Anette G Ziegler

Summary

Country: Germany

Publications

  1. pmc Does diabetes appear in distinct phenotypes in young people? Results of the diabetes mellitus incidence Cohort Registry (DiMelli)
    Katharina Warncke
    The Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Neuherberg, Germany Forschergruppe Diabetes e V, Neuherberg, Germany The Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    PLoS ONE 8:e74339. 2013
  2. pmc Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes
    Christiane Winkler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 7:e35410. 2012
  3. doi request reprint Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
    Anette G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Ingolstaedter Landstraße 1, Neuherberg, Germany 85764
    JAMA 309:2473-9. 2013
  4. pmc Long-term protective effect of lactation on the development of type 2 diabetes in women with recent gestational diabetes mellitus
    Anette G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Diabetes 61:3167-71. 2012
  5. doi request reprint Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
    A G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Diabetologia 55:1937-43. 2012
  6. pmc Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk
    Ezio Bonifacio
    Center for Regenerative Therapies, Dresden University of Technology, Dresden, Germany
    Diabetes 60:3300-6. 2011
  7. pmc Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes
    Maren Pflueger
    Forschergruppe Diabetes eV at Helmholtz Center Munich, Neuherberg, Germany
    Diabetes 60:2740-7. 2011
  8. pmc Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children
    Anette G Ziegler
    Institute of Diabetes Research, Helmholtz Center Munich, Neuherberg, Germany
    J Autoimmun 37:3-7. 2011
  9. doi request reprint IA-2 autoantibody affinity in children at risk for type 1 diabetes
    Stephanie Krause
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
    Clin Immunol 145:224-9. 2012
  10. pmc Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study
    Sandra Hummel
    Institute for Diabetes Research, Helmholtz Zentrum Munchen, Munich, Germany
    Diabetes Care 34:1301-5. 2011

