Christoph Wanner

Summary

Country: Germany

Publications

  1. pmc Fibrosis: a key feature of Fabry disease with potential therapeutic implications
    Frank Weidemann
    Department of Medicine, Divisions of Cardiology and Nephrology, The Comprehensive Heart Failure Center at the University of Würzburg
    Orphanet J Rare Dis 8:116. 2013
  2. pmc Minimizing risk of nephrogenic systemic fibrosis in cardiovascular magnetic resonance
    Theresa Reiter
    Department of Internal Medicine I, Division of Cardiology, University Hospital Wuerzburg, Wuerzburg, Germany
    J Cardiovasc Magn Reson 14:31. 2012
  3. pmc Impaired small fiber conduction in patients with Fabry disease: a neurophysiological case-control study
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
    BMC Neurol 13:47. 2013
  4. pmc Study design of DIACORE (DIAbetes COhoRtE) - a cohort study of patients with diabetes mellitus type 2
    Lena Dörhöfer
    Department of Internal Medicine II, Nephrology, University Hospital Regensburg, Franz Josef Straus Allee 11, 93042, Regensburg, Germany
    BMC Med Genet 14:25. 2013
  5. pmc Understanding competing risks: a simulation point of view
    Arthur Allignol
    Freiburg Center for Data Analysis and Modeling, University of Freiburg, Germany
    BMC Med Res Methodol 11:86. 2011
  6. pmc Prognostic indicators of renal disease progression in adults with Fabry disease: natural history data from the Fabry Registry
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Clin J Am Soc Nephrol 5:2220-8. 2010
  7. ncbi request reprint Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
  8. doi request reprint Recent advances in the treatment of atherogenic dyslipidemia in type 2 diabetes mellitus
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 34:209-17. 2011
  9. ncbi request reprint Lipid metabolism in chronic kidney disease: the role of statins in cardiovascular risk
    Christoph Wanner
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    J Ren Nutr 17:75-8. 2007
  10. doi request reprint Statins, inflammation and kidney disease
    Vera Krane
    Department of Medicine 1, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Nat Rev Nephrol 7:385-97. 2011

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. pmc Fibrosis: a key feature of Fabry disease with potential therapeutic implications
    Frank Weidemann
    Department of Medicine, Divisions of Cardiology and Nephrology, The Comprehensive Heart Failure Center at the University of Würzburg
    Orphanet J Rare Dis 8:116. 2013
    ....
  2. pmc Minimizing risk of nephrogenic systemic fibrosis in cardiovascular magnetic resonance
    Theresa Reiter
    Department of Internal Medicine I, Division of Cardiology, University Hospital Wuerzburg, Wuerzburg, Germany
    J Cardiovasc Magn Reson 14:31. 2012
    ....
  3. pmc Impaired small fiber conduction in patients with Fabry disease: a neurophysiological case-control study
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
    BMC Neurol 13:47. 2013
    ..Fabry disease is an inborn lysosomal storage disorder which is associated with small fiber neuropathy. We set out to investigate small fiber conduction in Fabry patients using pain-related evoked potentials (PREP)...
  4. pmc Study design of DIACORE (DIAbetes COhoRtE) - a cohort study of patients with diabetes mellitus type 2
    Lena Dörhöfer
    Department of Internal Medicine II, Nephrology, University Hospital Regensburg, Franz Josef Straus Allee 11, 93042, Regensburg, Germany
    BMC Med Genet 14:25. 2013
    ..We have thus initiated the DIAbetes COhoRtE study (DIACORE)...
  5. pmc Understanding competing risks: a simulation point of view
    Arthur Allignol
    Freiburg Center for Data Analysis and Modeling, University of Freiburg, Germany
    BMC Med Res Methodol 11:86. 2011
    ..A key feature of competing risks is that there are as many hazards as there are competing risks. This is not always well accounted for in the applied literature...
  6. pmc Prognostic indicators of renal disease progression in adults with Fabry disease: natural history data from the Fabry Registry
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Clin J Am Soc Nephrol 5:2220-8. 2010
    ..These analyses were designed to characterize renal disease progression in untreated adults with Fabry disease...
  7. ncbi request reprint Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  8. doi request reprint Recent advances in the treatment of atherogenic dyslipidemia in type 2 diabetes mellitus
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 34:209-17. 2011
    ..73 m(2) and with residual atherogenic dyslipidemia. The link between dyslipidemia treatment and diabetic retinopathy, nephropathy and neuropathy is an emerging new field and microvascular complications are targets for new treatments...
  9. ncbi request reprint Lipid metabolism in chronic kidney disease: the role of statins in cardiovascular risk
    Christoph Wanner
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    J Ren Nutr 17:75-8. 2007
    ..This review will focus on dyslipidemia in renal failure and its treatment. The data published so far is summarized and grouped according to the different stages of CKD...
