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Genomes and Genes | Cora WeigertSummaryCountry: Germany Publications
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Publications
PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38Anita M Hennige
Department of Internal Medicine IV, University of Tubingen, Otfried Mueller Strasse 10, D 72076 Tubingen, Germany
Biochem Biophys Res Commun 290:85-90. 2002..Our data suggest that PKC zeta is involved in basal as well as IGF-1-dependent mitogenesis in RIN 1046-38 cells, while none of the PKC isoforms tested seem to be related to glucose-stimulated insulin release...- Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cellsCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Germany
J Biol Chem 281:7060-7. 2006..Thus, the data provided evidence for a possible molecular mechanism of the physiological metabolic effects of IL-6 in skeletal muscle, thereby exerting short term beneficial effects on insulin action... - Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaBCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen 72076, Germany
J Biol Chem 279:23942-52. 2004..We conclude that IL-6 expression may be modulated by the composition of circulating FFA, e.g. by diet, and that skeletal muscle cells could be target cells for IL-6... 
Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivoAndreas Peter
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 58:1757-65. 2009..Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence insulin sensitivity and the cellular response to palmitate...- Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of AktCora Weigert
Dept. of Internal Medicine, Div. of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, , , , Germany
Am J Physiol Endocrinol Metab 289:E251-7. 2005..Together, our data demonstrate a novel insulin-sensitizing function of IL-6 on glycogen synthesis in skeletal muscle cells and indicate that IL-6 exerts cell/tissue-specific effects on insulin action... 
Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicityAndreas Peter
Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
Am J Physiol Endocrinol Metab 295:E339-49. 2008..These findings add a novel aspect to the atheroprotective actions of LXR activators in cardiovascular disease...- Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubesKarsten Müssig
Division of Endocrinology, Metabolism and Pathobiochemistry, Department of Internal Medicine, University Hospital of Tubingen, 72076 Tubingen, Germany
Biochem Biophys Res Commun 335:819-25. 2005.... - Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanismsCora Weigert
Dept of Internal Medicine, Division of Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, Univ of Tuebingen, Otfried Mueller Straaae 10, D 72076 Tuebingen, Germany
Am J Physiol Cell Physiol 293:C1139-47. 2007..The data suggest that IL-6 could act as autocrine factor upregulating its mRNA levels, thereby supporting its function as an exercise-activated factor in skeletal muscle cells... - Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architectureTina Sartorius
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tuebingen, Otfried Mueller Straße 10, D 72076 Tuebingen, Germany
FASEB J 26:1799-809. 2012..Together, our data suggest that the lack of functional TLR2/4 protects mice from a fat-mediated impairment in insulin action, brain activity, locomotion, and sleep architecture by an IL-6/osteopontin-dependent mechanism... - Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alphaAlbrecht Pfäfflin
Department of Internal Medicine, Division of Endocrinology, University of Tubingen, Tubingen, Germany
Cell Physiol Biochem 18:199-210. 2006..In conclusion our results link increased GLUT1 levels leading to excess glucose metabolism under normoglycemic conditions and altered gene expression of pathogenetic factors involved in diabetic kidney disease... - Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1Klaus Moeschel
Department of Internal Medicine IV, Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University Hospital Tubingen, D 72076 Tubingen, Germany
J Biol Chem 279:25157-63. 2004..These results, generated in BHK(IR) cells, suggest that phosphorylation of Ser(318) by PKC-zeta might contribute to the inhibitory effect of prolonged hyperinsulinemia on IRS-1 function... - Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemiaStefan Z Lutz
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 60:1566-76. 2011..However, the impact of a dysfunction of this pathway for glucose metabolism in vivo is unknown... - Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: up-regulation of USF activity by the hexosamine biosynthetic pathwayCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, D 72076 Tubingen, Germany
J Biol Chem 279:15908-15. 2004..Thus, we have provided evidence for a new molecular mechanism linking high glucose-enhanced HBP activity with increased nuclear USF protein levels and DNA binding activity and with up-regulated TGF-beta1 promoter activity... - Development and precise characterization of phospho-site-specific antibody of Ser(357) of IRS-1: elimination of cross reactivity with adjacent Ser(358)Rizwana Sanaullah Waraich
Department of Internal Medicine IV, Endocrinology, Metabolism, Pathobiochemistry and Clinical Chemistry, University Hospital Tuebingen, Germany
Biochem Biophys Res Commun 376:26-31. 2008..This antibody can be effectively used to further clarify the inhibitory role of Ser(357) in insulin signal transduction... - The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjectsCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
J Clin Endocrinol Metab 90:1639-43. 2005..In conclusion, we identified two polymorphisms in the 5'-flanking region of GFAT, of which the -913 SNP seems to alter the risk for obesity and IMCL accumulation in male subjects... - c-Fos-driven transcriptional activation of transforming growth factor beta-1: inhibition of high glucose-induced promoter activity by thiazolidinedionesCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, , , , Germany
Biochem Biophys Res Commun 304:301-7. 2003.... - Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferaseCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, , , , Germany
