F Wehner


Country: Germany


  1. Wehner F, Tinel H. Role of Na+ conductance, Na(+)-H+ exchange, and Na(+)-K(+)-2Cl- symport in the regulatory volume increase of rat hepatocytes. J Physiol. 1998;506 ( Pt 1):127-42 pubmed
    ..6. The prominent role of Na+ conductance in the RVI of rat hepatocytes could be confirmed on the basis of the pharmacological profile of this process, which was characterized by means of confocal laser-scanning microscopy. ..
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    Wehner F, Lawonn P, Tinel H. Ionic mechanisms of regulatory volume increase (RVI) in the human hepatoma cell-line HepG2. Pflugers Arch. 2002;443:779-90 pubmed
    ..In contrast, there is little if any contribution of K(+) conductance, Na(+)/H(+) antiport, Na(+)-K(+)-2Cl(-) symport, and Na(+)/K(+)-ATPase to this process. ..
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    Wehner F, Tinel H. Osmolyte and Na+ transport balances of rat hepatocytes as a function of hypertonic stress. Pflugers Arch. 2000;441:12-24 pubmed
    ..The set-point for the activation of RVI clearly lies below 327 mosmol/l. Na+/H+ antiport is the most sensitive Na+ importer involved in RVI, whereas Na+ conductance plays the prominent role from 360 mosmol/l upwards. ..
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    Wehner F, Shimizu T, Sabirov R, Okada Y. Hypertonic activation of a non-selective cation conductance in HeLa cells and its contribution to cell volume regulation. FEBS Lett. 2003;551:20-4 pubmed
    ..Whereas a significant contribution of Na(+)/H(+) antiport was also detectable, Na(+)-K(+)-2Cl(-) symport most likely did not contribute to RVI. ..
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    Wehner F, Tinel H. Uptake of bromosulfophthalein via SO2-4/OH- exchange increases the K+ conductance of rat hepatocytes. Am J Physiol. 1999;276:G1380-90 pubmed
    ..It is concluded that K+ channel activation by BSP (as well as by DIDS and indocyanine green) may reflect a physiological mechanism linking the sinusoidal uptake of certain anions to their electrogenic canalicular secretion. ..