Harald Wajant

Summary

Country: Germany

Publications

  1. ncbi Death receptors
    Harald Wajant
    Department of Molecular Internal Medicine, Medical Polyclinic, University of Wuerzburg, Roentgenring 11, 97 070 Wuerzburg, Germany
    Essays Biochem 39:53-71. 2003
  2. pmc NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
    Sebastian Kreuz
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    J Cell Biol 166:369-80. 2004
  3. ncbi A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95
    Constance Assohou-Luty
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany
    J Mol Med (Berl) 84:785-97. 2006
  4. doi Engineering death receptor ligands for cancer therapy
    Harald Wajant
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
    Cancer Lett 332:163-74. 2013
  5. doi TNFR1-induced activation of the classical NF-κB pathway
    Harald Wajant
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Germany
    FEBS J 278:862-76. 2011
  6. ncbi Targeting the FLICE Inhibitory Protein (FLIP) in cancer therapy
    Harald Wajant
    Department of Molecular Medicine Medical Polyclinic, University of Wuerzburg Roentgenring 11, 97070 Wuerzburg, Germany
    Mol Interv 3:124-7. 2003
  7. doi The role of TNF in cancer
    Harald Wajant
    Department of Molecular Medicine, Medical Clinic and Polyclinic II, University of Wurzburg, Rontgenring 11, 97070, Wuerzburg, Germany
    Results Probl Cell Differ 49:1-15. 2009
  8. doi Therapeutic targeting of CD95 and the TRAIL death receptors
    Jeannette Gerspach
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Recent Pat Anticancer Drug Discov 6:294-310. 2011
  9. ncbi Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation
    Mariola Fotin-Mleczek
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 279:677-85. 2004
  10. ncbi Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation
    Frank Henkler
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 278:29216-30. 2003

