A Ziegler

Summary

Country: Germany

Publications

  1. ncbi request reprint On confidence intervals for genotype relative risks and attributable risks from case parent trio designs for candidate-gene studies
    Daniel Franke
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, Haus 4, DE 23538 Lübeck, Germany
    Hum Hered 60:81-8. 2005
  2. doi request reprint Biostatistical aspects of genome-wide association studies
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Biom J 50:8-28. 2008
  3. doi request reprint Generalized estimating equations. Notes on the choice of the working correlation matrix
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Germany
    Methods Inf Med 49:421-5; discussion 426-32. 2010
  4. pmc Electrical stimulation and biofeedback for the treatment of fecal incontinence: a systematic review
    Reinhard Vonthein
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, Haus 24, 23562, Lubeck, Germany
    Int J Colorectal Dis 28:1567-77. 2013
  5. pmc Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium
    Claudia Schurmann
    Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    PLoS ONE 7:e50938. 2012
  6. doi request reprint A simplification and implementation of random-effects meta-analyses based on the exact distribution of Cochran's Q
    M Preus
    Prof Dr Andreas Ziegler, University of Lübeck University, Medical Center Schleswig Holstein Campus Lübeck, Institute of Medical Biometry and Statistics, Ratzeburger Allee 160, House 24, 23562 Lübeck, Germany, E mail
    Methods Inf Med 53:54-61. 2014
  7. doi request reprint Challenges in planning and conducting diagnostic studies with molecular biomarkers
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Dtsch Med Wochenschr 138:e2-24. 2013
  8. pmc Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy
    Annette Raabe
    Department of Radiotherapy and Radiooncology, Laboratory of Radiobiology and Experimental Radiooncology, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Radiat Oncol 7:65. 2012
  9. pmc Comparison of collapsing methods for the statistical analysis of rare variants
    Carmen Dering
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Maria Goeppert Str, 1, 23562 Lübeck, Germany
    BMC Proc 5:S115. 2011
  10. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint On confidence intervals for genotype relative risks and attributable risks from case parent trio designs for candidate-gene studies
    Daniel Franke
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, Haus 4, DE 23538 Lübeck, Germany
    Hum Hered 60:81-8. 2005
    ..A bias away from the null occurs only in uncommon study situations; it is small and can therefore be ignored for applications...
  2. doi request reprint Biostatistical aspects of genome-wide association studies
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Biom J 50:8-28. 2008
    ..Another aspect of GWAs requiring special attention is the search for gene-gene and gene-environment interactions. We finally describe multistage approaches to GWAs...
  3. doi request reprint Generalized estimating equations. Notes on the choice of the working correlation matrix
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Germany
    Methods Inf Med 49:421-5; discussion 426-32. 2010
    ..A major strength of GEE is that they do not require the correct specification of the multivariate distribution but only of the mean structure...
  4. pmc Electrical stimulation and biofeedback for the treatment of fecal incontinence: a systematic review
    Reinhard Vonthein
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, Haus 24, 23562, Lubeck, Germany
    Int J Colorectal Dis 28:1567-77. 2013
    ..Attention is given to type, strength, and application mode of the current for ES and to safety...
  5. pmc Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium
    Claudia Schurmann
    Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    PLoS ONE 7:e50938. 2012
    ..In summary, adjustment for a few selected technical factors greatly improved reliability of gene expression analyses. Such adjustments are particularly required for meta-analyses...
  6. doi request reprint A simplification and implementation of random-effects meta-analyses based on the exact distribution of Cochran's Q
    M Preus
    Prof Dr Andreas Ziegler, University of Lübeck University, Medical Center Schleswig Holstein Campus Lübeck, Institute of Medical Biometry and Statistics, Ratzeburger Allee 160, House 24, 23562 Lübeck, Germany, E mail
    Methods Inf Med 53:54-61. 2014
    ..Biggerstaff and Jackson derived the exact cumulative distribution function (CDF) of Q to account for the variability of τ^²...
  7. doi request reprint Challenges in planning and conducting diagnostic studies with molecular biomarkers
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Dtsch Med Wochenschr 138:e2-24. 2013
    ..It is finally shown that the required sample size for biomarker validation quadratically increases with the coefficient of variation, and the effect is illustrated using real data from different laboratory technologies...
