J Wiltfang

Summary

Country: Germany

Publications

  1. ncbi request reprint Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies
    J Wiltfang
    Department of Psychiatry, Georg August University, Gottingen, Germany
    Gerontology 47:65-71. 2001
  2. ncbi request reprint Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    J Neurochem 81:481-96. 2002
  3. ncbi request reprint Clozapine-associated elevation of plasma cholinesterase
    J Wiltfang
    Department of Psychiatry and Psychotherapy, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 251:269-71. 2001
  4. ncbi request reprint Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells
    J Wiltfang
    Department of Psychiatry, Molecular Neurobiology, and Department of Biochemistry II, University of Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 276:42645-57. 2001
  5. ncbi request reprint Elevated serum levels of astroglial S100beta in patients with liver cirrhosis indicate early and subclinical portal-systemic encephalopathy
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    Metab Brain Dis 14:239-51. 1999
  6. ncbi request reprint Sleep disorders and portal-systemic encephalopathy following transjugular intrahepatic portosystemic stent shunt in patients with liver cirrhosis. Relation to plasma tryptophan
    J Wiltfang
    Dept of Psychiatry, University of Gottingen, Germany
    Adv Exp Med Biol 467:169-76. 1999
  7. ncbi request reprint Psychiatric aspects of portal-systemic encephalopathy
    J Wiltfang
    Dept of Psychiatry, University of Gottingen, Germany
    Metab Brain Dis 13:379-89. 1998
  8. doi request reprint No clear effects of acute tryptophan depletion on processing affective prosody in male adults with ADHD
    M Grabemann
    Department of Psychiatry and Psychotherapy, University of Duisburg Essen, LVR Clinics Essen, Essen, Germany
    Acta Psychiatr Scand 128:142-8. 2013
  9. ncbi request reprint Reduced CSF carboxyterminally truncated Abeta peptides in frontotemporal lobe degenerations
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 114:621-8. 2007
  10. ncbi request reprint CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 113:1771-8. 2006

Detail Information

Publications60

  1. ncbi request reprint Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies
    J Wiltfang
    Department of Psychiatry, Georg August University, Gottingen, Germany
    Gerontology 47:65-71. 2001
    ....
  2. ncbi request reprint Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    J Neurochem 81:481-96. 2002
    ..The severity of dementia was significantly correlated to the fractional Abeta peptide pattern but not to the absolute Abeta peptide concentrations...
  3. ncbi request reprint Clozapine-associated elevation of plasma cholinesterase
    J Wiltfang
    Department of Psychiatry and Psychotherapy, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 251:269-71. 2001
    ..The goal of this study was to identify adverse effects of the atypical neuroleptic clozapine on liver function and lipid metabolism...
  4. ncbi request reprint Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells
    J Wiltfang
    Department of Psychiatry, Molecular Neurobiology, and Department of Biochemistry II, University of Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 276:42645-57. 2001
    ..Moreover, our results indicate that the latter Abeta peptide species could be generated by a beta(Asp/Ala)-secretase activity...
  5. ncbi request reprint Elevated serum levels of astroglial S100beta in patients with liver cirrhosis indicate early and subclinical portal-systemic encephalopathy
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    Metab Brain Dis 14:239-51. 1999
    ..Serum S100beta seems to be a promising biochemical surrogate marker for mild cognitive impairments due to portal-systemic encephalopathy...
  6. ncbi request reprint Sleep disorders and portal-systemic encephalopathy following transjugular intrahepatic portosystemic stent shunt in patients with liver cirrhosis. Relation to plasma tryptophan
    J Wiltfang
    Dept of Psychiatry, University of Gottingen, Germany
    Adv Exp Med Biol 467:169-76. 1999
    ..Among the biochemical parameters studied only an association between arterial ammonia levels and sleep disorders became apparent, whereas no significant relation was observed for peripheral tryptophan...
  7. ncbi request reprint Psychiatric aspects of portal-systemic encephalopathy
    J Wiltfang
    Dept of Psychiatry, University of Gottingen, Germany
    Metab Brain Dis 13:379-89. 1998
    ..Psychiatric symptoms of early PSE and sleep disorders in patients with chronic liver disease are of specific interest...
