M Wjst

Summary

Country: Germany

Publications

  1. ncbi request reprint When air is rare: behind the scenes of an asthma web site
    M Wjst
    Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Munich, Germany
    J Asthma 38:399-404. 2001
  2. pmc Cytokine profiles in asthma families depend on age and phenotype
    Katrin Pukelsheim
    Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 5:e14299. 2010
  3. pmc Meta-analysis of genome-wide linkage studies of asthma and related traits
    Samuel Denham
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 9:38. 2008
  4. pmc Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families
    Janine Altmuller
    GSF Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    BMC Pulm Med 5:1. 2005
  5. pmc A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS)
    Francesc Castro-Giner
    Public Health and Epidemiology Network Biomedical Research Center, Barcelona, Spain
    BMC Med Genet 10:128. 2009
  6. pmc G2D: a tool for mining genes associated with disease
    Carolina Perez-Iratxeta
    Ontario Genomics Innovation Centre, Ottawa Health Research Institute, ON K1H 8L6, Ottawa, Canada
    BMC Genet 6:45. 2005
  7. ncbi request reprint A genome-wide search for linkage to asthma. German Asthma Genetics Group
    M Wjst
    GSF Forschungszentrum fuer Umwelt und Gesundheit, Institut fuer Epidemiologie, Neuherberg, Germany
    Genomics 58:1-8. 1999
  8. pmc Latitude, birth date, and allergy
    Matthias Wjst
    Gruppe Molekulare Epidemiologie, Institut fur Epidemiologie, Forschungszentrum für Umwelt und Gesundheit, Munich, Germany
    PLoS Med 2:e294. 2005
  9. ncbi request reprint Asthma is associated with single-nucleotide polymorphisms in ADAM33
    M Werner
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse, Neuherberg, Germany
    Clin Exp Allergy 34:26-31. 2004
  10. ncbi request reprint A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families
    Matthias Wjst
    Institut fur Epidemiologie, Gruppe Molekulare Epidemiologie, GSF, Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg, Munich, Germany
    J Steroid Biochem Mol Biol 103:799-802. 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint When air is rare: behind the scenes of an asthma web site
    M Wjst
    Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Munich, Germany
    J Asthma 38:399-404. 2001
    ..While the quality of the content has also been on the rise, some questions are still open: Where are users referredfrom, how large is the target audience, and how do they behave during their visit?..
  2. pmc Cytokine profiles in asthma families depend on age and phenotype
    Katrin Pukelsheim
    Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 5:e14299. 2010
    ..Circulating cytokine patterns may be relevant for the diagnosis of asthma, for the discrimination of certain phenotypes, and prognostic factors for exacerbation of disease...
  3. pmc Meta-analysis of genome-wide linkage studies of asthma and related traits
    Samuel Denham
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 9:38. 2008
    ....
  4. pmc Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families
    Janine Altmuller
    GSF Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    BMC Pulm Med 5:1. 2005
    ..Regions on almost every chromosome have been linked to asthma and several genes have been associated. However, most of these associations are weak and are still awaiting replication...
  5. pmc A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS)
    Francesc Castro-Giner
    Public Health and Epidemiology Network Biomedical Research Center, Barcelona, Spain
    BMC Med Genet 10:128. 2009
    ..First, we assessed all markers in a subset of subjects using DNA pooling, and in a second stage we evaluated the most promising markers at an individual level...
  6. pmc G2D: a tool for mining genes associated with disease
    Carolina Perez-Iratxeta
    Ontario Genomics Innovation Centre, Ottawa Health Research Institute, ON K1H 8L6, Ottawa, Canada
    BMC Genet 6:45. 2005
    ..We previously developed an algorithm to prioritize genes on a chromosomal region according to their possible relation to an inherited disease using a combination of data mining on biomedical databases and gene sequence analysis...
  7. ncbi request reprint A genome-wide search for linkage to asthma. German Asthma Genetics Group
    M Wjst
    GSF Forschungszentrum fuer Umwelt und Gesundheit, Institut fuer Epidemiologie, Neuherberg, Germany
    Genomics 58:1-8. 1999
    ..007), and chromosome 12 (D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific immunoglobulin E (minimum P values at these regions were 0. 003, 0.001, 0.010, and 0.015, respectively)...
  8. pmc Latitude, birth date, and allergy
    Matthias Wjst
    Gruppe Molekulare Epidemiologie, Institut fur Epidemiologie, Forschungszentrum für Umwelt und Gesundheit, Munich, Germany
    PLoS Med 2:e294. 2005
    ..Allergy is believed to vary by month of birth, but multinational studies taking into account latitude have not been conducted...
  9. ncbi request reprint Asthma is associated with single-nucleotide polymorphisms in ADAM33
    M Werner
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse, Neuherberg, Germany
    Clin Exp Allergy 34:26-31. 2004
    ..The ADAM33 gene has recently been associated with asthma and bronchial hyper-reactivity. It codes for a disintegrin and metalloproteinase that triggers intra- and extracellular signalling by protein shedding...