  10. doi request reprint Statins, inflammation and kidney disease
    Vera Krane
    Department of Medicine 1, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Nat Rev Nephrol 7:385-97. 2011
    ....
  11. doi request reprint C-reactive protein and uremia
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wuerzburg, Wurzburg, Germany
    Semin Dial 22:438-41. 2009
    ..So far, no specific pharmacologic treatment, including atorvastatin, has been identified that can substantially reduce CRP and accompanying inflammation...
  12. ncbi request reprint Randomized controlled trial on the efficacy and safety of atorvastatin in patients with type 2 diabetes on hemodialysis (4D study): demographic and baseline characteristics
    Christoph Wanner
    Division of Nephrology, University Clinic, Wurzburg, Germany
    Kidney Blood Press Res 27:259-66. 2004
    ..The results of the study will provide important information on the efficacy and safety of atorvastatin to support its use in patients with an impaired renal function who are at a high risk of vascular morbidity and mortality...
  13. ncbi request reprint On statin treatment to prevent sepsis in dialysis patients
    Christoph Wanner
    University Hospital Wurzburg, Wurzburg, Germany
    Am J Kidney Dis 50:700-2. 2007
  14. ncbi request reprint Non-high-density lipoprotein cholesterol: a target of lipid-lowering in dialysis patients
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Germany
    Am J Kidney Dis 41:S72-5. 2003
    ..Measurement of atherogenic lipoproteins (remnant lipoprotein particles [RLPs], particularly intermediate-density lipoprotein [IDL]), is not routinely performed at the present time...
  15. doi request reprint Wasting and sudden cardiac death in hemodialysis patients: a post hoc analysis of 4D (Die Deutsche Diabetes Dialyse Studie)
    Christiane Drechsler
    Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Germany
    Am J Kidney Dis 58:599-607. 2011
    ..This study examined the effects of wasting on the various components of cardiovascular outcome and deaths caused by infection in hemodialysis patients...
  16. doi request reprint Differences in Fabry cardiomyopathy between female and male patients: consequences for diagnostic assessment
    Markus Niemann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    JACC Cardiovasc Imaging 4:592-601. 2011
    ..We hypothesized that Fabry cardiomyopathy in female patients might differ substantially from that in male patients and sought to prove this hypothesis in a large cohort consisting of 104 patients with Fabry disease...
  17. pmc Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes
    Vera Krane
    University Hospital Wurzburg, Department of Internal Medicine I, Division of Nephrology, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    Clin J Am Soc Nephrol 5:874-81. 2010
    ..Hemodialysis patients with type 2 diabetes exhibit an excessive cardiovascular risk and regularly receive heparin. We tested whether antibodies to the platelet factor 4-heparin complex (PF4-H-AB) contribute to outcome...
  18. doi request reprint Department-related tasks and organ-targeted therapy in Fabry disease: an interdisciplinary challenge
    Frank Weidemann
    Department of Medicine, Würzburg University Medical Center, Wurzburg, Wurzburg, Germany
    Am J Med 123:658.e1-658.e10. 2010
    ....
  19. doi request reprint Two-dimensional speckle tracking as a non-invasive tool for identification of myocardial fibrosis in Fabry disease
    Johannes Krämer
    Department of Medicine, Department of Cardiology, University of Wurzburg, Oberdürrbacherstrasse 6, Wurzburg, Germany
    Eur Heart J 34:1587-96. 2013
    ..Myocardial fibrosis is common in Fabry cardiomyopathy and is associated with disease progression and severe prognosis...
  20. ncbi request reprint L-Arginine does not affect renal morphology and cell survival in ischemic acute renal failure in rats
    Ulrike Raff
    Division of Nephrology, Department of Medicine, Julius Maximilian University, Wurzburg, Germany
    Nephron Physiol 101:p39-50. 2005
    ..L-Arginine (L-Arg), a substrate of nitric oxide synthases, improves renal function in ischemic acute renal failure (iARF). We evaluated whether L-Arg improves renal morphology and cell survival in the course of iARF...
  21. doi request reprint The right ventricle in Fabry disease: natural history and impact of enzyme replacement therapy
    Markus Niemann
    Medizinische Klinik und Poliklinik I, Zentrum fur Innere Medizin, Oberdurrbacher Strasse 6, Wurzburg, Germany
    Heart 96:1915-9. 2010
    ..Storage of globotriaosylceramides is present in the left and right ventricles of patients with Fabry disease. Improvement of left ventricular morphology and function during enzyme replacement therapy (ERT) has previously been reported...
  22. pmc Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis
    Vera Krane
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Clinic, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Clin J Am Soc Nephrol 4:394-400. 2009
    ..However, respective systematic evaluations are absent. Thus, the authors investigated whether routine ECG findings add prognostic information to standard risk assessment in hemodialysis...
