O von Bohlen und Halbach
von Bohlen und Halbach O. The renin-angiotensin system in the mammalian central nervous system. Curr Protein Pept Sci. 2005;6:355-71 pubmed
..This phenomenon appears to represent an important mechanism for neuromodulation. Moreover, there is evidence to suggest that the renin-angiotensin system is involved in neurological disorders, as e.g. Alzheimer's or Parkinson's disease. ..
Von Bohlen Und Halbach O. Synucleins and their relationship to Parkinson's disease. Cell Tissue Res. 2004;318:163-74 pubmed
..Several lines of evidence suggest that they play a role in the regulation of vesicular turnover under normal nonpathological conditions. ..
Von Bohlen Und Halbach O, Unsicker K. Age-related decline in the tyrosine hydroxylase-immunoreactive innervation of the amygdala and dentate gyrus in mice. Cell Tissue Res. 2003;311:139-43 pubmed
..This suggests that region-specific factors may be implicated in the regulation of maintenance vs. degeneration of TH-ir fibers during aging. ..
von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice. Regul Pept. 2001;99:209-16 pubmed
..These results show the contrary effects of both angiotensin receptors on cell growth and represent the first demonstration of their action on neuronal cell development evidenced in the adult mouse brain. ..
Von Bohlen Und Halbach O, Minichiello L, Unsicker K. Haploinsufficiency in trkB and/or trkC neurotrophin receptors causes structural alterations in the aged hippocampus and amygdala. Eur J Neurosci. 2003;18:2319-25 pubmed
..Together, these data indicate that endogenous ligands to the trkB and trkC receptors are essential to maintain neuronal integrity in the aged hippocampus and amygdala. ..
Von Bohlen Und Halbach O, Minichiello L, Unsicker K. Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. FASEB J. 2005;19:1740-2 pubmed
..We conclude that impairment in trkB and/or trkC signaling induces a phenotype in the aged SN, which includes two hallmarks of PD, losses of TH positive neurons and axons along with massive neuronal deposits of alpha-synuclein. ..
Von Bohlen Und Halbach O, Krause S, Medina D, Sciarretta C, Minichiello L, Unsicker K. Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies. Biol Psychiatry. 2006;59:793-800 pubmed
..TrkB functions in structural remodeling of hippocampal dendritic spines, which in turn may affect synaptic transmission and plasticity. ..