Thomas Wobrock

Summary

Country: Germany

Publications

  1. ncbi request reprint [Pharmacotherapy of schizophrenia and comorbid substance use disorder. A systematic review]
    T Wobrock
    Klinik fur Psychiatrie und Psychotherapie, Georg August Universitat Gottingen, 37075, Gottingen
    Nervenarzt 79:17-8, 20-2, 24-6 passim. 2008
  2. doi request reprint [Guideline intentions of the German Society of Psychiatry, Psychotherapy and Nervous Diseases (DGPPN)]
    T Wobrock
    Abteilung für Psychiatrie und Psychotherapie, Zentrum Psychosoziale Medizin, Universitatsmedizin Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Deutschland
    Nervenarzt 81:1041-8. 2010
  3. pmc Comorbid substance abuse and brain morphology in recent-onset psychosis
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:28-36. 2009
  4. pmc Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
  5. doi request reprint Motor circuit abnormalities in first-episode schizophrenia assessed with transcranial magnetic stimulation
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Pharmacopsychiatry 42:194-201. 2009
  6. pmc Reduced prefrontal gyrification in obsessive-compulsive disorder
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:455-64. 2010
  7. pmc Quality assurance in psychiatry: quality indicators and guideline implementation
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S219-26. 2009
  8. doi request reprint Cognition in hepatitis C patients treated with pegylated interferon
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    World J Biol Psychiatry 10:819-26. 2009
  9. pmc Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Psychopharmacology (Berl) 208:353-63. 2010
  10. pmc Effects of abstinence on brain morphology in alcoholism: a MRI study
    Thomas Wobrock
    Dept of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, Gottingen 37075, Germany
    Eur Arch Psychiatry Clin Neurosci 259:143-50. 2009

