O von Bohlen und Halbach

Summary

Country: Germany

Publications

  1. ncbi request reprint Age-related decline in the tyrosine hydroxylase-immunoreactive innervation of the amygdala and dentate gyrus in mice
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neuroscience IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 311:139-43. 2003
  2. ncbi request reprint Morphological alterations in the amygdala and hippocampus of mice during ageing
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 16:2434-40. 2002
  3. ncbi request reprint Angiotensin IV in the central nervous system
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 311:1-9. 2003
  4. ncbi request reprint Haploinsufficiency in trkB and/or trkC neurotrophin receptors causes structural alterations in the aged hippocampus and amygdala
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Eur J Neurosci 18:2319-25. 2003
  5. ncbi request reprint Nitric oxide imaging in living neuronal tissues using fluorescent probes
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Nitric Oxide 9:217-28. 2003
  6. ncbi request reprint Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices
    Oliver Von Bohlen Und Halbach
    Johannes Muller Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Tucholskystrasse 2, D 10117 Berlin, Germany
    Neuroimage 15:633-9. 2002
  7. ncbi request reprint Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice
    O von Bohlen und Halbach
    Johannes Müller Institute of Physiology Charité, Humboldt University, Tucholskystrasse 2, D 10117, Berlin, Germany
    Regul Pept 99:209-16. 2001
  8. ncbi request reprint The dopaminergic nigrostriatal system: development, physiology, disease
    Oliver Von Bohlen Und Halbach
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 318:3. 2004
  9. ncbi request reprint Synucleins and their relationship to Parkinson's disease
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 318:163-74. 2004
  10. ncbi request reprint Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    FASEB J 19:1740-2. 2005