  8. pmc Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy
    Annette Raabe
    Department of Radiotherapy and Radiooncology, Laboratory of Radiobiology and Experimental Radiooncology, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Radiat Oncol 7:65. 2012
    ..To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position -509), XPD (codon 751), and XRCC1 (codon 399) with the risk of severe erythema after breast conserving radiotherapy...
  9. pmc Comparison of collapsing methods for the statistical analysis of rare variants
    Carmen Dering
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Maria Goeppert Str, 1, 23562 Lübeck, Germany
    BMC Proc 5:S115. 2011
    ..Although the methods considered in this report are common approaches for analyzing rare variants, they performed poorly with respect to the simulated disease phenotype in the GAW17 data set...
  10. pmc Identifying rare variants from exome scans: the GAW17 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, Kolkata 700018, India
    BMC Proc 5:S1. 2011
    ....
  11. pmc Observation and execution of upper-limb movements as a tool for rehabilitation of motor deficits in paretic stroke patients: protocol of a randomized clinical trial
    Denis Ertelt
    Center for Clinical Trials, University of Lubeck, Maria Goeppert Straße 1, 23562, Lubeck, Germany
    BMC Neurol 12:42. 2012
    ..The results of this study would be of high health and economical relevance...
  12. doi request reprint Location tests for biomarker studies: a comparison using simulations for the two-sample case
    M O Scheinhardt
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, Haus 24, 23562 Lübeck, Germany
    Methods Inf Med 52:351-9. 2013
    ..Gene, protein, or metabolite expression levels are often non-normally distributed, heavy tailed and contain outliers. Standard statistical approaches may fail as location tests in this situation...
  13. pmc Personalized medicine using DNA biomarkers: a review
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Maria Goeppert Str 1, 23562 Lübeck, Germany
    Hum Genet 131:1627-38. 2012
    ..We specifically discuss the interpretability of treatment effects if a large set of DNA biomarker profiles is available and the number of therapies is identical to the number of different profiles...
  14. pmc Metachronous metastasis- and survival-analysis show prognostic importance of lymphadenectomy for colon carcinomas
    Tilman Laubert
    Department of Surgery, Laboratory for Surgical Research, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    BMC Gastroenterol 12:24. 2012
    ..We evaluated whether the nodal status impacts on the occurrence of distant metastases by analyzing a highly selected cohort of colon cancer patients...
  15. pmc Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension
    Grazyna Kwapiszewska
    Department of Pathology, Justus Liebig University Giessen, Germany
    Respir Res 6:109. 2005
    ..For specific investigation of the vascular compartment, laser-microdissection of intrapulmonary arteries was combined with array profiling...
  16. pmc Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk
    Jerome Carayol
    IntegraGen SA, Evry, France
    Mol Autism 1:4. 2010
    ..Genetic scores are designed to test for association of genetic markers with disease...
  17. pmc ACPA: automated cluster plot analysis of genotype data
    Arne Schillert
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, 23538 Lubeck, Germany
    BMC Proc 3:S58. 2009
    ..In a screening setting in which one aims at not losing any good SNP, we achieved 99% (95% CI: 98%-100%) specificity and still detected every second low-quality SNP...
  18. pmc Picking single-nucleotide polymorphisms in forests
    Daniel F Schwarz
    , , , , Ratzeburger Allee 160, , Germany
    BMC Proc 1:S59. 2007
    ..We showed that a two-staged approach with a screening of SNPs by RFs is suitable to detect candidate SNPs in genome-wide association studies for complex diseases...
  19. pmc Look who is calling: a comparison of genotype calling algorithms
    Maren Vens
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, 23538 Lubeck, Germany
    BMC Proc 3:S59. 2009
    ..Concordance dropped with the number of GCAs failing sQC. We conclude that JAPL and Chiamo++ are the GCAs of choice if the aim is to keep as many subjects and SNPs as possible, respectively...
  20. pmc Evaluation of single-nucleotide polymorphism imputation using random forests
    Daniel F Schwarz
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitätsklinikum Scleswig Holstein, Campus Lubeck, Maria Goeppert Str, 1, 23562 Lübeck, Germany
    BMC Proc 3:S65. 2009
    ..Our results indicate that RFs are faster but less accurate than alternative approaches for imputing untyped SNPs...
  21. pmc Genetic association studies for gene expressions: permutation-based mutual information in a comparison with standard ANOVA and as a novel approach for feature selection
    Silke Szymczak
    Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein, , , Ratzeburger Allee 160, , Germany
    BMC Proc 1:S9. 2007
    ..They merit further methodological investigation...
  22. pmc Haseman-Elston weighted by marker informativity
    Daniel Franke
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, Haus 4, 23538 Lubeck, Germany
    BMC Genet 6:S50. 2005
    ..We therefore recommend to use Haseman-Elston with marker informativity weights only in conjunction with empirical p-values. Whether this approach in fact yields an increase in power needs to be investigated further...
  23. pmc Haplotype-sharing analysis for alcohol dependence based on quantitative traits and the Mantel statistic
    Andre Kleensang
    Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein, Campus Lubeck, University at Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Genet 6:S75. 2005
    ..005 with a minimum p-value of < 0.0001 on chromosome 16 (tsc0520638 at 72.8 cM). Three of these four regions located on chromosome 4, 16, and 20 have been reported previously in the Genetic Analysis Workshop 11...
  24. pmc The behaviour of random forest permutation-based variable importance measures under predictor correlation
    Kristin K Nicodemus
    Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    BMC Bioinformatics 11:110. 2010
    ..Recent works on permutation-based variable importance measures (VIMs) used in RF have come to apparently contradictory conclusions. We present an extended simulation study to synthesize results...
  25. pmc Detection of divergent genes in microbial aCGH experiments
    Lars Snipen
    Biostatistics, Department of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, N 1432 As, Norway
    BMC Bioinformatics 7:181. 2006
    ..As experimental settings vary considerably, it is not possible to develop a classical discriminant or statistical learning approach...
  26. ncbi request reprint [Survival analysis: log rank test]
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Universitat zu Lubeck, Germany
    Dtsch Med Wochenschr 132:e39-41. 2007
  27. doi request reprint Introduction to genetic analysis workshop 17 summaries
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Genet Epidemiol 35:S1-4. 2011
    ..We conclude the supplement with a discussion of critical aspects in the analysis of next-generation sequencing data...
  28. ncbi request reprint Practical considerations on the use of extreme sib-pairs for obesity
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, 23538 Lubeck, Germany
    Methods Inf Med 45:419-23. 2006
    ..We hypothesized that the low weight of most sibs who were seemingly discordant to the obese index proband was influenced by other environmental and/or genetic factors like restrained eating or psychiatric disorders...
  29. ncbi request reprint [Survival analysis: properties and Kaplan-Meier method]
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Universitat zu Lubeck, Germany
    Dtsch Med Wochenschr 132:e36-8. 2007
  30. ncbi request reprint [Survival analysis: Cox regression]
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Universitat zu Lubeck, Germany
    Dtsch Med Wochenschr 132:e42-4. 2007
  31. ncbi request reprint Developmental dyslexia--recurrence risk estimates from a german bi-center study using the single proband sib pair design
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Universitat zu Lubeck, Lubeck, Germany
    Hum Hered 59:136-43. 2005
    ..The aims of this paper therefore are to demonstrate the practicability of the SPSP design and the estimation of recurrence risks for reading and writing...
  32. ncbi request reprint [Systematic reviews and meta-analyses]
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Universitat zu Lubeck, Germany
    Dtsch Med Wochenschr 132:e48-52. 2007
  33. doi request reprint Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Breast Cancer Res Treat 128:197-201. 2011
    ..The latter should only be investigated in control populations. In multicenter studies or meta-analysis, deviation from HWE should be analyzed using a meta-analytic approach...
  34. pmc Probability machines: consistent probability estimation using nonparametric learning machines
    J D Malley
    Center for Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, USA
    Methods Inf Med 51:74-81. 2012
    ..It has been shown recently that every statistical learning machine known to be consistent for a nonparametric regression problem is a probability machine that is provably consistent for this estimation problem...
  35. doi request reprint [Guidelines for research reports: an application of CONSORT 2010 statements]
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lübeck Maria Goeppert Str 123538 Lübeck
    Dtsch Med Wochenschr 136:e2-8. 2011
    ..In this study, we apply the CONSORT 2010 reporting guideline to illustrate its value as the first step in the critical appraisal...
  36. pmc More powerful haplotype sharing by accounting for the mode of inheritance
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Lubeck, Germany
    Genet Epidemiol 33:228-36. 2009
    ..In the re-analysis of the RA data, we identified three regions with point-wise P-values<0.005 containing six known genes (PMIP1, MC4R, PIGN, KIAA1468, TNFRSF11A and ZCCHC2) which might be worth follow-up...
  37. ncbi request reprint Analysis of pregnancy and other factors on detection of human papilloma virus (HPV) infection using weighted estimating equations for follow-up data
    Andreas Ziegler
    Institute of Medical Biometry and Statistics, University at Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Stat Med 22:2217-33. 2003
    ..027). We conclude that the WEE are useful for dealing with monotone missing data due to drop-outs in follow-up data...
  38. pmc Genome-wide association studies: quality control and population-based measures
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Germany
    Genet Epidemiol 33:S45-50. 2009
    ..The area under the curve can be constructed from summary data in some situations. Finally, we discuss how the population-attributable risk of a genetic variant that is only measured in a reference data set can be determined...
  39. ncbi request reprint Data mining, neural nets, trees--problems 2 and 3 of Genetic Analysis Workshop 15
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Genet Epidemiol 31:S51-60. 2007
    ..However, improved implementations that are able to deal with hundreds of thousands of SNPs at a time are required...
  40. pmc Patient-centered yes/no prognosis using learning machines
    I R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Int J Data Min Bioinform 2:289-341. 2008
    ..Data from the German Stroke Study Collaboration is used for illustration. We compare the results from learning machines to those obtained by a published logistic regression and discuss similarities and differences...
  41. ncbi request reprint Independence estimating equations for controlled clinical trials with small sample sizes--interval estimation
    G Dahmen
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, 23538 Lubeck, Germany
    Methods Inf Med 45:430-4. 2006
    ..Therefore a series of modifications has been proposed. In this paper we systematically compare confidence intervals (CIs) proposed in the literature for situations that are common in CCTs...
  42. doi request reprint An extensive comparison of quantitative trait Loci mapping methods
    A Kleensang
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, DE 23538 Lübeck, Germany
    Hum Hered 69:202-11. 2010
    ..Some recommendations are available in the literature, but an extensive comparison of robustness and power under several different conditions is lacking...
  43. ncbi request reprint Sample selection for microarray gene expression studies
    D Repsilber
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Lubeck, Germany
    Methods Inf Med 44:461-7. 2005
    ..We present a consistent, comprehensive framework to deal with the typical selection problems in microarray studies...
  44. ncbi request reprint Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci?
    K Lohmann-Hedrich
    Department of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neurology 70:686-94. 2008
    ..To date, no gene mutation has been found, but five gene loci have been mapped in primary RLS to chromosomes 12q, 14q, 9p, 2q, and 20p (RLS1 through 5)...
  45. ncbi request reprint Practical experiences on the necessity of external validation
    I R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Lubeck, Germany
    Stat Med 26:5499-511. 2007
    ..Even validating the model in patients recruited merely at a later time point does not suffice to predict how it may fare with regard to another clinic...
  46. doi request reprint Detecting SNP-expression associations: a comparison of mutual information and median test with standard statistical approaches
    S Szymczak
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Maria Goeppert Str 1, 23562 Lübeck, Germany
    Stat Med 28:3581-96. 2009
    ..Only the alternative approaches were able to identify three genes (ADM, FCGR3B and ADORA1) as promising candidates to clarify the molecular mechanism of the genetic association...
  47. doi request reprint [Clinical trials with medical devices: lack of quality illustrated for faecal incontinence]
    R Vonthein
    Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Institut fur Medizinische Biometrie und Statistik
    Zentralbl Chir 137:380-4. 2012
    ..Medical devices must be safe and functioning states the law. Treatments with medical devices need not be efficacious to be allowed. We investigated special requirements and problems arising from the law...
  48. doi request reprint [Percentiles of body mass index of 18-80-year-old German adults based on data from the Second National Nutrition Survey]
    C Hemmelmann
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck
    Dtsch Med Wochenschr 135:848-52. 2010
    ..The World Health Organization (WHO) defines obesity as a body mass index (BMI) > or = 30.0 kg/m2. In contrast, percentiles depending on age and sex are used in adolescence...