Detail Information

Publications47

  1. ncbi request reprint [Pharmacotherapy of schizophrenia and comorbid substance use disorder. A systematic review]
    T Wobrock
    Klinik fur Psychiatrie und Psychotherapie, Georg August Universitat Gottingen, 37075, Gottingen
    Nervenarzt 79:17-8, 20-2, 24-6 passim. 2008
    ....
  2. doi request reprint [Guideline intentions of the German Society of Psychiatry, Psychotherapy and Nervous Diseases (DGPPN)]
    T Wobrock
    Abteilung für Psychiatrie und Psychotherapie, Zentrum Psychosoziale Medizin, Universitatsmedizin Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Deutschland
    Nervenarzt 81:1041-8. 2010
    ..A major aim of the German Society of Psychiatry, Psychotherapy and Nervous Diseases (DGPPN) is to assure the quality of inpatient and outpatient care of the mentally ill by developing evidence-based consensus guidelines...
  3. pmc Comorbid substance abuse and brain morphology in recent-onset psychosis
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:28-36. 2009
    ....
  4. pmc Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
    ..In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia...
  5. doi request reprint Motor circuit abnormalities in first-episode schizophrenia assessed with transcranial magnetic stimulation
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Pharmacopsychiatry 42:194-201. 2009
    ....
  6. pmc Reduced prefrontal gyrification in obsessive-compulsive disorder
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 260:455-64. 2010
    ..In conclusion, prefrontal hypogyrification in OCD patients may be a structural correlate of the impairment in executive function of this patient group and may point to a neurodevelopmental origin of this disease...
  7. pmc Quality assurance in psychiatry: quality indicators and guideline implementation
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S219-26. 2009
    ..Carefully used, the use of quality indicators and improved guideline adherence can address suboptimal clinical outcomes, reduce practice variations, and narrow the gap between optimal and routine care...
  8. doi request reprint Cognition in hepatitis C patients treated with pegylated interferon
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    World J Biol Psychiatry 10:819-26. 2009
    ..We conclude that neurocognitive performance was influenced by antiviral IFN-alpha-based combination treatment only in single domains and not to a clinically relevant extent in contrast to the significant worsening of depression...
  9. pmc Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Psychopharmacology (Berl) 208:353-63. 2010
    ..Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking...
  10. pmc Effects of abstinence on brain morphology in alcoholism: a MRI study
    Thomas Wobrock
    Dept of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, Gottingen 37075, Germany
    Eur Arch Psychiatry Clin Neurosci 259:143-50. 2009
    ..It should be analyzed in further studies with larger sample sizes, if complete brain regeneration is possible maintaining abstinence over a longer period...
  11. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  12. doi request reprint Reduced cortical inhibition in first-episode schizophrenia
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, D 37075 Gottingen, Germany
    Schizophr Res 105:252-61. 2008
    ....
  13. doi request reprint Cognitive impairment of executive function as a core symptom of schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 10:442-51. 2009
    ..In conclusion, these results may suggest a cognitive endophenotype in schizophrenia and underline the role of the prefrontal cortex in schizophrenic pathophysiology...
  14. doi request reprint Pharmacotherapy of schizophrenia with comorbid substance use disorder--reviewing the evidence and clinical recommendations
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, D 37075 Gottingen, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1375-85. 2008
    ..The early initiation of treatment with antidepressants, depending on the patient's psychopathology, as well as add-on medication with anti-craving agents should be considered...
  15. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
    ..BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus...
  16. doi request reprint Deficient inhibitory cortical networks in antipsychotic-naive subjects at risk of developing first-episode psychosis and first-episode schizophrenia patients: a cross-sectional study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Biol Psychiatry 72:744-51. 2012
    ..However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis...
  17. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 14:2-44. 2013
    ..These guidelines are primarily concerned with the biological treatment (including antipsychotic medication and other pharmacological treatment options) of adults suffering from schizophrenia...
  18. ncbi request reprint Comorbid substance abuse and neurocognitive function in recent-onset schizophrenia
    Thomas Wobrock
    Dept of Psychiatry and Psychotherapy, University Hospital of Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 257:203-10. 2007
    ..The lack of higher cognitive disturbance in young schizophrenic patients with comorbid substance abuse may encourage clinicians to develop integrated treatment programmes using cognitive strategies of drug therapy...
  19. doi request reprint Impaired long-term depression in schizophrenia: a cathodal tDCS pilot study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Brain Stimul 5:475-83. 2012
    ..However, glutamate-dependent long-term depression (LTD)-like cortical plasticity has not yet been investigated...
  20. doi request reprint Planum temporale asymmetry to the right hemisphere in first-episode schizophrenia
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Street 5, 37075 Goettingen, Germany
    Psychiatry Res 193:56-9. 2011
    ..We investigated planum temporale (PT) volume and asymmetry in 23 first-episode schizophrenia patients compared to healthy controls and found for the first time an in vivo volume asymmetry of PT to the right hemisphere...
  21. doi request reprint Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Strasse 5, D 37075, Goettingen, Germany
    Behav Brain Res 224:15-22. 2011
    ..Disturbances of N-methyl-d-aspartate, gamma-aminobutyric acid and dopamine receptors may account for this plasticity deficit. LTP-like plasticity deficits might be related to disturbed information processing in schizophrenia patients...
  22. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: long-term treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 7:5-40. 2006
    ....
  23. doi request reprint A similar but distinctive pattern of impaired cortical excitability in first-episode schizophrenia and ADHD
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Neuropsychobiology 67:74-83. 2013
    ..Studies on cortical excitability comparing these two diseases directly are lacking...
  24. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 13:318-78. 2012
    ..This first part of the updated guidelines covers the general descriptions of antipsychotics and their side effects, the biological treatment of acute schizophrenia and the management of treatment-resistant schizophrenia...
  25. ncbi request reprint Pharmacotherapy of patients with schizophrenia and substance abuse
    Thomas Wobrock
    Georg August University, Department of Psychiatry and Psychotherapy, Von Siebold Strasse 5, D 37075 Gottingen, Germany
    Expert Opin Pharmacother 10:353-67. 2009