  10. ncbi request reprint A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families
    Matthias Wjst
    Institut fur Epidemiologie, Gruppe Molekulare Epidemiologie, GSF, Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg, Munich, Germany
    J Steroid Biochem Mol Biol 103:799-802. 2007
    ..The lead linkage region does not code for enzymes already known in the metabolic pathway of vitamin D and may therefore contain further genes relevant to the regulation of vitamin D serum levels...
  11. pmc Variants in the vitamin D receptor gene and asthma
    Matthias Wjst
    Gruppe Molekulare Epidemiologie, Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, D 85758 Neuherberg Munich, Germany
    BMC Genet 6:2. 2005
    ..As these effects are primarily mediated through the vitamin D receptor (VDR), single base variants in this gene may be risk factors for asthma or allergy...
  12. pmc Asthma in Africa
    Matthias Wjst
    Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, München Neuherberg, Germany
    PLoS Med 4:e72. 2007
  13. doi request reprint Epigenetic regulation of vitamin D converting enzymes
    Matthias Wjst
    Helmholtz Zentrum Munchen, Institute of Lung Biology and Disease, German Research Center for Environmental Health, Ingolstadter Landstr 1, Munchen, D 85764 Neuherberg, Germany
    J Steroid Biochem Mol Biol 121:80-3. 2010
    ..As PBLs represent an heterogeneous pool of cells, a further analysis of the seasonal methylation pattern in B or T cell subsets (or other tissues like liver or kidney) is warranted including an extended coverage of the CYP27B1 promotor...
  14. doi request reprint ORMDL3--guilt by association?
    M Wjst
    Institute of Inhalation Biology, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg Munich, Germany
    Clin Exp Allergy 38:1579-81. 2008
    ..There may be even unidentified RNA transcripts requiring a much more detailed genetic and functional analysis before finding ORMDL3 guilty by association...
  15. pmc STAT3 single-nucleotide polymorphisms and STAT3 mutations associated with hyper-IgE syndrome are not responsible for increased serum IgE serum levels in asthma families
    Matthias Wjst
    Institute of Inhalation Biology Molecular Pneumology, Helmholtz Zentrum Munchen, Munich Neuherberg, Germany
    Eur J Hum Genet 17:352-6. 2009
    ..A minor fraction of asthmatic children may possibly have an alternate STAT3 promoter architecture influencing joined IgE and eosinophil upregulation. While an overall effect of STAT3 mutations on serum IgE is unlikely in asthma children...
  16. ncbi request reprint Increasing prevalence of bronchial hyperresponsiveness in three selected areas in East Germany. Bitterfeld Study Group
    C Frye
    , Institut fur Epidemiologie, Neuherberg, Germany
    Eur Respir J 18:451-8. 2001
    ..The present results give indirect evidence, that less respiratory infections may be associated with higher bronchial hyperresponsiveness...
  17. ncbi request reprint [Housing conditions and allergic sensitization in children]
    J Heinrich
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Epidemiologie, Neuherberg
    Zentralbl Hyg Umweltmed 201:211-28. 1998
    ..Modern living conditions are associated with a higher odds of allergic sensitization...
  18. ncbi request reprint Early antibiotic treatment and later asthma
    M Wjst
    Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Eur J Med Res 6:263-71. 2001
    ..The high dose effect, the time dependency of the administration and the effect by non-pulmonary indications raises the possibility that early antibiotic treatment could itself be related to later asthma...
  19. ncbi request reprint Trends in allergies among children in a region of former East Germany between 1992-1993 and 1995-1996
    J Heinrich
    GSF Forshungszentrum fuer Umwelt und Gesundheit, Institut fuer Epidemiologie, Postfach 1129, D 85758 Neuherberg, Germany
    Eur J Med Res 4:107-13. 1999
    ..In conclusion, there were no significant changes in the prevalence of asthma, allergic rhinitis, or self-reported symptoms of allergic diseases...
  20. ncbi request reprint Association of beta(2)-adrenoreceptor variants with bronchial hyperresponsiveness
    M Ulbrecht
    Institut für Anthropologie und Humangenetik der Ludwig Maximilians Universität München, Munchen, Germany
    Am J Respir Crit Care Med 161:469-74. 2000
    ..Upon reanalysis by sex a significant association persisted only for female probands...
  21. ncbi request reprint Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma
    C Vollmert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Clin Exp Allergy 34:1841-50. 2004
    ....
  22. ncbi request reprint Trends in prevalence of atopic diseases and allergic sensitization in children in Eastern Germany
    J Heinrich
    GSF National Research Centre for Environment and Health Institute of Epidemiology, Neuherberg, Germany
    Eur Respir J 19:1040-6. 2002
    ....
