Hartwig Wolburg

Summary

Country: Germany

Publications

  1. ncbi request reprint Freeze-fracture studies of cerebral endothelial tight junctions
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Germany
    Methods Mol Med 89:51-66. 2003
  2. ncbi request reprint Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae
    Arne Warth
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076, Tubingen, Germany
    Acta Neuropathol 107:311-8. 2004
  3. ncbi request reprint Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival
    Arne Warth
    Institute of Pathology, University of Tuebingen, Tuebingen, Germany
    J Neurosci Res 85:1336-46. 2007
  4. doi request reprint Brain endothelial cells and the glio-vascular complex
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    Cell Tissue Res 335:75-96. 2009
  5. pmc Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis
    Yvonne S Eisele
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Science 330:980-2. 2010
  6. pmc Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro
    Ulrike Steinmann
    Department of Pediatrics, Pediatric Infectious Diseases, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    J Neuroinflammation 10:31. 2013
  7. doi request reprint The disturbed blood-brain barrier in human glioblastoma
    Hartwig Wolburg
    Department of General Pathology and Pathological Anatomy, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    Mol Aspects Med 33:579-89. 2012
  8. pmc Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis
    Corinna Wewer
    Department of General Pediatrics, University Children s Hospital, Heinrich Heine University, Dusseldorf, Germany
    J Neuroinflammation 8:51. 2011
  9. pmc Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier
    Juliane Kläs
    Ruprecht Karls University, Department of Pharmaceutical Technology, 69120 Heidelberg, Germany
    Cerebrospinal Fluid Res 7:11. 2010
  10. doi request reprint Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076, Tubingen, Germany
    Histochem Cell Biol 130:127-40. 2008

Detail Information

Publications73

  1. ncbi request reprint Freeze-fracture studies of cerebral endothelial tight junctions
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Germany
    Methods Mol Med 89:51-66. 2003
  2. ncbi request reprint Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae
    Arne Warth
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076, Tubingen, Germany
    Acta Neuropathol 107:311-8. 2004
    ..The restriction of AQP4/OAPs to the endfoot membrane may be dependent on the presence of agrin, and this might be essentially connected to the ability of astrocytes to maintain the integrity of the blood-brain barrier...
  3. ncbi request reprint Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival
    Arne Warth
    Institute of Pathology, University of Tuebingen, Tuebingen, Germany
    J Neurosci Res 85:1336-46. 2007
    ..In addition, our results provide unexpectedly high AQP4 levels in pilocytic astrocytomas and present AQP4 as tumor progression marker in WHO grade II-IV astrocytomas...
  4. doi request reprint Brain endothelial cells and the glio-vascular complex
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    Cell Tissue Res 335:75-96. 2009
    ....
  5. pmc Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis
    Yvonne S Eisele
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Science 330:980-2. 2010
    ..We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times...
  6. pmc Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro
    Ulrike Steinmann
    Department of Pediatrics, Pediatric Infectious Diseases, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    J Neuroinflammation 10:31. 2013
    ..In this study, we analyzed the cellular and molecular mechanisms of polymorphonuclear neutrophil (PMN) and monocyte transepithelial transmigration (TM) across the BCSFB after bacterial infection...
  7. doi request reprint The disturbed blood-brain barrier in human glioblastoma
    Hartwig Wolburg
    Department of General Pathology and Pathological Anatomy, Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    Mol Aspects Med 33:579-89. 2012
    ..However, the mechanism how the loss of polarity is related to the disturbance of microvascular tight junctions is completely unknown so far...
  8. pmc Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis
    Corinna Wewer
    Department of General Pediatrics, University Children s Hospital, Heinrich Heine University, Dusseldorf, Germany
    J Neuroinflammation 8:51. 2011
    ..Thus, we investigated the mechanism of PMN transmigration through the blood-CSF barrier under inflammatory conditions...
  9. pmc Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier
    Juliane Kläs
    Ruprecht Karls University, Department of Pharmaceutical Technology, 69120 Heidelberg, Germany
    Cerebrospinal Fluid Res 7:11. 2010
    ..Two rodent choroid plexus (CP) epithelial cell lines, Z310 and TR-CSFB, were compared with primary rat CP epithelial cells and intact CP tissue with respect to transport protein expression, function and tight junction (TJ) formation...
