Werz O, Greiner C, Koeberle A, Hoernig C, George S, Popescu L, et al
. Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008;51:5449-53 pubmed publisher
..6 microM). These derivatives may possess potential for intervention with inflammatory and allergic diseases. ..
Werz O. Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin. Planta Med. 2007;73:1331-57 pubmed
..In the second part, natural compounds that interfere with 5-LO product formation are compiled and grouped into structural classes, and the underlying molecular mechanisms and structure-activity relationships are discussed. ..