Research Topics
Genomes and GenesSpecies | A YilmazSummaryCountry: Germany Publications
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Publications
HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosisAtilla Yilmaz
Medical Clinic II, University Erlangen Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany
Atherosclerosis 172:85-93. 2004..Therefore, the use of statins as immunomodulators might also provide a new therapeutic approach to other immunological disorders...
Effects of amifostine in a patient with an advanced-stage myelodysplastic syndromeA Yilmaz
Department of Hematology Oncology, Georg August University, Gottingen, Germany
Ann Hematol 80:53-7. 2001..Thus, amifostine might be a therapeutic option in older patients with advanced MDS...
Predictive value of the decrease in circulating dendritic cell precursors in stable coronary artery diseaseAtilla Yilmaz
Medical Clinic II, University Hospital of Erlangen, Erlangen, Germany
Clin Sci (Lond) 116:353-63. 2009..Their decrease appears to be an independent predictor of the presence of, and subsequent therapeutic procedure in, stable CAD...
Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brainAtilla Yilmaz
Clinic of Internal Medicine I, Department of Cardiology, University Hospital Jena, Jena, Germany
Clin Sci (Lond) 118:147-57. 2010..In conclusion, acute stroke leads to a decrease in circulating DCPs. Potentially, circulating DCPs are recruited from the blood into the infarcted brain and probably trigger cerebral immune reactions there...
Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaquesAtilla Yilmaz
Medical Clinic II, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
Atherosclerosis 176:101-10. 2004..The results of the present study indicate that DC might contribute to plaque destabilization through an activation of T cells...
CD40/CD154 system and pro-inflammatory cytokines in young healthy male smokers without additional risk factors for atherosclerosisC D Garlichs
University of Erlangen Nuremberg, Medical Clinic 2, Erlangen, Germany
Inflamm Res 58:306-11. 2009..We investigated whether smoking affects the CD40/CD154 system and pro-inflammatory cytokines in young males without other risk factors for atherosclerosis...
Decrease in circulating myeloid dendritic cell precursors in coronary artery diseaseAtilla Yilmaz
Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
J Am Coll Cardiol 48:70-80. 2006....
Delay of neutrophil apoptosis in acute coronary syndromesC D Garlichs
Medicak Clinic II, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
J Leukoc Biol 75:828-35. 2004..Therapeutical modulation of these determinants of PMN lifespan may provide a new concept for the control of inflammation in ACS...
Elevated VEGF-plasma levels in young patients with mild essential hypertensionC Stumpf
Department of Cardiology, University of Erlangen Nuremberg, Erlangen, Germany
Eur J Clin Invest 39:31-6. 2009..To investigate the hypothesis that VEGF plays a role as an inflammatory mediator in EH we performed the present pilot study of young patients in a very early stage of EH...
Accumulation of immune cells and high expression of chemokines/chemokine receptors in the upstream shoulder of atherosclerotic carotid plaquesAtilla Yilmaz
Medical Clinic II, University of Erlangen Nuremberg Ulmenweg 18, 91054 Erlangen, Germany
Exp Mol Pathol 82:245-55. 2007..The abundance of SMC downstream provides an explanation for distal plaque growth. Enhanced recruitment of immune cells through neovessels into the upstream shoulder might be contributing to plaque destabilization...
Platelets contribute to enhanced MCP-1 levels in patients with chronic heart failureC Stumpf
Department of Cardiology, University of Erlangen Nuremberg, Erlangen, Germany
Heart 94:65-9. 2008..Recently, platelets were identified as inducing inflammation partly by releasing cytokines. This new aspect necessitates further studies about the contribution of platelets for the inflammatory setting of CHF...
Enhanced levels of CD154 (CD40 ligand) on platelets in patients with chronic heart failureChristian Stumpf
Laboratory for Molecular Cardiology, Medical Clinic II, University of Erlangen Nuremberg, Schwabachanlage 10, Ostfluegel, UG, Erlangen 91054, Germany
Eur J Heart Fail 5:629-37. 2003..Since CD154 initiates and maintains the release of proinflammatory cytokines from endothelial cells, its potential role for the development and progression of CHF is of interest...
