Sieker J, Kunz M, WeiÃŸenberger M, Gilbert F, Frey S, Rudert M, et al
. Direct bone morphogenetic protein 2 and Indian hedgehog gene transfer for articular cartilage repair using bone marrow coagulates. Osteoarthritis Cartilage. 2015;23:433-42 pubmed publisher
..Therefore IHH protein can be considered as an attractive alternative candidate growth factor for further preclinical research and development towards improved treatments for articular cartilage defects. ..
Steinert A, Weissenberger M, Kunz M, Gilbert F, Ghivizzani S, Göbel S, et al
. Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells. Arthritis Res Ther. 2012;14:R168 pubmed publisher
..As this study provides evidence for chondrogenic induction of MSC aggregates in vitro via IHH gene delivery, this technology may be efficiently employed for generating cartilaginous repair tissues in vivo. ..