Jeremias Wohlschlaeger

Summary

Country: Germany

Publications

  1. doi request reprint [Heart transplantation. Pathology, clinical work-up and therapy]
    H A Baba
    Institut für Pathologie und Neuropathologie, Universitat Duisburg Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 32:95-103. 2011
  2. doi request reprint [Glandular papilloma of the right main bronchus. Detection of an exon 2 mutation of the KRAS gene (c.35G>A)]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitätsklinik Essen, Universitat Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Pathologe 34:338-42. 2013
  3. doi request reprint [Rapid on-site evaluation (ROSE) in cytological diagnostics of pulmonary and mediastinal diseases]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 33:308-15. 2012
  4. doi request reprint [Congestive heart failure: reverse cardiac remodeling mediated by left ventricular assist devices]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitätsklinik Essen, Universitat Duisburg Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 33:175-82. 2012
  5. doi request reprint [New TNM classification of malignant lung tumours]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 31:355-60. 2010
  6. doi request reprint Immunocytochemical investigation of Langerin (CD207) is a valuable adjunct in the cytological diagnosis of Langerhans cell histiocytosis of the thyroid
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Pathol Res Pract 205:433-6. 2009
  7. doi request reprint [Lung transplantation and rejection. Basic principles, clinical aspects and histomorphology]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 32:104-12. 2011
  8. pmc GNAS1 T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma
    Klaus J Schmitz
    Institute of Pathology and Neuropathology, University of Duisburg Essen, Essen, Germany
    Neoplasia 9:159-65. 2007
  9. doi request reprint Assessment of a chloride-poor versus a chloride-containing version of a modified histidine-tryptophan-ketoglutarate solution in a rat liver transplantation model
    Christian D Fingas
    Institute of Physiological Chemistry, Biometry and Epidemiology, University Hospital Essen, Essen, Germany
    Liver Transpl 17:650-60. 2011
  10. doi request reprint Ventricular unloading is associated with increased 20s proteasome protein expression in the myocardium
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Heart Lung Transplant 29:125-32. 2010

