Jens Volkmann

Summary

Affiliation: Zoological Institute
Country: Germany

Publications

  1. ncbi request reprint Deep brain stimulation for the treatment of Parkinson's disease
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Clin Neurophysiol 21:6-17. 2004
  2. ncbi request reprint Improved sensory gating of urinary bladder afferents in Parkinson's disease following subthalamic stimulation
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Brain 131:132-45. 2008
  3. doi request reprint Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurol Sci 310:261-6. 2011
  4. ncbi request reprint Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
  5. doi request reprint Stimulation site within the MRI-defined STN predicts postoperative motor outcome
    Fritz Wodarg
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Mov Disord 27:874-9. 2012
  6. doi request reprint Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable?
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:2516-21. 2011
  7. ncbi request reprint Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial
    Karsten Witt
    Department of Neurology, Kiel University, Kiel, Germany
    Brain 136:2109-19. 2013
  8. ncbi request reprint Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    J Neuropsychiatry Clin Neurosci 18:397-401. 2006
  9. doi request reprint Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 25:1583-9. 2010
  10. doi request reprint The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting
    Rene Reese
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 27:544-8. 2012

Detail Information

Publications64

  1. ncbi request reprint Deep brain stimulation for the treatment of Parkinson's disease
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Clin Neurophysiol 21:6-17. 2004
    ....
  2. ncbi request reprint Improved sensory gating of urinary bladder afferents in Parkinson's disease following subthalamic stimulation
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Brain 131:132-45. 2008
    ..Furthermore, this is the first imaging study, which shows an effect of STN-DBS on sensory gating in PD patients and its neural basis...
  3. doi request reprint Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurol Sci 310:261-6. 2011
    ....
  4. ncbi request reprint Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
    ..To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment...
  5. doi request reprint Stimulation site within the MRI-defined STN predicts postoperative motor outcome
    Fritz Wodarg
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Mov Disord 27:874-9. 2012
    ..Precise targeting of the lateral region of the STN is essential for achieving sufficient stimulation efficacy. Preoperative T2-weighted MRI might be a useful component of the targeting procedure to improve the outcome of PD patients...
  6. doi request reprint Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable?
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:2516-21. 2011
    ..Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety...
  7. ncbi request reprint Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial
    Karsten Witt
    Department of Neurology, Kiel University, Kiel, Germany
    Brain 136:2109-19. 2013
    ..This study also stresses the importance of precise positioning of the active stimulating contact within the subthalamic volume to avoid adverse effects on semantic verbal fluency and response inhibition. ..
  8. ncbi request reprint Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    J Neuropsychiatry Clin Neurosci 18:397-401. 2006
    ..These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge...
  9. doi request reprint Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease
    Christine Daniels
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 25:1583-9. 2010
    ....
  10. doi request reprint The atypical subthalamic nucleus--an anatomical variant relevant for stereotactic targeting
    Rene Reese
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 27:544-8. 2012
    ..The improvement of PD motor symptoms by DBS of the STN depends on exact targeting...
  11. ncbi request reprint Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor
    Jan Herzog
    Department of Neurology, Christian Albrechts University Kiel, Germany
    Brain 130:1608-25. 2007
    ..The better efficacy of stimulation within the STA compared to thalamus proper favours the concept of a modulation of cerebello-thalamic projections underlying the improvement of these symptoms...
  12. ncbi request reprint The central oscillatory network of orthostatic tremor
    Muthuraman Muthuraman
    Department of Neurology, University Hospital Schleswig Holstein, University of Kiel, Kiel, Germany
    Mov Disord 28:1424-30. 2013
    ..This may add to the feeling of unsteadiness. It also makes the thalamus unlikely as the main source of orthostatic tremor...
  13. doi request reprint Differential effect of dopa and subthalamic stimulation on vestibular activity in Parkinson's disease
    Monika Pötter-Nerger
    Department of Neurology, Christian Albrecht University, Kiel, Germany
    Mov Disord 27:1268-75. 2012
    ..This suggests different pathways for the action of both treatment modalities in Parkinson's disease and may explain clinical differences in terms of postural disturbances. © 2012 Movement Disorder Society...
  14. ncbi request reprint Influence of subthalamic deep brain stimulation versus levodopa on motor perseverations in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts University, Schittenhelmstr 10, Kiel, Germany
    Mov Disord 24:1206-10. 2009
    ..7 +/- 2.6 (P < 0.001) whereas levodopa had no impact (R(2) reduction 3.7 +/- 1.6, P = 0.081). This demonstrates that STN-DBS, by reducing motor perseveration, influences higher order aspects of motor behavior of patients with PD...
  15. doi request reprint Inducing homeostatic-like plasticity in human motor cortex through converging corticocortical inputs
    Monika Pötter-Nerger
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Neurophysiol 102:3180-90. 2009
    ..These results provide evidence for a homeostatic response pattern in the human M1(HAND) that integrates acute plastic changes evoked through different "input channels."..
  16. doi request reprint Gait ataxia in essential tremor is differentially modulated by thalamic stimulation
    Alfonso Fasano
    Department of Neurology, Christian Albrechts University, 24105 Kiel, Germany
    Brain 133:3635-48. 2010
    ....
  17. ncbi request reprint A randomized trial of deep-brain stimulation for Parkinson's disease
    Gunther Deuschl
    Christian Albrechts University, Kiel, Germany
    N Engl J Med 355:896-908. 2006
    ..Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management...
  18. ncbi request reprint Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Brain 129:3366-75. 2006
    ..The data suggest that STN-DBS ameliorates bladder dysfunction and that this modulation may result from facilitated processing of afferent bladder information...
  19. doi request reprint Subthalamic deep brain stimulation increases pallidal firing rate and regularity
    Rene Reese
    Department of Neurology, University Hospitals Schleswig Holstein, Kiel, Germany
    Exp Neurol 229:517-21. 2011
    ..The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD...
  20. pmc Selecting deep brain stimulation or infusion therapies in advanced Parkinson's disease: an evidence-based review
    Jens Volkmann
    Department of Neurology, University Clinic of Würzburg, Josef Schneider Str 11, 97080, Wurzburg, Germany
    J Neurol 260:2701-14. 2013
    ..For each scenario, pragmatic and (if available) evidence-based recommendations are provided as to which patients could be candidates for either DBS, DLI, or subcutaneous apomorphine. ..
  21. doi request reprint Subthalamic nucleus stimulation restores corticospinal facilitation in Parkinson's disease
    Monika Pötter-Nerger
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 23:2210-5. 2008
    ..01). STN-HFS restores the normal facilitatory drive of a transcranially evoked motor cortical response to the spinal motoneuron pool. In addition to subcortical routes, STN-DBS also alters spinal excitability via transcortical pathways...
  22. ncbi request reprint Long-term results of bilateral pallidal stimulation in Parkinson's disease
    Jens Volkmann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Cologne, Germany
    Ann Neurol 55:871-5. 2004
    ..Replacement of pallidal electrodes into the subthalamic nucleus in four patients could restore the initial benefit of deep brain stimulation and allowed a significant reduction of dopaminergic drug therapy...
  23. ncbi request reprint Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease
    Jens Volkmann
    Neurologische Klinik der Christian Albrechts Universität, Kiel, Germany
    Mov Disord 24:1154-61. 2009
    ..Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health-related wellbeing over time...
  24. doi request reprint Cortical correlates of the basic and first harmonic frequency of Parkinsonian tremor
    Jan Raethjen
    Department of Neurology, University of Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Clin Neurophysiol 120:1866-72. 2009
    ..It has been hypothesized that the basic and first harmonic frequency of Parkinsonian tremor are somewhat independent oscillations the biological basis of which remains unclear...
  25. doi request reprint Modulation of gait coordination by subthalamic stimulation improves freezing of gait
    Alfonso Fasano
    Departments of Neurology and Neurosurgery, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:844-51. 2011
    ..This identifies poor leg coordination as a risk factor for causing freezing of gait...