  8. doi request reprint No clear effects of acute tryptophan depletion on processing affective prosody in male adults with ADHD
    M Grabemann
    Department of Psychiatry and Psychotherapy, University of Duisburg Essen, LVR Clinics Essen, Essen, Germany
    Acta Psychiatr Scand 128:142-8. 2013
    ..This study aimed to investigate whether diminished brain 5-HT synthesis, as achieved by acute tryptophan depletion (ATD), can impair the processing of affective prosody in adults with ADHD...
  9. ncbi request reprint Reduced CSF carboxyterminally truncated Abeta peptides in frontotemporal lobe degenerations
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 114:621-8. 2007
    ..Moreover, independent methods of measurement should be applied to CSF Abeta1-38...
  10. ncbi request reprint CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 113:1771-8. 2006
    ..Combined evaluation of these biomarkers provides a reasonable accuracy for differential diagnosis of AD and DLB...
  11. ncbi request reprint Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Mol Psychiatry 12:671-80. 2007
    ..CSF Abeta peptides may reflect disease-specific impact of distinct neurodegenerative processes on Abeta peptide metabolism and represent a potential diagnostic biomarker for AD, FTD and DLB...
  12. doi request reprint Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 223:366-70. 2010
    ..Our findings reconfirm the hypothesis that alterations of biomarker concentrations occur early in a preclinical AD stage and that these alterations are also reflected in plasma...
  13. ncbi request reprint Lithium decreases secretion of Abeta1-42 and C-truncated species Abeta1-37/38/39/40 in chicken telencephalic cultures but specifically increases intracellular Abeta1-38
    H Esselmann
    Department of Psychiatry, University of Gottingen, Gottingen, Germany
    Neurodegener Dis 1:236-41. 2004
    ..Therefore, we conclude that there are two independent mechanisms of lithium in intra- and extracellular Abeta peptide production...
  14. doi request reprint Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 15:138-45. 2010
    ..001), from the patients clinically assessed as having other dementias and supported by NDD untypical for AD. We conclude sAPP alpha and sAPP beta might be regarded as novel promising biomarkers supporting the clinical diagnosis of AD...
  15. ncbi request reprint Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia
    J Wiltfang
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    World J Biol Psychiatry 6:69-84. 2005
    ..Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed...
  16. ncbi request reprint Immune complexes of auto-antibodies against A beta 1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients
    A W Henkel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 12:601-10. 2007
    ..Our results assign a central role to the immune system in regulating A beta1-42 homeostasis by clustering this peptide in immunocomplexes...
  17. ncbi request reprint Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    J Neurochem 73:2485-90. 1999
    ..This study has determined that isoform-specific 14-3-3 antibodies against beta, gamma, and epsilon should be considered for the neurochemical differentiation of CJD from other neurodegenerative diseases...
  18. ncbi request reprint Persistence of haloperidol in human brain tissue
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Germany
    Am J Psychiatry 156:885-90. 1999
    ..The aim of this study was to directly examine haloperidol concentrations in human brain tissue in relation to drug-free time...
  19. doi request reprint Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
    M Wagner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neurology 78:379-86. 2012
    ..To compare cued recall measures with other memory and nonmemory tests regarding their association with a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients with mild cognitive impairment (MCI)...
  20. ncbi request reprint Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment
    H Hampel
    Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia Research Section and Memory Clinic, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Mol Psychiatry 9:705-10. 2004
    ..05). Our findings support the notion that CSF tau and Abeta(1-42) may be useful biomarkers in the early identification of AD in MCI subjects...
  21. ncbi request reprint Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43
    J Wiltfang
    Department of Psychiatry, University of Gottingen, Germany
    Electrophoresis 18:527-32. 1997
    ..They may help to define the neurotoxic potential of the longer A beta peptides in relation to their aggregation state...
  22. ncbi request reprint Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease
    B Mollenhauer
    Department of Neurology, Georg August University, Goettingen, Germany
    J Neural Transm 112:933-48. 2005
    ..Follow-up CSF analyses are of limited value for the differentiation of AD and DLB. We conclude that more specific markers have to be established for the differentiation and follow-up of these diseases...
