Research Topics
| T ZiemssenSummaryCountry: Germany Publications
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Publications
Psychoneuroimmunology - psyche and autoimmunityTjalf Ziemssen
MS Center Dresden, Neuroimmunological Lab, Department of Neurology, University Clinic Carl Gustavus Carus, Dresden University of Technology, Fetscherstra e 74, D 01307 Dresden, Germany
Curr Pharm Des 18:4485-8. 2012..For several diseases, the relevance of psychoneuroimmunological findings has already been demonstrated...
Cardiovascular autonomic dysfunction in Parkinson's diseaseTjalf Ziemssen
ANF lab, Neurological University Clinic, Dresden, Germany
J Neurol Sci 289:74-80. 2010..Supine hypertension is often associated with orthostatic hypotension. The prognostic role of cardiovagal and baroreflex dysfunction is still not yet known...
Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosisTjalf Ziemssen
MS Center, Neurological University Clinic, Technical University of Dresden, Dresden, Germany
Health Qual Life Outcomes 6:67. 2008..The objective of this prospective naturalistic study was to evaluate the impact of glatiramer acetate on fatigue and work absenteeism...- Multiple sclerosis beyond EDSS: depression and fatigueTjalf Ziemssen
MS Center, Neurological University Clinic, Dresden, Germany
J Neurol Sci 277:S37-41. 2009..There is growing evidence that immunomodulatory treatments, in particular glatiramer acetate, improve fatigue symptoms in patients with multiple sclerosis... - What can we learn from failed clinical trials in multiple sclerosis?Tjalf Ziemssen
MS Center Dresden, Neuroimmunological Lab, Department of Neurology, University Clinic Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
J Neurol 255:97-101. 2008..Failed trials can provide valuable information how studies and outcome measures should be designed for future trials. So it is important that negative trials are published and available for the MS community... - Potential side effect of high-dose corticosteroid relapse treatment: acute generalized exanthematous pustulosis (AGEP)T Ziemssen
Department of Neurology, Multiple Sclerosis Center, University Clinic Carl Gustav Carus, University of Technology Dresden, Dresden, Germany
Mult Scler 15:275-7. 2009..High-dose glucocorticosteroids (GC) are the treatment of choice for acute relapses in patients with multiple sclerosis as proven by several controlled clinical trials. The common adverse effects of GC are well known... - Treatment of dysautonomia in extrapyramidal disordersTjalf Ziemssen
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, 01307 Dresden, Germany
J Neurol 258:S339-45. 2011..This review elaborates a limited overview on the treatment of cardiovascular, gastrointestinal, urogenital and sudomotor autonomic dysfunction in various extrapyramidal syndromes... - Cardiovascular autonomic testing in extrapyramidal disordersTjalf Ziemssen
ANF lab, Neurological University Clinic, Dresden, Germany
J Neurol Sci 310:129-32. 2011..In all patients with extrapyramidal disease, screening for autonomic dysfunction should be performed. In the case of pathological findings, detailed autonomic testing should be considered with repeated measurements at follow up visits... - Circadian cortisol, depressive symptoms and neurological impairment in early multiple sclerosisS Kern
Neurology, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany
Psychoneuroendocrinology 36:1505-12. 2011..At the same time, depressive symptoms are often associated with an elevated circadian cortisol secretion. So far, little is known about the interplay between depressive symptoms and circadian HPA axis abnormalities in MS... - Loss of nocturnal blood pressure fall in various extrapyramidal syndromesClaudia Schmidt
Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Mov Disord 24:2136-42. 2009..Pathological loss of nocturnal BP fall may account for increased cardiovascular mortality in extrapyramidal syndromes... - Valsalva manoeuvre in patients with different Parkinsonian disordersC Schmidt
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, Dresden 01307, Germany
J Neural Transm 116:875-80. 2009..Metronomic breathing and tilt-table test seem more capable as parasympathetic resp. and sympathetic function tests to identify cardiovascular abnormalities in PS patients... - Neurological disability, psychological distress, and health-related quality of life in MS patients within the first three years after diagnosisS Kern