  26. pmc Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease
    Janne Ludwig
    Division of Neurological Pain Research and Therapy, University of Kiel, Kiel, Germany
    J Neurol Neurosurg Psychiatry 78:742-5. 2007
    ..Since less pharmacotherapy is needed after STN stimulation, reduced levodopa intake results in relative improvement of autonomic function in deep brain stimulated PD patients...
  27. doi request reprint Deep brain stimulation in Parkinson's disease following fetal nigral transplantation
    Jan Herzog
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 23:1293-6. 2008
    ..These findings, based on two case reports, highlight the pivotal role of the GPi in mediating dyskinesia-related neural activity within the basal ganglia loop...
  28. ncbi request reprint Effect of cabergoline on parkinsonian tremor assessed by long-term actigraphy
    Sabine Binder
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany
    Eur Neurol 61:149-53. 2009
    ..One reason is the substantial fluctuation of tremor severity over time, which is difficult to capture and may render momentary clinical assessments unreliable...
  29. doi request reprint Cost-effectiveness of deep brain stimulation in patients with Parkinson's disease
    Judith Dams
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Mov Disord 28:763-71. 2013
    ..Our data support adopting and reimbursing deep brain stimulation within the German health care system...
  30. doi request reprint Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Lancet Neurol 11:1029-38. 2012
    ..We assessed the safety and efficacy of pallidal neurostimulation in patients with primary generalised or segmental dystonia prospectively followed up for 5 years in a controlled multicentre trial...
  31. ncbi request reprint Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Germany
    Mov Disord 19:1050-4. 2004
    ..g., zona incerta, were significantly less effective. We suggest that the dorsolateral STN border should be covered by STN-DBS...
  32. ncbi request reprint The impact of normal aging and Parkinson's disease on response preparation in task-switching behavior
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein Campus Kiel, Schittenhelmstrasse 10, D 24105 Kiel, Germany
    Brain Res 1114:173-82. 2006
    ..This argues for different mechanisms that underlie the changes in task-switching behavior in healthy aging and PD...
  33. doi request reprint Motor outcome of dystonic camptocormia treated with pallidal neurostimulation
    Rene Reese
    Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany Department of Neurology, Julius Maximilians University, Wurzburg, Germany
    Parkinsonism Relat Disord 20:176-9. 2014
    ..Deep brain stimulation of the internal pallidum (GPi-DBS) is effective for various types of drug-refractory primary dystonias. Rare clinical forms as dystonic camptocormia may profit but available data are scarce...
  34. doi request reprint Factors associated with neuropsychiatric side effects after STN-DBS in Parkinson's disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Parkinsonism Relat Disord 18:S168-70. 2012
    ..In this review the role of the preoperative factors and also the relevance of the intraoperative and postoperative management is analyzed...
  35. doi request reprint Camptocormia in idiopathic Parkinson's disease: a focal myopathy of the paravertebral muscles
    Nils G Margraf
    Department of Neurology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Mov Disord 25:542-51. 2010
    ..The cause of camptocormia in idiopathic PD is a focal myopathy. Our findings suggest that the myopathy has a progressive course, which finally leads to degeneration of the paravertebral muscles...
  36. ncbi request reprint Update on surgery for Parkinson's disease
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Curr Opin Neurol 20:465-9. 2007
    ....
  37. ncbi request reprint Effect of subthalamic deep brain stimulation on the function of the urinary bladder
    Christoph Seif
    Department of Urology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Ann Neurol 55:118-20. 2004
    ..In a series of 16 patients, we demonstrated that subthalamic deep brain stimulation has a significant and urodynamically recordable effect leading to a normalization of pathologically increased bladder sensibility...
  38. doi request reprint Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease
    Jens Volkmann
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany
    Nat Rev Neurol 6:487-98. 2010
    ..Here, we summarize the neuropsychiatric changes observed after STN HFS and try to disentangle their various etiologies...
