Cora Weigert

Summary

Country: Germany

Publications

  1. ncbi PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38
    Anita M Hennige
    Department of Internal Medicine IV, University of Tubingen, Otfried Mueller Strasse 10, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 290:85-90. 2002
  2. ncbi Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Germany
    J Biol Chem 281:7060-7. 2006
  3. ncbi Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen 72076, Germany
    J Biol Chem 279:23942-52. 2004
  4. pmc Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:1757-65. 2009
  5. ncbi Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt
    Cora Weigert
    Dept of Internal Medicine, Div of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, Univ of Tübingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Am J Physiol Endocrinol Metab 289:E251-7. 2005
  6. doi Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity
    Andreas Peter
    Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
    Am J Physiol Endocrinol Metab 295:E339-49. 2008
  7. ncbi Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes
    Karsten Müssig
    Division of Endocrinology, Metabolism and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Biochem Biophys Res Commun 335:819-25. 2005
  8. ncbi Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms
    Cora Weigert
    Dept of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, Univ of Tuebingen, Otfried Mueller Straaae 10, D 72076 Tuebingen, Germany
    Am J Physiol Cell Physiol 293:C1139-47. 2007
  9. pmc Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 8:e61903. 2013
  10. doi Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture
    Tina Sartorius
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tuebingen, Otfried Mueller Straße 10, D 72076 Tuebingen, Germany
    FASEB J 26:1799-809. 2012

Collaborators

Detail Information

Publications39

  1. ncbi PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38
    Anita M Hennige
    Department of Internal Medicine IV, University of Tubingen, Otfried Mueller Strasse 10, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 290:85-90. 2002
    ..Our data suggest that PKC zeta is involved in basal as well as IGF-1-dependent mitogenesis in RIN 1046-38 cells, while none of the PKC isoforms tested seem to be related to glucose-stimulated insulin release...
  2. ncbi Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Germany
    J Biol Chem 281:7060-7. 2006
    ..Thus, the data provided evidence for a possible molecular mechanism of the physiological metabolic effects of IL-6 in skeletal muscle, thereby exerting short term beneficial effects on insulin action...
  3. ncbi Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen 72076, Germany
    J Biol Chem 279:23942-52. 2004
    ..We conclude that IL-6 expression may be modulated by the composition of circulating FFA, e.g. by diet, and that skeletal muscle cells could be target cells for IL-6...
  4. pmc Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:1757-65. 2009
    ..Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate...
  5. ncbi Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt
    Cora Weigert
    Dept of Internal Medicine, Div of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, Univ of Tübingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Am J Physiol Endocrinol Metab 289:E251-7. 2005
    ..Together, our data demonstrate a novel insulin-sensitizing function of IL-6 on glycogen synthesis in skeletal muscle cells and indicate that IL-6 exerts cell/tissue-specific effects on insulin action...
  6. doi Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity
    Andreas Peter
    Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
    Am J Physiol Endocrinol Metab 295:E339-49. 2008
    ..These findings add a novel aspect to the atheroprotective actions of LXR activators in cardiovascular disease...
  7. ncbi Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes
    Karsten Müssig
    Division of Endocrinology, Metabolism and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
    Biochem Biophys Res Commun 335:819-25. 2005
    ....
  8. ncbi Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms
    Cora Weigert
    Dept of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, Univ of Tuebingen, Otfried Mueller Straaae 10, D 72076 Tuebingen, Germany
    Am J Physiol Cell Physiol 293:C1139-47. 2007
    ..The data suggest that IL-6 could act as autocrine factor upregulating its mRNA levels, thereby supporting its function as an exercise-activated factor in skeletal muscle cells...
  9. pmc Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    PLoS ONE 8:e61903. 2013
    ....
  10. doi Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture
    Tina Sartorius
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tuebingen, Otfried Mueller Straße 10, D 72076 Tuebingen, Germany
    FASEB J 26:1799-809. 2012
    ..Together, our data suggest that the lack of functional TLR2/4 protects mice from a fat-mediated impairment in insulin action, brain activity, locomotion, and sleep architecture by an IL-6/osteopontin-dependent mechanism...
  11. ncbi Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha
    Albrecht Pfäfflin
    Department of Internal Medicine, Division of Endocrinology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 18:199-210. 2006
    ..In conclusion our results link increased GLUT1 levels leading to excess glucose metabolism under normoglycemic conditions and altered gene expression of pathogenetic factors involved in diabetic kidney disease...
  12. ncbi Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
    Klaus Moeschel
    Department of Internal Medicine IV, Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University Hospital Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 279:25157-63. 2004
    ..These results, generated in BHK(IR) cells, suggest that phosphorylation of Ser(318) by PKC-zeta might contribute to the inhibitory effect of prolonged hyperinsulinemia on IRS-1 function...
  13. ncbi Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: up-regulation of USF activity by the hexosamine biosynthetic pathway
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 279:15908-15. 2004
    ..Thus, we have provided evidence for a new molecular mechanism linking high glucose-enhanced HBP activity with increased nuclear USF protein levels and DNA binding activity and with up-regulated TGF-beta1 promoter activity...
  14. pmc Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia
    Stefan Z Lutz
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 60:1566-76. 2011
    ..However, the impact of a dysfunction of this pathway for glucose metabolism in vivo is unknown...
  15. doi Development and precise characterization of phospho-site-specific antibody of Ser(357) of IRS-1: elimination of cross reactivity with adjacent Ser(358)
    Rizwana Sanaullah Waraich
    Department of Internal Medicine IV, Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University Hospital Tuebingen, Germany
    Biochem Biophys Res Commun 376:26-31. 2008
    ..This antibody can be effectively used to further clarify the inhibitory role of Ser(357) in insulin signal transduction...
  16. ncbi The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 90:1639-43. 2005
    ..In conclusion, we identified two polymorphisms in the 5'-flanking region of GFAT, of which the -913 SNP seems to alter the risk for obesity and IMCL accumulation in male subjects...
  17. pmc Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity
    Tina Sartorius
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, Member of the German Center for Diabetes Research DZD, University of Tuebingen, Germany German Center for Diabetes Research DZD, Tuebingen, Germany Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen IDM, Tuebingen, Germany
    PLoS ONE 9:e92358. 2014
    ..This work intends to elucidate the impact of cinnamon effects on the brain by using isolated astrocytes, and an obese and diabetic mouse model...
  18. ncbi Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobio Chemistry, University of Tubingen, Germany
    Diabetes 52:527-35. 2003
    ..Our data indicate that increased glucose uptake and metabolism induce PKC-dependent AP-1 activation that is sufficient for enhanced fibronectin production, but not for increased TGF-beta1 expression...
  19. ncbi Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Diabetes 52:650-6. 2003
    ..No correlation was found between the palmitate-induced increase in GFAT protein and the insulin resistance in the respective subjects. The findings reveal a new mechanism for how FFAs induce the activation of the HBP...
  20. ncbi c-Fos-driven transcriptional activation of transforming growth factor beta-1: inhibition of high glucose-induced promoter activity by thiazolidinediones
    Cora Weigert
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 304:301-7. 2003
    ....
  21. doi Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors
    Magnus Wolf
    Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry, and Clinical Chemistry, Department of Internal Medicine, University Tübingen, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 98:E1137-42. 2013
    ..It is unknown whether the production of acylcarnitines in primary human myotubes obtained from lean, metabolically healthy subjects reflects the fat oxidation in vivo...
  22. doi Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907
    Louise Fritsche
    Dept of Internal Medicine, Div of Pathobiochemistry and Clinical Chemistry, Univ of Tuebingen, Otfried Mueller Straße 10, 72076 Tuebingen, Germany
    Am J Physiol Endocrinol Metab 300:E824-36. 2011
    ....
  23. pmc Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation
    Rainer Lehmann
    Central Laboratory, Division of Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany
    PLoS ONE 5:e11519. 2010
    ..We aimed to identify and characterize metabolites, which are components of the regulatory network mediating the beneficial metabolic adaptation to exercise...
  24. ncbi Role of glucoxidation and lipid oxidation in the development of atherosclerosis
    Erwin Schleicher
    Department of Internal Medicine Endocrinology, Metabolism and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Ann N Y Acad Sci 1043:343-54. 2005
    ..Its formation via lipid oxidation may be involved in the development of atherosclerosis...
  25. ncbi The stress response of the liver to physical exercise
    Miriam Hoene
    Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tuebingen, Germany
    Exerc Immunol Rev 16:163-83. 2010
    ..These results give rise to the question whether these molecular events are linked not only to stress defense but to the metabolic adaptations of the liver to exercise...
  26. ncbi Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells
    Dorothea I Siegel-Axel
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    Diabetologia 57:1057-66. 2014
    ..The aim was to examine whether fetuin-A influences PVFC and vascular cell growth and the expression and secretion of proinflammatory and angiogenic proteins, and whether TLR4-independent pathways are involved...
  27. doi The secretome of the working human skeletal muscle-a promising opportunity to combat the metabolic disaster?
    Cora Weigert
    Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine, University of Tuebingen, Tuebingen, Germany Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum Muenchen, University of Tuebingen, Tuebingen, Germany German Center for Diabetes Research DZD, Neuherberg, Germany
    Proteomics Clin Appl 8:5-18. 2014
    ..The identification of these metabolites will lead to a more comprehensive view described by a new myo(metabo)kinome consisting of peptides, proteins, and metabolites. ..
  28. ncbi Insulin glulisine: insulin receptor signaling characteristics in vivo
    Anita M Hennige
    University of Tuebingen, Department of Internal Medicine IV, D 72076, Tuebingen, Germany
    Diabetes 54:361-6. 2005
    ..Moreover, insulin signaling in hypothalamic tissue determined by PI 3-kinase activity was comparable. Therefore, insulin glulisine may be a useful tool for diabetes treatment...
  29. ncbi The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal
    Cora Weigert
    Department of Internal Medicine IV, University Hospital Tuebingen, Germany
    J Biol Chem 280:37393-9. 2005
    ..We conclude that Ser(318) phosphorylation of IRS-1 is an early physiological event in insulin-stimulated signal transduction, which attenuates the continuing action of insulin...
  30. ncbi Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1
    Anita M Hennige
    University of Tuebingen, Department of Internal Medicine IV, Tuebingen D 72076, Germany
    FASEB J 20:1206-8. 2006
    ..In summary, these data suggest that phosphorylation of Ser-318 in Irs1 mediates the inhibitory signal of leptin on the insulin-signaling cascade in obese subjects...
  31. ncbi Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
    Cora Weigert
    J Appl Physiol 102:820-1; author reply 825. 2007
  32. doi Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells
    Rizwana Sanaullah Waraich
    Division of Clinical Chemistry and Pathobiochemistry, University of Tuebingen, Tuebingen, Germany
    J Biol Chem 283:11226-33. 2008
    ..Together, these data suggest that phosphorylation of Ser(357) mediates at least in part the adverse effects of PKC-delta activation on insulin action...
  33. ncbi Sense or antisense? False priming reverse transcription controls are required for determining sequence orientation by reverse transcription-PCR
    Thomas Beiter
    Medical Clinic, Department of Sports Medicine, University of Tubingen, D 72076 Tubingen, Germany
    Anal Biochem 369:258-61. 2007
  34. ncbi Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription
    Perikles Simon
    Medical Clinic, Department of Sports Medicine, University of Tuebingen, Tuebingen Germany
    Cell Physiol Biochem 20:715-28. 2007
    ..In conclusion, the present observations disclose the transcription of three distinct SGK1 splice variants, which are all markedly upregulated in tumor tissue but differentially upregulated following differentiation or hypoxia...
  35. ncbi The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals
    Kilian Rittig
    Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    Atherosclerosis 198:338-46. 2008
    ..This might be due to reduced subendothelial inflammation, mediated by reduced transendothelial monocyte-migration ability...
  36. ncbi Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines
    Beatrice E Bachmeier
    Department Clinical Chemistry and Clinical Biochemistry, Hospital of Surgery, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Exp Cell Res 305:83-98. 2005
    ..Our data provide clear evidence that cell density regulates major MMPs and TIMPs which are controlled by AP-1 activity so that ultimately a major regulation pathway for the control of the invasive potential of tumor cells is presented...
  37. ncbi Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1
    Karl S Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Kidney Int 64:1338-47. 2003
    ..To explore the interplay of cytosolic pH and glycolysis, rat mesangial cells transfected with the glucose transporter GLUT1 (GLUT1 cells) were compared with those transfected with beta-galactosidase (LacZ cells)...
  38. ncbi Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis
    Simone Waerntges
    Department for Physiology, University of Tuebingen, Germany
    Cell Physiol Biochem 12:135-42. 2002
    ..In conclusion, in lung fibrosis, the serine/threonine kinase hSGK1 is upregulated, an effect at least partially accounted for by TGFbeta1. The full effect of TGFbeta1 requires the activation of p38 kinase...
  39. ncbi How insulin receptor substrate proteins regulate the metabolic capacity of the liver--implications for health and disease
    Louise Fritsche
    Department of Internal Medicine 4, Division of Clinical Chemistry and Pathobiochemistry, Central Laboratory, University Hospital Tuebingen, Tuebingen, Germany
    Curr Med Chem 15:1316-29. 2008
    ....