  49. ncbi request reprint Two-color microarray experiments. Technology and sources of variance
    D Repsilber
    Institut für Medizinische Biometrie und Statistik Universitätsklinikum Schleswig Holstein, Campus Lübeck Ratzeburger Allee 160, Haus 4 23538 Lübeck, Germany
    Methods Inf Med 44:400-4. 2005
    ..Here, we introduce the necessary details for the so-called two-color microarray experiments and review major sources of technical variance...
  50. doi request reprint Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Clin Sci (Lond) 115:309-15. 2008
    ....
  51. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
    ..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
  52. pmc Weighting affected sib pairs by marker informativity
    Daniel Franke
    Institute of Medical Biometry and Statistics, University at Lubeck, Lubeck, Germany
    Am J Hum Genet 77:230-41. 2005
    ..Finally, we illustrate the use of the weighted mean test by reanalyzing two published data sets. In both applications, the maximum LOD score of the weighted mean test is 0.6 higher than that of the classical mean test...
  53. doi request reprint A general approach for sample size and power calculations based on the Haseman-Elston method
    Oliver Hädicke
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, Haus 4, 23538 Lubeck, Deutschland
    Biom J 50:257-69. 2008
    ....
  54. doi request reprint Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials
    Inke R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Stroke 39:1821-6. 2008
    ..Herein we demonstrate the applicability of our models in an independent sample of patients from controlled clinical trials...
  55. ncbi request reprint Data rotation improves genomotyping efficiency
    Dirk Repsilber
    Institut fur Medizinische Biometrie und Statistik, Ratzeburger Allee 160, Universitat zu Lubeck, 23538 Lubeck, Germany
    Biom J 47:585-98. 2005
    ..We approximately halve the proportion of false positives in the list of candidate absent genes for the example comparative genomic hybridization experiment as well as for the simulation experiments...
  56. ncbi request reprint SNPtoGO: characterizing SNPs by enriched GO terms
    Daniel F Schwarz
    Institut fur Medizinische Biometrie und Statistik, Lubeck, Germany
    Bioinformatics 24:146-8. 2008
    ..The tool presented here hence adds external information, i.e. GeneOntology (GO) terms (Gene Ontology Consortium), to the analysis of SNP data...
  57. pmc New susceptibility locus for coronary artery disease on chromosome 3q22.3
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
    Nat Genet 41:280-2. 2009
    ..We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11)...
  58. ncbi request reprint Reducing sample sizes in genome scans: group sequential study designs with futility stops
    Inke R Konig
    Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein, Campus Lubeck, University at Lubeck, Lubeck, Germany
    Genet Epidemiol 25:339-49. 2003
    ..Depending on the applied design, almost half of the sample size is spared on average. These enormous savings are expected to have a special impact on costs and time of large-scale studies such as genome scans...
  59. doi request reprint Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Mol Med (Berl) 86:1163-70. 2008
    ..In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either...
  60. doi request reprint MDR1 variants and risk of Parkinson disease. Association with pesticide exposure?
    Katja Zschiedrich
    Dept of Neurology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Neurol 256:115-20. 2009
    ..74; confidence interval=[1.009; 22.306]); p=0.047), suggesting that common MDR1 variants might influence the risk to develop PD in conjunction with exposure to pesticides...
  61. pmc Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study
    Patrick Linsel-Nitschke
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    PLoS ONE 3:e2986. 2008
    ..Less is known about the implications of common genetic variation in the LDLR gene regarding the variability of cholesterol levels and risk of CAD...
  62. pmc On safari to Random Jungle: a fast implementation of Random Forests for high-dimensional data
    Daniel F Schwarz
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Maria Goeppert Strasse 1, 23562 Lübeck, Germany
    Bioinformatics 26:1752-8. 2010
    ..Important single nucleotide polymorphisms are detected by permutation importance measures. To this day, the application to GWA data was highly cumbersome with existing implementations because of the high computational burden...
  63. ncbi request reprint Two models for outcome prediction - a comparison of logistic regression and neural networks
    R Linder
    Institut für Medizinische Informatik, Universitat zu Lubeck, Lubeck, Germany
    Methods Inf Med 45:536-40. 2006
    ..Our comparison has the advantage of being based on two large independent data sets allowing for elaborate model development and independent validation...
  64. ncbi request reprint Linkage analyses of chromosomal region 18p11-q12 in dyslexia
    J Schumacher
    Institut fur Humangenetik, Lubeck, Germany
    J Neural Transm 113:417-23. 2006
    ..Possible explanations for our non-replication include differences in study design, limited power of our study and overestimation of the effect of the chromosome 18 locus in the original study...