  23. doi request reprint Differential processing and secretion of Abeta peptides and sAPPalpha in human platelets is regulated by thrombin and prostaglandine 2
    A Smirnov
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Germany
    Neurobiol Aging 30:1552-62. 2009
    ..Treatment of platelets with prostaglandine 2 slowed this process down. Intracellular Abeta peptide concentrations decreased steadily until no peptides could be detected after 20 h (control) or after 4 h (thrombin) in cultured platelets...
  24. doi request reprint The impact of acute tryptophan depletion on attentional performance in adult patients with ADHD
    C Mette
    Department of Psychiatry and Psychotherapy, LVR Clinics Essen, University of Duisburg Essen, Essen, Germany
    Acta Psychiatr Scand 128:124-32. 2013
    ....
  25. ncbi request reprint Homocysteine induces cell death of rat astrocytes in vitro
    J M Maler
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Neurosci Lett 347:85-8. 2003
    ..g. Alzheimer's disease, glaucomatous optic neuropathy). This is the first study to report that homocysteine induces cell death of astrocytes. The mechanisms by which homocysteine induces cell death of astrocytes warrant further study...
  26. ncbi request reprint The N-methyl-D-aspartate receptor channel blocker amantadine does not cause histopathological alterations in human brain tissue
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Germany
    Acta Neuropathol 98:85-90. 1999
    ..In conclusion, histopathological examination of the hippocampus, retrosplenial cortex, and cingulate gyrus of human brain did not reveal changes suggested to be specific for previous amantadine treatment...
  27. ncbi request reprint Decreased circulating CD34+ stem cells in early Alzheimer's disease: Evidence for a deficient hematopoietic brain support?
    J M Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 11:1113-5. 2006
    ..467; P = 0.025) and most pronounced the Abeta42/40 ratio (r = -0.688; P = 0.005). Our data suggest a deficient regenerative hematopoietic support for the central nervous system in early AD...
  28. ncbi request reprint Oxidative stress and an altered methionine metabolism in alcoholism
    S Bleich
    Department of Psychiatry, Georg August University, Von Siebold Strasse 5, D 37075, Gottingen, Germany
    Neurosci Lett 293:171-4. 2000
    ..120; P<0.01). We postulate that excitatory neurotransmitters and mechanisms of oxidative stress in patients with chronic alcoholism may partly mediate excitotoxic neuronal damage and hereby cause brain shrinkage...
  29. ncbi request reprint Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication
    J Kornhuber
    Department of Psychiatry, University of Gottingen, Federal Republic of Germany
    J Neural Transm 106:857-67. 1999
    ..This makes flupirtine the prototype of a clinically applicable substance group with analgesic, muscle-relaxant and neuroprotective properties...
  30. ncbi request reprint Blue light improves cognitive performance
    S Lehrl
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neural Transm 114:457-60. 2007
    ..We report a longitudinal study in 44 adults, showing that a significant increase in alertness and speed of information processing could be achieved by blue light as compared to normal light...
  31. ncbi request reprint The German Competence Net Dementias: standard operating procedures for the neurochemical dementia diagnostics
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Neural Transm 113:1075-80. 2006
    ....
  32. doi request reprint A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 72:1735-40. 2009
    ..Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS...
  33. ncbi request reprint Unaltered apoptotic behaviour of mononuclear cells from patients with sporadic Creutzfeldt-Jakob disease
    P Ratzka
    Department of Neurology, University of Gottingen, Germany
    J Neurol 248:690-4. 2001
    ..It remains open to question whether this mechanism plays an important role in forms of transmissible encephalopathy other than sporadic CJD, especially after oral transmission...
  34. ncbi request reprint Boxing and running lead to a rise in serum levels of S-100B protein
    M Otto
    Department of Neurology, University Hospital, Gottingen, Germany
    Int J Sports Med 21:551-5. 2000
    ..Levels of S-100B protein known to be associated with neuropsychological deficits were not reached in our study. In professional boxing, much higher levels are to be expected and would be worthy of investigation...
  35. ncbi request reprint [Neuronal potassium channel opening with flupirtine]
    J Kornhuber
    Psychiatrische Klinik, Universitat Gottingen
    Fortschr Neurol Psychiatr 67:466-75. 1999
    ..The experimental basis for this working hypothesis and the resulting model concepts are presented from the perspective of a four-stage approach...
