; however, the mechanism(s) of its action is (are) unknown...
  2. ncbi request reprint Adamantiades-Behçet's disease: interleukin-8 is increased in serum of patients with active oral and neurological manifestations and is secreted by small vessel endothelial cells
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Arch Dermatol Res 292:279-84. 2000
    ..Human microvascular endothelial cells may, at least partially, be responsible for the enhanced IL-8 secretion in the active stage of the disease...
  3. ncbi request reprint Epidemiology of Adamantiades-Behçet's disease
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Ann Med Interne (Paris) 150:488-98. 1999
    ..Diagnosis can be established 2 to 15 years after the onset of the disease. Male gender, early development of the disease, and HLA-B51 positivity are markers of severe prognosis (mortality rates of 0-6%)...
  4. ncbi request reprint Epidemiological features of Adamantiades-Behçet's disease in Germany and in Europe
    C C Zouboulis
    German Registry of Adamantiades Behçet s Disease, Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Yonsei Med J 38:411-22. 1997
    ..HLA-B5 was confirmed as a marker of severe prognosis. Cardiolipin autoantibodies were associated with cutaneous vasculitis and superficial thrombophlebitis was correlated with systemic vessel involvement...
  5. ncbi request reprint The human sebocyte culture model provides new insights into development and management of seborrhoea and acne
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Dermatology 196:21-31. 1998
    ....
  6. ncbi request reprint Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Invest Dermatol 113:1011-20. 1999
    ..Thus SZ95 is an immortalized human sebaceous gland cell line that shows the morphologic, phenotypic and functional characteristics of normal human sebocytes...
  7. ncbi request reprint Cryosurgery in dermatology
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, D 12 200, Berlin, Germany
    Eur J Dermatol 8:466-74. 1998
    ..Pain during and/or shortly after treatment, bulla formation and local oedema are the major, temporary adverse effects; lesional hypopigmentation and/or peripheral hyperpigmentation is the most common by occurring long-term complication...
  8. ncbi request reprint Inhibition of the androgen receptor by antisense oligonucleotides regulates the biological activity of androgens in SZ95 sebocytes
    S Fimmel
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:149-56. 2007
    ....
  9. ncbi request reprint Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3
    N Booken
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Leukemia 22:393-9. 2008
    ..Furthermore, CDO1 catalyzes taurine synthesis and taurine inhibits apoptosis and promotes chemoprotection. In summary, CDO1 and DNM3 may improve the diagnosis of SS and open novel clues to its pathogenesis...
  10. ncbi request reprint Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands
    K Krause
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:166-70. 2007
    ..However, further investigations into the downstream effects of CRH and Uct are required to elucidate the mechanism by which these neuropeptides could establish a stress-related pathophysiological condition in the skin...
  11. doi request reprint Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany
    Br J Dermatol 165:269-76. 2011
    ..On the other hand, fatty acid delta-6 desaturase-2 (FADS2) catalyses the conversion of LA to AA...
  12. ncbi request reprint Sebocytes are the key regulators of androgen homeostasis in human skin
    M Fritsch
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 116:793-800. 2001
    ..Sebocytes are able to synthesize testosterone from adrenal precursors and to inactivate it in order to maintain androgen homeostasis, whereas keratinocytes are responsible for androgen degradation...
  13. doi request reprint Hormonal therapy of intrinsic aging
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Rejuvenation Res 15:302-12. 2012
    ..Vitamin D substitution and antioxidant treatment may also be beneficial. Replacement therapy with androgens, GH, IGF-I, progesterone, melatonin, cortisol, and thyroid hormones still remains controversial...
  14. ncbi request reprint Vitamins as hormones
    J Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Horm Metab Res 39:71-84. 2007
    ..This review summarizes existing knowledge on vitamins A and D, the major vitamin-hormones of the skin...
  15. ncbi request reprint Responsiveness to androgens and effectiveness of antisense oligonucleotides against the androgen receptor on human epidermal keratinocytes is dependent on the age of the donor and the location of cell origin
    S Fimmel
    Laboratory of Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Horm Metab Res 39:157-65. 2007
    ..Our results demonstrate an enhanced androgen sensitivity of keratinocytes from aged individuals associated with an origin-specific type of response...
  16. ncbi request reprint Molecular mechanisms of skin aging: state of the art
    E Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute Clinical Pharmacology and Toxiology, Berlin, Berlin, Germany
    Ann N Y Acad Sci 1119:40-50. 2007
    ..Understanding the molecular mechanisms of aging may open new strategies in dealing with the various diseases accompanying aging, including cancer...