Collaborators

Detail Information

Publications54

  1. ncbi Death receptors
    Harald Wajant
    Department of Molecular Internal Medicine, Medical Polyclinic, University of Wuerzburg, Roentgenring 11, 97 070 Wuerzburg, Germany
    Essays Biochem 39:53-71. 2003
    ..This review is focused on the molecular mechanisms of apoptotic and non-apoptotic death receptor signalling in light of the phenotype of mice deficient in the various death receptors...
  2. pmc NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
    Sebastian Kreuz
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    J Cell Biol 166:369-80. 2004
    ..Thus, protection against Fas-induced apoptosis in a FLIP-independent manner converted a proapoptotic Fas signal into an inflammatory NFkappaB-related response...
  3. ncbi A CD40-CD95L fusion protein interferes with CD40L-induced prosurvival signaling and allows membrane CD40L-restricted activation of CD95
    Constance Assohou-Luty
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany
    J Mol Med (Berl) 84:785-97. 2006
    ....
  4. doi Engineering death receptor ligands for cancer therapy
    Harald Wajant
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
    Cancer Lett 332:163-74. 2013
    ..Here, we summarize strategies how these limitations can be overcome by genetic engineering...
  5. doi TNFR1-induced activation of the classical NF-κB pathway
    Harald Wajant
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Germany
    FEBS J 278:862-76. 2011
    ..Here, we sum up the known details of TNFR1-induced IKK activation, address arising contradictions and discuss possible explanations resolving the apparent discrepancies...
  6. ncbi Targeting the FLICE Inhibitory Protein (FLIP) in cancer therapy
    Harald Wajant
    Department of Molecular Medicine Medical Polyclinic, University of Wuerzburg Roentgenring 11, 97070 Wuerzburg, Germany
    Mol Interv 3:124-7. 2003
    ..Thus, FLIP, which normally prevents inappropriate apoptosis, may become a tumor progression factor. Strategies to overcome this FLIP-mediated blockade of programmed cell death in tumors might become useful for positive prognoses...
  7. doi The role of TNF in cancer
    Harald Wajant
    Department of Molecular Medicine, Medical Clinic and Polyclinic II, University of Wurzburg, Rontgenring 11, 97070, Wuerzburg, Germany
    Results Probl Cell Differ 49:1-15. 2009
    ....
  8. doi Therapeutic targeting of CD95 and the TRAIL death receptors
    Jeannette Gerspach
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Recent Pat Anticancer Drug Discov 6:294-310. 2011
    ....
  9. ncbi Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation
    Mariola Fotin-Mleczek
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 279:677-85. 2004
    ....
  10. ncbi Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation
    Frank Henkler
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 278:29216-30. 2003
    ....
  11. doi Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway
    Claudia Roos
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
    J Immunol 185:1593-605. 2010
    ....
  12. doi TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes
    Steffen Salzmann
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, 97070 Wurzburg, Germany
    J Immunol 191:2308-18. 2013
    ....
  13. pmc Signaling active CD95 receptor molecules trigger co-translocation of inactive CD95 molecules into lipid rafts
    Isabell Lang
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Biol Chem 287:24026-42. 2012
    ..In sum, this shows that signaling-active CD95 molecules not only enhance their own association with the lipid raft-containing membrane fraction but also those of inactive CD95 molecules...
  14. doi Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways
    Daniela Berg
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Germany
    FEBS J 276:6912-27. 2009
    ....
  15. pmc Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing
    Daniela Siegmund
    Department of Molecular Internal Medicine, Medical Polyclinic, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Mol Cell Biol 25:6363-79. 2005
    ..Overexpression of FLIP(L) and FLIP(S) inhibited Fas- as well as TRAIL-mediated NF-kappaB activation and apoptosis induction in IFN-gamma-primed cells suggesting that both responses are coregulated at the level of the DISC...
  16. pmc The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
    Frank Henkler
    Department of Molecular Internal Medicine, Medical Polyclinic, University of Wuerzburg, 97070 Wuerzburg, Germany
    J Cell Biol 168:1087-98. 2005
    ....
  17. pmc Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis
    Daniela Siegmund
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Mol Med 8:725-32. 2002
    ..The expression of the cellular FLICE-like inhibitory protein (cFLIP) is regarded as a major cause of TRAIL resistance. We therefore analyzed the usefulness of targeting FLIP to sensitize tumor cells for TRAIL-induced apoptosis...
  18. ncbi Non-apoptotic Fas signaling
    Harald Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, Germany
    Cytokine Growth Factor Rev 14:53-66. 2003
    ..This review is focused on the non-apoptotic functions of the FasL/Fas system. In particular, the similarities and differences of the molecular mechanisms of apoptotic and non-apoptotic Fas signaling are addressed...
  19. doi Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects
    Jeannette Gerspach
    Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
    Biofactors 35:364-72. 2009
    ..Here, we review the progress made toward improving the efficacy of TNF by genetic engineering, tumor targeting, and introduction of prodrug concepts...
  20. pmc Studies of binding of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) to fibroblast growth factor inducible 14 (Fn14)
    Andrea Fick
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Biol Chem 287:484-95. 2012
    ..Thus, although ∼25 activated TNFR1 trimers were sufficient to trigger half-maximal IL8 production, more than 2500 cell-bound oligomerized TWEAK trimers were required to elicit a similar response...
  21. pmc A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death
    Roman Fischer
    Institute of Cell Biology and Immunology, University Stuttgart, Stuttgart, Germany
    PLoS ONE 6:e27621. 2011