  36. ncbi request reprint Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease
    M Otto
    Neurologische Klinik und Poliklinik, Georg August Universitat Gottingen, Germany
    Neurology 58:192-7. 2002
    ..Both tests in a larger group of patients with the differential diagnosis of CJD were evaluated...
  37. ncbi request reprint Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
    M Otto
    Neurologische Klinik und Poliklinik, Georg August Universitat Gottingen, Germany
    Neurology 54:1099-102. 2000
    ....
  38. ncbi request reprint Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study
    M Otto
    Departments of Neurology, University of Goettingen, Germany
    Neurology 62:714-8. 2004
    ..As FLU is a clinically safe drug, the authors started a double-blind placebo-controlled study in patients with Creutzfeldt-Jakob disease (CJD)...
  39. ncbi request reprint High activity of acid sphingomyelinase in major depression
    J Kornhuber
    Department of Psychiatry, University of Erlangen, Germany
    J Neural Transm 112:1583-90. 2005
    ..09, df=21.33, P<0.05). In addition, we demonstrate that the antidepressants imipramine and amitriptyline induce a long-term reduction of the activity of A-SMase in cultured cells...
  40. ncbi request reprint Region specific distribution of levomepromazine in the human brain
    J Kornhuber
    Department of Psychiatry, University of Erlangen, Germany
    J Neural Transm 113:387-97. 2006
    ..The aim of this study was to examine concentrations of levomepromazine and its metabolite desmethyl-levomepromazine in different regions of human brain and in relationship to drug-free time...
  41. ncbi request reprint Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy
    B J Steinhoff
    Department of Clinical Neurophysiology, Zentrum Neurologische Medizin, Georg August Universitat, Gottingen, Germany
    Epilepsy Res 36:75-82. 1999
    ..We conclude that interictal temporal lobe dysfunction corresponds with neuronal and glial marker elevations in the extracellular space and that site-specific elevations may predict the site of seizure origin biochemically...
  42. ncbi request reprint Development of a capillary isoelectric focusing immunoassay to measure DJ-1 isoforms in biological samples
    D Besong Agbo
    LVR Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg Essen, 45147 Essen, Germany
    Anal Biochem 443:197-204. 2013
    ..Taken together, the capillary isoelectric focusing immunoassay for DJ-1 represents a promising tool that may ultimately serve in clinical biomarker studies. ..
  43. ncbi request reprint Production of follistatin in porcine endothelial cells: differential regulation by bacterial compounds and the synthetic glucocorticoid RU 28362
    U Michel
    Department of Neurology and Psychiatry, University of Gottingen, Germany
    Endocrinology 137:4925-34. 1996
    ....
  44. ncbi request reprint Memantine fails to facilitate partial cigarette deprivation in smokers--no role of Memantine in the treatment of nicotine dependency?
    N Thuerauf
    Department of Psychiatry and Psychotherapy, University of Erlangen Nurnberg, Erlangen, Germany
    J Neural Transm 114:351-7. 2007
    ..Memantine failed to facilitate smoking reduction and did not influence the perception of nicotine with the exception of a weak reduction of olfactory intensity estimates reaching statistical significance for one nicotine enantiomer only...
  45. ncbi request reprint Non-pharmacologic prevention of Alzheimer's disease: nutritional and life-style risk factors
    M Weih
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen, Germany
    J Neural Transm 114:1187-97. 2007
    ..modestly increased AD risk, fish, mediterranean diet and unsaturated fat or n-3 fatty acids and social activity are protective in observational cohorts, but interventional studies are lacking...
  46. ncbi request reprint Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias
    M Riemenschneider
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 8:343-7. 2003
    ..Although the results have to be confirmed in a larger sample, the preliminary data suggest that simultaneous measurement of total tau and P-tau in CSF may be useful to identify patients with CJD...
  47. doi request reprint Social cognition in attention-deficit hyperactivity disorder (ADHD)
    J Uekermann
    LVR Clinics Essen, University of Duisburg Essen, Department of Psychiatry and Psychotherapy, Essen, Germany
    Neurosci Biobehav Rev 34:734-43. 2010
    ..So far only few studies have addressed the issue of social cognition deficits in ADHD...
