Research Topics
Genomes and GenesSpecies | Ulrich S ZimmermannSummaryCountry: Germany Publications
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Publications
Modeling alcohol self-administration in the human laboratoryUlrich S Zimmermann
Department of Psychiatry and Psychotherapy, University Hospital, Technische Universitat Dresden, Dresden, Germany
Curr Top Behav Neurosci 13:315-53. 2013..Peak exposures in the CASE studies ranged from 60 to 80 mg% in HSD and up to 240 mg% in NTSA...
Withdrawal phenomena and dependence syndrome after the consumption of "spice gold"Ulrich S Zimmermann
Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der TU Dresden, 01307 Dresden, Germany
Dtsch Arztebl Int 106:464-7. 2009....- Development and pilot validation of computer-assisted self-infusion of ethanol (CASE): a new method to study alcohol self-administration in humansUlrich S Zimmermann
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
Alcohol Clin Exp Res 32:1321-8. 2008..We sought to improve the subjects' opportunity to control their brain alcohol exposure by computer-assisted i.v. self-administration... - Offspring of parents with an alcohol use disorder prefer higher levels of brain alcohol exposure in experiments involving computer-assisted self-infusion of ethanol (CASE)Ulrich S Zimmermann
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
Psychopharmacology (Berl) 202:689-97. 2009..Acute alcohol effects may differ in social drinkers with a positive family history of alcohol use disorders (FHP) compared to FH negative (FHN) controls... - Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathersUlrich S Zimmermann
Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
Psychoneuroendocrinology 34:996-1003. 2009.... - Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-oldsBrigitte Schmid
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Int J Neuropsychopharmacol 13:703-14. 2010..These findings extend previous reports by demonstrating that the CRHR1 gene and stressful life events interact to predict both drinking initiation in adolescence and progression of heavy alcohol use in young adulthood... - Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adultsArlette F Buchmann
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany
J Psychiatr Res 43:1205-12. 2009.... - Drinking against unpleasant emotions: possible outcome of early onset of alcohol use?Arlette F Buchmann
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Alcohol Clin Exp Res 34:1052-7. 2010..The purpose of this study was to examine whether this effect may be the consequence of a higher susceptibility to develop "drinking to cope" motives among early initiators... - Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphismManfred Laucht
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Biol Psychiatry 66:102-9. 2009..The present study aims to further explore G x E between 5-HTTLPR and exposure to psychosocial adversity on alcohol consumption in a high-risk community sample of young adults... - Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesisManfred Laucht
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
J Child Psychol Psychiatry 53:351-9. 2012..Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene-environment interplay (genetic vulnerability vs. differential susceptibility)... - Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adultsManfred Laucht
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Int J Neuropsychopharmacol 12:737-47. 2009..No evidence for GxE was obtained with regard to current stressful life events and trait anxiety. One possible source for the conflicting findings might be attributed to heterogeneity in depression phenotypes and environmental adversity... - The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-oldsBrigitte Schmid
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
Addict Biol 14:489-99. 2009..Further studies are required to confirm these findings... - Quality of early mother-child interaction associated with depressive psychopathology in the offspring: a prospective study from infancy to adulthoodBrigitte Schmid
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
J Psychiatr Res 45:1387-94. 2011..The results suggest that the amount of maternally initiated contact behavior in a very early developmental stage may be crucial for children's mental health, regardless of child and maternal responsiveness... - Impact of early parental child-rearing behavior on young adults' cardiometabolic risk profile: a prospective studyArlette F Buchmann
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, 68159 Mannheim, Germany
Psychosom Med 72:156-62. 2010..Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile... 
Alcohol administration acutely inhibits ghrelin secretion in an experiment involving psychosocial stressUlrich S Zimmermann
Max Planck Institute of Psychiatry, Germany
Addict Biol 12:17-21. 2007..We could not observe a stress effect on ghrelin, which does not support a role for ghrelin in stress-induced anorexia...- How gene-stress-behavior interactions can promote adolescent alcohol use: the roles of predrinking allostatic load and childhood behavior disordersUlrich S Zimmermann
Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, J5, Mannheim, Germany
Pharmacol Biochem Behav 86:246-62. 2007..They are targets for preventive interventions, which should start as early as possible in subjects at-risk... - Concurrent alcohol and tobacco use during early adolescence characterizes a group at riskBrigitte Schmid
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, P O Box 122120, D 68072 Mannheim, Germany
Alcohol Alcohol 42:219-25. 2007..To investigate whether concurrent alcohol and tobacco use during early adolescence characterizes a subgroup that differs from users of one substance only regarding several risk factors for later substance use problems... - High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress responseMarcus Ising
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Neuropsychopharmacology 32:1941-9. 2007..NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders...