- The evolution of domain arrangements in proteins and interaction networksE Bornberg-Bauer
Bioinformatics Division, School of Biological Sciences, University of Munster, Schlossplatz 4, 48143 Münster, Germany
Cell Mol Life Sci 62:435-45. 2005..In this review we summarise facts and hypotheses about the evolution of domains in multi-domain proteins and protein complexes, and the tools and data resources available to study them...
- Just how versatile are domains?January Weiner
Institute for Evolution and Biodiversity, Evolutionary Bioinformatics Group, Westphalian Wilhelms University, Munster, Germany
BMC Evol Biol 8:285. 2008..This ability, which is often referred to as versatility or promiscuity of domains, its a random evolutionary model in which a domain's promiscuity is based on its relative frequency of domains...
- Evolution of circular permutations in multidomain proteinsJanuary Weiner
Division of Bioinformatics, School of Biological Sciences, University of Munster, Schlossplatz 4, Munster, Germany
Mol Biol Evol 23:734-43. 2006..This can be partly attributed to highly mobile domains. Duplication/deletion has been found in modular proteins such as peptide synthases...
- Automated Improvement of Domain ANnotations using context analysis of domain arrangements (AIDAN)Francois Beaussart
Evolutionary Bioinformatics, Institute for Evolution and Biodiversity, Westfalische Wilhelms University, Schlossplatz 4, D48149 Munster, Germany
Bioinformatics 23:1834-6. 2007..AVAILABILITY: http://www.uni-muenster.de/Evolution/ebb/Services/AIDAN. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online...
- The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction networkFrauke Friedrichs
Department of Genetic Epidemiology, Leibniz Institute for Arteriosclerosis Research, University Munster, Munster, Germany
J Mol Med (Berl) 86:423-32. 2008..As there is substantial crosstalk between CARD-mediated pathways, both CD susceptibility genes, NOD2 and DLG5, may interact functionally to contribute to CD risk...
- Domain deletions and substitutions in the modular protein evolutionJanuary Weiner
Division of Bioinformatics, School of Biological Sciences, , Germany
FEBS J 273:2037-47. 2006..This is explained by a case study on the bacterial formate dehydrogenases...
- Rapid motif-based prediction of circular permutations in multi-domain proteinsJanuary Weiner
Division of Bioinformatics, School of Biology, Institute of Botany, , Germany
Bioinformatics 21:932-7. 2005..Several true CPs which have not been reported in literature so far could be identified from Swiss-Prot/TrEMBL within minutes...
- Expressed sequence tags from the flower pathogen Claviceps purpureaBirgitt Oeser
Institut fur Botanik, Westf Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
Mol Plant Pathol 10:665-84. 2009..In summary, the analysis of axenic and in planta ESTs yielded a collection of candidate genes to be evaluated for functional roles in this plant-microbe interaction...
- Comparative analysis of expressed sequence tag (EST) libraries in the seagrass Zostera marina subjected to temperature stressThorsten B H Reusch
Institute for Evolution and Biodiversity, Plant Evolutionary Ecology, University of Munster, Munster, Germany
Mar Biotechnol (NY) 10:297-309. 2008..A total of 210 TUGs contain one or more microsatellites as potential candidates for gene-linked genetic markers. Data are publicly available in a user-friendly database at http://www.uni-muenster.de/Evolution/ebb/Services/zostera ...
- Phylogenetic profiling of protein interaction networks in eukaryotic transcription factors reveals focal proteins being ancestral to hubsGregory D Amoutzias
Bioinformatics Group, School of Biological Sciences, Biology Department, , Scholossplatz 4 D-48149, Germany
Gene 347:247-53. 2005..However, the overall scaling behaviour does not always precisely confer to some theoretical models on network evolution. In conclusion, new models which reflect the biological details of molecular evolution, need to be developed...
- Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegansHinrich Schulenburg
Department of Animal Evolutionary Ecology, Zoological Institute, University of Tuebingen, Auf der Morgenstelle 28, 72076 Tuebingen, Germany
Immunobiology 213:237-50. 2008..Taken together, our evaluation reveals high potential for immune specificity in C. elegans that may enhance the nematode's ability to fight off pathogens...
- A putative transcription factor inducing mobility in Mycoplasma pneumoniaeErich Bornberg-Bauer
Microbiology 148:3764-5. 2002