  23. doi request reprint Association of LDL cholesterol and inflammation with cardiovascular events and mortality in hemodialysis patients with type 2 diabetes mellitus
    Vera Krane
    Department of Medicine I, Division of Nephrology, University of Wurzburg, Germany
    Am J Kidney Dis 54:902-11. 2009
    ..In hemodialysis patients, the additive value is unknown. The association between LDL cholesterol level and outcome previously was suggested to be inverse and confounded by inflammation...
  24. doi request reprint Effect of atorvastatin on inflammation and outcome in patients with type 2 diabetes mellitus on hemodialysis
    Vera Krane
    Division of Nephrology, University Clinic, Wurzburg, Germany
    Kidney Int 74:1461-7. 2008
    ....
  25. doi request reprint Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors
    Gülmisal Güder
    Medizinische Klinik und Poliklinik I, University Hospital Wurzburg, Wurzburg, Germany
    Circ Heart Fail 2:563-71. 2009
    ..We estimated the prognostic role of these risk factors in unselected patients with heart failure...
  26. doi request reprint Endogenous erythropoietin and the association with inflammation and mortality in diabetic chronic kidney disease
    Martin Wagner
    Department of Medicine I, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    Clin J Am Soc Nephrol 6:1573-9. 2011
    ..In this cohort study, we aimed to identify factors associated with endogenous EPO levels and investigate their relation to all-cause mortality...
  27. doi request reprint Monomeric C-reactive protein decreases acetylated LDL uptake in human endothelial cells
    Susanne B Schwedler
    Department of Medicine I, University of Wurzburg, Wurzburg, Germany
    Clin Chem 55:1728-31. 2009
    ..Here, we tested the impact of mCRP and nCRP on the uptake of acetylated LDL (acLDL), which is internalized by receptors similar to those of oxLDL in human endothelial cells...
  28. ncbi request reprint Ischemic acute renal failure in the rat: effects of L-arginine and superoxide dismutase on renal function
    Lothar Schramm
    Division of Nephrology, Department of Medicine, Julius Maximilians University, Wurzburg, Germany
    J Nephrol 21:229-35. 2008
    ..Thus, it is of interest to elucidate whether the potential beneficial effects of L-Arg in reperfusion can be augmented by additional treatment with superoxide dismutase (SOD)...
  29. doi request reprint Bisphenol A in chronic kidney disease
    Detlef H Krieter
    Department of Medicine, Division of Nephrology, University of Wurzburg, Oberdurrbacher Strasse 6, Wurzburg, Germany
    Artif Organs 37:283-90. 2013
    ..Due to high protein binding, the removal of BPA by hemodialysis is limited...
  30. doi request reprint Interdisciplinary approach towards female patients with Fabry disease
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Eur J Clin Invest 42:455-62. 2012
    ..Fabry disease (FD) is a rare X-linked lysosomal storage disorder leading to an accumulation of globotriaosylceramides in the lysosomes of various organs...
  31. ncbi request reprint Dialyzer membrane characteristics and outcome of patients with type 2 diabetes on maintenance hemodialysis
    Vera Krane
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Hospital Wurzburg
    Am J Kidney Dis 49:267-75. 2007
    ..Effects of dialyzer membrane characteristics on morbidity and mortality are highly controversial...
  32. doi request reprint Apolipoprotein E genotype predicts cardiovascular endpoints in dialysis patients with type 2 diabetes mellitus
    Karl Winkler
    Division of Clinical Chemistry, Department of Medicine, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg, Germany
    Atherosclerosis 208:197-202. 2010
    ..Lipid metabolism is influenced by environmental and genetic factors. Among the latter, the apolipoprotein E (apoE) genotype is known to be associated with CVD risk and thus may affect cardiovascular outcome...
  33. doi request reprint Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration
    Detlef H Krieter
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Nephrol Dial Transplant 25:212-8. 2010
    ..In the present study, the impact of the albumin permeability of recently introduced advanced high-flux dialysis membranes on the removal of such substances was tested in haemodialysis and online post-dilution haemodiafiltration...
  34. doi request reprint Tei index in fabry disease
    Markus Niemann
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Am Soc Echocardiogr 24:1026-32. 2011
    ..The aim of this study was to investigate the diagnostic value of the Tei index, a marker for combined diastolic and systolic function, in patients with Fabry disease...
  35. doi request reprint Heart valve involvement in Fabry cardiomyopathy
    Frank Weidemann
    Department of Internal Medicine Centres of Rare Diseases and Cardiovascular Medicine, Wurzburg, Germany
    Ultrasound Med Biol 35:730-5. 2009
    ..Mild left ventricular valve regurgitations are frequent in Fabry disease. However, these valve abnormalities are not the major limitations for the Fabry heart...