Collaborators

Detail Information

Publications44

  1. doi request reprint [Heart transplantation. Pathology, clinical work-up and therapy]
    H A Baba
    Institut für Pathologie und Neuropathologie, Universitat Duisburg Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 32:95-103. 2011
    ..Whether or not non-invasive diagnostic approaches (e.g. gene array profile analysis on leukocytes) can replace morphological investigations needs to be clarified in randomised, prospective clinical studies...
  2. doi request reprint [Glandular papilloma of the right main bronchus. Detection of an exon 2 mutation of the KRAS gene (c.35G>A)]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitätsklinik Essen, Universitat Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Pathologe 34:338-42. 2013
    ..This article presents the case of a 64-year-old patient with a glandular papilloma of the right main bronchus including the immunohistochemical and molecular work-up as well as a review of the current literature. ..
  3. doi request reprint [Rapid on-site evaluation (ROSE) in cytological diagnostics of pulmonary and mediastinal diseases]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 33:308-15. 2012
    ....
  4. doi request reprint [Congestive heart failure: reverse cardiac remodeling mediated by left ventricular assist devices]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitätsklinik Essen, Universitat Duisburg Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 33:175-82. 2012
    ..The underlying process is termed reverse cardiac remodelling and is characterized by a significant decrease in the size of cardiomyocytes and reversible regulation of numerous molecular systems in the myocardium...
  5. doi request reprint [New TNM classification of malignant lung tumours]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 31:355-60. 2010
    ..Malignant pleural and pericardial effusions have been reclassified from T4 to M1a. Separate tumour nodules in the contralateral lung have been reclassified from T4 to M1a. M1b designates distant metastasis...
  6. doi request reprint Immunocytochemical investigation of Langerin (CD207) is a valuable adjunct in the cytological diagnosis of Langerhans cell histiocytosis of the thyroid
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Pathol Res Pract 205:433-6. 2009
    ....
  7. doi request reprint [Lung transplantation and rejection. Basic principles, clinical aspects and histomorphology]
    J Wohlschlager
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Hufelandstr 55, 45147, Essen, Deutschland
    Pathologe 32:104-12. 2011
    ..In 2006, the International Society for Heart and Lung Transplantation (ISHLT) provided a revised version of the grading system for acute and chronic rejection of pulmonary grafts...
  8. pmc GNAS1 T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma
    Klaus J Schmitz
    Institute of Pathology and Neuropathology, University of Duisburg Essen, Essen, Germany
    Neoplasia 9:159-65. 2007
    ..We have recently shown that TT genotypes of the single-nucleotide polymorphism T393C in the gene GNAS1 predict the clinical outcome of patients with various carcinomas...
  9. doi request reprint Assessment of a chloride-poor versus a chloride-containing version of a modified histidine-tryptophan-ketoglutarate solution in a rat liver transplantation model
    Christian D Fingas
    Institute of Physiological Chemistry, Biometry and Epidemiology, University Hospital Essen, Essen, Germany
    Liver Transpl 17:650-60. 2011
    ..These results suggest an overall beneficial effect of chloride in HTK-based liver preservation solutions...
  10. doi request reprint Ventricular unloading is associated with increased 20s proteasome protein expression in the myocardium
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Heart Lung Transplant 29:125-32. 2010
    ....
  11. doi request reprint Cardiomyocyte survivin protein expression is associated with cell size and DNA content in the failing human heart and is reversibly regulated after ventricular unloading
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Germany
    J Heart Lung Transplant 29:1286-92. 2010
    ..Survivin initiates cell cycle progression by increased cyclinD1/cdk4 complexes by abrogation of the inhibitory effect of p16(INK4a) on cdk4. Accordingly, the role of survivin in CHF and after unloading was explored...
  12. doi request reprint Reversible regulation of the retinoblastoma protein/E2F-1 pathway during "reverse cardiac remodelling" after ventricular unloading
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    J Heart Lung Transplant 29:117-24. 2010
    ..Accordingly, the hypothesis whether the Rb/E2F-1 pathway is altered by ventricular unloading was tested, and correlations with the cyclin D1 protein expression and cardiomyocyte diameters were explored...
  13. doi request reprint Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin-resected hepatocellular carcinoma
    Hideo A Baba
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Liver Int 29:399-405. 2009
    ..This study was undertaken to determine the prevalence and clinicopathological relevance of phospho-p70S6 (p-p70S6) kinase in hepatocellular carcinoma (HCC) and to investigate the effects of rapamycin on HCC in vitro...
  14. doi request reprint Increase of ABCG2/BCRP+ side population stem cells in myocardium after ventricular unloading
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Heart Lung Transplant 31:318-24. 2012
    ..In this study we sought to determine, whether there is an increase of ABCG2(+) SPC and CD117(+) stem cells after unloading...
  15. ncbi request reprint Roles of cyclooxygenase-2 and phosphorylated Akt (Thr308) in cardiac hypertrophy regression mediated by left-ventricular unloading
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Germany
    J Thorac Cardiovasc Surg 133:37-43. 2007
    ..Therefore, the expression of cyclooxygenase-2, phosphorylated Akt (p-Akt), and p-Erk 1/2, as well as cardiac hypertrophy before and after left ventricular assist device insertion, was investigated...