  65. ncbi request reprint Tutorial on microarray gene expression experiments. An introduction
    D Repsilber
    Institute für Medizinische Biometrie und Statistik, Universität za Lübeck, Lubeck, Germany
    Methods Inf Med 44:392-9. 2005
    ..The reader should get comprehensive directions to understand both the overall structure of this approach as well as the decisive details, which enable--or thwart--a meaningful data analysis...
  66. ncbi request reprint Prospective studies in patients with intraventricular haemorrhage without the capacity to give consent in Germany--a legal dilemma
    S Spuck
    Klinik für Neurochirurgie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Zentralbl Neurochir 67:183-7. 2006
    ..Several authors recommend its use only in the frame of prospective studies, meaning that intraventricular administration of thrombolytic agents within an individual therapy trial could be viewed as medical malpractice...
  67. doi request reprint [German-language questionnaires for the standardized assessment of fecal incontinence and quality of life]
    I R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Lubeck, Germany
    Dtsch Med Wochenschr 134:239-42. 2009
    ..Similarly, the impact of fecal incontinence on quality of life needs to be assessed with a specific assessment. The Fecal Incontinence Quality of Life Scale (FIQoL) is available for this, but not yet a German-language version...
  68. ncbi request reprint Analysis of SNPs in pooled DNA: a decision theoretic model
    Inke R Konig
    Centre for Genetic Epidemiological Methods, Institute of Medical Biometry and Statistics, University at Lubeck, Lubeck, Germany
    Genet Epidemiol 26:31-43. 2004
    ..Using Monte-Carlo simulations, we show that for a given situation, the genotyping rates and hence the costs can be reduced remarkably while maintaining acceptable overall error rates...
  69. ncbi request reprint Group sequential study designs in genetic-epidemiological case-control studies
    Inke R Konig
    Centre for Genetic Epidemiological Methods, Institute of Medical Biometry and Statistics, University Hospital Schleswig Holstein, University at Lubeck, Lubeck, Germany
    Hum Hered 56:63-72. 2003
    ..To reduce the number of required phenotypings and genotypings and thus facilitate analyzing complex traits, sequential study designs can be applied...
  70. doi request reprint [The care situation of patients with interstitial cystitis in Germany: results of a survey of 270 patients]
    D Jocham
    Urologische Klinik und Poliklinik, Universitat zu Lubeck, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Deutschland
    Urologe A 52:691-702. 2013
    ..Despite comprehensive literature on IC (62,000 citations in PubMed) almost nothing is known of the everyday care and quality of patient care in Germany...
  71. ncbi request reprint Sample size calculations for controlled clinical trials using generalized estimating equations (GEE)
    G Dahmen
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, Haus 4, 23538 Lubeck, Germany
    Methods Inf Med 43:451-6. 2004
    ..Although several approaches for sample size and power calculation have been proposed, we have shown that most of these procedures are very specific and not as general as required for designing clinical trials...
  72. ncbi request reprint Lack of association between the MEF2A gene and myocardial infarction
    Wolfgang Lieb
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:185-91. 2008
    ..In addition, genetic variants within the gene have been associated with MI in case-control settings, producing inconsistent results...
  73. ncbi request reprint [Predicted functional outcome 100 days after ischemic strokes: design of a prospective study about the external validation of a prognostic model]
    Inke R Konig
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck
    Z Arztl Fortbild Qualitatssich 97:717-22. 2003
    ..The resulting prognostic models will be useful for adequately stratifying treatment groups in clinical trials and to accurately predicting the outcome variable...
  74. ncbi request reprint Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction
    Björn Mayer
    Medizinische Klinik II, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    J Hypertens 24:1965-70. 2006
    ..The present study aimed to investigate the impact of the functionally relevant T8590C polymorphism of this gene on blood pressure and the prevalence of hypertension in MI patients...
  75. ncbi request reprint [Present state of radio frequency ablation of liver tumors in Germany]
    M Birth
    Klinik fur Chirurgie, Universitatsklinikum Schleswig Holstein, Campus Lubeck
    Chirurg 75:417-23. 2004
    ..Radio frequency ablation (RFA) represents a new technique for local destruction of liver tumors. Indication and procedure are poorly validated at present...