  10. doi request reprint Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076, Tubingen, Germany
    Histochem Cell Biol 130:127-40. 2008
    ..The tight junctions of the OECs are discussed to be responsible for micro-compartmentalization within the olfactory fiber tract providing a benefit for axonal growth...
  11. ncbi request reprint Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse
    H Wolburg
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, D 72076, Tubingen, Germany
    Neurosci Lett 307:77-80. 2001
    ..Their unique molecular composition, with claudin-11 accompanied by claudin-1 and claudin-2 points to a unique regulatory mechanism of the blood-CSF-barrier function...
  12. doi request reprint Choroid plexus: biology and pathology
    Hartwig Wolburg
    Institute of Pathology, University Hospital Tubingen, Tubingen, Germany
    Acta Neuropathol 119:75-88. 2010
    ..We here revive some of the classical studies and review recent insight into the biology and pathology of the choroid plexus...
  13. doi request reprint Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Tubingen, Germany
    Neuroscientist 15:180-93. 2009
    ....
  14. ncbi request reprint Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact
    Hartwig Wolburg
    Institute for Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076, Tubingen, Germany
    Acta Neuropathol 109:181-90. 2005
    ....
  15. ncbi request reprint Tight junctions of the blood-brain barrier: development, composition and regulation
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Liebermeisterstr 8, D 72076 Tubingen, Germany
    Vascul Pharmacol 38:323-37. 2002
    ..4. Important new molecular aspects of tight junction regulation were recently elucidated. This review provides an integration of these new results...
  16. ncbi request reprint Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme
    Hartwig Wolburg
    Institute for Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076, Tubingen, Germany
    Acta Neuropathol 105:586-92. 2003
    ....
  17. doi request reprint Structure and functions of aquaporin-4-based orthogonal arrays of particles
    Hartwig Wolburg
    Institute of Pathology, University of Tubingen, Tubingen, Germany
    Int Rev Cell Mol Biol 287:1-41. 2011
    ..In particular, astrocytes and glioma cells will play the major part in this review, not only due to our own work but also due to the fact that most studies on structure and function of AQP4 were done in the nervous system...
  18. doi request reprint Dynamics of expression patterns of AQP4, dystroglycan, agrin and matrix metalloproteinases in human glioblastoma
    Susan Noell
    Department of Neurosurgery, University of Tubingen, Tubingen, Germany
    Cell Tissue Res 347:429-41. 2012
    ..The results underline our concept of the loss of glioma cell polarity as one of the factors responsible for the disturbance of the neurovascular unit and as an explanation for the formation of edemas in the glioblastoma...
  19. doi request reprint Labeling of human mesenchymal stromal cells with superparamagnetic iron oxide leads to a decrease in migration capacity and colony formation ability
    Richard SchAfer
    Institute of Clinical and Experimental Transfusion Medicine, University Hospital Tubingen, Germany
    Cytotherapy 11:68-78. 2009
    ....
  20. ncbi request reprint The use of clinically approved small particles of iron oxide (SPIO) for labeling of mesenchymal stem cells aggravates clinical symptoms in experimental autoimmune encephalomyelitis and influences their in vivo distribution
    Richard SchAfer
    Institute of Clinical and Experimental Transfusion Medicine, University Hospital Tubingen, Tubingen, Germany
    Cell Transplant 17:923-41. 2008
    ....
  21. pmc An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment
    Susan Noell
    Department of Neurosurgery, University of Tubingen, Tubingen, Germany
    PLoS ONE 7:e36555. 2012
    ..In contrast, primary rat or mouse astrocytes in culture did not lose their ability to express AQP4, and they were able to form few OAPs...
  22. pmc Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles
    Richard SchAfer
    Institute of Clinical and Experimental Transfusion Medicine, University Hospital of Tubingen, Tubingen, Germany
    BMC Cell Biol 11:22. 2010
    ..To evaluate the imaging properties, quantification of the total iron load per cell (TIL), electron microscopy, and MRI at 3.0 T were performed...