Department of Neurology, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany
Mult Scler 15:752-8. 2009..Psychological distress and psychiatric co-morbidity are common in multiple sclerosis (MS) and is often associated with neurological disability as well as reduced quality of life... - CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and functionD Jing
Department of Hematology and Oncology, University Hospital Dresden, Dresden, Germany
Bone Marrow Transplant 45:1489-96. 2010..Our data indicate that G-CSF and CD49d blockade mobilize different HSC subsets and suggest that both strategies may be differentially applied in specific cell therapy approaches... - Rapidly progressive course of very late onset multiple sclerosis presenting with Parkinsonism: case reportT Schultheiss
Department of Neurology, University Hospital Gustav Carus, Technische Universitat Dresden, Germany
Mult Scler 17:245-9. 2011..Future trials to elucidate potential benefit of immunosuppressive (and neuroprotective) therapies in these age groups are mandatory... - Trigonometric regressive spectral analysis reliably maps dynamic changes in baroreflex sensitivity and autonomic tone: the effect of gender and ageManja Reimann
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
PLoS ONE 5:e12187. 2010..We evaluated a novel algorithm based on trigonometric regression regarding its ability to map dynamic changes in BRS and autonomic tone during cardiovascular provocation in relation to gender and age... - Treatment strategies for nonmotor manifestations of Parkinson's diseaseHeinz Reichmann
Department of Neurology, University of Technology Dresden, Dresden, Germany
Expert Opin Pharmacother 10:773-84. 2009..Unfortunately, hardly any double-blind, randomized, controlled studies are available, with the consequence that most recommendations are not based on the highest level of evidence... - Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and functionManja Reimann
Department of Internal Medicine III, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Obesity (Silver Spring) 17:2210-5. 2009..Our findings suggest a possible role of visfatin in the cardiovascular system that seems to be independent of obesity in the African women... - LDL apheresis improves deranged cardiovagal modulation in hypercholesterolemic patientsManja Reimann
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany
Atherosclerosis 213:212-7. 2010..To evaluate the impact of LDL apheresis on autonomic cardiovascular control we investigated hypercholesterolemic patients before and after a single LDL apheresis in comparison to an age-matched control group... - Comprehensive autonomic assessment does not differentiate between Parkinson's disease, multiple system atrophy and progressive supranuclear palsyManja Reimann
Department of Neurology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
J Neural Transm 117:69-76. 2010..Thus, clinical combination of motor and non-motor symptoms does not exclusively point at MSA. Pupillography, ABPM and the questionnaire may assist in delineating the three syndromes when applied in combination... - Non-motor dysfunction in Parkinson's diseaseTjalf Ziemssen
Neurological University Clinic, Technische Universitat Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
Parkinsonism Relat Disord 13:323-32. 2007..The early recognition of these symptoms may well perhaps lead to an earlier diagnosis of PD, but in any case should lead to more prompt and effective treatment of the relatively unrecognized non-motor problems associated with PD... - Retinal vessel analysis in hypercholesterolemic patients before and after LDL apheresisManja Reimann
Autonomic and Neuroendocrinological Laboratory, Dept of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany
Atheroscler Suppl 10:39-43. 2009..Using retinal vascular imaging techniques, we attempted to investigate the microvascular benefit of a single LDL apheresis in hypercholesterolemia... - Regular lipoprotein apheresis maintains residual cardiovascular and microvascular function in patients with advanced atherosclerotic diseaseM Reimann
Autonomic and Neuroendocrinological Laboratory, Dept of Neurology, University Hospital Carl Gustav Carus, Dresden Fetscherstr 74, 01307 Dresden, Germany