  17. ncbi request reprint Chronological ageing and photoageing of the human sebaceous gland
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Clin Exp Dermatol 26:600-7. 2001
    ..Topical and systemic oestrogens offer treatment options for skin xerosis in menopausal females. A combination of isotretinoin and interferon-alpha may prevent tumour development in patients with Muir-Torre syndrome...
  18. doi request reprint Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?
    M Schuster
    Department of Dermatology, Venereology and Allergology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt Main 60590, Germany
    Br J Dermatol 164:182-6. 2011
    ..As peroxisome proliferator-activated receptors (PPARs) are known to control lipid metabolism in several human tissues they have been considered to be involved in the pathogenesis of acne vulgaris...
  19. ncbi request reprint Sexual hormones in human skin
    C C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Horm Metab Res 39:85-95. 2007
    ..However, they reliably reduce acne. Cyproterone acetate and spironolactone are similarly effective as anti-androgens in reducing hirsutism, although there is wide variability in individual responses...
  20. ncbi request reprint Topical all-trans retinoic acid (RA) induces an early, coordinated increase in RA-inducible skin-specific gene/psoriasin and cellular RA-binding protein II mRNA levels which precedes skin erythema
    C C Zouboulis
    Department of Dermatology, University Medical Center, Benjamin Franklin, Free University of Berlin, Germany
    Arch Dermatol Res 288:664-9. 1996
    ..We conclude, therefore, that induction of RIS-1 and CRABP II mRNA levels by topical RA in human skin are early, coordinated molecular events which precede the clinical cutaneous erythematous response to RA...
  21. ncbi request reprint Alternative versus classical activation of macrophages
    S Goerdt
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Pathobiology 67:222-6. 1999
    ..Thus, classically and alternatively activated APC secure the balance between proinflammatory and anti-inflammatory immune reactions...
  22. ncbi request reprint Exploration of retinoid activity and the role of inflammation in acne: issues affecting future directions for acne therapy
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Eur Acad Dermatol Venereol 15:63-7. 2001
    ..Therefore, future compounds targeting acne have to inhibit pro-inflammatory lipids in sebum, and thus down-regulate acne-related inflammatory signals and reduce the LTB4-induced migration of inflammatory cells...
  23. ncbi request reprint Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes
    E Makrantonaki
    Laboratory of Biogerontology, Dermatopharmacology and Dermatoendocrinology, Institute of Clinical Pharmacology and Toxicology, Charite University Medicine Berlin, Berlin, Germany
    Br J Dermatol 156:428-32. 2007
    ..This contradiction led to the assumption that cofactors may be required for lipid regulation and peroxisome proliferator-activated receptor (PPAR) ligands were suggested to be adequate candidates...
  24. ncbi request reprint Mycophenolate mofetil is ineffective in the treatment of mucocutaneous Adamantiades-Behçet's disease
    Y D Adler
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Dermatology 203:322-4. 2001
    ..0 +/- 1.0 to 0.0 +/- 0.0. No adverse effects were detected under MMF treatment. CONCLUSION: MMF (2-3 g/day) is unable to control the signs of mucocutaneous Adamantiades-Behçet's disease...
  25. ncbi request reprint Influence of physiological androgen levels on wound healing and immune status in men
    S Fimmel
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Aging Male 8:166-74. 2005
    ....
  26. ncbi request reprint Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades-Behçet's disease in Greece
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Clin Exp Rheumatol 21:S19-26. 2003
    ..To examine the onset signs, clinical course, prognosis, treatment and outcome of Adamantiades-Behçet's disease in adult Greek patients during a 10-year follow-up period, and to compare the results with those of other series reported...
  27. ncbi request reprint Retinoids--which dermatological indications will benefit in the near future?
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Skin Pharmacol Appl Skin Physiol 14:303-15. 2001
    ....
  28. pmc Superimposed primary chancre in a patient with Adamantiades-Behçet's disease
    N Meljanac
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Sex Transm Infect 75:124-5. 1999
    ..The genital lesion healed 4 weeks after initiation of treatment with tetracycline 2 mg/day by mouth for 15 days...
  29. ncbi request reprint All-trans-retinoic acid and 13-cis-retinoic acid: pharmacokinetics and biological activity in different cell culture models of human keratinocytes
    M Schroeder
    Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Horm Metab Res 39:136-40. 2007
    ..On the other hand, induced keratinocyte proliferation in low seeding densities may provide an explanation for the acanthosis induced by topical retinoids in aged and steroid-damaged skin...