  23. doi request reprint N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation
    Jeannette Hübener
    Department of Medical Genetics, University of Tubingen, 72076 Tubingen, Germany
    Brain 134:1925-42. 2011
    ..Consistent with the disease in humans, gene trap mice develop cytoplasmic inclusion bodies and implicate impaired unfolded protein response in the pathogenesis of spinocerebellar ataxia type 3...
  24. doi request reprint The impact of agrin on the formation of orthogonal arrays of particles in cultured astrocytes from wild-type and agrin-null mice
    Petra Fallier-Becker
    Institute of Pathology, University of Tubingen, Medical School, Tubingen, Germany
    Brain Res 1367:2-12. 2011
    ....
  25. doi request reprint Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis
    Karen Wolburg-Buchholz
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    Acta Neuropathol 118:219-33. 2009
    ..Our data suggest that during EAE, loss of beta-dystroglycan-mediated astrocyte foot process anchoring to the basement membrane leads to loss of polarized AQP4 localization in astrocytic endfeet, and thus to edema formation in EAE...
  26. pmc Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
    Janaky Coomaraswamy
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Graduate School of Cellular and Molecular Neuroscience, University of Tubingen, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 107:7969-74. 2010
    ..Our results support the concept of the amyloid hypothesis for AD and related dementias, and suggest that different proteins prone to amyloid formation can drive strikingly similar pathogenic pathways in the brain...
  27. ncbi request reprint Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in cultured astrocytes
    Susan Noell
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, D 72076 Tubingen, Germany
    Eur J Neurosci 26:2109-18. 2007
    ..Implications for the regulation and maintenance of the blood-brain barrier including oedema formation under pathological conditions are discussed...
  28. doi request reprint Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia
    Stefan A Grathwohl
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Nat Neurosci 12:1361-3. 2009
    ..Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia...
  29. pmc Evidence for a role of dystroglycan regulating the membrane architecture of astroglial endfeet
    Susan Noell
    Department of Neurosurgery, Tübingen Medical School, Tubingen, Germany
    Eur J Neurosci 33:2179-86. 2011
    ..However, the decreased number of perivascular AQP4 molecules obviously did form a few OAPs, even in the absence of DG...
  30. ncbi request reprint Growing axons in fish optic nerve are accompanied by astrocytes interconnected by tight junctions
    Andreas F Mack
    Institute of Anatomy, University of Tubingen, Osterbergstr 3 72074 Tübingen, Germany
    Brain Res 1103:25-31. 2006
    ....
  31. ncbi request reprint Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin
    Gesa Rascher
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, Germany
    Acta Neuropathol 104:85-91. 2002
    ..These results support the view that in human GBM, BBB breakdown is reflected by the changes of the molecular compositions of both the endothelial TJ and the basal lamina...
  32. ncbi request reprint Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir4.1 differs in low- and high-grade human brain tumors
    Arne Warth
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    Acta Neuropathol 109:418-26. 2005
    ..The redistribution of AQP4 in glioblastoma cells is discussed as a reaction to the vasogenic edema, as induced by the breakdown of the BBB, to facilitate reabsorption of excess fluid...
  33. doi request reprint Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes
    Susan Noell
    Institute of Pathology, University of Tubingen, Germany
    Cell Tissue Res 337:185-95. 2009
    ..These results clearly demonstrate, for the first time, that agrin plays a pivotal role for the clustering of OAPs in the endfoot membranes of astrocytes, whereas the mere presence of AQP4 is not sufficient for OAP clustering...
  34. ncbi request reprint Expression of the water channel protein aquaporin-9 in malignant brain tumors
    Arne Warth
    Institutes of Pathology, University of Tubingen, Tubingen, Germany
    Appl Immunohistochem Mol Morphol 15:193-8. 2007
    ..In addition, the increased level of AQP9 immunoreactivity could be involved in the energy metabolism of the glioma and/or surrounding neuronal cells...