  36. ncbi request reprint Effects of a polyelectrolyte additive on the selective dialysis membrane permeability for low-molecular-weight proteins
    Detlef H Krieter
    University Hospital Wurzburg, Division of Nephrology, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Nephrol Dial Transplant 22:491-9. 2007
    ..To approach this goal, a novel polyelectrolyte additive process was applied to a polyethersulphone (PES) membrane...
  37. pmc Aldosterone and cortisol affect the risk of sudden cardiac death in haemodialysis patients
    Christiane Drechsler
    Division of Nephrology, Department of Internal Medicine 1, University Hospital Wurzburg, University of Wurzburg, Oberdürrbacherstr 6, D 97080, Wurzburg, Germany
    Eur Heart J 34:578-87. 2013
    ..Sudden cardiac death is common and accounts largely for the excess mortality of patients on maintenance dialysis. It is unknown whether aldosterone and cortisol increase the incidence of sudden cardiac death in dialysis patients...
  38. doi request reprint [Females with Fabry's disease - an interdisciplinary diagnostic and therapeutic challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Wurzburg, Germany
    Med Klin (Munich) 105:627-34. 2010
    ..This synopsis wants to systematically review the typical organ involvement in female Fabry patients. Moreover, therapy recommendations especially for female patients are discussed...
  39. ncbi request reprint Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species
    Susanne B Schwedler
    Department of Medicine I, University Hospital Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Atherosclerosis 195:e76-84. 2007
    ..We evaluated the effects of two conformers of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) on vessel function and production of reactive oxygen species (ROS) in an in-vivo model of atherosclerosis...
  40. pmc Copeptin levels associate with cardiovascular events in patients with ESRD and type 2 diabetes mellitus
    Wiebke Fenske
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    J Am Soc Nephrol 22:782-90. 2011
    ..Whether vasopressin receptor antagonists will improve these outcomes requires further studies...
  41. pmc Change in N-terminal-pro-B-type-natriuretic-peptide and the risk of sudden death, stroke, myocardial infarction, and all-cause mortality in diabetic dialysis patients
    Karl Winkler
    Division of Clinical Chemistry, Department of Medicine, University Medical Center Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany
    Eur Heart J 29:2092-9. 2008
    ..This study examined the effect of baseline and change from baseline NT-pro-BNP on cardiovascular outcome and mortality in haemodialysis patients...
  42. pmc Homoarginine and progression of chronic kidney disease: results from the Mild to Moderate Kidney Disease Study
    Christiane Drechsler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 8:e63560. 2013
    ..We aimed to investigate the relation between homoarginine, kidney function and progression of chronic kidney disease (CKD)...
  43. pmc Predicting erythropoietin resistance in hemodialysis patients with type 2 diabetes
    Andreas Schneider
    Department of Medicine, Division of Nephrology, University Hospital Wuerzburg, Wuerzburg, Germany
    BMC Nephrol 14:67. 2013
    ..The aim of this study was to identify predictors for ESA resistance and to develop a prediction model for the risk stratification in these patients...
  44. ncbi request reprint The variation of morphological and functional cardiac manifestation in Fabry disease: potential implications for the time course of the disease
    Frank Weidemann
    Department of Internal Medicine I, Divisions of Cardiology and Nephrology, Medical University Clinic, University of Wurzburg, 97080 Wuerzburg, Germany
    Eur Heart J 26:1221-7. 2005
    ..The aim of this clinical cross-sectional study was to investigate the cardiac interrelation of morphological and functional abnormalities in patients with Fabry disease...
  45. pmc The effect of high-flux hemodialysis on hemoglobin concentrations in patients with CKD: results of the MINOXIS study
    Andreas Schneider
    Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Germany
    Clin J Am Soc Nephrol 7:52-9. 2012
    ..This study sought to determine whether high-flux dialysis would help improve markers of renal anemia, inflammation, and oxidative stress compared with low-flux dialysis...
  46. doi request reprint Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy
    Jan Galle
    Department of Internal Medicine, University Hospital, Wurzburg, Germany
    Nephrol Dial Transplant 23:3174-83. 2008
    ..Experimental evidence demonstrates that angiotensin receptor blockers (ARBs) possess anti-inflammatory potential, which might contribute to reducing proteinuria and providing renoprotection...
  47. ncbi request reprint Dyslipidemia, inflammation and dialysis outcomes: what we know now
    Vera Krane
    Department of Medicine, Division of Nephrology, University of Wurzburg, Germany
    Curr Opin Nephrol Hypertens 15:566-70. 2006
    ..The limited prognosis of patients with chronic kidney disease starts when renal function begins to decline...