    ..Since TNFR2 is not only promoting anti-apoptotic responses but also plays an important role in tissue regeneration, activation of TNFR2 signaling by TNC-scTNF(R2) appears a promising strategy to ameliorate neurodegenerative processes...
  22. doi Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand
    Agnes Wyzgol
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
    J Immunol 183:1851-61. 2009
    ..Furthermore, surface immobilization might be exploited to gain locally enhanced ligand activity...
  23. ncbi Tumor therapeutics by design: targeting and activation of death receptors
    Harald Wajant
    Department of Internal Molecular Medicine, Medical Polyclinic, University of Wuerzburg, Germany
    Cytokine Growth Factor Rev 16:55-76. 2005
    ....
  24. ncbi Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner
    Andreas Wicovsky
    Department of Molecular Internal Medicine, Medical Clinic and Polyclinic II, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Biol Chem 282:2174-83. 2007
    ..Thus, sustained JNK activation by TNF has no obligate role in TNF-induced cell death and is mediated by caspases and reactive oxygen species in a cell type-specific manner...
  25. doi Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization
    Nicole Muller
    Department of Molecular Internal Medicine, Medical Clinic and Polyclinic II, University of Wuerzburg, Germany
    FEBS J 275:2296-304. 2008
    ..Trimeric single chain OX40L fusion proteins therefore represent a novel type of OX40L-derived immunostimulatory molecule with potentially reduced systemic side effects...
  26. doi Production, purification, and characterization of scFv TNF ligand fusion proteins
    Andrea Fick
    Division for Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
    Methods Mol Biol 907:597-609. 2012
    ....
  27. pmc Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2)
    Hilka Rauert
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Biol Chem 285:7394-404. 2010
    ..Thus, we identified activation of the alternative NFkappaB pathway as a TNF signaling effect that can be specifically assigned to TNFR2 and membrane TNF...
  28. pmc The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors
    Hilka Rauert-Wunderlich
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 8:e59292. 2013
    ..In accordance with the latter, we further observed that concomitant knockdown of IKK1 and IKK2 did not have any major short-term adverse effect on the viability of MM cells...
  29. pmc Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity
    Steffen Salzmann
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Biol Chem 288:13455-66. 2013
    ..Fn14 is a therapeutic target in various diseases...
  30. doi Superior serum half life of albumin tagged TNF ligands
    Nicole Muller
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Biochem Biophys Res Commun 396:793-9. 2010
    ..In conclusion, our data suggest that genetic fusion to serum albumin is a powerful and generally applicable mean to improve bioavailability and in vivo activity of TNF ligands...
  31. ncbi Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells
    Daniela Siegmund
    Department of Molecular Internal Medicine, Medical Clinic and Polyclinic II, University of Wuerzburg, and Division of Molecular Oncology, Clinic for General Surgery and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Cell Signal 19:1172-84. 2007
    ..Consequently, an NFkappaB and ERK stimulating, caspase-dependent factor must operate downstream of the DISC in Colo357-BclxL cells...
  32. ncbi CD95L/FasL and TRAIL in tumour surveillance and cancer therapy
    Harald Wajant
    Department of Molecular Internal Medicine, Medical Polyclinic, University of Wuerzburg, Roentgenring 11, 97070 Wuerzburg, Germany
    Cancer Treat Res 130:141-65. 2006
    ..This chapter focuses on the relevance of CD95L/FasL and TRAIL for the tumour surveillance function of natural killer cells and cytotoxic T-cells and discuss current concepts of utilizing these ligands in tumour therapy...
  33. ncbi Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8
    Mariola Fotin-Mleczek
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Cell Sci 115:2757-70. 2002
    ..Hence, TNF-R2 triggering can interfere with TNF-R1-induced apoptosis by inhibition of NF-kappaB-dependent production of anti-apoptotic factors and by blocking the action of anti-apoptotic factors at the post-transcriptional level...
  34. ncbi Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis
    Monika Weingärtner
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 277:34853-9. 2002
    ..Moreover, we give evidence that this mechanism circumvents the need of the prolonged presence of exogenous soluble TNF for TNF-R1-mediated apoptosis induction...
  35. doi Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands
    Jeannette Gerspach
    Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
    Results Probl Cell Differ 49:241-73. 2009
    ..Preclinical data on newly derived variants and fusion proteins based on these death ligands, designed to act in a tumor restricted manner, thereby preventing a systemic, potentially harmful action, will also be discussed...
  36. ncbi Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4)
    Heike Glauner
    Institute of Cell Biology and Immunology and Institute of Industrial Genetics, University of Stuttgart, Germany Institute of Immunology, Christian Albrechts University of Kiel, Germany
    Eur J Biochem 269:4819-29. 2002
    ..These data suggest that activation of the NF-kappaB pathway is involved in up-regulation of TRAF4 in T-cells...
  37. ncbi Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface
    Jeannette Gerspach
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, Stuttgart, 70569, Germany
    Cancer Immunol Immunother 55:1590-600. 2006
    ..Processing optimised TNF prodrugs should increase the proportion of active therapeutic within the targeted tissue and thus potentially enhance tumor response rate...
  38. pmc Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1
    Martin Chopra
    Department of Internal Medicine II, Würzburg University Clinics, Wurzburg, Germany Center for Interdisciplinary Clinical Research, Wurzburg University, Wurzburg, Germany
    PLoS ONE 8:e75737. 2013
