M Weinmann

Summary

Country: Germany

Publications

  1. pmc Monte Carlo vs. pencil beam based optimization of stereotactic lung IMRT
    Marcin Sikora
    Section for Biomedical Physics, University Hospital for Radiation Oncology, Hoppe Seyler Str, 3, 72076 Tubingen, Germany
    Radiat Oncol 4:64. 2009
  2. pmc Definitive radiotherapy and single-agent radiosensitizing ifosfamide in patients with localized, irresectable soft tissue sarcoma: a retrospective analysis
    Franziska Eckert
    Eberhard Karls University Tuebingen, Department of Radiooncology, Tuebingen, Germany
    Radiat Oncol 5:55. 2010
  3. ncbi Soluble levels of CD-95, CD 95-L and various cytokines after exposing human leukocytes to ionizing radiation
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Anticancer Res 20:1813-8. 2000
  4. ncbi Biological effects of ionizing radiation on human blood compounds ex vivo
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    J Cancer Res Clin Oncol 126:584-8. 2000
  5. ncbi Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Strahlenther Onkol 177:105-11. 2001
  6. pmc Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: role of oxygenation status and tumour size
    M Weinmann
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Br J Cancer 86:1355-61. 2002
  7. ncbi Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours
    M Weinmann
    Klinik für Radioonkologie, Universitat Tubingen, Germany
    Onkologie 27:83-90. 2004
  8. ncbi Hypoxic radiosensitizers and hypoxic cytotoxins in radiation oncology
    Martin Weinmann
    Klinik für Radioonkologie, Universitat Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Curr Med Chem Anticancer Agents 3:364-74. 2003
  9. ncbi Chemotherapy in the treatment of recurrent glioblastoma multiforme: ifosfamide versus temozolomide
    F Paulsen
    Department of Radiotherapy, University of Tubingen, Germany
    J Cancer Res Clin Oncol 125:411-8. 1999
  10. doi In vitro hypoxic cytotoxicity and hypoxic radiosensitization. Efficacy of the novel 2-nitroimidazole N,N,N-tris[2-(2-nitro-1H-imidazol-1-yl)ethyl]amine
    M Langenbacher
    Department of Radiation Oncology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Strahlenther Onkol 189:246-54. 2013