Diabetes 52:650-6. 2003..No correlation was found between the palmitate-induced increase in GFAT protein and the insulin resistance in the respective subjects. The findings reveal a new mechanism for how FFAs induce the activation of the HBP... - Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transportersCora Weigert
Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobio-Chemistry, , Germany
Diabetes 52:527-35. 2003..Our data indicate that increased glucose uptake and metabolism induce PKC-dependent AP-1 activation that is sufficient for enhanced fibronectin production, but not for increased TGF-beta1 expression... - Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907Louise Fritsche
Dept of Internal Medicine, Div of Pathobiochemistry and Clinical Chemistry, Univ of Tuebingen, Otfried Mueller Straße 10, 72076 Tuebingen, Germany
Am J Physiol Endocrinol Metab 300:E824-36. 2011.... - Role of glucoxidation and lipid oxidation in the development of atherosclerosisErwin Schleicher
Department of Internal Medicine Endocrinology, Metabolism and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
Ann N Y Acad Sci 1043:343-54. 2005..Its formation via lipid oxidation may be involved in the development of atherosclerosis... - Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidationRainer Lehmann
Central Laboratory, Division of Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany
PLoS ONE 5:e11519. 2010..We aimed to identify and characterize metabolites, which are components of the regulatory network mediating the beneficial metabolic adaptation to exercise... - The stress response of the liver to physical exerciseMiriam Hoene
Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tuebingen, Germany
Exerc Immunol Rev 16:163-83. 2010..These results give rise to the question whether these molecular events are linked not only to stress defense but to the metabolic adaptations of the liver to exercise... - Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cellsRizwana Sanaullah Waraich
Division of Clinical Chemistry and Pathobiochemistry, University of Tuebingen, Tuebingen, Germany
J Biol Chem 283:11226-33. 2008..Together, these data suggest that phosphorylation of Ser(357) mediates at least in part the adverse effects of PKC-delta activation on insulin action... - Insulin glulisine: insulin receptor signaling characteristics in vivoAnita M Hennige
University of Tuebingen, Department of Internal Medicine IV, D-72076, Tuebingen, Germany
Diabetes 54:361-6. 2005..Moreover, insulin signaling in hypothalamic tissue determined by PI 3-kinase activity was comparable. Therefore, insulin glulisine may be a useful tool for diabetes treatment... - The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signalCora Weigert
Department of Internal Medicine IV, University Hospital Tuebingen, Germany
J Biol Chem 280:37393-9. 2005..We conclude that Ser(318) phosphorylation of IRS-1 is an early physiological event in insulin-stimulated signal transduction, which attenuates the continuing action of insulin... - Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1Anita M Hennige
University of Tuebingen, Department of Internal Medicine IV, Tuebingen D-72076, Germany
FASEB J 20:1206-8. 2006..In summary, these data suggest that phosphorylation of Ser-318 in Irs1 mediates the inhibitory signal of leptin on the insulin-signaling cascade in obese subjects... - Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasisCora Weigert
J Appl Physiol 102:820-1; author reply 825. 2007 - How insulin receptor substrate proteins regulate the metabolic capacity of the liver--implications for health and diseaseLouise Fritsche
Department of Internal Medicine 4, Division of Clinical Chemistry and Pathobiochemistry, Central Laboratory, University Hospital Tuebingen, Tuebingen, Germany
Curr Med Chem 15:1316-29. 2008.... - Sense or antisense? False priming reverse transcription controls are required for determining sequence orientation by reverse transcription-PCRThomas Beiter
Medical Clinic, Department of Sports Medicine, University of Tubingen, D 72076 Tubingen, Germany
Anal Biochem 369:258-61. 2007 - Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell linesBeatrice E Bachmeier
Department Clinical Chemistry and Clinical Biochemistry, Hospital of Surgery, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
Exp Cell Res 305:83-98. 2005..Our data provide clear evidence that cell density regulates major MMPs and TIMPs which are controlled by AP-1 activity so that ultimately a major regulation pathway for the control of the invasive potential of tumor cells is presented... - The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individualsKilian Rittig
Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Germany
Atherosclerosis 198:338-46. 2008..This might be due to reduced subendothelial inflammation, mediated by reduced transendothelial monocyte-migration ability... - Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1Karl S Lang
Department of Physiology, University of Tubingen, Tubingen, Germany
Kidney Int 64:1338-47. 2003..To explore the interplay of cytosolic pH and glycolysis, rat mesangial cells transfected with the glucose transporter GLUT1 (GLUT1 cells) were compared with those transfected with beta-galactosidase (LacZ cells)... - Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosisSimone Waerntges
Department for Physiology, University of Tuebingen, Germany
Cell Physiol Biochem 12:135-42. 2002..In conclusion, in lung fibrosis, the serine/threonine kinase hSGK1 is upregulated, an effect at least partially accounted for by TGFbeta1. The full effect of TGFbeta1 requires the activation of p38 kinase... - Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcriptionPerikles Simon
Medical Clinic, Department of Sports Medicine, University of Tuebingen, Tuebingen Germany
Cell Physiol Biochem 20:715-28. 2007..In conclusion, the present observations disclose the transcription of three distinct SGK1 splice variants, which are all markedly upregulated in tumor tissue but differentially upregulated following differentiation or hypoxia...