Tobias C Walther

Summary

Country: Germany

Publications

  1. ncbi request reprint RanGTP mediates nuclear pore complex assembly
    Tobias C Walther
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 424:689-94. 2003
  2. doi request reprint Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution
    Ivan Matic
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Proteome Res 7:4050-7. 2008
  3. pmc The life of lipid droplets
    Tobias C Walther
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Martinsried, Germany
    Biochim Biophys Acta 1791:459-66. 2009
  4. pmc Pkh-kinases control eisosome assembly and organization
    Tobias C Walther
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
    EMBO J 26:4946-55. 2007
  5. pmc Seg1 controls eisosome assembly and shape
    Karen E Moreira
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 198:405-20. 2012
  6. pmc A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling
    Florian Fröhlich
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 185:1227-42. 2009
  7. doi request reprint Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
    Lyris M F de Godoy
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Nature 455:1251-4. 2008
  8. pmc Pil1 controls eisosome biogenesis
    Karen E Moreira
    Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 20:809-18. 2009
  9. pmc Eisosome proteins assemble into a membrane scaffold
    Lena Karotki
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Biol 195:889-902. 2011
  10. doi request reprint Eisosome-driven plasma membrane organization is mediated by BAR domains
    Natasza E Ziółkowska
    Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, Martinsried, Germany
    Nat Struct Mol Biol 18:854-6. 2011

Collaborators

Detail Information

Publications24

  1. ncbi request reprint RanGTP mediates nuclear pore complex assembly
    Tobias C Walther
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 424:689-94. 2003
    ..The data demonstrate that RanGTP triggers distinct steps of NPC assembly, and suggest a mechanism for the spatial restriction of NPC assembly to the surface of chromatin...
  2. doi request reprint Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution
    Ivan Matic
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Proteome Res 7:4050-7. 2008
    ..Our finding that SUMO can be modified may point to an additional level of complexity through modifying a protein-modifier...
  3. pmc The life of lipid droplets
    Tobias C Walther
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Martinsried, Germany
    Biochim Biophys Acta 1791:459-66. 2009
    ..Here we examine what we know of the life of lipid droplets. We review emerging data concerning their cellular biology and present our thoughts on some of the most salient questions for investigation...
  4. pmc Pkh-kinases control eisosome assembly and organization
    Tobias C Walther
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
    EMBO J 26:4946-55. 2007
    ..Taken together with our previous results that link eisosomes to endocytosis, these observations suggest that Pkh-kinase signaling relayed to Pil1 may help regulate endocytic events to modulate the organization of the plasma membrane...
  5. pmc Seg1 controls eisosome assembly and shape
    Karen E Moreira
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 198:405-20. 2012
    ..The function of Seg1 in the stepwise biogenesis of eisosomes reveals striking architectural similarities between eisosomes in yeast and caveolae in mammals...
  6. pmc A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling
    Florian Fröhlich
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 185:1227-42. 2009
    ..Furthermore, Nce102 inhibits Pkh kinase signaling and is required for plasma membrane organization. Therefore, Nce102 might act as a sensor of sphingolipids that regulates plasma membrane function...
  7. doi request reprint Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
    Lyris M F de Godoy
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Nature 455:1251-4. 2008
    ..Systems-wide, precise quantification directly at the protein level opens up new perspectives in post-genomics and systems biology...
  8. pmc Pil1 controls eisosome biogenesis
    Karen E Moreira
    Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 20:809-18. 2009
    ..Pil1 expression is regulated by the cell cycle, which synchronizes eisosome formation with plasma membrane growth. Our results establish a first framework of the molecular principles that define eisosome assembly and distribution...
  9. pmc Eisosome proteins assemble into a membrane scaffold
    Lena Karotki
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Biol 195:889-902. 2011
    ..Our data suggest that the mechanism of membrane organization by eisosomes is mediated by self-assembly of its core components into a membrane-bound protein scaffold with lipid-binding specificity...
  10. doi request reprint Eisosome-driven plasma membrane organization is mediated by BAR domains
    Natasza E Ziółkowska
    Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, Martinsried, Germany
    Nat Struct Mol Biol 18:854-6. 2011
    ..Our data reveal a previously unrecognized family of BAR-domain proteins involved in plasma membrane organization...
  11. ncbi request reprint Eisosomes mark static sites of endocytosis
    Tobias C Walther
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, 600 16th Street, San Francisco, California 94143 2200, USA
    Nature 439:998-1003. 2006
    ..Loss of Pil1 leads to clustering of eisosome remnants and redirects endocytosis and endocytic effector proteins to these clusters...
  12. pmc TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain
    Doris Berchtold
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried Munich, Germany
    Mol Biol Cell 20:1565-75. 2009
    ..From these data, we suggest that the TOR complexes are spatially separated to determine downstream signaling specificity and their responsiveness to different inputs...
  13. pmc Mass spectrometry-based proteomics in cell biology
    Tobias C Walther
    Organelle Architecture and Dynamics and 2 Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Biol 190:491-500. 2010
    ....
  14. doi request reprint Lysine acetylation targets protein complexes and co-regulates major cellular functions
    Chunaram Choudhary
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
    Science 325:834-40. 2009
    ..Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications...
  15. pmc Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating
    Pablo S Aguilar
    Departments of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:4170-5. 2010
    ..Thus, a two-atom change in the aliphatic moiety of ergosterol is sufficient to obstruct cell shape remodeling and cell fusion...
  16. doi request reprint Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
    Doris Berchtold
    Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, 82152 Martinsried, Germany
    Nat Cell Biol 14:542-7. 2012
    ..The components of this pathway and their involvement in signalling after membrane stretch are evolutionarily conserved...
  17. doi request reprint Organized living: formation mechanisms and functions of plasma membrane domains in yeast
    Natasza E Ziółkowska
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82158 Martinsried, Germany
    Trends Cell Biol 22:151-8. 2012
    ..We review the mechanisms generating plasma membrane domains and the functional consequences of this organization, focusing on recent findings from research on the yeast model system...
  18. doi request reprint Yeast expression proteomics by high-resolution mass spectrometry
    Tobias C Walther
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Martinsried, Germany
    Methods Enzymol 470:259-80. 2010
    ..Here, we provide background information on proteomics by mass-spectrometry and describe the practice of a comprehensive yeast proteome analysis...
  19. pmc Comparing cellular proteomes by mass spectrometry
    Florian Fröhlich
    Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried Munich, Germany
    Genome Biol 10:240. 2009
    ..Mass spectrometry and cryo-electron tomography together enable the determination of the absolute and relative abundances of proteins and their localization, laying the groundwork for comprehensive systems analyses of cells...
  20. pmc Cellular Fatty Acid metabolism and cancer
    Erin Currie
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Metab 18:153-61. 2013
    ..Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation. ..
  21. pmc Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)
    Andrew D Nguyen
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    J Biol Chem 288:8627-35. 2013
    ..We conclude that circulating progranulin exists as a dimer and is not likely a component of HDL...
  22. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
    ..In light of this newfound respect, we discuss emerging views on lipid droplet biology and speculate on the major advances to come...
  23. pmc Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    Yi Guo
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 453:657-61. 2008
    ..These phenotypes are conserved in mammalian cells, suggesting that insights from these studies are likely to be central to our understanding of human diseases involving excessive lipid storage...
  24. pmc The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA
    Cell Metab 15:570-3. 2012
    ..Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions...