Christof Weinbrenner

Summary

Country: Germany

Publications

  1. ncbi request reprint Remote preconditioning by infrarenal occlusion of the aorta protects the heart from infarction: a newly identified non-neuronal but PKC-dependent pathway
    Christof Weinbrenner
    Department of Cardiology, Medical Clinic II, University of Technology, P O Box 95, Fetscherstr 76, D 01307 Dresden, Germany
    Cardiovasc Res 55:590-601. 2002
  2. ncbi request reprint Remote preconditioning by infrarenal aortic occlusion is operative via delta1-opioid receptors and free radicals in vivo in the rat heart
    Christof Weinbrenner
    Department of Cardiology, Medical Clinic II, University of Technology Dresden, PO Box 95, Fetscherstr 76 D 01307 Dresden, Germany
    Cardiovasc Res 61:591-9. 2004
  3. doi request reprint Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction
    Bernd Ebner
    Department of Medicine Cardiology, Heart Center Dresden, University Hospital, University of Technology Dresden, Dresden, Germany
    Mol Cell Biochem 373:115-23. 2013
  4. doi request reprint Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition
    Antje Hönisch
    Department of Medicine and Cardiology, Heart Center Dresden University Hospital, University of Technology Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Basic Res Cardiol 105:155-67. 2010
  5. doi request reprint Pharmacological postconditioning by bolus injection of phosphodiesterase-5 inhibitors vardenafil and sildenafil
    Bernd Ebner
    Department of Medicine Cardiology, Heart Center Dresden, University Hospital, University of Technology Dresden, Dresden, Germany
    Mol Cell Biochem 379:43-9. 2013
  6. doi request reprint Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3beta, and apoptosis
    Claudia Wagner
    Department of Medicine and Cardiology, Heart Center Dresden University Hospital, University of Technology Dresden, P O Box 95, Fetscherstr 76, Dresden 01307, Germany
    Mol Cell Biochem 339:135-47. 2010
  7. doi request reprint The calcium channel blocker felodipine attenuates the positive hemodynamic effects of the beta-blocker metoprolol in severe dilated cardiomyopathy--a prospective, randomized, double-blind and placebo-controlled study with invasive hemodynamic assessment
    Martin Braun
    Department of Internal Medicine and Cardiology, Medical Clinic, University of Technology Dresden, Germany
    Int J Cardiol 132:248-56. 2009
  8. doi request reprint Cardioprotection by postconditioning is lost in WOKW rats with metabolic syndrome: role of glycogen synthase kinase 3beta
    Claudia Wagner
    University of Technology Dresden, Department of Medicine, Cardiology, and Intensive Care, Germany
    J Cardiovasc Pharmacol 52:430-7. 2008
  9. ncbi request reprint Transregulation of the alpha2-adrenergic signal transduction pathway by chronic beta-blockade: a novel mechanism for decreased platelet aggregation in patients
    Carsten Schwencke
    Medical Clinic II, Department of Cardiology, University of Technology Dresden, Dresden, Germany
    J Cardiovasc Pharmacol 45:253-9. 2005
  10. ncbi request reprint Ischemic preconditioning promotes a transient, but not sustained translocation of protein kinase C and sensitization of adenylyl cyclase
    Gregor Simonis
    Dept of Cardiology, Dresden University of Technology, Fetscherstr 76, 01307 Dresden, Germany
    Basic Res Cardiol 98:104-13. 2003

Collaborators

  • Stefan A Lange
  • Joerg T Fuhrmann
  • G Simonis
  • Ruth H Strasser
  • Bernd Ebner
  • Claudia Wagner
  • Carsten Schwencke
  • Annette Ebner
  • Antje Hönisch
  • Martin Braun
  • Thomas Eckert
  • Rüdiger C Braun-Dullaeus
  • Carsten Wunderlich
  • Anna Reetz
  • Clementine Wischniowski
  • Antje Schauer
  • Stefanie Böhme
  • Diana Tillack
  • Norman Theuring
  • Mathias Borst
  • Steffen Schön
  • Markus Knapp
  • Frank Edelmann
  • Ingrid Kloeting
  • Ruediger C Braun-Dullaeus
  • Alexander Schmeisser
  • Rainer Marquetant