  16. doi request reprint Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart
    Jeremias Wohlschlaeger
    Institute of Pathology, University Hospital Essen, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    Circulation 121:989-96. 2010
    ..Hence, the cardiomyocyte DNA content, nuclear morphology, and number of nuclei per cell were assessed before and after left ventricular assist device support...
  17. doi request reprint Metallothionein overexpression and its prognostic relevance in intrahepatic cholangiocarcinoma and extrahepatic hilar cholangiocarcinoma (Klatskin tumors)
    Klaus Jürgen Schmitz
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Hum Pathol 40:1706-14. 2009
    ..In comparison, lack of metallothionein expression seems to be associated with cholangiocarcinoma with a papillary phenotype, which is generally recognized to have a better prognosis...
  18. ncbi request reprint Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma
    Klaus Jürgen Schmitz
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Int J Colorectal Dis 24:1287-96. 2009
    ..The present study aimed to analyse the prognostic impact of HIF-1alpha and MT expression in colorectal cancer and to evaluate a possible link of combined HIF-1alpha and MT expression with colorectal cancer progression...
  19. doi request reprint Survivin is upregulated during liver regeneration in rats and humans and is associated with hepatocyte proliferation
    Hideo A Baba
    Institute of Pathology and Neuropathology, University of Duisburg Essen, Essen, Germany
    Liver Int 29:585-92. 2009
    ..Survivin regulates cell division and inhibits apoptosis. Liver regeneration is a complex process involving both proliferation and apoptosis. The role of survivin is not well elucidated and no data exist in humans...
  20. doi request reprint Decreased myocardial chromogranin a expression and colocalization with brain natriuretic peptide during reverse cardiac remodeling after ventricular unloading
    Jeremias Wohlschlaeger
    Department of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Germany
    J Heart Lung Transplant 27:442-9. 2008
    ..This study investigated whether chromogranin A and neural cell adhesion molecule (NCAM)/CD56 are associated with cardiac hypertrophy and regulated by LVAD...
  21. ncbi request reprint Circulating 20S proteasome in patients with non-metastasized breast cancer
    Oliver Hoffmann
    Clinic of Obstetrics and Gynecology, Medical Faculty, University of Duisburg Essen, Hufelandstr 55, D 45147 Essen, Germany
    Anticancer Res 31:2197-201. 2011
    ..We tested the hypothesis that the plasma c-proteasome concentration is a biomarker associated with tumor stage and nodal status in patients with the primary diagnosis of non-metastatic breast cancer...
  22. doi request reprint The prognostic impact of circulating proteasome concentrations in patients with epithelial ovarian cancer
    Martin Heubner
    Clinic of Obstetrics and Gynaecology, Medical Faculty, University of Duisburg Essen, Germany
    Gynecol Oncol 120:233-8. 2011
    ..We tested the hypothesis that the c-proteasome plasma concentration is a biomarker associated with the clinical course of ovarian cancer patients...
  23. pmc Diagnostic approach to interstitial pneumonias in a single centre: report on 88 cases
    Dirk Theegarten
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Hufelandstrasse 55, Essen 45147, Germany
    Diagn Pathol 7:160. 2012
    ..The aim of this study was to compare the results of histological evaluations with the final diagnosis after interdisciplinary case evaluation...
  24. ncbi request reprint No association of the NFKB1 insertion/deletion promoter polymorphism with survival in colorectal and renal cell carcinoma as well as disease progression in B-cell chronic lymphocytic leukemia
    Kathrin Riemann
    Institute of Pharmacogenetics, University Hospital Essen, Essen, Germany
    Pharmacogenet Genomics 16:783-8. 2006
    ..The purpose of this study was, therefore, to investigate associations of the -94ins/delATTG polymorphism with susceptibility and survival of patients with different types of cancer...
  25. ncbi request reprint Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    Klaus Juergen Schmitz
    Institute of Pathology and Neuropathology, University Hospital of Essen, Germany
    J Hepatol 48:83-90. 2008
    ..The aim of the study was to determine the prognostic relevance of AKT and extracellular regulated kinases (ERK1/2), which are implied in the regulation of cell proliferation and apoptosis, in hepatocellular carcinoma (HCC)...
  26. ncbi request reprint Feasibility of preemptive biomarker profiling for personalised early clinical drug development at a Comprehensive Cancer Center
    Marcel Wiesweg
    Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Eur J Cancer 49:3076-82. 2013
    ..Multiple investigational drugs are currently explored in cancer patient populations defined by specific biomarkers. This demands a new process of patient selection for clinical trials...
  27. ncbi request reprint Mdm2 protein expression is strongly associated with survival in malignant pleural mesothelioma
    Fabian D Mairinger
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Future Oncol 10:995-1005. 2014
    ..Conclusion: Expression of Mdm2 is a strong prognostic factor associated with shortened overall survival in MPM. ..
  28. doi request reprint Hypothermic reconditioning of porcine kidney grafts by short-term preimplantation machine perfusion
    Anja Gallinat
    Department for General, Visceral and Transplantation Surgery, University Hospital of Essen, Essen, Germany
    Transplantation 93:787-93. 2012
    ..This study evaluates whether short-term MP after cold storage (CS) is also effective...
  29. doi request reprint ERCC1, MLH1, MSH2, MSH6, and βIII-tubulin: resistance proteins associated with response and outcome to platinum-based chemotherapy in malignant pleural mesothelioma
