Research Topics
| M WilkeSummaryCountry: Germany Publications
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Detail Information
Publications
LI-tool: a new toolbox to assess lateralization in functional MR-dataMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
J Neurosci Methods 163:128-36. 2007..To allow a more standardized, reproducible and accessible evaluation of laterality effects, current and new approaches have been implemented in a versatile toolbox running within the spm2 or spm5 software environment...
Template-O-Matic: a toolbox for creating customized pediatric templatesMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
Neuroimage 41:903-13. 2008..We compare the performance of this approach with the current method of template generation and discuss the implications of our approach...
An iterative jackknife approach for assessing reliability and power of FMRI group analysesMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Tubingen, Germany
PLoS ONE 7:e35578. 2012..The approach is tested using different scenarios from a recent fMRI study (children performing a "dual-use" fMRI task, n = 39), and the implications of this approach are discussed...- An alternative approach towards assessing and accounting for individual motion in fMRI timeseriesMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, and Department of Neuroradiology, University of Tubingen, Germany
Neuroimage 59:2062-72. 2012..A more individualized approach to explaining motion-related variance may therefore be beneficial, depending on the scenario... - Global and local development of gray and white matter volume in normal children and adolescentsMarko Wilke
Imaging Research Center, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Exp Brain Res 178:296-307. 2007..The knowledge of such influence allows for the consideration of age- and gender-effects in future pediatric neuroimaging studies and advances our understanding of normal and abnormal brain development... - An fMRI task battery for assessing hemispheric language dominance in childrenMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, Germany
Neuroimage 32:400-10. 2006..It may thus be a useful tool in assessing normal and pathological language organization... - Comprehensive language mapping in children, using functional magnetic resonance imaging: what's missing countsMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
Neuroreport 16:915-9. 2005..They also allow robust mapping of receptive language areas... - Somatosensory system in two types of motor reorganization in congenital hemiparesis: topography and functionMarko Wilke
Pediatric Neurology and Developmental Medicine, University Children s Hospital, University of Tubingen, Tubingen, Germany
Hum Brain Mapp 30:776-88. 2009..This preserved pattern of somatosensory organization argues in favor of a differential lesion effect on motor and somatosensory functions and demonstrates a limited compensatory potential for the latter... - Voxel-based morphometry in adolescents with bipolar disorder: first resultsMarko Wilke
Imaging Research Center and Department of Psychiatry, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Psychiatry Res 131:57-69. 2004..VBM confirmed bilaterally larger basal ganglia. Localized gray matter deficits in bipolar subjects were found in the medial temporal lobe, orbito-frontal cortex, and the anterior cingulate, confirming and extending earlier studies... - Combined functional and causal connectivity analyses of language networks in children: a feasibility studyMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, University Children s Hospital, Tubingen, Tubingen, Germany
Brain Lang 108:22-9. 2009.... - Functional magnetic resonance imaging in pediatricsM Wilke
Imaging Research Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Neuropediatrics 34:225-33. 2003..We conclude that fMRI can successfully be applied in children and holds great promise for both research and clinical purposes... - Manual, semi-automated, and automated delineation of chronic brain lesions: a comparison of methodsMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
Neuroimage 56:2038-46. 2011..The detection of indirect lesion effects may be another application of such approaches in the future... - Clinical functional MRI of the language domain in children with epilepsyMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
Hum Brain Mapp 32:1882-93. 2011..We conclude that important confounds need to be considered and that the pattern of language reorganization may be distinct from the patterns seen in later-onset epilepsy... - Normative pediatric brain data for spatial normalization and segmentation differs from standard adult dataM Wilke
Imaging Research Center, Cincinnati Children s Hospital Medical Center, Ohio, USA
