T Wedel

Summary

Country: Germany

Publications

  1. ncbi request reprint Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon
    Thilo Wedel
    Department of Anatomy, Medical Universitiy of Luebeck, Luebeck, Germany
    Gastroenterology 123:1459-67. 2002
  2. ncbi request reprint Mitochondrial myopathy (complex I deficiency) associated with chronic intestinal pseudo-obstruction
    T Wedel
    Department of Anatomy, University of Lubeck, Lubeck, Germany
    Eur J Pediatr Surg 13:201-5. 2003
  3. doi request reprint Diverticular disease is associated with an enteric neuropathy as revealed by morphometric analysis
    T Wedel
    Department of Anatomy, Christian Albrechts University of Kiel, Kiel, Germany
    Neurogastroenterol Motil 22:407-14, e93-4. 2010
  4. ncbi request reprint Oligoneuronal hypoganglionosis in patients with idiopathic slow-transit constipation
    T Wedel
    Department of Anatomy, Medical University of Lubeck, Germany
    Dis Colon Rectum 45:54-62. 2002
  5. ncbi request reprint Topical treatment of ocular surface defects: comparison of the epitheliotrophic capacity of fresh frozen plasma and serum on corneal epithelial cells in an in vitro cell culture model
    D Hartwig
    Institute of Immunology and Transfusion Medicine, University of Lubeck, Lubeck, Germany
    Transfus Med 15:107-13. 2005
  6. doi request reprint Cell-free supernatants of Escherichia coli Nissle 1917 modulate human colonic motility: evidence from an in vitro organ bath study
    F Bar
    Department of Anatomy, University of Luebeck, Luebeck, Germany
    Neurogastroenterol Motil 21:559-66, e16-7. 2009
  7. pmc Expression of estrogen receptors in the hypothalamo-pituitary-ovarian axis in middle-aged rats after re-instatement of estrus cyclicity
    M Bottner
    Department of Anatomy, University of Kiel, Otto Hahn Platz 8, Kiel, Germany
    Biogerontology 11:75-85. 2010
  8. ncbi request reprint Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders
    T Wedel
    Department of Anatomy, University of Luebeck, Luebeck, Germany
    Neurogastroenterol Motil 18:526-38. 2006
  9. ncbi request reprint Epitheliotrophic capacity of a growth factor preparation produced from platelet concentrates on corneal epithelial cells: a potential agent for the treatment of ocular surface defects?
    Dirk Hartwig
    Institute of Immunology and Transfusion Medicine, Department of Ophthalmology, Institute of Anatomy, University of Luebeck, Luebeck, Germany
    Transfusion 44:1724-31. 2004
  10. doi request reprint Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca
    Hans Christian Jacobsen
    Department of Maxillofacial Surgery, University of Luebeck, Germany
    J Craniomaxillofac Surg 36:227-33. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon
    Thilo Wedel
    Department of Anatomy, Medical Universitiy of Luebeck, Luebeck, Germany
    Gastroenterology 123:1459-67. 2002
    ..This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 severe human colorectal motility disorders...
  2. ncbi request reprint Mitochondrial myopathy (complex I deficiency) associated with chronic intestinal pseudo-obstruction
    T Wedel
    Department of Anatomy, University of Lubeck, Lubeck, Germany
    Eur J Pediatr Surg 13:201-5. 2003
    ..Therefore, a mitochondrial myopathy associated with CIP requires a subtle assessment of both the intestinal smooth muscle and the enteric nervous system to identify the underlying pathology...
  3. doi request reprint Diverticular disease is associated with an enteric neuropathy as revealed by morphometric analysis
    T Wedel
    Department of Anatomy, Christian Albrechts University of Kiel, Kiel, Germany
    Neurogastroenterol Motil 22:407-14, e93-4. 2010
    ..Although the enteric nervous system (ENS) is the key-regulator of intestinal motility, data on neuropathological alterations are limited. The study aimed to investigate the ENS by a systematic morphometric analysis...
  4. ncbi request reprint Oligoneuronal hypoganglionosis in patients with idiopathic slow-transit constipation
    T Wedel
    Department of Anatomy, Medical University of Lubeck, Germany
    Dis Colon Rectum 45:54-62. 2002
    ....
  5. ncbi request reprint Topical treatment of ocular surface defects: comparison of the epitheliotrophic capacity of fresh frozen plasma and serum on corneal epithelial cells in an in vitro cell culture model
    D Hartwig
    Institute of Immunology and Transfusion Medicine, University of Lubeck, Lubeck, Germany
    Transfus Med 15:107-13. 2005
    ..Blood clotting strongly influences the growth factor pattern. The superior epitheliotrophic capacity of serum might be due to the higher concentration of proliferation mediators such as EGF and PDGF and its higher content of vitamin A...
  6. doi request reprint Cell-free supernatants of Escherichia coli Nissle 1917 modulate human colonic motility: evidence from an in vitro organ bath study
    F Bar
    Department of Anatomy, University of Luebeck, Luebeck, Germany
    Neurogastroenterol Motil 21:559-66, e16-7. 2009
    ..The data provide a rationale for therapeutical application of probiotics in gastrointestinal motility disorders...
  7. pmc Expression of estrogen receptors in the hypothalamo-pituitary-ovarian axis in middle-aged rats after re-instatement of estrus cyclicity
    M Bottner
    Department of Anatomy, University of Kiel, Otto Hahn Platz 8, Kiel, Germany
    Biogerontology 11:75-85. 2010
    ..This treatment leads to the occurrence of preovulatory LH, FSH and prolactin surges which are accompanied by differential modulation of ERs in the hypothalamus, the pituitary and the ovary...
  8. ncbi request reprint Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders
    T Wedel
    Department of Anatomy, University of Luebeck, Luebeck, Germany
    Neurogastroenterol Motil 18:526-38. 2006
    ....
  9. ncbi request reprint Epitheliotrophic capacity of a growth factor preparation produced from platelet concentrates on corneal epithelial cells: a potential agent for the treatment of ocular surface defects?
    Dirk Hartwig
    Institute of Immunology and Transfusion Medicine, Department of Ophthalmology, Institute of Anatomy, University of Luebeck, Luebeck, Germany
    Transfusion 44:1724-31. 2004
    ..Platelets (PLTs) are rich in growth factors and easily available as PLT concentrates (PCs) from blood banks. Therefore, growth factor preparations from PCs may serve as a new and superior therapeutic agent for such defects...
  10. doi request reprint Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca
    Hans Christian Jacobsen
    Department of Maxillofacial Surgery, University of Luebeck, Germany
    J Craniomaxillofac Surg 36:227-33. 2008
    ..The aim of this study was to assess the long-term results of autologous submandibular gland transfer for surgical correction of severe keratoconjunctivitis sicca...
  11. ncbi request reprint Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model
    Julia Beutel
    Department of Ophthalmology, University Hospital Schleswig Holstein, Luebeck, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1347-55. 2007
    ..To evaluate the radioprotective effect of lidocaine, amifostine and pilocarpine on lacrimal glands...
  12. ncbi request reprint Corneal epitheliotrophic capacity of three different blood-derived preparations
    Lei Liu
    Department of Ophthalmology, University of Lubeck, Germany
    Invest Ophthalmol Vis Sci 47:2438-44. 2006
    ..To test whether FFP or platelet-derived growth factor solutions could be used for ocular surface diseases, we compared the epitheliotrophic capacity of platelet releasate and FFP with that of serum in cell culture models...
  13. ncbi request reprint The role of myoepithelial cells in the short-term radiogenic impairment of salivary glands. An immunohistochemical, ultrastructural and scintigraphic study
    Samer G Hakim
    Department of Maxillofacial Surgery, Medical University of Luebeck, Germany
    Anticancer Res 22:4121-8. 2002
    ..The aim of this study was to evaluate the early dose-related functional impairment of salivary glands after radiation, using sialoscintigraphy, immunohistochemistry and electron microscopy in an established rabbit experimental model...
  14. pmc Early and late immunohistochemical and ultrastructural changes associated with functional impairment of the lachrymal gland following external beam radiation
    Samer G Hakim
    Department of Maxillofacial Surgery, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Exp Pathol 87:65-71. 2006
    ..These changes may represent objective surrogate parameters for radiogenic dysfunction and prerequisites for further investigations on radioprotection of lachrymal glands during radiotherapy of the periorbital region...
  15. ncbi request reprint A comparative study on the protection profile of lidocaine, amifostine, and pilocarpin on the parotid gland during radiotherapy
    Samer G Hakim
    Department of Maxillofacial Surgery, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer Res 65:10486-93. 2005
    ..Associated immunohistochemical and ultrastructural findings could prove the prevailed protection profile of lidocaine. This may provide a prophylactic approach in the field of radioprotection of salivary glands...
  16. ncbi request reprint Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model
    Martina Kohl
    Department of Pediatrics, University Hospital, Luebeck, Germany
    J Pediatr Gastroenterol Nutr 44:237-44. 2007
    ..High doses of intravenous lipids may be involved in the pathogenesis of hepatobiliary dysfunction. The purpose of this study was to determine whether the use of 2 newly developed lipid emulsions could reduce liver damage...
  17. ncbi request reprint Intestinal gas retention in patients with idiopathic slow-transit constipation
    Ana Cristina Hernando-Harder
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3, D 68167, Mannheim, Germany
    Dig Dis Sci 52:2667-75. 2007
    ..In STC, disturbances of intestinal gas dynamics include basal intestinal gas retention, and this is virtually not affected by acute hyperglycemia or duodenal lipids...
  18. ncbi request reprint Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice
    Petra Niessen
    Department of Genetics and Cell Biology, Cardiovascular Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Gastroenterology 129:1592-601. 2005
    ..A smoothelin-deficient mouse model may help to establish the role of smoothelin-A in intestinal contraction and provide a model for myogenic chronic intestinal pseudo-obstruction...
  19. ncbi request reprint Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures
    Charli Kruse
    Fraunhofer lnstitute of Biomedical Engineering, Group of Cell Differentiation and Cell Technology at the University of Lübeck, MFC Innovationscampus 1, Maria Goeppert Strasse 1, D 23538 Lubeck, Germany
    Ann Anat 188:503-17. 2006
    ..These results suggest that exocrine glands, such as pancreas may be a potential source of adult stem/progenitor cells, suitable for cell therapy of degenerative diseases...