  35. doi request reprint EpCAM, a human tumor-associated antigen promotes Th2 development and tumor immune evasion
    Alexandra Ziegler
    Department of Dermatology, University Medical Center, Eberhard Karls University Tubingen, Tubingen, Germany
    Blood 113:3494-502. 2009
    ..Preventing activation-associated death of Th1 cells further increased intratumoral IFN-gamma expression and improved therapeutic efficacy. Thus, human TAA may promote tumor immune evasion by strongly favoring Th2 development...
  36. doi request reprint A novel look at astrocytes: aquaporins, ionic homeostasis, and the role of the microenvironment for regeneration in the CNS
    Andreas F Mack
    Institute of Anatomy, University of Tubingen, Tubingen, Germany
    Neuroscientist 19:195-207. 2013
    ..It is hypothesized that highly polarized AQP4 expression and the lack of tight junctions on astrocytes increase ionic homeostasis, thus improving neuronal performance possibly at the expense of restraining neurogenesis and regeneration...
  37. pmc Effective chemokine secretion by dendritic cells and expansion of cross-presenting CD4-/CD8+ dendritic cells define a protective phenotype in the mouse model of coxsackievirus myocarditis
    Andreas Oliver Weinzierl
    Department of Molecular Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    J Virol 82:8149-60. 2008
    ..We conclude that MHC-independent genetic factors involving DC-related IP-10 secretion and TLR3 expression are beneficial in the prevention of chronic coxsackievirus myocarditis...
  38. doi request reprint Astroglial structures in the zebrafish brain
    Larissa Grupp
    Institute of Anatomy, University of Tubingen, D 72074 Tubingen, Germany
    J Comp Neurol 518:4277-87. 2010
    ..Thus, astroglial cells in the zebrafish differ in many aspects from mammalian astrocytes...
  39. pmc Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae
    Christine Weinl
    Department for Molecular Biology, Interfaculty Institute of Cell Biology, University of Tubingen, Tubingen, Germany
    J Clin Invest 123:2193-206. 2013
    ....
  40. doi request reprint Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?
    Marena Rebekka Niewisch
    Department of General Paediatrics and Oncology Haematology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 29:373-80. 2012
    ..Therefore, DCA at low millimolar concentrations seems to be only of minor efficacy for neuroblastoma treatment...
  41. pmc Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Nicole Kieper
    Center of Neurology and Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Exp Cell Res 316:1213-24. 2010
    ..Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders...
  42. ncbi request reprint The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines
    Friederike Schmidt
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Medical School, D 72076 Tuebingen, Germany
    Oncol Rep 19:1061-6. 2008
    ..Thus, genistein-like protein kinase inhibitors are promising agents for the experimental treatment of malignant gliomas...
  43. ncbi request reprint Nucleosomes induce lymphocyte necrosis
    Patrice Decker
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Eur J Immunol 33:1978-87. 2003
    ..Taken together, this is the first report indicating that nucleosomes are able to induce necrosis,which in turn could result in an amplification loop of the disease causing the inflammation observed in lupus patients...
  44. ncbi request reprint Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death
    Joachim P Steinbach
    Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, School of Medicine, Tubingen, Germany
    Cancer Res 64:1575-8. 2004
    ..These results caution that therapies targeting EGFR signaling pathways can protect tumor cells from acute hypoxia...
  45. doi request reprint Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice
    Silke Nuber
    Department of Medical Genetics, University of Tubingen, Calwerstr 7, 72076 Tubingen, Germany
    Neurogenetics 11:107-20. 2010
    ..These findings suggest a pathological role of overexpressed synphilin-1 in vivo and will help to further elucidate the mechanisms of protein aggregation and neuronal cell death...
  46. pmc Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
    Guido Krebiehl
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e9367. 2010
    ..Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has been recognized, the effects on mitochondrial dynamics and downstream consequences remain to be determined...
  47. pmc Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
    Rebecca Radde
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, Otfried Muller Strasse 27, D 72076 Tubingen, Germany
    EMBO Rep 7:940-6. 2006
    ....
  48. ncbi request reprint Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence
    Ulrike Bichelmeier
    Department of Medical Genetics, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 27:7418-28. 2007
    ..These studies indicate that nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3 in vivo...