  39. ncbi request reprint Deep brain stimulation for gait and postural symptoms in Parkinson's disease
    Monika Pötter-Nerger
    Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    Mov Disord 28:1609-15. 2013
    ....
  40. doi request reprint Botulinum neurotoxin treatment improves force regulation in writer's cramp
    Kirsten E Zeuner
    Department of Neurology, Kiel University, Neurozentrum, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany
    Parkinsonism Relat Disord 19:611-6. 2013
    ..In conclusion, force regulation was disturbed in patients and improved after BoNT treatment. This is not compatible with a simple muscle weakening and might thus reflect improved sensorimotor integration...
  41. ncbi request reprint Deep brain stimulation in late stage Parkinson's disease: a retrospective cost analysis in Germany
    Wassilios Meissner
    Department of Neurology, Charite Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    J Neurol 252:218-23. 2005
    ..The present study provides first data of an important number of patients on clinical effectiveness and expenses in relation to STNDBS...
  42. ncbi request reprint Introduction to the programming of deep brain stimulators
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 17:S181-7. 2002
    ..They also describe noninvasive technical trouble shooting by using programming features of the commercially available neurostimulation devices...
  43. ncbi request reprint Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1332-7. 2003
    ..The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary...
  44. doi request reprint Acquired stuttering after pallidal deep brain stimulation for dystonia
    Adelheid Nebel
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    J Neural Transm 116:167-9. 2009
    ..This emphasizes a role of the sensorimotor part of the internal globus pallidus in regulating speech fluency...
  45. ncbi request reprint Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration
    Martin Krause
    Department of Neurology, Ruprecht Krals University, INF 400, Heidelberg, Germany
    Mov Disord 21:2255-7. 2006
    ..The impact of DBS on the progression and life expectancy in PKAN is unknown. We present a 5-year outcome and video documentation of bilateral GPi-DBS of an adolescent patient suffering from genetically defined PKAN...
  46. ncbi request reprint Deep brain stimulation: postoperative issues
    Gunther Deuschl
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 21:S219-37. 2006
    ..The report has been endorsed by the Scientific Issues Committee of the Movement Disorder Society and the American Society of Stereotactic and Functional Neurosurgery...
  47. ncbi request reprint Patients with Parkinson's disease learn to control complex systems-an indication for intact implicit cognitive skill learning
    Karsten Witt
    Department of Neurology, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Neuropsychologia 44:2445-51. 2006
    ..These results demonstrate a functional independence of implicit cognitive skill learning and certain aspects of executive functions...
  48. ncbi request reprint Basic algorithms for the programming of deep brain stimulation in Parkinson's disease
    Jens Volkmann
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 21:S284-9. 2006
    ..The basic programming algorithms for thalamic, subthalamic, and pallidal stimulation in PD are explained and summarized in flowcharts...
  49. ncbi request reprint The cerebral oscillatory network of parkinsonian resting tremor
    Lars Timmermann
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Brain 126:199-212. 2003
    ..The main frequency of cerebro-cerebral coupling corresponds to double the tremor frequency...
  50. doi request reprint The impact of age and disease duration on the long term outcome of neurostimulation of the subthalamic nucleus
    Ali Shalash
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Kiel Campus, Christian Albrechts University Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Parkinsonism Relat Disord 20:47-52. 2014
    ..Selection of patients with Parkinson's disease for neurostimulation of subthalamic nucleus (STN-DBS) is still poorly studied...
  51. ncbi request reprint Praying-induced oromandibular dystonia
    Tihomir V Ilic
    Department of Neurology, Christian Albrechts University of Kiel, Kiel, Germany
    Mov Disord 20:385-6. 2005
    ..His speech was affected exclusively while reciting Islamic prayers in Arabic language, which he otherwise did not speak...
