Jason C Young

Summary

Country: Germany

Publications

  1. ncbi request reprint More than folding: localized functions of cytosolic chaperones
    Jason C Young
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Trends Biochem Sci 28:541-7. 2003
  2. pmc Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
    Alexander Brychzy
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 22:3613-23. 2003
  3. ncbi request reprint Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange
    Yasuhito Shomura
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell 17:367-79. 2005
  4. ncbi request reprint A stress sensor for the bacterial periplasm
    Jason C Young
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Cell 113:1-2. 2003
  5. ncbi request reprint Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
    Jason C Young
    Cellular Biochemistry, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 112:41-50. 2003
  6. ncbi request reprint Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae
    Holger Sondermann
    Department of Cellular Biochemistry, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Biol Chem 277:33220-7. 2002
  7. ncbi request reprint Post-translational integration of tail-anchored proteins is facilitated by defined molecular chaperones
    Benjamin M Abell
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 120:1743-51. 2007
  8. ncbi request reprint Pathways of chaperone-mediated protein folding in the cytosol
    Jason C Young
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Nat Rev Mol Cell Biol 5:781-91. 2004
  9. doi request reprint Functional divergence between co-chaperones of Hsc70
    Stefan Tzankov
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 283:27100-9. 2008
  10. ncbi request reprint Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor
    Ulrike Schmidt
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Biol Chem 278:4926-31. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint More than folding: localized functions of cytosolic chaperones
    Jason C Young
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Trends Biochem Sci 28:541-7. 2003
    ..Such flexibility is unique to the cytosolic Hsp70 and Hsp90 chaperone system...
  2. pmc Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
    Alexander Brychzy
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 22:3613-23. 2003
    ..We propose a novel mechanism in which Tpr2 mediates the retrograde transfer of substrates from Hsp90 onto Hsp70. At normal levels substoichiometric to Hsp90 and Hsp70, this activity optimizes the function of the multichaperone machinery...
  3. ncbi request reprint Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange
    Yasuhito Shomura
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Mol Cell 17:367-79. 2005
    ..In contrast, BAG-1 and GrpE trigger a conserved conformational change in lobe II of the ATPase domain. Thus, nucleotide exchange on eukaryotic Hsp70 occurs through two distinct mechanisms...
  4. ncbi request reprint A stress sensor for the bacterial periplasm
    Jason C Young
    Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Cell 113:1-2. 2003
    ..This interaction relieves the inhibition of the neighboring protease domain of DegS, triggering a proteolysis cascade that leads to the sigma(E)-driven expression of periplasmic chaperones...
  5. ncbi request reprint Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
    Jason C Young
    Cellular Biochemistry, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 112:41-50. 2003
    ..We outline a novel mechanism in which chaperones are recruited for a specific targeting event by a membrane-bound receptor...
  6. ncbi request reprint Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae
    Holger Sondermann
    Department of Cellular Biochemistry, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Biol Chem 277:33220-7. 2002
    ..Thus, Snl1p is the first Bag domain protein identified in S. cerevisiae, and its interaction with Hsp70 is essential for biological activity...
  7. ncbi request reprint Post-translational integration of tail-anchored proteins is facilitated by defined molecular chaperones
    Benjamin M Abell
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 120:1743-51. 2007
    ..On the basis of this in vitro analysis, we conclude that this chaperone pair can efficiently facilitate the ATP-dependent integration of TA proteins...
  8. ncbi request reprint Pathways of chaperone-mediated protein folding in the cytosol
    Jason C Young
    Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Nat Rev Mol Cell Biol 5:781-91. 2004
    ....
  9. doi request reprint Functional divergence between co-chaperones of Hsc70
    Stefan Tzankov
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 283:27100-9. 2008
    ..These results suggest a more complex model of Hsc70 mechanism than has been previously thought, with notable functional divergence between Hsc70 co-chaperones...
  10. ncbi request reprint Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor
    Ulrike Schmidt
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Biol Chem 278:4926-31. 2003
    ..Thus, DNA binding and hsp70 interaction are required in cis. We propose that the nonsequence-specific DNA-binding protein BAG-1 acts at specific chromosomal loci by interacting with other proteins...
  11. ncbi request reprint Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import
    Anna C Y Fan
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 281:33313-24. 2006
    ..This suggests a novel active role for Hsp90 in import steps subsequent to Tom70 targeting. Our results outline the mechanisms of Hsp90 function in preprotein targeting and transport...
  12. ncbi request reprint Chaperones and transcriptional regulation by nuclear receptors
    Jason C Young
    Nat Struct Biol 9:640-2. 2002
  13. pmc Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import
    Melanie K Bhangoo
    Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada
    Mol Biol Cell 18:3414-28. 2007
    ..The Hsp90 cochaperones p23 and Aha1 also regulated Hsp90-preprotein interactions. We suggest that multiple cochaperones with similar yet partially specialized properties cooperate in optimal chaperone-preprotein complexes...
  14. ncbi request reprint Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    FEBS Lett 560:35-8. 2004
    ..Importantly, similar results were obtained with a constitutively active GR. Thus, the action of p23 on the nuclear stage of GR regulation requires its Hsp90 co-chaperone function, but not its chaperone activity...