  49. ncbi request reprint Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction
    Arne Warth
    Institute of Pathology, University Hospital Tubingen, Tubingen, Germany
    Cardiology 107:402-10. 2007
    ....
  50. ncbi request reprint Hypoxia sensitizes human malignant glioma cells towards CD95L-induced cell death
    Joachim P Steinbach
    Laboratory of Molecular Neuro Oncology, Department of Neurology, University of Tubingen, Medical School, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neurochem 92:1340-9. 2005
    ..These results suggest that death ligands may be useful to target hypoxic tumour cells resistant to conventional therapies or to complement strategies aiming at the induction of tumour hypoxia...
  51. ncbi request reprint Palmitoylation is a sorting determinant for transport to the myelin membrane
    Anja Schneider
    Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strausse 3, 72076 Tubingen, Germany
    J Cell Sci 118:2415-23. 2005
    ..Thus, we conclude that palmitoylation is a sorting determinant for transport to the myelin membrane...
  52. pmc Dendritic cell tumor in a salivary gland lymph node: a rare differential diagnosis of salivary gland neoplasms
    Sebastian P Schraven
    Department of Otolaryngology, Head and Neck Surgery, University of Tubingen, Germany
    Diagn Pathol 6:94. 2011
    ..Awareness that dendritic cell tumors may occur in this localization, careful histologic evaluation and ancillary immunohistochemical and electron microscopical analyses should allow for recognition of this entity...
  53. ncbi request reprint Transferrin receptor upregulation: in vitro labeling of rat mesenchymal stem cells with superparamagnetic iron oxide
    Richard SchAfer
    Institute of Clinical and Experimental Transfusion Medicine, University Medical Center Tübingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Radiology 244:514-23. 2007
    ....
  54. pmc The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    Anna Cattelino
    FIRC Institute of Molecular Oncology, 16 20139, Milan, Italy
    J Cell Biol 162:1111-22. 2003
    ..This may become more marked when the vessels are exposed to high or turbulent flow, such as at bifurcations or in the beating heart, leading to fluid leakage or hemorrhages...
  55. ncbi request reprint A potassium channel-linked mechanism of glial cell swelling in the postischemic retina
    Thomas Pannicke
    Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    Mol Cell Neurosci 26:493-502. 2004
    ..Inhibition of these water fluxes may be beneficial to prevent ischemia-evoked glial cell swelling...
  56. ncbi request reprint A transmembrane tight junction protein selectively expressed on endothelial cells and platelets
    Ines Nasdala
    Institute of Cell Biology, ZMBE, University of Munster, 48149 Munster, Germany
    J Biol Chem 277:16294-303. 2002
    ..The 1G8 antigen supports homophilic interactions on transfected Chinese hamster ovary cells. Based on the similarity to the JAM molecules, it is plausible that the 1G8 antigen might be involved in interendothelial cell adhesion...
  57. ncbi request reprint Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
    Britta Engelhardt
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 34:2955-63. 2004
    ..On the basis of the current experimental evidence, we propose consideration that both pathways are equally possible for a leukocyte's journey from the apical surface of the endothelium to its basal side...
  58. ncbi request reprint Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts
    Stefan Hamm
    Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Cell Tissue Res 315:157-66. 2004
    ..Thus, opening of BBB TJs is not readily accompanied by the complete loss of the junctional localization of TJ proteins...
  59. ncbi request reprint Glial cell-mediated spread of retinal degeneration during detachment: a hypothesis based upon studies in rabbits
    Mike Francke
    Paul Flechsig Institute of Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    Vision Res 45:2256-67. 2005
    ..A down-regulation of the K(+) conductance of Müller cells may prevent effective retinal K(+) and water clearance, and may favor photoreceptor cell degeneration and edema development...
  60. ncbi request reprint Formation of tight junction: determinants of homophilic interaction between classic claudins
    Jörg Piontek
    Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Str 10, 13125 Berlin, Germany
    FASEB J 22:146-58. 2008
    ..Since nearly all these residues are conserved in most claudins, our findings are of general relevance for all classical claudins. On the basis of the data we have established a novel molecular concept for tight junction formation...