  48. ncbi request reprint [German-speaking memory clinics: state of the art and practical recommendations]
    J Diehl
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, TU Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Z Gerontol Geriatr 36:189-96. 2003
    ..The following paper is a summary of the results of a workshop in Göttingen and gives practical recommendations based on the experiences of the memory clinics...
  49. ncbi request reprint Biochemical markers of cerebrovascular injury in sleep apnoea syndrome
    W Jordan
    Dept of Psychiatry and Psychotherapy, University Göttingen, Germany
    Eur Respir J 20:158-64. 2002
    ..There is a need for biochemical markers and more sensitive methods for detecting small cerebral injury in sleep apnoea syndrome...
  50. ncbi request reprint [Neurochemical early and differential diagnostics for Alzheimer's disease]
    J Wiltfang
    Klinik mit Poliklinik für Psychiatrie und Psychotherapie Friedrich Alexander Universität Erlangen Nürnberg
    MMW Fortschr Med 146:38-40. 2004
    ..As a result, future preventive drug treatment strategies can be employed early and selectively...
  51. pmc Selective reduction of amyloid beta42 discriminates Alzheimer's disease from Huntington's disease: indication for distinct pathological events in amyloid beta peptide aggregation
    B Mollenhauer
    J Neurol Neurosurg Psychiatry 77:1201-3. 2006
  52. ncbi request reprint Specific 14-3-3 isoform detection and immunolocalization in prion diseases
    H C Baxter
    Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Biochem Soc Trans 30:387-91. 2002
    ..In this study, monitoring specifically for the gamma 14-3-3 isoform in the CSF by both Western-blot analysis and ELISA we can show a level of correlation between the assays...
  53. doi request reprint Plasma lipoprotein beta-amyloid in subjects with Alzheimer's disease or mild cognitive impairment
    J C L Mamo
    Division of Health Sciences, Curtin University of Technology and ATN Centre for Metabolic Health and Fitness
    Ann Clin Biochem 45:395-403. 2008
    ..The objectives of this study were to investigate the distribution of lipoprotein-bound plasma-Abeta isoforms...
  54. doi request reprint Prediction of Alzheimer's disease using a cerebrospinal fluid pattern of C-terminally truncated beta-amyloid peptides
    K Hoglund
    Neurochemistry Lab, Department of Neuroscience and Physiology, Goteborg University, Molndal, Sweden
    Neurodegener Dis 5:268-76. 2008
    ..Identifying individuals at high risk of developing Alzheimer's disease (AD) is important for future therapeutic strategies, and there is a clinical need for diagnostic biomarkers to identify incipient AD...
  55. ncbi request reprint Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease
    N Itoh
    Department of Neurology, Mie University School of Medicine, Tsu, Japan
    Ann Neurol 50:150-6. 2001
    ..Thus, we suggest that CSF/phospho-tau199 may be a novel and logical biomarker in supporting antemortem diagnosis of AD...
  56. ncbi request reprint Innate immunity in human bone
    P H Warnke
    Dept of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Str 16, 24105 Kiel, Germany
    Bone 38:400-8. 2006
    ..We provide the first evidence of a previously unrecognized innate immunological function of bone through the demonstration of the presence of the human beta-defensins hBD-1, -2 and -3 in bone...
  57. ncbi request reprint A new method of monitoring osteomyelitis
    I N G Springer
    Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Str 16, D 24105 Kiel, Germany
    Int J Oral Maxillofac Surg 36:527-32. 2007
    ..An inexpensive tool (US$5 per analysis) for the monitoring of osteomyelitis is described...
  58. ncbi request reprint Aminoterminally truncated and oxidized amyloid-beta peptide species in Alzheimer's disease
    M Bibl
    Neuroscience 146:17-8. 2007
  59. ncbi request reprint Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes
    J Park
    Department of Oro Maxillo Facial Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Gene Ther 10:1089-98. 2003
    ....
  60. doi request reprint Life-threatening bite injury of the lower lip after use of metamizole
    S T Becker
    Department of Oral and Maxillofacial Surgery, University of Kiel, 24105 Kiel, Germany
    Oral Maxillofac Surg 12:39-41. 2008
    ..We present the case of a 37-year-old woman with an ulcer of the mucosa of the lower lip, which had been present for 10 days, and leucopenia...