Detail Information

Publications12

  1. ncbi request reprint Remote preconditioning by infrarenal occlusion of the aorta protects the heart from infarction: a newly identified non-neuronal but PKC-dependent pathway
    Christof Weinbrenner
    Department of Cardiology, Medical Clinic II, University of Technology, P O Box 95, Fetscherstr 76, D 01307 Dresden, Germany
    Cardiovasc Res 55:590-601. 2002
    ..Furthermore, the signal transduction pathways of classical and remote preconditioning regarding protein kinase C, which is one of the key enzymes in classical preconditioning, were compared...
  2. ncbi request reprint Remote preconditioning by infrarenal aortic occlusion is operative via delta1-opioid receptors and free radicals in vivo in the rat heart
    Christof Weinbrenner
    Department of Cardiology, Medical Clinic II, University of Technology Dresden, PO Box 95, Fetscherstr 76 D 01307 Dresden, Germany
    Cardiovasc Res 61:591-9. 2004
    ....
  3. doi request reprint Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction
    Bernd Ebner
    Department of Medicine Cardiology, Heart Center Dresden, University Hospital, University of Technology Dresden, Dresden, Germany
    Mol Cell Biochem 373:115-23. 2013
    ....
  4. doi request reprint Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition
    Antje Hönisch
    Department of Medicine and Cardiology, Heart Center Dresden University Hospital, University of Technology Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Basic Res Cardiol 105:155-67. 2010
    ..Whether the reduction of mortality in cardiogenic shock by levosimendan may in part be based on this postconditioning effect remains to be elucidated in clinical setting...
  5. doi request reprint Pharmacological postconditioning by bolus injection of phosphodiesterase-5 inhibitors vardenafil and sildenafil
    Bernd Ebner
    Department of Medicine Cardiology, Heart Center Dresden, University Hospital, University of Technology Dresden, Dresden, Germany
    Mol Cell Biochem 379:43-9. 2013
    ....
  6. doi request reprint Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3beta, and apoptosis
    Claudia Wagner
    Department of Medicine and Cardiology, Heart Center Dresden University Hospital, University of Technology Dresden, P O Box 95, Fetscherstr 76, Dresden 01307, Germany
    Mol Cell Biochem 339:135-47. 2010
    ..The role of apoptosis and/or autophagy in post-conditioning has to be further elucidated to find therapeutic targets to protect the heart from the consequences of acute myocardial infarction...
  7. doi request reprint The calcium channel blocker felodipine attenuates the positive hemodynamic effects of the beta-blocker metoprolol in severe dilated cardiomyopathy--a prospective, randomized, double-blind and placebo-controlled study with invasive hemodynamic assessment
    Martin Braun
    Department of Internal Medicine and Cardiology, Medical Clinic, University of Technology Dresden, Germany
    Int J Cardiol 132:248-56. 2009
    ..The role of calcium antagonists in CHF however remains controversial. To evaluate if a combination therapy of metoprolol and felodipine might improve hemodynamic parameters, a randomized and placebo-controlled study was designed...
  8. doi request reprint Cardioprotection by postconditioning is lost in WOKW rats with metabolic syndrome: role of glycogen synthase kinase 3beta
    Claudia Wagner
    University of Technology Dresden, Department of Medicine, Cardiology, and Intensive Care, Germany
    J Cardiovasc Pharmacol 52:430-7. 2008
    ..Metabolic disorders undermine the protection of preconditioning. The present study tested whether postconditioning protects hearts from rats with established metabolic syndrome [Wistar-Ottawa-Karlsburg W rats (WOKW)]...
  9. ncbi request reprint Transregulation of the alpha2-adrenergic signal transduction pathway by chronic beta-blockade: a novel mechanism for decreased platelet aggregation in patients
    Carsten Schwencke
    Medical Clinic II, Department of Cardiology, University of Technology Dresden, Dresden, Germany
    J Cardiovasc Pharmacol 45:253-9. 2005
    ..The functional transregulation of alpha2-adrenergic receptors by chronic beta-blockade in platelets and the consequent impairment of platelet activation may contribute to the therapeutic success of beta-blocker therapy...
  10. ncbi request reprint Ischemic preconditioning promotes a transient, but not sustained translocation of protein kinase C and sensitization of adenylyl cyclase
    Gregor Simonis
    Dept of Cardiology, Dresden University of Technology, Fetscherstr 76, 01307 Dresden, Germany
    Basic Res Cardiol 98:104-13. 2003
    ..The goal of this study was, therefore, to determine the activation of those signaling molecules after 1 - 3 cycles of myocardial ischemia and reperfusion...
  11. doi request reprint Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction
    Joerg T Fuhrmann
    Department of Internal Medicine and Cardiology, Heart Center Dresden University Hospital, University of Technology, Dresden, Germany
    Crit Care Med 36:2257-66. 2008
    ....
  12. ncbi request reprint Chronic angiotensin II receptor blockade induces cardioprotection during ischemia by increased PKC-epsilon expression in the mouse heart
    Stefan A Lange
    Department of Internal Medicine and Cardiology, Dresden University of Technology, Dresden, Germany
    J Cardiovasc Pharmacol 49:46-55. 2007
    ..To address one of the most important signal molecules in iPC, the PKC system was investigated in an ischemia/reperfusion model using isolated mouse hearts...