  61. ncbi request reprint A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo
    M Gabriele Bixel
    Institute of Cell Biology, Zentrum für Molekularbiologie der Entzündung ZMBE, Interdisziplinäres Klinisches Forschungszentrum Münster, University of Munster, Munster, Germany
    Blood 109:5327-36. 2007
    ..Our results establish CD99L2 as a new endothelial surface protein involved in neutrophil extravasation. In addition, this is the first evidence for a role of CD99 and CD99L2 in the process of leukocyte diapedesis in vivo...
  62. ncbi request reprint The different structures containing tight junction proteins in epidermal and other stratified epithelial cells, including squamous cell metaplasia
    Holger Schlüter
    Division of Cell Biology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Eur J Cell Biol 86:645-55. 2007
    ....
  63. pmc A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells
    Sandra Iden
    Institute of Medical Biochemistry, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
    EMBO Rep 7:1239-46. 2006
    ..They also point to a direct role of a cadherin in the regulation of cell polarity in vertebrates...
  64. ncbi request reprint Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
    Karsten M Strauss
    Center of Neurology and Hertie Institute for Clinical Brain Research, Leicester, UK
    Hum Mol Genet 14:2099-111. 2005
    ..On the basis of functional genomics, our results provide a novel link between mitochondrial dysfunction and neurodegeneration in PD...
  65. ncbi request reprint Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences
    Andrea Lundkvist
    Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Medicinaregatan 9C, SE 41390 Göteborg, Sweden
    J Cell Sci 117:3481-8. 2004
    ..Furthermore, the absence of IFs in Müller cells leads to an abnormal response of the vascular system to ischemia, specifically decreased ability of newly formed blood vessels to traverse the ILM...
  66. pmc Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins
    Joseph H McCarty
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:7667-77. 2002
    ..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
  67. doi request reprint ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish
    Benjamin M Hogan
    Hubrecht Institute KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Hum Mol Genet 17:2424-32. 2008
    ..Finally, we show that ccm1 function is cell autonomous, suggesting that it is endothelial cellular morphogenesis that is regulated by CCM proteins during development and pathogenesis...
  68. pmc Wnt/beta-catenin signaling controls development of the blood-brain barrier
    Stefan Liebner
    Institute of Neurology Edinger Institute, Johann Wolfgang Goethe University, 60325 Frankfurt, Germany
    J Cell Biol 183:409-17. 2008
    ..These findings may open new therapeutic avenues to modulate endothelial barrier function and to limit the devastating effects of BBB breakdown...
  69. ncbi request reprint Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development
    Armin A Dorner
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rössie Strasse10, 13125 Berlin, Germany
    J Cell Sci 118:3509-21. 2005
    ..We conclude that CAR is required for embryonal heart development, most likely due to its function during the organization of myofibrils in cardiomyocytes...
  70. pmc Viscoelastic properties of individual glial cells and neurons in the CNS
    Yun Bi Lu
    Department of Pharmacology, School of Medicine, Zhejiang University, Yan An Road 353, Hangzhou 310031, China
    Proc Natl Acad Sci U S A 103:17759-64. 2006
    ....
  71. ncbi request reprint Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development
    Sebastian Baumer
    Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
    Blood 107:4754-62. 2006
    ..No signs for enhanced endothelial apoptosis or proliferation were observed. Thus, the activity of VE-PTP is not required for the initial formation of blood vessels, yet it is essential for their maintenance and remodeling...
  72. ncbi request reprint Peeling of the basal membrane in the human retina: ultrastructural effects
    Sebastian Wolf
    Department of Ophthalmology and Eye Clinic, Leipzig University, Leipzig, Germany
    Ophthalmology 111:238-43. 2004
    ..To study the effects of internal limiting membrane (ILM) peeling, usually performed in cases of macular hole formation, on the structural integrity of the human retina...
  73. doi request reprint Angiopoietin-2 deficiency decelerates age-dependent vascular changes in the mouse retina
    Yuxi Feng
    5th Medical Clinic, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Cell Physiol Biochem 21:129-36. 2008
    ..This effect links to higher levels of survival factors such as VEGF and Ang-1, suggesting that the ratio of these factors is critical for capillary cell survival...