Diego J Walther

Summary

Country: Germany

Publications

  1. ncbi 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors
    Diego J Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cancer 94:3135-40. 2002
  2. ncbi Synthesis of serotonin by a second tryptophan hydroxylase isoform
    Diego J Walther
    , , D-13092 Berlin-Buch, Germany
    Science 299:76. 2003
  3. ncbi Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension
    Ian Morecroft
    Division of Neuroscience and Biomedical Systems, Faculty of Biomedical and Life Sciences, Glasgow University, Glasgow, Scotland
    Hypertension 49:232-6. 2007
  4. ncbi Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
    Kathrin Scheuch
    Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
    Biol Psychiatry 62:1288-94. 2007
  5. ncbi Platelet-derived serotonin mediates liver regeneration
    Mickael Lesurtel
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Science 312:104-7. 2006
  6. ncbi Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
  7. ncbi Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release
    Diego J Walther
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Cell 115:851-62. 2003
  8. ncbi A unique central tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Biochem Pharmacol 66:1673-80. 2003
  9. ncbi Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
    Jens Uwe Peter
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Cell Biochem 295:205-15. 2007
  10. ncbi The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake
    Irene Brunk
    Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    J Biol Chem 281:33373-85. 2006

Collaborators

  • P Zill
  • Pierre Alain Clavien
  • Michael Bader
  • Jens Uwe Peter
  • Ian Morecroft
  • Kathrin Scheuch
  • Mickael Lesurtel
  • Nurgul Carkaci-Salli
  • Claudia Zahn
  • Irene Brunk
  • Manabu Matsuda
  • Andreas Heinz
  • Lynn Loughlin
  • Josef Priller
  • Maik Grohmann
  • Marion Lautenschlager
  • Margaret R MacLean
  • Natalia Alenina
  • Jens-Uwe Peter
  • Margaret Nilsen
  • Julia Kirchheiner
  • Yvonne Dempsie
  • Silke Stahlberg
  • Katarina Kotnik
  • Matthew K Martz
  • Boris Aleil
  • Gudrun Ahnert-Hilger
  • Wolfram Jochum
  • Yinghua Tian
  • Kent E Vrana
  • Markus Höltje
  • Sandra Winter
  • Lei Lu
  • Ugur Salli
  • John M Flanagan
  • Christian Gachet
  • Hans-Georg Joost
  • Christian Blex
  • Ingrid Pahner
  • Angela Hommel
  • Wanjin Hong
  • Sivaramakrishna Rachakonda
  • Rolf Graf
  • Hans Georg Joost
  • Simone Florian
  • Annette Schurmann
  • Jason P Bailey
  • Nelson D Horseman
  • Meenakshi Mistry
  • Archie J Vomachka
  • Kathryn M Nieport
  • Gary A Gudelsky
  • Tatsuhiko Imaoka
  • Zhaoyuan Hou

Detail Information

Publications12

  1. ncbi 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors
    Diego J Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cancer 94:3135-40. 2002
    ..Therefore, there is still a need for more specific and potent chemotherapeutic agents in the fight against serotonin-producing tumors...
  2. ncbi Synthesis of serotonin by a second tryptophan hydroxylase isoform
    Diego J Walther
    , , D-13092 Berlin-Buch, Germany
    Science 299:76. 2003
  3. ncbi Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension
    Ian Morecroft
    Division of Neuroscience and Biomedical Systems, Faculty of Biomedical and Life Sciences, Glasgow University, Glasgow, Scotland
    Hypertension 49:232-6. 2007
    ..In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy...
  4. ncbi Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
    Kathrin Scheuch
    Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
    Biol Psychiatry 62:1288-94. 2007
    ..Although dysfunction of 5-HT neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human TPH2 promoter has not been characterized in vitro...
  5. ncbi Platelet-derived serotonin mediates liver regeneration
    Mickael Lesurtel
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Science 312:104-7. 2006
    ..This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration...
  6. ncbi Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
    ..Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution...
  7. ncbi Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release
    Diego J Walther
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Cell 115:851-62. 2003
    ..Our data provides evidence for a receptor-independent signaling mechanism, termed herein as "serotonylation," which leads to alpha-granule exocytosis from platelets...
  8. ncbi A unique central tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Biochem Pharmacol 66:1673-80. 2003
    ..In fact, there are two serotonin systems in vertebrates, independently regulated and with distinct functions...
  9. ncbi Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
    Jens Uwe Peter
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Cell Biochem 295:205-15. 2007
    ..Therefore, this Tph1-specific miniribozyme may provide a novel and effective form of gene therapy that may be applicable to a variety of thrombotic diseases...
  10. ncbi The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake
    Irene Brunk
    Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    J Biol Chem 281:33373-85. 2006
    ..The first luminal loop of VMATs may represent a G-protein-coupled receptor that adapts vesicular filling...
  11. ncbi Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells
    Claudia Zahn
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Membr Biol 23:475-85. 2006
    ..These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi...
  12. ncbi Functional domains of human tryptophan hydroxylase 2 (hTPH2)
    Nurgul Carkaci-Salli
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033 2360, USA
    J Biol Chem 281:28105-12. 2006
    ..These data identify the NH(2)-terminal regulatory domain as the source of hTPH2 instability and reduced solubility...