  48. doi request reprint A new synthetic dialyzer with advanced permselectivity for enhanced low-molecular weight protein removal
    Detlef H Krieter
    University of Wurzburg, Department of Medicine, Division of Nephrology, Wurzburg, Germany
    Artif Organs 32:547-54. 2008
    ..This improved performance may be regarded as a contribution to optimal dialysis therapy...
  49. ncbi request reprint A new echocardiographic approach for the detection of non-ischaemic fibrosis in hypertrophic myocardium
    Frank Weidemann
    Department of Medicine I Center of Cardiovascular Medicine, Universitat Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    Eur Heart J 28:3020-6. 2007
    ..We investigated in a prospective study whether regional non-ischaemic fibrosis in hypertrophic myocardium can also be detected by ultrasonic strain-rate imaging based on specific visual features of the myocardial deformation traces...
  50. doi request reprint Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease
    Hector Tamez
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am Heart J 164:902-9.e2. 2012
    ..We assessed the effect of an activated vitamin D analog on left atrial volume index (LAVi) in a post hoc analysis of the PRIMO trial (clinicaltrials.gov: NCT00497146)...
  51. pmc The association between parathyroid hormone and mortality in dialysis patients is modified by wasting
    Christiane Drechsler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Germany
    Nephrol Dial Transplant 24:3151-7. 2009
    ..We hypothesized that wasting, a common condition potentially related to adynamic bone disease, modifies the association of PTH with mortality and cardiovascular events (CVE), respectively...
  52. doi request reprint Prominent papillary muscles in Fabry disease: a diagnostic marker?
    Markus Niemann
    Department of Internal Medicine I Center of Cardiovascular Disease, University of Wuerzburg, Germany
    Ultrasound Med Biol 37:37-43. 2011
    ..In conclusion, this study confirmed the assumption that the prominent papillary muscle could be an echocardiographic marker for detection of Fabry patients with concentric LV hypertrophy...
  53. pmc Homoarginine, heart failure, and sudden cardiac death in haemodialysis patients
    Christiane Drechsler
    Department of Internal Medicine 1, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Eur J Heart Fail 13:852-9. 2011
    ..Homoarginine deficiency may lead to decreased nitric oxide availability and endothelial dysfunction. Based on this rationale we assessed whether homoarginine deficiency is a risk factor for SCD in dialysis patients...
  54. doi request reprint Matching efficacy of online hemodiafiltration in simple hemodialysis mode
    Detlef H Krieter
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Artif Organs 32:903-9. 2008
    ..Therefore, HD with PES may have beneficial effects on the outcome of maintenance dialysis patients similar to high-efficiency HDF...
  55. doi request reprint Glycemic control and cardiovascular events in diabetic hemodialysis patients
    Christiane Drechsler
    Department of Medicine, Division of Nephrology, University Hospital, Oberdürrbacherstrasse 6, D 97080 Wurzburg, Germany
    Circulation 120:2421-8. 2009
    ..Poor glycemic control is associated with cardiovascular comorbidities in the general population. This study investigated the impact of glycemic control on cardiac and vascular outcomes in diabetic hemodialysis patients...
  56. ncbi request reprint L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats
    Reinhard Schneider
    Division of Nephrology, Department of Medicine, Julius Maximilians University, Wurzburg, Germany
    Kidney Int 64:216-25. 2003
    ..Here we further analyzed the impact of l-Arg on functional and biochemical parameters of nitric oxide signaling during the course of ischemic ARF...
  57. doi request reprint Cross-sectional baseline analysis of electrocardiography in a large cohort of patients with untreated Fabry disease
    Markus Niemann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    J Inherit Metab Dis 36:873-9. 2013
    ..However, the value of electrocardiography (ECG) in relation to these two techniques remains largely unknown...
  58. ncbi request reprint Hidden population substructures in an apparently homogeneous population bias association studies
    Mario Berger
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Eur J Hum Genet 14:236-44. 2006
    ..13-0.57), indicating a protective effect against the development of type 2 diabetes. Our study demonstrates that unconsidered population substructures (ethnicity-dependent factors) can severely bias association studies...
  59. ncbi request reprint At which stage of chronic kidney disease should dyslipidemia be treated?
    Vera Krane
    Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Nat Clin Pract Nephrol 2:176-7. 2006
  60. ncbi request reprint Effects of pravastatin treatment on blood pressure regulation after renal transplantation
    Kai Lopau
    Division of Nephrology, Department of Internal Medicine I, University Hospital Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 29:329-37. 2006
    ..We examined whether treatment with a statin interferes with blood pressure regulation and antihypertensive treatment after renal transplantation...
  61. ncbi request reprint Update on Fabry disease: kidney involvement, renal progression and enzyme replacement therapy
    Frank Breunig
    Division of Nephrology, Department of Medicine I, University Hospital, Wurzburg, Germany
    J Nephrol 21:32-7. 2008
    ..Subsequent follow-up assessments should be carried out in all patients on a regular basis to evaluate treatment outcomes...
  62. ncbi request reprint Progression of Fabry cardiomyopathy
    Jörg Strotmann
    University of Wurzburg, Medical Clinic and Policlinic I, Center of Cardiovascular Disease, Wurzburg, Germany
    Clin Ther 29:S13-4. 2007
  63. ncbi request reprint Effect of dialysis flux and membrane material on dyslipidaemia and inflammation in haemodialysis patients
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University Clinic of Würzburg, Germany
    Nephrol Dial Transplant 19:2570-5. 2004
    ..Dialysis modalities affect uraemic dyslipidaemia, possibly by modifying oxidative stress, but the effects of dialyser flux and membrane material on atherogenic remnant particles and oxidized low-density lipoproteins (LDL) are unknown...
  64. doi request reprint Endothelial progenitor cells in patients on extracorporeal maintenance dialysis therapy
    Detlef H Krieter
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Nephrol Dial Transplant 25:4023-31. 2010
    ..Chronic renal failure patients have a high cardiovascular disease burden, low numbers and impaired function of endothelial progenitor cells (EPCs). We hypothesized that enhanced uraemic toxin removal restores EPCs in haemodialysis patients...
  65. ncbi request reprint Impact of enzyme replacement therapy on cardiac morphology and function and late enhancement in Fabry's cardiomyopathy
    Meinrad Beer
    Institut für Röntgendiagnostik, Wurzburg, Germany
    Am J Cardiol 97:1515-8. 2006
    ..Late enhancement may predict the effect of enzyme replacement therapy on left ventricular mass and cardiac function...
  66. doi request reprint Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Am J Nephrol 33:139-49. 2011
    ..In chronic kidney disease (CKD), left ventricular hypertrophy (LVH) is prevalent and is associated with increased cardiovascular morbidity and mortality. Vitamin D receptor (VDR) activation attenuates LVH progression in animal models...
  67. doi request reprint The Fabry cardiomyopathy: models for the cardiologist
    Frank Weidemann
    Department of Medicine, Division of Cardiology, University Hospital, Wuerzburg, Germany
    Annu Rev Med 62:59-67. 2011
    ..As the models can be extrapolated to other diseases, they might contribute to more optimal clinical management of patients with other cardiac disorders...
  68. pmc Vitamin D deficiency is associated with sudden cardiac death, combined cardiovascular events, and mortality in haemodialysis patients
    Christiane Drechsler
    Department of Internal Medicine 1, Division of Nephrology, University of Wurzburg, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Eur Heart J 31:2253-61. 2010
    ..Accumulating evidence suggests a role of vitamin D for myocardial and overall health. This study investigated the impact of vitamin D status on cardiovascular outcomes and fatal infections in haemodialysis patients...
  69. doi request reprint Changes in adiponectin and the risk of sudden death, stroke, myocardial infarction, and mortality in hemodialysis patients
    Christiane Drechsler
    Division of Nephrology, Department of Medicine, University Hospital Wurzburg, Josef Schneider Strasse 2, Würzburg D 97080, Germany
    Kidney Int 76:567-75. 2009
    ..Most likely, this rise is a counter-regulatory response to worsening health in keeping with adiponectin's potential to counteract inflammation...
  70. ncbi request reprint C-reactive protein: a family of proteins to regulate cardiovascular function
    Susanne B Schwedler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Germany
    Am J Kidney Dis 47:212-22. 2006
    ....
  71. ncbi request reprint Inflammation in uremic patients: what is the link?
    Jan Galle
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 26:65-75. 2003
    ..Based on pathophysiological considerations valid for uremic patients, we discuss therapeutical options that might help to reduce cardiovascular disease in uremic patients...
  72. ncbi request reprint Transmission of oxLDL-derived lipid peroxide radicals into membranes of vascular cells is the main inducer of oxLDL-mediated oxidative stress
    Thomas E Hansen-Hagge
    Department of Medicine, Division of Nephrology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Atherosclerosis 197:602-11. 2008
    ..The novel data may help to design adequate therapeutic strategies against oxLDL-induced cardiovascular diseases...
  73. doi request reprint Lipid abnormalities and cardiovascular risk in renal disease
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 19:1065-70. 2008
    ..Admittedly, in the absence of definite evidence in dialysis patients, we still conclude that the administration of statins is appropriate in patients with manifest coronary disease...
  74. doi request reprint The challenge of sudden death in dialysis patients
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University of Heidelberg, Germany
    Clin J Am Soc Nephrol 3:920-9. 2008
  75. ncbi request reprint Down-regulation of MTUS1 in human colon tumors
    Christina Zuern
    Department of Medicine, Division of Nephrology, University Clinic of Wuerzburg, Wuerzburg, Germany
    Oncol Rep 23:183-9. 2010
    ..Since reduced expression of MTUS1 results in increased cellular proliferation, these data suggest that MTUS1 could be involved in the loss of proliferative control in human colon cancer...
  76. ncbi request reprint The metabolic burden of diabetes and dyslipidaemia in chronic kidney disease
    Vera Krane
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Nephrol Dial Transplant 17:23-7. 2002
    ..These changes result in a highly atherogenic environment, perpetuating the vicious cycle of accelerated atherogenesis. The terminal pathway is an elevation of C-reactive protein, a biomarker of both overall and cardiovascular outcome...
  77. doi request reprint Impact of mycophenolate mofetil on wound complications and lymphoceles after kidney transplantation
    Kai Lopau
    Department of Internal Medicine I, Division of Nephrology, University of Wuerzburg, Wuerzburg, Germany
    Kidney Blood Press Res 33:52-9. 2010
    ..Despite improved efficacy, modern immunosuppressive agents may show unanticipated side effects. In this study we investigated the possible interactions of mycophenolate mofetil (MMF) with wound healing and lymphocele formation...
  78. ncbi request reprint Fabry disease model: a rational approach to the management of Fabry disease
    Christoph Wanner
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Hospital Wurzburg, Wurzburg, Germany
    Clin Ther 29:S2-5. 2007
    ....
  79. ncbi request reprint Impact of oxidized low density lipoprotein on vascular cells
    Jan Galle
    Department of Medicine, Division of Nephrology, Julius Maximilians University, Wurzburg, Germany
    Atherosclerosis 185:219-26. 2006
    ..Thus, through a variety of mechanisms, OxLDL importantly contributes to vascular dysfunction and remodeling...
  80. ncbi request reprint Native C-reactive protein increases whereas modified C-reactive protein reduces atherosclerosis in apolipoprotein E-knockout mice
    Susanne B Schwedler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Circulation 112:1016-23. 2005
    ..We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model...
  81. ncbi request reprint C-reactive protein a marker for all-cause and cardiovascular mortality in haemodialysis patients
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University Clinic of Würzburg, Germany
    Nephrol Dial Transplant 17:29-32; discussion 39-40. 2002
    ..Recent data are in favour of a direct involvement in the pathogenesis of disease, since binding of CRP to degraded LDL enhances complement activation and induces the expression of tissue factor...
  82. doi request reprint [Division-related function and organ-related therapy in Fabry's disease. An interdisciplinary challenge]
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Med Klin (Munich) 104:10-9. 2009
    ....
  83. ncbi request reprint Advanced renal insufficiency in a 34-year-old man with Lowe syndrome
    Lothar Schramm
    Department of Medicine, Division of Nephrology, University Hospital, Wurzburg, Germany
    Am J Kidney Dis 43:538-43. 2004
    ..Clinical course, possible molecular consequences of this novel mutation, and correlation between genotype and phenotype are discussed...
  84. ncbi request reprint Enzyme replacement therapy in Fabry disease: clinical implications
    Frank Breunig
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Curr Opin Nephrol Hypertens 12:491-5. 2003
    ..In this review we would like to give a current overview on recent advances in therapy and an outlook on future aspects in the management of Fabry disease...
  85. pmc Predicting mortality in incident dialysis patients: an analysis of the United Kingdom Renal Registry
    Martin Wagner
    Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Am J Kidney Dis 57:894-902. 2011
    ..No prediction tool is used widely in current clinical practice. We aimed to predict long-term mortality in incident dialysis patients using easily obtainable variables...
  86. ncbi request reprint Umbilical angiectases as the sole clinical sign of Fabry disease in a 9-year-old boy
    Andreas O Eggert
    Department of Dermatology, Julius Maximilians University Würzburg, Josef Schneider Str 2, 97080, Wurzburg, Germany
    Eur J Pediatr 165:205-6. 2006
  87. ncbi request reprint Beta(2)-microglobulin removal by extracorporeal renal replacement therapies
    Detlef H Krieter
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Biochim Biophys Acta 1753:146-53. 2005
    ..Whether these innovative hemodiafiltration options will become accepted in clinical routine use needs to be proven in future...
  88. ncbi request reprint Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA
    Jan Galle
    Department of Medicine, Julius Maximilians Universitat, Wurzburg, Germany
    J Am Soc Nephrol 14:1471-9. 2003
    ..Lysophosphatidylcholine mimics the OxLDL effect, consistent with a causal role of this OxLDL compound. Stimulation of RhoA by OxLDL may contribute to vasospasm in atherosclerotic arteries...
  89. ncbi request reprint Identification of a new tumor suppressor gene located at chromosome 8p21.3-22
    Stefan Seibold
    Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Medical Faculty University of Cologne, Cologne, Germany
    FASEB J 17:1180-2. 2003
    ..In conclusion, we identified a tumor suppressor gene at chromosome 8p21.3-22, encoding a mitochondrial protein, controlling cellular proliferation...