Interleukin-10 improves left ventricular function in rats with heart failure subsequent to myocardial infarctionChristian Stumpf
Department of Cardiology, University of Erlangen Nuremberg, Erlangen, Germany
Eur J Heart Fail 10:733-9. 2008..This effect was associated with a significant decrease in pro-inflammatory cytokine and chemokine levels (TNF-alpha, IL-6, MCP-1) and furthermore resulted in a reduced myocardial infiltration of macrophages...
Differential effects of statins on relevant functions of human monocyte-derived dendritic cellsAtilla Yilmaz
Medical Clinic II, Department of Dermatology, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
J Leukoc Biol 79:529-38. 2006..However, statin preincubation of LPS-stimulated DC caused a further increase in their secretion of proinflammatory cytokines...
Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertensionChristian Stumpf
Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
J Hypertens 23:995-1000. 2005..Therefore, the present pilot study was designed to examine the role of platelet P-selectin and various inflammatory mediators in young patients with moderate AH without signs of target organ damage...
Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failureChristian Stumpf
Department of Cardiology, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
Clin Sci (Lond) 105:45-50. 2003..Since IL-10 is known as a potent anti-inflammatory cytokine, its decrease in advanced CHF may favour the inflammatory milieu in CHF...
Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarctionChristian Stumpf
Department of Cardiology, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
Clin Sci (Lond) 116:45-52. 2009....
Upregulation of CD40-CD40 ligand (CD154) in patients with acute cerebral ischemiaC D Garlichs
Medical Clinic II, Friedrich Alexander University Erlangen Nuremberg, David Morgenstern Weg 14, 91056 Erlangen, Germany
Stroke 34:1412-8. 2003..Both can be mediated by the CD40 system. This study investigated whether the CD40 system and related mediators are upregulated in patients with transient ischemic attack (TIA) or stroke...
Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitroIwona Cicha
Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
Arterioscler Thromb Vasc Biol 25:1008-13. 2005..To assess the hypothesis that CTGF is involved in atherosclerotic plaque progression, we investigated CTGF protein expression and distribution in the different types of plaque morphology...
Activated myeloid dendritic cells accumulate and co-localize with CD3+ T cells in coronary artery lesions in patients with Kawasaki diseaseAtilla Yilmaz
Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
Exp Mol Pathol 83:93-103. 2007..This suggests that mature arterial myeloid DCs might be activating T cells in situ and may be a significant factor in the pathogenesis of coronary arteritis in KD...
Connective tissue growth factor is released from platelets under high shear stress and is differentially expressed in endothelium along atherosclerotic plaquesIwona Cicha
Medical Clinic II, University of Erlangen Nuremberg, Germany
Clin Hemorheol Microcirc 35:203-6. 2006..Furthermore, disturbed flow along atherosclerotic vessels may induce endothelial CTGF expression and contribute to the progress of atherosclerotic lesions...
Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-alpha and monocytic cell recruitment in a simplified model of arterial bifurcationsIwona Cicha
Laboratory of Molecular Cardiology, Medical Clinic 2, University of Erlangen Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany
Atherosclerosis 207:93-102. 2009..This study investigated the endothelial response to shear stress in combination with the inflammatory cytokine TNF-alpha in a simplified model of arterial bifurcation...
Monitoring the cellular effects of HMG-CoA reductase inhibitors in vitro and ex vivoIwona Cicha
Medical Clinic IV, University of Erlangen-Nuremberg, Erlangen, Germany
Arterioscler Thromb Vasc Biol 24:2046-50. 2004..CONCLUSIONS: 2D-electrophoresis is a sensitive method for detecting changes in the amount of nonisoprenylated Rho proteins, allowing monitoring the direct cellular effects of statins...
Endothelial dysfunction and monocyte recruitment in cells exposed to non-uniform shear stressIwona Cicha
Medical Clinic 2, University of Erlangen Nuremberg, Erlangen, Germany
Clin Hemorheol Microcirc 39:113-9. 2008....
Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stressIwona Cicha
Medical Clinic 2, University of Erlangen Nuremberg, Erlangen, Germany
Atherosclerosis 196:136-45. 2008..Interference with shear stress-induced protein expression may inhibit endothelial dysfunction in atheroprone vessel regions...
Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitizationNicolas W J Schröder
Pediatric Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, CA, USA
J Allergy Clin Immunol 122:595-602.e5. 2008..A mechanistic reconciliation of these findings has not yet emerged. In particular, the role of innate immunity in this context is unclear...