Collaborators

Detail Information

Publications28

  1. pmc Monte Carlo vs. pencil beam based optimization of stereotactic lung IMRT
    Marcin Sikora
    Section for Biomedical Physics, University Hospital for Radiation Oncology, Hoppe Seyler Str, 3, 72076 Tubingen, Germany
    Radiat Oncol 4:64. 2009
    ..The purpose of the present study is to compare finite size pencil beam (fsPB) and Monte Carlo (MC) based optimization of lung intensity-modulated stereotactic radiotherapy (lung IMSRT)...
  2. pmc Definitive radiotherapy and single-agent radiosensitizing ifosfamide in patients with localized, irresectable soft tissue sarcoma: a retrospective analysis
    Franziska Eckert
    Eberhard Karls University Tuebingen, Department of Radiooncology, Tuebingen, Germany
    Radiat Oncol 5:55. 2010
    ..For primary radiotherapy local control rates of 30-45% have been reported. We analyzed retrospectively 11 cases of radiochemotherapy with single-agent ifosfamide in patients with macroscopic soft-tissue sarcomas...
  3. ncbi Soluble levels of CD-95, CD 95-L and various cytokines after exposing human leukocytes to ionizing radiation
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Anticancer Res 20:1813-8. 2000
    ..Local radiotherapy induces systemic effects and influences the immune system. Some of these effects can hardly be explained by direct cellular reactions, but might be triggered by humoral factors...
  4. ncbi Biological effects of ionizing radiation on human blood compounds ex vivo
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    J Cancer Res Clin Oncol 126:584-8. 2000
    ..To determine effects on blood cells we examined the impact of various doses of ionizing radiation...
  5. ncbi Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Strahlenther Onkol 177:105-11. 2001
    ....
  6. pmc Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: role of oxygenation status and tumour size
    M Weinmann
    Institute of Physiology and Pathophysiology, University of Mainz, 55099 Mainz, Germany
    Br J Cancer 86:1355-61. 2002
    ..This may indicate that the serum level of plasminogen activator inhibitor type 1 is not a reliable surrogate marker of tumour hypoxia...
  7. ncbi Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours
    M Weinmann
    Klinik für Radioonkologie, Universitat Tubingen, Germany
    Onkologie 27:83-90. 2004
    ..This article reviews in brief the specific pathophysiology of tumour oxygenation and its implications for prognosis, tumour treatment and biology...
  8. ncbi Hypoxic radiosensitizers and hypoxic cytotoxins in radiation oncology
    Martin Weinmann
    Klinik für Radioonkologie, Universitat Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Curr Med Chem Anticancer Agents 3:364-74. 2003
    ..This article reviews in brief the clinical experience with different generations of hypoxic radiosensitizers and hypoxic cytotoxins, which have been applied in combination with primary radiotherapy during the last three decades...
  9. ncbi Chemotherapy in the treatment of recurrent glioblastoma multiforme: ifosfamide versus temozolomide
    F Paulsen
    Department of Radiotherapy, University of Tubingen, Germany
    J Cancer Res Clin Oncol 125:411-8. 1999
    ..In vitro analysis revealed activity for ifosfamide and temozolomide. The usefulness of these agents in recurrent disease was investigated...
  10. doi In vitro hypoxic cytotoxicity and hypoxic radiosensitization. Efficacy of the novel 2-nitroimidazole N,N,N-tris[2-(2-nitro-1H-imidazol-1-yl)ethyl]amine
    M Langenbacher
    Department of Radiation Oncology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Strahlenther Onkol 189:246-54. 2013
    ..Nitroimidazole-containing compounds are oxygen mimetics accumulating in hypoxic tumor areas. However, the broad use of 2-nitroimidazoles as a hypoxic radiosensitizer is limited by their partially low efficacy and/or high neurotoxicity...
  11. ncbi Clinical indications and biological mechanisms of splenic irradiation in chronic leukaemias and myeloproliferative disorders
    M Weinmann
    Department of Radiation Oncology, , Hoppe-Seylerstrasse 3, , Germany
    Radiother Oncol 58:235-46. 2001
    ..Different mechanisms underlying SI such as direct cell kill, immune modulation via changes in lymphocyte subsets or cytokine induction or "radiotherapeutic" splenectomy with high doses are discussed...
  12. doi Reirradiation with alternating docetaxel-based chemotherapy for recurrent head and neck squamous cell carcinoma: update of a single-center prospective phase II protocol
    Bernhard Berger
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Strahlenther Onkol 186:255-61. 2010
    ....
  13. doi Advanced-stage III/IV follicular lymphoma: treatment strategies for individual patients
    Frank Heinzelmann
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Strahlenther Onkol 186:247-54. 2010
    ..In patients with advanced-stage III/IV follicular lymphoma (FL), there are many treatment options available. The current challenge is to choose the optimal strategy for the individual patient...
  14. ncbi Postmastectomy electron-beam-rotation irradiation in locally advanced breast cancer prognostic factors of locoregional tumor control
    Thomas Hehr
    Department of Radiation Oncology, University of Tuebingen, Germany
    Strahlenther Onkol 178:624-32. 2002