  76. doi request reprint What do we mean by 'replication' and 'validation' in genome-wide association studies?
    Bernd Wolfgang Igl
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Lubeck, Germany
    Hum Hered 67:66-8. 2009
    ..Based on a number of applications from the literature producing a certain amount of confusion, our aim therefore is to clarify the definition of 'replication' and 'validation' and propose standards of their usage...
  77. pmc CDKN2A germline mutations in familial pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Institute of Biometrics and Medical Epidemiology, Philipps University, Marburg, Germany
    Ann Surg 236:730-7. 2002
    ..To evaluate the prevalence of mutations in the CDKN2A gene encoding p16 and p14 in familial pancreatic cancer (FPC)...
  78. ncbi request reprint HLA-DRB genotyping in Gilles de la Tourette patients and their parents
    Sarah Schoenian
    Department of Neurology, Philipps University Marburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 119:60-4. 2003
    ..741, Monte Carlo P = 0.4998). Our results imply that the HLA-DRB locus does not confer genetic susceptibility to GTS...
  79. ncbi request reprint Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Stroke 34:2817-21. 2003
    ..Their activity is controlled predominantly by tissue inhibitors of metalloproteinases (TIMPs). To investigate the possible impact of genetic variants within the genes encoding TIMP-1, -2, and -3, we conducted this case-control study...
  80. ncbi request reprint Cytokine gene polymorphisms in allergic contact dermatitis
    Götz A Westphal
    Department of Occupational Health, Georg August University, Gottingen, Germany
    Contact Dermatitis 48:93-8. 2003
    ..These findings suggest a possible relationship between the TNFA-308 polymorphism and contact allergy. The results need to be confirmed in future studies...
  81. ncbi request reprint Detection rates for genotyping errors in SNPs using the trio design
    Frank Geller
    Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Marburg, Germany
    Hum Hered 54:111-7. 2002
    ..We conclude that detection rates are probably substantially higher than those reported by Gordon et al...
  82. ncbi request reprint BRCA2 germline mutations in familial pancreatic carcinoma
    Stephan A Hahn
    Department of Internal Medicine, Knappschaftskrankenhaus University of Bochum, Germany
    J Natl Cancer Inst 95:214-21. 2003
    ..To study these relationships in more detail, we examined whether BRCA2 germline mutations are associated with familial pancreatic cancer...
  83. ncbi request reprint Genome scan for childhood and adolescent obesity in German families
    Kathrin Saar
    Molecular Genetics and Gene Mapping Center, Max Delbruck Center, Berlin, Germany
    Pediatrics 111:321-7. 2003
    ....
  84. ncbi request reprint Secular trends in body mass index measurements in preschool children from the City of Aachen, Germany
    Beate Herpertz-Dahlmann
    Department of Child and Adolescent Psychiatry, Technical University of Aachen, Neuenhofer Weg 21, 52074 Aachen, Germany
    Eur J Pediatr 162:104-9. 2003
    ..While significant increases occurred for any given BMI percentile, the annual increase for both sexes was most prominent in the upper range. No change in body height was observed during the study period...
  85. ncbi request reprint Polymorphisms of the NADPH oxidase P22PHOX gene in a Caucasian population with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Cerebrovasc Dis 16:363-8. 2003
    ..We conducted a case-control study to investigate the relationship of five polymorphisms of the P22PHOX gene and the occurrence of cerebral aneurysms...
  86. ncbi request reprint Effects of covariates: a summary of Group 5 contributions
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 25:S43-9. 2003
    ..Finally, the results of Group 5 studies show that inclusion of covariates can increase the power to detect genes for complex traits, and has the potential to advance an understanding of the role of genes in these complex traits...
  87. ncbi request reprint GEE approaches to marginal regression models for medical diagnostic tests
    Peter Martus
    Department of Medical Informatics, Biometry and Epidemiology, Free University Berlin, Germany
    Stat Med 23:1377-98. 2004
    ....
  88. ncbi request reprint Prevalence of familial pancreatic cancer in Germany
    Detlef K Bartsch
    National Case Collection of Familial Pancreatic Cancer, Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Int J Cancer 110:902-6. 2004
    ..This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer...