    ..This suggests that TNFR1 has basically the capability in the Panc02 model to trigger pro-and anti-tumoral effects but the spatiotemporal availability of TNF seems to determine finally the overall outcome. ..
  39. doi Integrin-linked kinase is dispensable for multiple myeloma cell survival
    Torsten Steinbrunn
    Department of Internal Medicine II, Comprehensive Cancer Center Mainfranken, University Hospital of Wurzburg, Wurzburg, Germany
    Leuk Res 36:1165-71. 2012
    ..Although this effect was largely tumor cell-specific it is unlikely to have been mediated via ILK. We conclude that ILK does not play a prominent role in the promotion or sustenance of established MM...
  40. ncbi TRAIL and NFkappaB signaling--a complex relationship
    Harald Wajant
    Department of Molecular Internal Medicine Medical Polyclinic, University of Wurzburg, D 97070 Wurzburg, Germany
    Vitam Horm 67:101-32. 2004
    ..Third, the TRAIL death receptors can activate the NFkappaB pathway. This chapter summarizes basic knowledge regarding the understanding of the NFkappaB pathway and focuses on its multiple roles in TRAIL signaling...
  41. pmc SMAC mimetic BV6 induces cell death in monocytes and maturation of monocyte-derived dendritic cells
    Nicole Müller-Sienerth
    Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e21556. 2011
    ..In view of the overwhelming importance of the NFκB transcription factors in the immune system, we analyzed here the effects of the SMAC mimetic BV6 on immune cells...
  42. ncbi Interferons induce proteolytic degradation of TRAILR4
    Andreas Wicovsky
    Department of Molecular Internal Medicine, Medical Polyclinic, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Biochem Biophys Res Commun 337:184-90. 2005
    ..Thus, the apoptosis-inducing action of interferons may not only rely on the well-established induction of TRAIL in effector cells but also on concomitant down-regulation of its antagonizing decoy receptor TRAILR4 in target cells...
  43. ncbi Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation
    Dierk Samel
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 278:32077-82. 2003
    ..The principle described here for the first time, in which cell-surface antigen-mediated activation of Fas permits local activation of Fas in vivo, opens novel avenues for the use of Fas signaling in cancer therapy...
  44. doi Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor
    Roman Fischer
    Institute of Cell Biology and Immunology, University Stuttgart, Stuttgart, Germany
    Glia 62:272-83. 2014
    ..Addition of LIF neutralizing antibodies inhibited oligodendrocyte differentiation, indicating a crucial role of TNFR2-induced astrocyte derived LIF for oligodendrocyte maturation...
  45. doi Apoptosis is not required for acantholysis in pemphigus vulgaris
    Enno Schmidt
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Cell Physiol 296:C162-72. 2009
    ..Taken together, we conclude that apoptosis is not a prerequisite for skin blistering in PV but may occur secondary to acantholysis...
  46. ncbi The Fas signaling pathway: more than a paradigm
    Harald Wajant
    Institute of Cell Biology and Immunology, Allmandring 31, University of Stuttgart, 70 569 Stuttgart, Germany
    Science 296:1635-6. 2002
    ....
  47. doi The role of FasL and Fas in health and disease
    Martin Ehrenschwender
    Department of Molecular Internal Medicine, Medical Clinic and Polyclinic II, University of Wuerzburg, Roentgenring 11, 97070, Wuerzburg, Germany
    Adv Exp Med Biol 647:64-93. 2009
    ..In this chapter, we will briefly introduce essential general aspects of the FasL-Fas system before reviewing its physiological and pathophysiological relevance. Finally, FasL-Fas-related therapeutic tools and concepts will be addressed...
  48. pmc Exogenous administration of a recombinant variant of TWEAK impairs healing after myocardial infarction by aggravation of inflammation
    Christina Pachel
    Department of Internal Medicine I, University Hospital Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 8:e78938. 2013
    ..They modulate inflammation and the extracellular matrix, and could therefore be important for healing and remodeling after MI. However, the function of TWEAK after MI remains poorly defined...
  49. doi Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis
    Martin Chopra
    Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
    Carcinogenesis 34:1296-303. 2013
    ..Loss of either TNF or TNFR2 prevents the accumulation of Treg cells and results in a less tolerogenic environment, enabling the immune system to control B16F10 tumor metastasis and growth...
  50. ncbi Enhanced basal AP-1 activity and de-regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1
    Svetla Chaneva
    Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany
    Eur J Immunol 34:3006-15. 2004
    ..The constitutive activation of AP-1 may thus serve to precondition resting T cells for an enhanced expression of many immunologically relevant genes during activation...
  51. pmc Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta
    Hanspeter Lauble
    Institut für Organische Chemie der Universität Stuttgart, D 70569 Stuttgart, Germany
    Protein Sci 11:65-71. 2002
    ..1 A resolution shows the presence of two hydroxybenzaldehyde molecules in a sandwich type arrangement in the active site with an additional hydrogen bridge to the reacting center...
  52. ncbi The CD95 receptor: apoptosis revisited
    Marcus E Peter
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Cell 129:447-50. 2007
    ..Recent evidence suggests, however, that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions...
  53. doi Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis
    Jan Hendrik Egberts
    Division of Molecular Oncology, Department of General Surgery and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 68:1443-50. 2008
    ..Thus, tumor cell-derived TNFalpha plays a profound role in malignancy of PDAC, and inhibition of TNFalpha represents a promising therapeutic option particularly in adjuvant therapy after subtotal pancreatectomy...
  54. ncbi CD95 and TRAF2 promote invasiveness of pancreatic cancer cells
    Anna Trauzold
    Molecular Oncology Unit, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    FASEB J 19:620-2. 2005
    ..Thus, TRAF2 overexpression does not only block apoptosis induction by CD95 but also converts this death receptor into a mediator of invasiveness...