Magn Reson Med 50:749-57. 2003..To assess the effects of using pediatric a priori brain information, the data obtained in this study is available to the scientific community from our website (www.irc.cchmc.org)... - Bright spots: correlations of gray matter volume with IQ in a normal pediatric populationMarko Wilke
Imaging Research Center, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Neuroimage 20:202-15. 2003..The implications of our findings for normal development, pathological processes, and our understanding of cognition are discussed and related to previous findings... - Why one task is not enough: functional MRI for atypical language organization in two childrenMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
Eur J Paediatr Neurol 14:474-8. 2010..These cases underline the necessity to use more than one fMRI task for the determination of hemispheric dominance, whenever possible. This is particularly relevant in children as unusual patterns of reorganization may be more likely... - Variability of gray and white matter during normal development: a voxel-based MRI analysisMarko Wilke
Pediatric Psychiatry Imaging Research Center ML 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Neuroreport 14:1887-90. 2003..Our results emphasize the necessity to take this variability into account when planning pediatric neuroimaging studies... - A combined bootstrap/histogram analysis approach for computing a lateralization index from neuroimaging dataMarko Wilke
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Hoppe Seyler Str 1, 72076 Tubingen, Germany
Neuroimage 33:522-30. 2006..We conclude that the proposed methods yield a robust and specific lateralization index, sensitively detect outliers and allow to assess the underlying data quality... - Reorganization of the cerebro-cerebellar network of language production in patients with congenital left-hemispheric brain lesionsK Lidzba
Department of Developmental Neurology, University Children s Hospital, Hoppe Seyler Str 1, Tubingen 72076, Germany
Brain Lang 106:204-10. 2008..We suggest that the developing brain reacts to early focal lesions in the left hemisphere with a mirror-image organization of the entire cerebro-cerebellar network engaged in speech production... - BOLD fMRI signal increases with age in selected brain regions in childrenMark B Schapiro
Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Neuroreport 15:2575-8. 2004..Thus, BOLD effect increases with age in children during sensorimotor and language tasks... - Increases in language lateralization in normal children as observed using magnetoencephalographyVolker Ressel
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Hoppe Seyler Str 1, Tubingen 72076, Germany
Brain Lang 106:167-76. 2008..As performance in the VI task showed no correlation with age, this increase seems to be unrelated to performance. These results confirm an increase in hemispheric specialization as a function of normal brain maturation... - Language lateralization in magnetoencephalography: two tasks to investigate hemispheric dominanceVolker Ressel
Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
Neuroreport 17:1209-13. 2006..Our new vowel identification task yields significant left-lateralization in posterior language regions, making this silent and child-friendly task a valuable alternative for non-invasive language assessment in difficult populations... - Lesion-induced right-hemispheric language and organization of nonverbal functionsKaren Lidzba
Department of Pediatric Neurology and Developmental Medicine, University Children s Hospital, Tubingen, Germany
Neuroreport 17:929-33. 2006..Instead, verbal and nonverbal functions were mediated by a common right-hemispheric network. This argues in favour of the 'crowding hypothesis'... - Visuospatial deficits in patients with early left-hemispheric lesions and functional reorganization of language: consequence of lesion or reorganization?Karen Lidzba
Department of Pediatric Neurology and Developmental Medicine, University Children s Hospital, Hoppe Seyler Str 1, D 72076 Tubingen, Germany
Neuropsychologia 44:1088-94. 2006..The scope of this study was to examine the relations between visuospatial skills and hemispheric preference for language, and between visuospatial skills and cerebral lesion size... - Cognitive functions correlate with white matter architecture in a normal pediatric population: a diffusion tensor MRI studyVincent J Schmithorst
Imaging Research Center, Cincinnati Children s Hospital Medical Center, OH 45229, USA
Hum Brain Mapp 26:139-47. 2005..The results are consistent with the hypothesis that regionally specific increased fiber organization is a mechanism responsible for the normal development of white matter tracts... - Language processing during natural sleep in a 6-year-old boy, as assessed with functional MR imagingMarko Wilke
