S Walitza

Summary

Country: Germany

Publications

  1. ncbi request reprint [Genetic findings in obsessive-compulsive disorder in childhood and adolescence and in adulthood]
    Susanne Walitza
    Klinik für Kinder und Jugendpsychiatrie und Psychotherapie der Universität Würzburg
    Z Kinder Jugendpsychiatr Psychother 36:45-52. 2008
  2. pmc Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?
    Veit Roessner
    Department of Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
    Behav Brain Funct 3:64. 2007
  3. ncbi request reprint Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm 111:817-25. 2004
  4. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder
    S Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 10:1126-32. 2005
  5. doi request reprint Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 115:1071-8. 2008
  6. doi request reprint Children and adolescents with obsessive-compulsive disorder and comorbid attention-deficit/hyperactivity disorder: preliminary results of a prospective follow-up study
    S Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 115:187-90. 2008
  7. doi request reprint Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12
    M Romanos
    ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 13:522-30. 2008
  8. doi request reprint Allelic variants of SNAP25 in a family-based sample of ADHD
    T J Renner
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 115:317-21. 2008
  9. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
  10. ncbi request reprint No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD
    B G Schimmelmann
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
    J Neural Transm 114:523-6. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint [Genetic findings in obsessive-compulsive disorder in childhood and adolescence and in adulthood]
    Susanne Walitza
    Klinik für Kinder und Jugendpsychiatrie und Psychotherapie der Universität Würzburg
    Z Kinder Jugendpsychiatr Psychother 36:45-52. 2008
    ..The phenotypic and genetic heterogeneity of OCD complicate the identification of specific genetic factors. Further studies have to be designed in consideration of subtypes, e.g. age at onset, symptom dimensions, or comorbid disorders...
  2. pmc Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?
    Veit Roessner
    Department of Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
    Behav Brain Funct 3:64. 2007
    ..abstract:..
  3. ncbi request reprint Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm 111:817-25. 2004
    ..We did not detect transmission disequilibrium of the investigated polymorphisms in OCD. Hence, these polymorphisms do not play a major role in the genetic predisposition to early onset OCD...
  4. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder
    S Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 10:1126-32. 2005
    ..064). Our results link potentially functional TPH2 variations to the pathophysiology of ADHD, and further support the relevance of 5-HT in disorders related to altered motor activity and cognitive processes...
  5. doi request reprint Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 115:1071-8. 2008
    ..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group...
  6. doi request reprint Children and adolescents with obsessive-compulsive disorder and comorbid attention-deficit/hyperactivity disorder: preliminary results of a prospective follow-up study
    S Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 115:187-90. 2008
    ..Both groups appear to develop different patterns of comorbid disorders...
  7. doi request reprint Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12
    M Romanos
    ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 13:522-30. 2008
    ..Our study provides further evidence for common gene effects throughout different populations despite the complex multifactorial etiology of ADHD...
  8. doi request reprint Allelic variants of SNAP25 in a family-based sample of ADHD
    T J Renner
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 115:317-21. 2008
    ..In our German ADHD sample no preferential transmission of either variant could be observed. Further investigation considering sub-sample analysis regarding response to D-amphetamine could enlight the role of SNAP25 in ADHD...
  9. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
    ..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p...
  10. ncbi request reprint No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD
    B G Schimmelmann
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
    J Neural Transm 114:523-6. 2007
    ..We did not find support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in our sample...
  11. doi request reprint Exploring the genetic link between RLS and ADHD
    B G Schimmelmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, LVR Klinikun Essen, Virchowstr 174, 45147 Essen, Germany
    J Psychiatr Res 43:941-5. 2009
    ..Genes relevant to RLS remain interesting candidates for ADHD; particularly BTBD9 needs further study, as it has been related to iron storage, a potential pathophysiological link between RLS and certain subtypes of ADHD...
  12. doi request reprint No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample
    T J Renner
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Germany
    Atten Defic Hyperact Disord 3:285-9. 2011
    ..5%, P = 0.55). We conclude that A-3081T is not a major risk variant in our ADHD sample, though SLC6A2 remains an interesting candidate gene in ADHD, especially for the inattentive subtype...
  13. ncbi request reprint Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
    J Neural Transm 114:513-21. 2007
    ..We cannot rule out the possibility that other variations in the investigated genes contribute to the etiology of ADHD...
  14. ncbi request reprint 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 7:1054-7. 2002
    ..05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD...
  15. ncbi request reprint Brief review of available evidence concerning the potential induction of genomic damage by methylphenidate
    H Stopper
    Department of Toxicology, University of Wuerzburg, Wuerzburg, Germany
    J Neural Transm 115:331-4. 2008
    ..In conclusion, changes in treatment strategies do not seem justified currently. Larger studies are under way and will hopefully eliminate any remaining doubt about potential genotoxic or carcinogenic consequences of MPH treatment...
  16. doi request reprint [Diagnosis of attention-deficit hyperactivity disorder in childhood and adolescence]
    M Romanos
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Klinische Forschergruppe ADHS KFO 125, Universitat Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg
    Nervenarzt 79:782-90. 2008
    ..Diagnosis of comorbid disorders is obligatory due to their high prevalence rates. In some cases successful treatment of a child suffering from ADHD requires the additional diagnosis and treatment of ADHD in further family members...
  17. ncbi request reprint [Obsessive-compulsive disorder in children and adolescents]
    Thomas Jans
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie des Universtätsklinikums Würzburg
    Prax Kinderpsychol Kinderpsychiatr 57:429-56. 2008
    ..This paper gives a review on juvenile obsessive-compulsive disorder and addresses issues of classification, epidemiology, symptoms, co-morbidity, diagnostics, aetiology, treatment strategies and the course of the disorder...
  18. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  19. doi request reprint Genotoxicity of the neurotransmitter dopamine in vitro
    Helga Stopper
    Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D 97078 Wuerzburg, Germany
    Toxicol In Vitro 23:640-6. 2009
    ....
  20. doi request reprint Reduced NoGo-anteriorisation during continuous performance test in deletion syndrome 22q11.2
    Marcel Romanos
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Fuechsleinstrasse 15, 97074 Wuerzburg, Germany
    J Psychiatr Res 44:768-74. 2010
    ..Despite recent reports of structural alterations of the ACC in DS22q11.2 our findings suggest that response-inhibition mediated by the ACC is not impaired in DS22q11.2...
  21. ncbi request reprint [Severe early-childhood obsessive-compulsive disorder--case report on a 4-year-old girl]
    Renner Tobias
    Klinik für Kinder und Jugendpsychiatrie und Psychotherapie der Universität Würzburg
    Z Kinder Jugendpsychiatr Psychother 34:287-93. 2006
    ..OCD is seldom diagnosed in children younger than six years of age. The present report deals with the diagnosis and therapy of OCD at a very early onset in childhood...
  22. ncbi request reprint Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007
    ..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center...
  23. doi request reprint Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
    ..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability...
  24. doi request reprint No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080 Wuerzburg, Germany
    Toxicol Lett 184:38-43. 2009
    ..Furthermore, micronuclei were analyzed in a second tissue, buccal mucosa...
  25. pmc Does methylphenidate cause a cytogenetic effect in children with attention deficit hyperactivity disorder?
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Environ Health Perspect 115:936-40. 2007
    ..Assessment and treatment of patients were performed during inpatient or outpatient health care. The measure for genomic damage was the frequency of micronuclei, a subset of chromosomal aberrations, in peripheral lymphocytes...
  26. ncbi request reprint Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 21:833-6. 2007
    ..51 (95% CI 0.36-0.65). This argues against an involvement of the 5-HT(3A) receptor in the polygenic aetiology of early-onset OCD...
  27. ncbi request reprint Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorder
    Rainald Mossner
    Int J Neuropsychopharmacol 8:133-6. 2005
  28. ncbi request reprint [Validation of the German version of the Australian Scale of Asperger's Syndrome (ASAS)]
    Siebke Melfsen
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie und Psychotherapie, Universitat Wurzburg
    Z Kinder Jugendpsychiatr Psychother 33:27-34. 2005
    ..The aim of the study was to validate the German version of the Australian Scale for Asperger's Syndrome (ASAS). Furthermore, the scoring of the ASAS as applied by the Australian authors was verified...
  29. ncbi request reprint The extent of social anxiety in combination with mental disorders
    Siebke Melfsen
    Dept of Psychiatry for Children and Adolescents, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Eur Child Adolesc Psychiatry 15:111-7. 2006
    ..In none of these disorders, however, did the mean total score exceed the cut-off of 20...
  30. ncbi request reprint Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder
    Andreas Lazar
    Department of Pharmacology, University of Cologne, Cologne, Germany
    Int J Neuropsychopharmacol 11:35-48. 2008
    ..Heterologous expression of mutant cDNA revealed a 40% decline of transport capacity for norepinephrine. Rare mutations in the EMT gene suggest a causative or modulating role in genetic subtypes of OCD...
  31. ncbi request reprint [Genetics of child and adolescent psychiatric disorders]
    Gerd Schulte-Körne
    Z Kinder Jugendpsychiatr Psychother 36:5. 2008
  32. ncbi request reprint Effects of methylphenidate on multiple components of attention in children with attention deficit hyperactivity disorder
    Oliver Tucha
    Department of Experimental Psychology, University of Regensburg, 93040 Regensburg, Germany
    Psychopharmacology (Berl) 185:315-26. 2006
    ..Although a variety of studies have been performed, there is little available information as to which components of attentional functioning are disturbed in ADHD...