  30. ncbi request reprint Ulerythema ophryogenes and keratosis pilaris in a child with monosomy 18p
    C C Zouboulis
    Department of Dermatology, University Medical Center Steglitz, Germany
    Pediatr Dermatol 11:172-5. 1994
    ..The association of chromosome 18p deletion defect and ulerythema ophryogenes may be helpful in future attempts to localize the gene defect responsible for follicular genokeratoses...
  31. doi request reprint Ocular involvement is associated with HLA-B51 in Adamantiades-Behçet's disease
    L Krause
    Department of Ophthalmology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Eye (Lond) 23:1182-6. 2009
    ..To evaluate the association of HLA-B51 and ocular involvement in Adamantiades-Behçet's disease...
  32. ncbi request reprint Overexpression of c-myb in leukaemic and non-leukaemic variants of cutaneous T-cell lymphoma
    N Poenitz
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
    Dermatology 211:84-92. 2005
    ....
  33. ncbi request reprint A novel tetracycline-controlled transactivator-transrepressor system enables external control of oncolytic adenovirus replication
    H Fechner
    Department of Cardiology and Pneumology, University Medical Center Benjamin Franklin, Freie Universitat, Berlin, Germany
    Gene Ther 10:1680-90. 2003
    ..The concept of external control of RRCAs may help to improve the safety of cancer gene therapy...
  34. ncbi request reprint Adamantiades-Behçet's disease with inner ear involvement
    Y D Adler
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    Clin Exp Rheumatol 20:S40-2. 2002
    ..Inner ear involvement is an uncommon manifestation of Adamantiades-Behçet's disease. In case of relevant signs or history, such as hearing disturbance, tinnitus and/or vertigo, patients should be examined for inner ear involvement...
  35. ncbi request reprint Effect of 5alpha-dihydrotestosterone and testosterone on apoptosis in human dermal papilla cells
    A Winiarska
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Skin Pharmacol Physiol 19:311-21. 2006
    ..These data suggest that DPC from nonbalding scalp regions do have the capacity to undergo apoptosis, but need a high androgen stimulus. The present study provides an interesting new pathogenetic approach in androgenetic alopecia...
  36. doi request reprint Oral eosinophilic ulcer, an Epstein-Barr virus-associated CD30+ lymphoproliferation?
    M B Abdel-Naser
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Dermatology 222:113-8. 2011
    ..The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder...
  37. ncbi request reprint Human skin: an independent peripheral endocrine organ
    C C Zouboulis
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Horm Res 54:230-42. 2000
    ..Therefore, the human skin fulfils all requirements for being the largest, independent peripheral endocrine organ...
  38. ncbi request reprint Regression of multiple viral warts in a human immunodeficiency virus-infected patient treated by triple antiretroviral therapy
    J R Turnbull
    Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Fabeckstr 60 62, D 12200 Berlin, Germany
    Br J Dermatol 146:330. 2002
  39. ncbi request reprint Current concepts in the treatment of recurrent aphthous stomatitis
    A Altenburg
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Skin Therapy Lett 13:1-4. 2008
    ....
  40. ncbi request reprint Expression of the c-kit receptor in hypomelanosis: a comparative study between piebaldism, naevus depigmentosus and vitiligo
    E Dippel
    Department of Dermatology, University Hospital R Virchow, , Germany
    Br J Dermatol 132:182-9. 1995
    ....
  41. ncbi request reprint Linear IgA dermatosis presenting with erythema annulare centrifugum lesions: report of three cases in adults
    E Dippel
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany
    J Eur Acad Dermatol Venereol 15:167-70. 2001
    ..Common antibody-related immunological mechanisms indicate that the two distinct clinical pictures are probably stages of the same pathogenic entity...
  42. ncbi request reprint Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis
    J H Martens
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    J Pathol 208:574-89. 2006
    ....
  43. ncbi request reprint Prognostic factors and prediction of prognosis by the CTCL Severity Index in mycosis fungoides and Sézary syndrome
    C D Klemke
    Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Br J Dermatol 153:118-24. 2005
    ..Cutaneous T-cell lymphoma (CTCL) is a slowly progressive malignancy for which there is no cure. Therefore, accurate prediction of prognosis is important for the conduct of clinical trials and for counselling of individuals...
  44. ncbi request reprint Cutaneous large B-cell lymphoma of the leg masquerading as a chronic venous ulcer
    A Garbea
    Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Br J Dermatol 146:144-7. 2002
    ..Local radiotherapy was started and combined photon and electron beam irradiation induced complete remission of the B-cell lymphoma...