  52. doi request reprint Levetiracetam in primary orthostatic tremor: a double-blind placebo-controlled crossover study
    Helge Hellriegel
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 26:2431-4. 2011
    ..In a double-blind crossover study we evaluated the antitremor effect of a 4-week treatment with either escalating dosages of levetiracetam or placebo in orthostatic tremor...
  53. ncbi request reprint Pallidal stimulation for dystonia
    Martin Krause
    Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany
    Neurosurgery 55:1361-8; discussion 1368-70. 2004
    ..Yet only few studies have been published to date regarding this treatment. We present the results of DBS of the GPi in 17 patients with severe dystonia of different causes...
  54. ncbi request reprint Deep brain stimulation for dystonia: patient selection and evaluation
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Mov Disord 17:S112-5. 2002
    ..This article discusses the different factors influencing patient selection for surgical treatment and describes standardized methods and the caveats for clinical documentation of treatment results in dystonia...
  55. doi request reprint ATP13A2 variants in early-onset Parkinson's disease patients and controls
    Ana Djarmati
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Mov Disord 24:2104-11. 2009
    ..Although heterozygous variants are present in a considerable number of patients, they are-based on this relatively small sample-not significantly more frequent in patients compared to controls...
  56. ncbi request reprint Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position
    Jurgen Voges
    Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany
    J Neurosurg 96:269-79. 2002
    ..The goal of this study was to relate the degree of clinical improvement and that of energy consumption to the anatomical position of electrode poles used for long-term stimulation...
  57. ncbi request reprint Deep brain stimulation of the subthalamic nucleus enhances emotional processing in Parkinson disease
    Frank Schneider
    Department of Psychiatry and Psychotherapy, University of Dusseldorf, Germany
    Arch Gen Psychiatry 60:296-302. 2003
    ..Clinical observations indicate additional influence on emotional behavior...
  58. ncbi request reprint Depression and Parkinson's disease
    Matthias R Lemke
    Rhine Clinic Bonn, Kaiser Karl Ring 20, 53111 Bonn, Germany
    J Neurol 251:VI/24-7. 2004
    ..New dopamine agonists pramipexole and ropinirole appear to ameliorate depressive symptoms in PD in addition to effects on motor symptoms. There is a lack of appropriate rating scales and controlled studies regarding depression in PD...
  59. ncbi request reprint Dementia in idiopathic Parkinson's syndrome
    Gerd A Fuchs
    Parkinson Clinic Wolfach, Kreuzbergstr 12 24, 77709 Wolfach, Germany
    J Neurol 251:VI/28-32. 2004
    ..The demented Parkinsonian patients then present with improvement in cognitive function while motor skills do not deteriorate...
  60. ncbi request reprint Premutations in the FMR1 gene as a modifying factor in Parkin-associated Parkinson's disease?
    Katja Hedrich
    Department of Human Genetics, University of Lubeck, Lubeck, Germany
    Mov Disord 20:1060-2. 2005
    ..Of note, 1 of the affected premutation carriers had a heterozygous Parkin mutation...
  61. ncbi request reprint [Non-medical neurosurgical Parkinson treatment]
    Jan Herzog
    Neurologische Klinik der Christian Albrechts Universität, Kiel
    Pharm Unserer Zeit 35:234-40. 2006
  62. ncbi request reprint Pallidal deep-brain stimulation in primary generalized or segmental dystonia
    Andreas Kupsch
    Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
    N Engl J Med 355:1978-90. 2006
    ..Neurostimulation of the internal globus pallidus has been shown to be effective in reducing symptoms of primary dystonia. We compared this surgical treatment with sham stimulation in a randomized, controlled clinical trial...
  63. ncbi request reprint Managing Parkinson's disease with continuous dopaminergic stimulation
    Erik Wolters
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    CNS Spectr 13:1-14; quiz 15-6. 2008
    ..b>Jens Volkmann, MD, discusses selection criteria for STN DBS and duodenal L-dopa/carbidopa infusion...
  64. ncbi request reprint Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial
    Joerg Mueller
    Mov Disord 23:131-4. 2008
    ..The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia...