Diego J Walther

Summary

Country: Germany

Publications

  1. ncbi 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors
    Diego J Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cancer 94:3135-40. 2002
  2. ncbi Synthesis of serotonin by a second tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Science 299:76. 2003
  3. ncbi A unique central tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Biochem Pharmacol 66:1673-80. 2003
  4. ncbi Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension
    Ian Morecroft
    Division of Neuroscience and Biomedical Systems, Faculty of Biomedical and Life Sciences, Glasgow University, Glasgow, Scotland
    Hypertension 49:232-6. 2007
  5. ncbi Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
    Kathrin Scheuch
    Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
    Biol Psychiatry 62:1288-94. 2007
  6. ncbi Platelet-derived serotonin mediates liver regeneration
    Mickael Lesurtel
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Science 312:104-7. 2006
  7. ncbi Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
  8. ncbi Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release
    Diego J Walther
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Cell 115:851-62. 2003
  9. ncbi Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
    Jens Uwe Peter
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Cell Biochem 295:205-15. 2007
  10. ncbi The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake
    Irene Brunk
    Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    J Biol Chem 281:33373-85. 2006

Collaborators

  • P Zill
  • Pierre Alain Clavien
  • Michael Bader
  • Ian Morecroft
  • Jens Uwe Peter
  • Kathrin Scheuch
  • Irene Brunk
  • Mickael Lesurtel
  • Claudia Zahn
  • Nurgul Carkaci-Salli
  • Manabu Matsuda
  • Julia Kirchheiner
  • Marion Lautenschlager
  • Yvonne Dempsie
  • Silke Stahlberg
  • Katarina Kotnik
  • Josef Priller
  • Margaret R MacLean
  • Andreas Heinz
  • Margaret Nilsen
  • Maik Grohmann
  • Lynn Loughlin
  • Natalia Alenina
  • Christian Blex
  • Boris Aleil
  • Matthew K Martz
  • Sandra Winter
  • Markus Höltje
  • Simone Florian
  • Gudrun Ahnert-Hilger
  • Kent E Vrana
  • Hans Georg Joost
  • Angela Hommel
  • Ugur Salli
  • Sivaramakrishna Rachakonda
  • Yinghua Tian
  • Rolf Graf
  • Lei Lu
  • Ingrid Pahner
  • Annette Schurmann
  • John M Flanagan
  • Wolfram Jochum
  • Christian Gachet
  • Wanjin Hong
  • Tatsuhiko Imaoka
  • Meenakshi Mistry
  • Gary A Gudelsky
  • Kathryn M Nieport
  • Archie J Vomachka
  • Zhaoyuan Hou
  • Nelson D Horseman
  • Jason P Bailey

Detail Information

Publications12

  1. ncbi 7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors
    Diego J Walther
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cancer 94:3135-40. 2002
    ..Therefore, there is still a need for more specific and potent chemotherapeutic agents in the fight against serotonin-producing tumors...
  2. ncbi Synthesis of serotonin by a second tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Science 299:76. 2003
  3. ncbi A unique central tryptophan hydroxylase isoform
    Diego J Walther
    Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, D 13092 Berlin Buch, Germany
    Biochem Pharmacol 66:1673-80. 2003
    ..In fact, there are two serotonin systems in vertebrates, independently regulated and with distinct functions...
  4. ncbi Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension
    Ian Morecroft
    Division of Neuroscience and Biomedical Systems, Faculty of Biomedical and Life Sciences, Glasgow University, Glasgow, Scotland
    Hypertension 49:232-6. 2007
    ..In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy...
  5. ncbi Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
    Kathrin Scheuch
    Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
    Biol Psychiatry 62:1288-94. 2007
    ..Although dysfunction of 5-HT neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human TPH2 promoter has not been characterized in vitro...
  6. ncbi Platelet-derived serotonin mediates liver regeneration
    Mickael Lesurtel
    Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland
    Science 312:104-7. 2006
    ..This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration...
  7. ncbi Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
    ..Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution...
  8. ncbi Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release
    Diego J Walther
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Cell 115:851-62. 2003
    ..Our data provides evidence for a receptor-independent signaling mechanism, termed herein as "serotonylation," which leads to alpha-granule exocytosis from platelets...
  9. ncbi Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
    Jens Uwe Peter
    Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195, Berlin, Germany
    Mol Cell Biochem 295:205-15. 2007
    ..Therefore, this Tph1-specific miniribozyme may provide a novel and effective form of gene therapy that may be applicable to a variety of thrombotic diseases...
  10. ncbi The first luminal domain of vesicular monoamine transporters mediates G-protein-dependent regulation of transmitter uptake
    Irene Brunk
    Functional Cell Biology, Centre for Anatomy, Charite Universitatsmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    J Biol Chem 281:33373-85. 2006
    ..The first luminal loop of VMATs may represent a G-protein-coupled receptor that adapts vesicular filling...
  11. ncbi Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells
    Claudia Zahn
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Membr Biol 23:475-85. 2006
    ..These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi...
  12. ncbi Functional domains of human tryptophan hydroxylase 2 (hTPH2)
    Nurgul Carkaci-Salli
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033 2360, USA
    J Biol Chem 281:28105-12. 2006
    ..These data identify the NH(2)-terminal regulatory domain as the source of hTPH2 instability and reduced solubility...