  89. ncbi request reprint Variations in the peroxisome proliferator-activated receptor-gamma gene and melanoma risk
    Rotraut Mossner
    Department of Dermatology, Georg August University, von Siebold Strasse 3, D 37075 Gottingen, Germany
    Cancer Lett 246:218-23. 2007
    ..We therefore conclude that the investigated PPARG polymorphisms are not likely to constitute a significant risk factor for the development of melanoma among German Caucasians...
  90. ncbi request reprint SNP-based analysis of genetic substructure in the German population
    Michael Steffens
    Institute of Medical Biometry, Informatics and Epidemiology, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Hum Hered 62:20-9. 2006
    ..Two of the three samples, POPGEN (n = 720) and SHIP (n = 709), are from north and north-east Germany, respectively, and one sample, KORA (n = 730), is from southern Germany...
  91. ncbi request reprint Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma
    Rotraut Mossner
    Department of Dermatology, Georg August University, von Siebold Strasse 3, 37075, Gottingen, Germany
    Arch Dermatol Res 298:371-9. 2007
    ..047). There was no effect of homozygous GST M1 or T1 deletions on melanoma risk. In contrast to previous data, there was no evidence that GSTM1 deficiency influences melanoma risk in the subgroup of individuals with red or blond hair...
  92. ncbi request reprint Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas
    Heike Görgens
    Department of Surgical Research, Technische Universitat Dresden, D 01307 Dresden, Germany
    Oral Oncol 43:791-5. 2007
    ..This does not exclude the involvement of the three BER genes in the tumorigenesis of SCCHN through other mechanisms such as promotor hypermethylation, genomic rearrangements or mutations involving regulatory sequences...
  93. pmc Genome-wide linkage analysis of malaria infection intensity and mild disease
    Christian Timmann
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Genet 3:e48. 2007
    ..7%; 95% confidence interval, 15.7%-59.7%). The identification of genetic variants underlying the linkage signals may reveal as yet unrecognized pathways influencing human resistance to malaria...
  94. ncbi request reprint Haplotypes and haplotype-tagging single-nucleotide polymorphism: presentation Group 8 of Genetic Analysis Workshop 14
    Lars Beckmann
    German Cancer Research Center Deutsches Krebsforschungszontrum DKFZ, Heidelberg, Germany
    Genet Epidemiol 29:S59-71. 2005
    ..In conclusion, regardless of the task, results were similar in chromosomal regions of high LD. However, based on the differing results observed here, methodological improvements are required for chromosomal regions of low to moderate LD...
  95. ncbi request reprint Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study
    Sandra Blankenburg
    Department of Dermatology, Georg August University, Goettingen, Germany
    Carcinogenesis 26:1085-90. 2005
    ..Our results should be validated in independent samples in order to guard against false positive findings...
  96. pmc Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
    ..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...
  97. doi request reprint Multiple test procedures using an upper bound of the number of true hypotheses and their use for evaluating high-dimensional EEG data
    Claudia Hemmelmann
    Institute of Medical Statistics, Computer Sciences and Documentation, Friedrich Schiller University of Jena, Bachstrasse 18, Jena, Germany
    J Neurosci Methods 170:158-64. 2008
    ..The gain in power of our procedures is demonstrated in an example using EEG data on the processing of memorized lexical items...
  98. pmc Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 78:52-62. 2006
    ....
  99. doi request reprint Further evidence for a susceptibility locus contributing to reading disability on chromosome 15q15-q21
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Psychiatr Genet 18:137-42. 2008
    ..Linkage and association studies in dyslexia suggest that a susceptibility locus exists on chromosome 15q15-q21...
  100. ncbi request reprint Matrix metalloproteinase-9 coding sequence single-nucleotide polymorphisms in caucasians with intracranial aneurysms
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Neurosurgery 55:207-12; discussion 212-3. 2004
    ..We performed a case-control study to investigate whether single-nucleotide polymorphisms (SNPs) within the coding region of the MMP-9 gene might affect the development of intracranial aneurysms...
  101. ncbi request reprint Extended single nucleotide polymorphism and haplotype analysis of the elastin gene in Caucasians with intracranial aneurysms provides evidence for racially/ethnically based differences
    Dietmar Krex
    Department of Neurosurgery, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany
    Cerebrovasc Dis 18:104-10. 2004
    ..Recently, the genetic locus around the elastin gene (7q11) has been identified as linked to IA in a Japanese population. Our aim was to confirm these results in Caucasian populations...