Atheroscler Suppl 14:135-41. 2013..To determine whether previously demonstrated beneficial short-term effects on cardiovascular function in regular users of lipoprotein apheresis would be sustainable over time... - [Adherence to neurologic treatment. Lessons from multiple sclerosis]S Kern
Klinik und Poliklinik fur Neurologie, Multiple Sklerose Zentrum, Carl Gustav Carus Universitätsklinik, Fetscherstrasse 74, 01307, Dresden
Nervenarzt 79:877-8, 880-2, 884-6 passim. 2008..Factors affecting treatment motivation in multiple sclerosis patients are summarized focusing on neurologic treatment issues, and specific intervention strategies for patients, doctors, and nurses are discussed... - Education research: cognitive performance is preserved in sleep-deprived neurology residentsM Reimann
ANF Laboratory, Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Neurology 73:e99-e103. 2009..To test the hypotheses that sleep deprivation in neurology residents is associated with performance deficits and that vigilance and cognitive performance is more compromised after overnight on-call duty compared to night shift... - Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromesConstanze Friedrich
Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany
Mov Disord 25:315-24. 2010.... - Effect of BEMER magnetic field therapy on the level of fatigue in patients with multiple sclerosis: a randomized, double-blind controlled trialJoachim Piatkowski
Neurological Outpatient Center Reichenbachstrasse, Dresden, Germany
J Altern Complement Med 15:507-11. 2009..This study was designed to evaluate the long-term effects of Bio-Electro-Magnetic-Energy-Regulation (BEMER) on MS-related fatigue... - Autonomic dysfunction in patients with progressive supranuclear palsyClaudia Schmidt
Autonomic and Neuroendocrinological Laboratory ANF, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany
Mov Disord 23:2083-9. 2008..Our findings have a profound implication on the diagnosis and treatment of PSP patients... - Metabolomic distinction of microvascular effects of lipoprotein apheresis--a pilot studyM Reimann
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Fetscherstr 74, 01307 Dresden, Germany
Atheroscler Suppl 14:143-9. 2013..The study of small-molecule metabolites may assist in cardiovascular risk monitoring during therapy. We assessed whether acute changes in the metabolome by lipoprotein apheresis are able to predict changes in microvascular function... - Baroreflex sensitivity and power spectral analysis in different extrapyramidal syndromesC Friedrich
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
J Neural Transm 115:1527-36. 2008..This may have fundamental impact on the cardiovascular prognosis of patients with extrapyramidal disease... - Autonomic dysfunction in different subtypes of multiple system atrophyClaudia Schmidt
Autonomic and Neuroendocrinological Laboratory, University of Dresden, Germany
Mov Disord 23:1766-72. 2008..Our results suggest that there are only minor differences in the pattern of autonomic dysfunction between the two clinical MSA phenotypes... - Influence of ECG sampling frequency on spectral analysis of RR intervals and baroreflex sensitivity using the EUROBAVAR data setTjalf Ziemssen
Autonomic Lab, Department of Neurology, University Clinic Carl Gustav Carus, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
J Clin Monit Comput 22:159-68. 2008..Only if there is a pathologically decreased variability of RR intervals in patients, spectral and baroreflex parameters could be significantly influenced by lower ECG sampling frequencies of up to 100 Hz, but only to a minor degree... - Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromesClaudia Schmidt
Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany
Mov Disord 22:2123-6. 2007..4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes... - Glatiramer acetate: mechanisms of action in multiple sclerosisWiebke Schrempf
Multiple Sclerosis Center, Department of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
Autoimmun Rev 6:469-75. 2007..In addition glatiramer acetate was demonstrated to influence antigen presenting cells (APC) such as monocytes and dendritic cells. Furthermore secretion of neurotrophic factors with potential neuroprotective effects was shown... - The effects of venlafaxine on autonomic functions in healthy volunteersTimo Siepmann
Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstrasse 27, Dresden, Germany
J Clin Psychopharmacol 27:687-91. 2007..The decrease in amplitude and increase in latency of the pupillary light reflex could be indicative of centrally mediated parasympathetic inhibition... - Psychoneuroimmunology--cross-talk between the immune and nervous systemsTjalf Ziemssen
MS Center Dresden, Neuroimmunological laboratory, Neurological Clinic, University Clinic Carl Gustav Carus Dresden, Fetscherstr 74, 01307, Dresden, Germany
J Neurol 254:II8-11. 2007..Over recent decades, reasonable evidence has emerged that these brain-to-immune interactions are highly modulated by psychological factors which influence immunity and immune system-mediated disease... - Brain-immune communication psychoneuroimmunology of multiple sclerosisS Kern
Technische Universitat Dresden, Klinik und Poliklinik fur Neurologie, Multiple Sklerose Zentrum Dresden, Fetscherstr 74, 01307 Dresden, Germany
Mult Scler 14:6-21. 2008..Findings from the field of PNI might also help to gain a better understanding regarding the origin and course of MS clinical symptoms such as fatigue and depression... - The cold hand sign in multiple system atrophy: skin perfusion revisitedK Pietzarka
Autonomic and Neuroendocrinological Laboratory, Department of Neurology, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
J Neural Transm 117:475-9. 2010..By measuring skin temperature and blood flow, the presence of CHS can be diagnosed in MSA patients. Further studies are necessary to understand regulation of skin perfusion in patients with extrapyramidal disease... - Secretion of brain-derived neurotrophic factor by glatiramer acetate-reactive T-helper cell lines: Implications for multiple sclerosis therapyTjalf Ziemssen
Neuroimmunological Lab, Neurological University Clinic, Dresden, Germany
J Neurol Sci 233:109-12. 2005..The different assays and different TCLs yielded similar, consistent results. All GA-specific TH1, TH2 and TH0 lines could be stimulated to produce BDNF... - Modulating processes within the central nervous system is central to therapeutic control of multiple sclerosisTjalf Ziemssen
Neurological University Clinic, Technical University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstr 74, 01307, Dresden, Germany
J Neurol 252:v38-45. 2005..In conclusion, selective treatment strategies aimed at preventing axonal injury within the central nervous system are required to complement existing, peripherally acting treatments targeting the immune system... - The role of the humoral immune system in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE)Tjalf Ziemssen
Neuroimmunological Lab, Department of Neurology, Neurological University Clinic Dresden Carl Gustav Carus, Fetscherstr 74, D 01307 Dresden, Germany
Autoimmun Rev 4:460-7. 2005..So, affecting the humoral immune system in MS would be a reasonable therapeutic option... - The effects of lorazepam on skin conductance responses to aversive stimuli in healthy subjectsMartin Siepmann
Institute of Clinical Pharmacology, Medical Faculty, Technical University, 01307, Dresden, Germany
Clin Auton Res 17:160-4. 2007..The present study aimed to examine the effects of non-sedative doses of lorazepam on skin cutaneous responses to aversive stimuli and subjective mood... - Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain-derived neurotrophic factorTjalf Ziemssen
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
Brain 125:2381-91. 2002..The different assays and different TCLs yielded similar, consistent results. All four GA-specific T-cell lines, representing the major different TH phenotypes, could be stimulated to produce BDNF... - Neuroprotection and glatiramer acetate: the possible role in the treatment of multiple sclerosisTjalf Ziemssen
Max-Planck-Institute of Neurobiology, Department of Neuroimmunology, 82152 Martinsried, Germany
Adv Exp Med Biol 541:111-34. 2004 - Glatiramer acetate: mechanisms of action in multiple sclerosisTjalf Ziemssen
Multiple Sclerosis Center Dresden, Neurological University Clinic Dresden University of Technology, Dresden 01307, Germany
Int Rev Neurobiol 79:537-70. 2007..This might help tip the balance in favor of more beneficial influences because there is a complex interplay between detrimental and beneficial factors and mediators in the inflammatory milieu of MS lesions...