Collaborators

Detail Information

Publications18

  1. pmc Does diabetes appear in distinct phenotypes in young people? Results of the diabetes mellitus incidence Cohort Registry (DiMelli)
    Katharina Warncke
    The Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Neuherberg, Germany Forschergruppe Diabetes e V, Neuherberg, Germany The Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    PLoS ONE 8:e74339. 2013
    ..We also assessed whether metabolic markers predicted the immune status...
  2. pmc Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes
    Christiane Winkler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 7:e35410. 2012
    ..To investigate whether type 2 diabetes susceptibility genes and body weight influence the development of islet autoantibodies and the rate of progression to type 1 diabetes...
  3. doi request reprint Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
    Anette G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Ingolstaedter Landstraße 1, Neuherberg, Germany 85764
    JAMA 309:2473-9. 2013
    ..Type 1 diabetes usually has a preclinical phase identified by circulating islet autoantibodies, but the rate of progression to diabetes after seroconversion to islet autoantibodies is uncertain...
  4. pmc Long-term protective effect of lactation on the development of type 2 diabetes in women with recent gestational diabetes mellitus
    Anette G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Diabetes 61:3167-71. 2012
    ..On the basis of these results, we recommend that breastfeeding should be encouraged among these women because it offers a safe and feasible low-cost intervention to reduce the risk of subsequent diabetes in this high-risk population...
  5. doi request reprint Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
    A G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Diabetologia 55:1937-43. 2012
    ..Seroconversion to islet autoantibodies precedes type 1 diabetes. This study aimed to identify periods of high seroconversion incidence, which could be targeted for mechanistic and therapeutic studies...
  6. pmc Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk
    Ezio Bonifacio
    Center for Regenerative Therapies, Dresden University of Technology, Dresden, Germany
    Diabetes 60:3300-6. 2011
    ..We examine associations between cesarean delivery, islet autoimmunity and type 1 diabetes, and genes involved in type 1 diabetes susceptibility...
  7. pmc Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes
    Maren Pflueger
    Forschergruppe Diabetes eV at Helmholtz Center Munich, Neuherberg, Germany
    Diabetes 60:2740-7. 2011
    ..To support this notion, we examined whether serum metabolite profiles differ between children with respect to islet autoantibody status and the age of islet autoantibody development...
  8. pmc Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children
    Anette G Ziegler
    Institute of Diabetes Research, Helmholtz Center Munich, Neuherberg, Germany
    J Autoimmun 37:3-7. 2011
    ..01). The findings suggest that recent increasing incidence of type 1 diabetes in young children could be due to weakening of mechanisms that normally regulate autoimmune destruction of islet beta cells...
  9. doi request reprint IA-2 autoantibody affinity in children at risk for type 1 diabetes
    Stephanie Krause
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
    Clin Immunol 145:224-9. 2012
    ..IA-2A affinity did not stratify diabetes risk. In conclusion, the IA-2A response in children is intense with rapid maturation against immunogenic epitopes and a strong association with diabetes development...
  10. pmc Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study
    Sandra Hummel
    Institute for Diabetes Research, Helmholtz Zentrum Munchen, Munich, Germany
    Diabetes Care 34:1301-5. 2011
    ..To determine whether delaying the introduction of gluten in infants with a genetic risk of islet autoimmunity is feasible, safe, and may reduce the risk of type 1 diabetes-associated islet autoimmunity...
  11. doi request reprint Early determinants of type 1 diabetes: experience from the BABYDIAB and BABYDIET studies
    Sandra Hummel
    Forschergruppe Diabetes der TU München, Munich, Germany
    Am J Clin Nutr 94:1821S-1823S. 2011
    ....
  12. ncbi request reprint Continuous rise of insulin resistance before and after the onset of puberty in children at increased risk for type 1 diabetes - a cross-sectional analysis
    Jennifer Raab
    Forschergruppe Diabetes e V, Neuherberg, Germany Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Neuherberg, Germany
    Diabetes Metab Res Rev 29:631-5. 2013
    ..To address the question of how insulin resistance develops with age and how this is related to puberty onset, we examined insulin resistance and pubertal development over time in children at increased risk for T1D...
  13. pmc Postpartum outcomes in women with gestational diabetes and their offspring: POGO study design and first-year results
    Sandra Hummel
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany
    Rev Diabet Stud 10:49-57. 2013
    ..The aim of the ongoing POGO study is to identify long-lasting changes in the maternal and fetal metabolism and microbiome, after GDM, which contribute to subsequent development of T2D and obesity...
  14. ncbi request reprint GAD autoantibody affinity in adult patients with latent autoimmune diabetes, the study participants of a GAD65 vaccination trial
    Stephanie Krause
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Neuherberg, Germany
    Diabetes Care 37:1675-80. 2014
    ..GADA affinity has been shown to predict progression to type 1 diabetes. Here, we asked whether GADA affinity was affected by the GAD65 antigen-specific vaccination and/or associated with β-cell function in participants of this trial...
  15. pmc Activation of islet autoreactive naïve T cells in infants is influenced by homeostatic mechanisms and antigen-presenting capacity
    Anne Kristin Heninger
    DFG Research Center and Cluster of Excellence, Center for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany
    Diabetes 62:2059-66. 2013
    ..These findings are relevant for early prevention of type 1 diabetes...
  16. doi request reprint A simplified method to assess affinity of insulin autoantibodies
    Peter Achenbach
    Institut fuer Diabetesforschung, Helmholtz Zentrum Muenchen, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    Clin Immunol 137:415-21. 2010
    ..0 nM competitor including 89 (94%) of 95 sera with multiple islet autoantibodies (P<0.0001). Thus, increased IAA specificity can be achieved with simple modification to existing assays...
  17. ncbi request reprint Compromised gut microbiota networks in children with anti-islet cell autoimmunity
    David Endesfelder
    Scientific Computing Research Unit, Helmholtz Zentrum Munchen, GermanyInstitute of Diabetes Research, Helmholtz Zentrum Munchen, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    Diabetes 63:2006-14. 2014
    ..5 and 2 years in the children in whom anti-islet cell autoantibodies developed. The findings underscore a role of the microbiome in the pathogenesis of anti-islet cell autoimmunity and type 1 diabetes...
  18. ncbi request reprint Severe pretreatment cerebral edema in newly diagnosed type 1 diabetes
    Katharina Warncke
    Department of Pediatrics, Kinderklinik München Schwabing, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Horm Res Paediatr 81:285-8. 2014
    ..In typical cases, it may develop during several hours after the beginning of ketoacidosis therapy. Nevertheless, CE sometimes occurs before the start of any therapy - as for the patient in this report here...