  90. doi request reprint Implementation of an in vitro model system for investigation of reperfusion damage after renal ischemia
    Christoph Sauvant
    Physiologisches Institut, Bay Julius Maximilians Universitat Wurzburg, Germany
    Cell Physiol Biochem 24:567-76. 2009
    ..g. acidosis alone, hypoxia alone, aglycemia alone), in order to obtain more insight into the mechanistic events that lead to reperfusion damage in the kidney on the cellular level...
  91. ncbi request reprint Lipids in end-stage renal disease
    Christoph Wanner
    Department of Medicine, University of Wurzburg, Germany
    J Nephrol 15:202-4. 2002
  92. ncbi request reprint Uremia-specific alterations in lipid metabolism
    Christoph Wanner
    Department of Medicine, Division of Nephrology, University of Wurzburg, Germany
    Blood Purif 20:451-3. 2002
    ..Since it is also still unclear whether we have therapeutics available with a sufficient impact on LDL size, remnant lipoprotein lowering and restoration of HDL function, we urgently need specific intervention trials...
  93. ncbi request reprint Advanced glycation end products and mortality in hemodialysis patients
    Susanne B Schwedler
    Division of Nephrology, Department of Medicine, University of Würzburg Biocenter, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Kidney Int 62:301-10. 2002
    ..The net effects on markers of inflammation and acute phase proteins in vivo as well as their influence on survival in hemodialysis patients are unknown...
  94. doi request reprint Long-term effects of enzyme replacement therapy on fabry cardiomyopathy: evidence for a better outcome with early treatment
    Frank Weidemann
    Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Josef Schneider Str 2, Bau 4, 97080 Wurzburg, Germany
    Circulation 119:524-9. 2009
    ..Whether enzyme replacement therapy is effective in all stages of Fabry cardiomyopathy during long-term follow-up is unknown...
  95. ncbi request reprint Efficacy and safety of preemptive anti-CMV therapy with valganciclovir after kidney transplantation
    Kai Lopau
    Department of Internal Medicine I, Division of Nephrology, University Hospital Wuerzburg, Wuerzburg, Germany
    Clin Transplant 21:80-5. 2007
    ..The substance is approved in North America and Europe for anti-CMV prophylaxis after organ transplantation. In this pilot study, we examined if VGCV could also be administered in preemptive treatment of CMV infections...
  96. ncbi request reprint Improvement of cardiac function during enzyme replacement therapy in patients with Fabry disease: a prospective strain rate imaging study
    Frank Weidemann
    Department of Medicine, Division of Cardiology, University Hospital Wurzburg, Germany
    Circulation 108:1299-301. 2003
    ..Whether these results can be translated into an improvement of myocardial function has yet to be demonstrated...
  97. ncbi request reprint Diabetic nephropathy: an inherited disease or just a diabetic complication?
    Mario Berger
    Division of Nephrology, Department of Medicine, University Hospital, Wurzburg, Germany
    Kidney Blood Press Res 26:143-54. 2003
    ..Comparing the expression levels of thousands of genes in patients and controls may identify key players in the pathogenesis of diabetic nephropathy and targets for pharmacologic intervention in the future...
  98. ncbi request reprint L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation
    Lothar Schramm
    Department of Medicine, Division of Nephrology, Julius Maximilians University, Wurzburg, Germany
    Kidney Int 61:1423-32. 2002
    ..Thus, we investigated the effects of L-Arg supplementation immediately after kidney transplantation in 54 patients...
  99. ncbi request reprint The importance of diabetic nephropathy in current nephrological practice
    Francesco Locatelli
    Department of Nephrology and Dialysis, Azienda Ospedale di Lecco, Ospedale A Manzoni, Lecco, Italy
    Nephrol Dial Transplant 18:1716-25. 2003
    ..Diabetic nephropathy has become the major cause of end-stage renal disease (ESRD) in the western world and is forecast to become the most frequent cause of ESRD in the African continent and in developing countries in other areas...
  100. ncbi request reprint Vasopeptidase inhibition normalizes blood pressure and restores endothelial function in renovascular hypertension
    Thomas Quaschning
    Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
    Kidney Blood Press Res 29:351-9. 2006
    ..The present study investigated the effect of the vasopeptidase inhibitor AVE7688 in comparison to the ACE inhibitor ramipril on systolic blood pressure (SBP) and endothelial function in renovascular hypertension...
  101. ncbi request reprint Glucose degradation products in PD fluids: do they disappear from the peritoneal cavity and enter the systemic circulation?
    Martin Zeier
    Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany
    Kidney Int 63:298-305. 2003
    ..They are thought to adversely affect the peritoneal membrane. The fate of GDP within the peritoneal cavity has not been well characterized...