Imaging Research Center and Department of Psychiatry, Cincinnati Children's Hospital Medical Center, OH 45229, USA
AJNR Am J Neuroradiol 24:42-4. 2003..Our findings suggest that language processing does occur during natural sleep, even in young children. This potentially allows for an assessment of language functions, even in sleeping children... - Automated detection of gray matter malformations using optimized voxel-based morphometry: a systematic approachM Wilke
Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Neuroimage 20:330-43. 2003..Our approach, involving systematic alterations of parameters and evaluation, may be useful for other studies... - Differences in white matter architecture between musicians and non-musicians: a diffusion tensor imaging studyVincent J Schmithorst
Imaging Research Center, Children s Hospital Medical Center, Suite R056A, Cincinnati, OH 45229, USA
Neurosci Lett 321:57-60. 2002..Further areas also showed significant differences. We hypothesize that these changes are due to the cognitive and motor effects, respectively, of musical training... - Assessment of spatial normalization of whole-brain magnetic resonance images in childrenMarko Wilke
Imaging Research Center, Children s Hospital Research Foundation at Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Hum Brain Mapp 17:48-60. 2002..Also, to minimize the amount of deformation during non-linear spatial normalization, a pediatric template should be used. Further implications of our findings on developmental neuroimaging studies are discussed... - Motor cortex plasticity in ischemic perinatal stroke: a transcranial magnetic stimulation and functional MRI studyMichael Walther
Department of Neuropediatrics and Muscle Disorders, University Children s Hospital, Freiburg, Germany
Pediatr Neurol 41:171-8. 2009.... - Infant brain probability templates for MRI segmentation and normalizationMekibib Altaye
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Neuroimage 43:721-30. 2008..These templates may be used as prior probability distributions for segmentation and normalization; a key to improving the accuracy of these procedures in special populations... - Correlation of white matter diffusivity and anisotropy with age during childhood and adolescence: a cross-sectional diffusion-tensor MR imaging studyVincent J Schmithorst
Imaging Research Center, Children s Hospital Medical Center, 3333 Burnet Ave, Suite R050A, Cincinnati, OH 45229, USA
Radiology 222:212-8. 2002..To evaluate differences in white matter diffusion properties as a function of age in healthy children and adolescents... - Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophreniaNICOLAS RUSCH
IRCCS Fondazione Santa Lucia, Rome, Italy
Schizophr Res 93:79-89. 2007.... - Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging studyCaleb M Adler
Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
Bipolar Disord 6:197-203. 2004..In this study we utilized diffusion tensor imaging (DTI) to examine prefrontal white matter in patients with bipolar disorder... - Anatomical signatures of dyslexia in children: unique information from manual and voxel based morphometry brain measuresMark A Eckert
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA
Cortex 41:304-15. 2005..We conclude that manual and automated methods provide valuable and complementary approaches to the search for functionally significant neurobiological characteristics of dyslexia... - Voxel-based morphometry in the detection of dysplasia and neoplasia in childhood epilepsy: combined grey/white matter analysis augments detectionJason M Bruggemann
Sydney Children s Hospital and University of New South Wales, Randwick, New South Wales, Australia
Epilepsy Res 77:93-101. 2007..The aim of this exploratory study was to evaluate combined analysis of grey and white matter using VBM for detecting focal lesions underlying childhood epilepsy, and to establish the optimal statistical parameters in this context... - Brain representation of active and passive hand movements in childrenAndrea Guzzetta
Department of Developmental Neuroscience, Stella Maris Scientific Institute, Pisa, Italy
Pediatr Res 61:485-90. 2007..Passive and active tasks confirmed to be tightly coupled, thus supporting the idea of the former as a helpful performance-independent paradigm in the study of brain reorganization and presurgical assessment... - Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsySimon S Keller
Magnetic Resonance and Image Analysis Research Centre MARIARC, University of Liverpool, Pembroke Place, PO Box 147, Liverpool L69 3BX, UK
Neuroimage 23:860-8. 2004..We suggest that in studies of neurological disorders, optimized VBM analyses of GMV may reveal subtle neuroanatomical changes that are not identified in analyses of GMC...