  23. ncbi request reprint [Environmental surveys in the areas of Bitterfeld, Hettstedt and a comparative area in 1992-2000]
    J Heinrich
    GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Institut fur Epidemiologie, Neuherberg
    Gesundheitswesen 64:675-82. 2002
    ....
  24. ncbi request reprint The association between baseline lung function and bronchial responsiveness to methacholine
    G Wassmer
    GSF, Institut fur Epidemiologie, Neuherberg, Germany
    Eur J Med Res 2:47-54. 1997
    ..Furthermore, our data support the superiority of the dose response slope for the analysis of bronchial responsiveness in epidemiologic surveys...
  25. ncbi request reprint Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes
    T Immervoll
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Hum Mutat 18:327-36. 2001
    ..022). In summary, fine mapping data enable us to confine asthma candidate regions, while variants of EDN1 and NOS1, or nearby genes, may play an important role in this context...
  26. ncbi request reprint Maternal oral contraceptive use and atopic diseases in the offspring
    C Frye
    GSF National Research Center for Environment and Health Institute of Epidemiology, Neuherberg, Germany
    Allergy 58:229-32. 2003
    ..This study examined the association of maternal oral contraceptive (OC) use - before and after birth - and atopic manifestations in the offspring...
  27. ncbi request reprint An Internet linkage and mutation database for the complex phenotype asthma
    M Wjst
    GSF National Research Center for Environment and Health, P O B 1129, D 85758 Oberschleissheim, Germany
    Bioinformatics 14:827-8. 1998
    ..The paper presents details of database construction, website installation and server architecture of the asthma and allergy gene database...
  28. ncbi request reprint Arsenic burden among children in industrial areas of eastern Germany
    M J Trepka
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Epidemiologie, Neuherberg, Germany
    Sci Total Environ 180:95-105. 1996
    ..59 micrograms As/g creatinine; 95% C.I. 4.20-5.02). This suggests that the arsenic contamination in Hettstedt is not substantially increasing the internal burden of arsenic among children above that found in other German children...
  29. ncbi request reprint [European Community Respiratory Health Survey in Adults (ECRHS)]
    J Heinrich
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Epidemiologie, Neuherberg, Deutschland
    Pneumologie 56:297-303. 2002
    ....
  30. ncbi request reprint Public data mining shows extended linkage disequilibrium around ADAM33
    M Wjst
    Institut fur Epidemiologie, GSF Foschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany
    Allergy 62:444-6. 2007
    ..ADAM33 has been described to be the first positional cloned asthma gene. Consecutive association studies have found inconsistent results. At present no functional relevant variation is being known...
  31. pmc Genomewide scans of complex human diseases: true linkage is hard to find
    J Altmuller
    Institute of Epidemiology, GSF corrected National Research Center for Environment and Health, Neuherberg, Germany
    Am J Hum Genet 69:936-50. 2001
    ..Positional cloning based on whole-genome screens in complex human disease has proved more difficult than originally had been envisioned; detection of linkage and positional cloning of specific disease-susceptibility loci remains elusive...
  32. ncbi request reprint Margarine consumption and allergy in children
    G Bolte
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Respir Crit Care Med 163:277-9. 2001
    ..Increased intake of certain polyunsaturated fatty acids might further stimulate IgE production in boys...
  33. ncbi request reprint Serum immunoglobulin level and skin prick test response
    M Wjst
    GSF Forschungszentrum fuer Umwelt und Gesundheit, Institut fuer Epidemiologie, Ingolstaedter Landstrasse 1, Neuherberg, D 85758, Germany
    Eur J Med Res 2:177-81. 1997
    ..Methods: In a population-based study of 2,470 children, 2,188 skin prick tests, and 2,042 blood samples could be analyzed...
  34. ncbi request reprint Asthma and IL-4 receptor alpha gene variants
    M Wjst
    German Asthma Genetics Group, Munich, Germany
    Eur J Immunogenet 29:263-8. 2002
    ..As there could be interactions with multiple genetic and environmental factors, IL4Ralpha could still be involved in asthma pathogenesis...
  35. ncbi request reprint Is the increase in allergic asthma associated with an inborn Th1 maturation or with an environmental Th1 trigger defect?
    M Wjst
    Gruppe Molekulare Epidemiologie, Institut fur Epidemiologie, GSF Forschungszentrum für Umwelt und Gesundheit, Ingolstadter Landstrasse 1, Neuherberg Munich, Germany
    Allergy 59:148-50. 2004
    ..Both, a Th1 maturation and a Th1 trigger defect may contribute to a dual Th1 allergy theory...
  36. ncbi request reprint Vitamin D serum levels and allergic rhinitis
    M Wjst
    Molecular Epidemiology Group, GSF National Research for Environment and Health, Ingolstaedter Landstrasse 1, Munich Neuherberg, Germany
    Allergy 62:1085-6. 2007
    ..The association could be due to unrecognized confounding, however, could also point towards an altered metabolism or an increased sensitivity to vitamin D in allergic patients...