    ..Additional treatment with antidepressants, depending on the patient's psychopathology, as well as with anti-craving agents should be considered...
  26. doi request reprint SNAP-25 genotype influences NAA/Cho in left hippocampus
    Harald Scherk
    Department of Psychiatry and Psychotherapy, Georg August University Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    J Neural Transm 115:1513-8. 2008
    ..The SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus...
  27. doi request reprint The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls--a randomized placebo-controlled, double-blind fMRI study
    Birgit Guse
    University Medical Centre, Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Str 5, D 37075 Gottingen, Germany
    Behav Brain Res 237:300-7. 2013
    ..This is the first fMRI study that has systematically investigated this topic within a randomized, placebo-controlled, double-blind design, contrasting the effects in schizophrenia patients and healthy controls...
  28. pmc Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:415-23. 2012
    ..Dysfunctional N-methyl D-aspartate receptors or modulation of dopaminergic transmission can explain these findings. Nevertheless, the effects of antipsychotic medication still need to be considered...
  29. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: acute treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 6:132-91. 2005
    ....
  30. pmc Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence
    Berend Malchow
    Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Georg August University, Germany
    Eur Arch Psychiatry Clin Neurosci 263:3-13. 2013
    ..There is some weak evidence that cannabis abuse could affect brain structures in high-risk subjects, but replication of these studies is needed...
  31. doi request reprint The effects of combined acamprosate and integrative behaviour therapy in the outpatient treatment of alcohol dependence: a randomized controlled trial
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Drug Alcohol Depend 118:417-22. 2011
    ..The aim of this randomized, controlled, multisite trial was to evaluate the efficacy of combined treatment with integrative behaviour therapy (IBT) and acamprosate on drinking behaviour in detoxified alcohol-dependent patients...
  32. pmc Prefrontal cortex gyrification index in twins: an MRI study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:459-65. 2011
    ..The nonexistence of a pronounced similarity in MZ twins compared to DZ twins concerning prefrontal GI raises questions about the extent of genetic influence on GI...
  33. doi request reprint Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia
    Berend Malchow
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University LMU Munich, Nußbaumstraße 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:S155-68. 2013
    ..Future longitudinal studies in first-episode patients with quantification of cannabis abuse and assessment of schizophrenia risk genes are warranted...
  34. doi request reprint Effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) on clinical global impression in chronic schizophrenia
    Joachim Cordes
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Bergische Landstr 2, D 40629 Düsseldorf, Germany
    Psychiatry Res 177:32-6. 2010
    ..However, in our study this beneficial effect was restricted to subjects with pronounced negative symptoms...
  35. pmc Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosi
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Bull 37:S111-21. 2011
    ..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...
  36. pmc Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review
    Birgit Guse
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    J Neural Transm 117:105-22. 2010
    ....
  37. doi request reprint Impaired motor cortex responses in non-psychotic first-degree relatives of schizophrenia patients: a cathodal tDCS pilot study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany Electronic address
    Brain Stimul 6:821-9. 2013
    ..Little is known about the impact of genetic liability on cortical plasticity and connectivity in schizophrenia...
  38. doi request reprint The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nußbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:469-73. 2013
    ..However, respective exercise effects might be attenuated in chronic schizophrenia, which should be verified in a larger sample...
  39. doi request reprint Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies
    Andrea Schmitt
    Dept of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Strasse 5, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:35-9. 2008
    ..In animal models of ischemia/hypoxia, NRG1 has been shown to act as a therapeutic, neuroprotective agent and should be investigated in more detail in transgenic animal models...
  40. doi request reprint Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    J Clin Psychopharmacol 30:190-2. 2010
    ....
  41. doi request reprint [Schizophrenia as a brain disorder and its development]
    P Falkai
    Abteilung für Psychiatrie und Psychotherapie, Georg August Universitat Gottingen, Germany
    Fortschr Neurol Psychiatr 76:S63-7. 2008
    ..The outlined pathophysiological hypotheses are used to discuss possible causal pharmacological treatment options...
  42. doi request reprint Schizophrenia guidelines across the world: a selective review and comparison
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, LVR Klinikum Düsseldorf, Heinrich Heine University Dusseldorf, Germany
    Int Rev Psychiatry 23:379-87. 2011
    ..Nevertheless, core guideline recommendations should be adapted to regional conditions using available tools for adaptation...
  43. doi request reprint Achieving symptomatic remission in out-patients with schizophrenia--a naturalistic study with quetiapine
    T Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Acta Psychiatr Scand 120:120-8. 2009
    ..To evaluate the symptomatic remission criterion in clinical practice and to determine predictors for achieving symptomatic remission, a 12-week non-interventional study (NIS) with quetiapine was conducted in Germany...
  44. doi request reprint Combination therapy in the treatment of schizophrenia
    C Wolff-Menzler
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany cwolff gwdg de
    Pharmacopsychiatry 43:122-9. 2010
    ....
  45. doi request reprint Predictors of symptomatic remission in first-episode psychosis outpatients treated with quetiapine: a naturalistic study
    Katrin Gade
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Int J Psychiatry Clin Pract 17:148-53. 2013
    ..The aim of this naturalistic study was to assess course and predictors of symptomatic remission in outpatients with first-episode psychosis during quetiapine monotherapy...
  46. doi request reprint Repetitive transcranial magnetic stimulation for the treatment of negative symptoms in residual schizophrenia: rationale and design of a sham-controlled, randomized multicenter study
    Joachim Cordes
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Bergische Landstr 2, 40629 Düsseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S189-97. 2009
    ..Main limitations of the trial are the potential influence of antipsychotic dosage changes and the difficulty to ensure adequate blinding...
  47. ncbi request reprint Combination treatment with nefazodone and cognitive-behavioral therapy for relapse prevention in alcohol-dependent men: a randomized controlled study
    Hermann Wetzel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Clin Psychiatry 65:1406-13. 2004
    ....