    ..Different radiotherapy techniques are used for postmastectomy irradiation. We review the results with the electron-beam-rotation technique in advanced breast cancer patients. Main endpoint was local tumor control...
  15. doi Nodal follicular lymphoma: the role of radiotherapy for stages I and II
    Frank Heinzelmann
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Strahlenther Onkol 186:191-6. 2010
    ..To clarify the role of external-beam radiotherapy (RT) in patients with stage I and II nodal follicular lymphoma (FL)...
  16. doi Intensity-modulated radiotherapy optimization in a quasi-periodically deforming patient model
    Matthias Söhn
    Section for Biomedical Physics, University Hospital for Radiation Oncology, Hoppe Seyler Strasse 3, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 75:906-14. 2009
    ..This is termed "optimization in tissue's-eye-view"...
  17. ncbi The blockade of endothelin A receptor protects astrocytes against hypoxic injury: common effects of BQ-123 anderythropoietin on the rejuvenation of the astrocyte population
    Lusine Danielyan
    Department of Clinical Pharmacology, University Hospital of Tubingen, Otfried Müller Strasse 45, D 72076 Tubingen, Germany
    Eur J Cell Biol 84:567-79. 2005
    ..The benefits in the functional states of astrocytes obtained by combined treatment of HC with BQ-123 and EPO suggest a new therapeutic strategy in treatment of hypoxic brain injury...
  18. doi Adjuvant radiochemotherapy in patients with locally advanced high-risk cervical cancer
    F Heinzelmann
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    Strahlenther Onkol 188:568-75. 2012
    ..Furthermore, acute and late effects of treatment were recorded...
  19. ncbi Impressive remission in a patient with locally advanced malignant pleural mesothelioma treated with gemcitabine
    M Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Anticancer Drugs 10:33-7. 1999
    ..Because of these characteristics gemcitabine seems a suitable antineoplastic substance, especially in palliative settings. It would be worthwhile to test its activity in pleural mesotheliomas in controlled trials...
  20. ncbi Curative approaches to lung cancer in the elderly
    Martin Weinmann
    Department of Radiation Oncology, University Hospital, Tubingen, Germany
    Semin Surg Oncol 21:182-9. 2003
    ..When adequate patient selection is provided, standard treatment approaches appear to be feasible for elderly (>70 years) patients with good performance status...
  21. doi Gene expression analysis in chronic postradiation proctopathy
    F Traub
    Department of General, Visceral and Transplant Surgery, University Tübingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Int J Colorectal Dis 27:879-84. 2012
    ..Endothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability...
  22. doi Postoperative versus definitive chemoradiation in early-stage anal cancer. Results of a matched-pair analysis
    B Berger
    Department of Radiation Oncology, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    Strahlenther Onkol 188:558-63. 2012
    ..The goal of the present study was to comparatively assess the results of definitive chemoradiation (CRT) with or without previous macroscopically complete resection in patients with early-stage node-negative (T1-2 N0) anal carcinoma...
  23. ncbi Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection
    Martin Weinmann
    Department of Radiation Oncology, University of Tuebingen, Germany
    Oncogene 24:5914-22. 2005
    ..Most importantly, hypoxic selection was not associated with changes of single apoptosis relevant genes, but with alterations in gene expression levels of a wide variety of genes indicating a more complex adaptation process...
  24. ncbi Treatment of lung cancer in the elderly. Part I: non-small cell lung cancer
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Lung Cancer 39:233-53. 2003
    ..Currently, single-agent CHT should be considered as the standard treatment of advanced NSCLC elderly patients...
  25. ncbi Treatment of lung cancer in elderly part II: small cell lung cancer
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Lung Cancer 40:1-16. 2003
    ..For the comparison of trials in elderly patients it will be of key importance to include a comprehensive and standardised geriatric assessment in such studies...
  26. ncbi Influence of hypoxia on TRAIL-induced apoptosis in tumor cells
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Hoppe Seylerstrasse 3, 72076 Tubingen, Germany
    Int J Radiat Oncol Biol Phys 58:386-96. 2004
    ..The impact of hypoxia on TRAIL-induced apoptosis was examined in this study...
  27. ncbi Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    FASEB J 18:1906-8. 2004
    ..In summary, it could be demonstrated that hypoxic stress confers a selection pressure on mitochondrial apoptotic pathways and, consecutively, to an increased resistance toward mitochondrial death triggers...
  28. ncbi Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner
    Martin Weinmann
    Department of Radiation Oncology, University of Tubingen, Germany
    Oncogene 23:3757-69. 2004
    ..Thus, in human tumors, hypoxia will mainly lead to the selection of hypoxia-resistant cells with defects in mitochondrial apoptosis signaling pathways...