    Saskia Ting
    Institute of Pathology and Neuropathology, West German Cancer Center, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Clin Lung Cancer 14:558-567.e3. 2013
    ..This study evaluated enzymes involved in repair of platinum-caused DNA damage, potentially resulting in a biomarker panel associated with patient response and outcome to platinum-based chemotherapy...
  30. doi request reprint Oil Red O-assessed macrosteatosis in liver transplant donor biopsies predicts ischemia-reperfusion injury and clinical outcome
    Henning Reis
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Virchows Arch 464:165-74. 2014
    ..Computerized analysis is a precise tool though not superior to semiquantitative analyses. ..
  31. ncbi request reprint Degraded collagen induces calpain-mediated apoptosis and destruction of the X-chromosome-linked inhibitor of apoptosis (xIAP) in human vascular smooth muscle cells
    Karin von Wnuck Lipinski
    Institute of Pathophysiology, Center of Internal Medicine, Hufelandstrasse 55, 45122 Essen, Germany
    Cardiovasc Res 69:697-705. 2006
    ....
  32. ncbi request reprint Roles of MMP-2/-9 in cardiac dysfunction during early multiple organ failure in an ovine animal model
    Jeremias Wohlschlaeger
    Institute of Pathology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Pathol Res Pract 201:809-17. 2005
    ..This study underscores the pivotal roles of MMP in acute cardiac dysfunction during early multiple organ failure in combined vasoconstrictor-masked hypovolemic and endotoxemia shock...
  33. doi request reprint Circulating extracellular proteasome in the cerebrospinal fluid: a study on concentration and proteolytic activity
    Oliver Mueller
    Department of Neurosurgery, University Hospital Essen, Hufelandstr 55, 45122, Essen, Germany
    J Mol Neurosci 46:509-15. 2012
    ....
  34. doi request reprint FFPE tissue as a feasible source for gene expression analysis--a comparison of three reference genes and one tumor marker
    Robert Fred Henry Walter
    Department of Interventional Pneumology, Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University of Duisburg Essen, Essen, Germany Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Essen, Germany Electronic address
    Pathol Res Pract 209:784-9. 2013
    ..Three potential reference genes for pulmonary tumors with neuroendocrine differentiation were included and tested for their robust expression...
  35. doi request reprint Mammalian target of rapamycin pathway activity in alveolar soft part sarcoma
    Henning Reis
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45147 Essen, NW, Germany
    Hum Pathol 44:2266-74. 2013
    ..Small molecule-based targeting of mTOR might therefore represent a potential mechanism in ASPS alone or in combination with contemporary upstream approaches. ..
  36. ncbi request reprint Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes
    Jeremias Wohlschlaeger
    Institut fur Pathologie, Universitätsklinik Essen, Universitat Duisburg Essen, Hufelandstrasse 55, D 45147 Essen, Germany
    Cardiovasc Res 68:376-86. 2005
    ....
  37. pmc Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma
    Klaus Jürgen Schmitz
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    Virchows Arch 450:135-41. 2007
    ..This study demonstrates the independent prognostic value of the COX-2 expression in resected ICC, thus, offering a potential additional adjuvant therapeutic approach with COX-2 inhibitors...
  38. ncbi request reprint GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer
    Ulrich H Frey
    Institute of Pharmacology, University Hospital of Essen, Essen, Germany
    Clin Cancer Res 11:5071-7. 2005
    ....
  39. ncbi request reprint Differential expression of microRNA 181b and microRNA 21 in hyperplastic polyps and sessile serrated adenomas of the colon
    Klaus Juergen Schmitz
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
    Virchows Arch 455:49-54. 2009
    ..In contrast to HPs, SSAs are characterised by high levels of miR-181b and miR-21 expression. However, due to the overlap of values, miR-181b and miR-21 evaluation did not allow discrimination of the two lesions in every case...
  40. doi request reprint [Diagnosis of pulmonary tuberculosis using Ziehl-Neelsen stain and polymerase chain reaction]
    D Theegarten
    Institut für Pathologie and Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Pathologe 34:305-9. 2013
    ..Therefore, the aim of this work was to determine whether established methods used in general pathology can be efficiently used with cytological material...
  41. doi request reprint Alveolar extracellular 20S proteasome in patients with acute respiratory distress syndrome
    Stephan Urs Sixt
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, Essen, Germany
    Am J Respir Crit Care Med 179:1098-106. 2009
    ..Repair mechanisms resulting in alveolar protein degradation in acute respiratory distress syndrome (ARDS) are largely unknown...
  42. pmc High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome
    Klaus Jürgen Schmitz
    Institute of Pathology, University Hospital of Essen Duisburg, Essen, Germany
    Breast Cancer Res 7:R194-203. 2005
    ..In particular, with regard to lymph node-negative breast cancer it is important to identify high-risk patients who would benefit from further adjuvant therapy...
  43. ncbi request reprint Evaluation of a modified HTK solution containing the new iron chelator LK 614 in an isolated rat liver perfusion model
    Shengli Wu
    Institut fur Physiologische Chemie, Universitatsklinikum, Essen, Germany
    J Invest Surg 22:340-7. 2009
    ..We here evaluated a modified HTK solution including, among others, a new, membrane-permeable iron chelator, LK 614, in the isolated perfused rat liver model...
  44. pmc Morphological and molecular changes of the myocardium after left ventricular mechanical support
    Hideo A Baba
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Germany
    Curr Cardiol Rev 4:157-69. 2008
    ....