Detail Information

Publications56

  1. ncbi request reprint Age-related decline in the tyrosine hydroxylase-immunoreactive innervation of the amygdala and dentate gyrus in mice
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neuroscience IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 311:139-43. 2003
    ..This suggests that region-specific factors may be implicated in the regulation of maintenance vs. degeneration of TH-ir fibers during aging...
  2. ncbi request reprint Morphological alterations in the amygdala and hippocampus of mice during ageing
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 16:2434-40. 2002
    ..Thus, mechanisms underlying age-related dysfunction depend on parameters other than neuronal numbers, at least in the hippocampal formation and the amygdala...
  3. ncbi request reprint Angiotensin IV in the central nervous system
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 311:1-9. 2003
    ..Furthermore, angiotensin IV may also be involved in neuronal development. Collectively, the available evidence suggests that angiotensin IV is a potent neuropeptide, involved in a broad range of brain functions...
  4. ncbi request reprint Haploinsufficiency in trkB and/or trkC neurotrophin receptors causes structural alterations in the aged hippocampus and amygdala
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Eur J Neurosci 18:2319-25. 2003
    ..Together, these data indicate that endogenous ligands to the trkB and trkC receptors are essential to maintain neuronal integrity in the aged hippocampus and amygdala...
  5. ncbi request reprint Nitric oxide imaging in living neuronal tissues using fluorescent probes
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Nitric Oxide 9:217-28. 2003
    ..This article summarizes recent advances and current trends in the visualization of NO in living neuronal tissues...
  6. ncbi request reprint Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices
    Oliver Von Bohlen Und Halbach
    Johannes Muller Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Tucholskystrasse 2, D 10117 Berlin, Germany
    Neuroimage 15:633-9. 2002
    ..Our results are consistent with the hypothesis that NO can serve as a retrograde messenger during induction of LTP in the hippocampus...
  7. ncbi request reprint Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice
    O von Bohlen und Halbach
    Johannes Müller Institute of Physiology Charité, Humboldt University, Tucholskystrasse 2, D 10117, Berlin, Germany
    Regul Pept 99:209-16. 2001
    ..These results show the contrary effects of both angiotensin receptors on cell growth and represent the first demonstration of their action on neuronal cell development evidenced in the adult mouse brain...
  8. ncbi request reprint The dopaminergic nigrostriatal system: development, physiology, disease
    Oliver Von Bohlen Und Halbach
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 318:3. 2004
  9. ncbi request reprint Synucleins and their relationship to Parkinson's disease
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 318:163-74. 2004
    ..Several lines of evidence suggest that they play a role in the regulation of vesicular turnover under normal nonpathological conditions...
  10. ncbi request reprint Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    FASEB J 19:1740-2. 2005
    ..We conclude that impairment in trkB and/or trkC signaling induces a phenotype in the aged SN, which includes two hallmarks of PD, losses of TH positive neurons and axons along with massive neuronal deposits of alpha-synuclein...
  11. ncbi request reprint The renin-angiotensin system in the mammalian central nervous system
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Curr Protein Pept Sci 6:355-71. 2005
    ..This phenomenon appears to represent an important mechanism for neuromodulation. Moreover, there is evidence to suggest that the renin-angiotensin system is involved in neurological disorders, as e.g. Alzheimer's or Parkinson's disease...
  12. ncbi request reprint Genes, proteins, and neurotoxins involved in Parkinson's disease
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Prog Neurobiol 73:151-77. 2004
    ..In addition, we will review the current animal models of PD...
  13. ncbi request reprint Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies
    Oliver Von Bohlen Und Halbach
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, Heidelberg, Germany
    Biol Psychiatry 59:793-800. 2006
    ..Conditionally gene-targeted mice in which the ablation of trkB is restricted to the forebrain and occurs only during postnatal development display impaired learning and LTP...
  14. doi request reprint Roles of exogenous and endogenous FGF-2 in animal models of depression
    J Jarosik
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, Heidelberg, Germany
    Restor Neurol Neurosci 29:153-65. 2011
    ..Several members of the fibroblast growth factor (FGF) family have been shown to be dysregulated in individuals with major depression, and treatment with antidepressants has been reported to increase FGF-2 mRNA levels in the forebrain...
  15. ncbi request reprint Tracing of axonal connectivities in a combined slice preparation of rat brains--a study by rhodamine-dextran-amine-application in the lateral nucleus of the amygdala
    O von Bohlen und Halbach
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    J Neurosci Methods 81:169-75. 1998
    ..To test the usefulness of this preparation for electrophysiological studies, extracellular field potentials were recorded...
  16. ncbi request reprint Visualization of specific angiotensin II binding sites in the rat limbic system
    O von Bohlen und Halbach
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Neuropeptides 32:241-5. 1998
    ..The co-incubation of fluorescence-coupled angiotensin II together with angiotensin II in excess and with saralasin, respectively, suppressed the angiotensin staining in structures investigated...
  17. ncbi request reprint Expression of trkB and trkC receptors and their ligands brain-derived neurotrophic factor and neurotrophin-3 in the murine amygdala
    S Krause
    Interdisziplinäres Zentrum für Neurowissenschaften IZN, Neuroanatomie, Ruprecht Karls Universitat Heidelberg, Heidelberg, Germany
    J Neurosci Res 86:411-21. 2008
    ..These results can serve as a basis for studies elucidating the physiological roles of these receptors in the amygdala...
  18. ncbi request reprint TrkB but not trkC receptors are necessary for postnatal maintenance of hippocampal spines
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Neurobiol Aging 29:1247-55. 2008
    ..This indicates that trkB, but not trkC, receptors are necessary for the maintenance of hippocampal spines during postnatal life...
  19. ncbi request reprint Interaction between Mas and the angiotensin AT1 receptor in the amygdala
    O von Bohlen und Halbach
    Johannes Müller Institute of Physiology Charité, Humboldt University, D 10117 Berlin, Germany
    J Neurophysiol 83:2012-21. 2000
    ..The use of different angiotensin receptor antagonists provides the first in vitro evidence for a functional interaction between the Mas-protooncogene and the AT1 receptor...
  20. ncbi request reprint FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice
    S Zechel
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 23:1671-5. 2006
    ....
  21. ncbi request reprint Angiotensin II inhibits long-term potentiation within the lateral nucleus of the amygdala through AT1 receptors
    O von Bohlen und Halbach
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Peptides 19:1031-6. 1998
    ..The coadministration of the AT2 receptor antagonist PD 123,319 failed to block the inhibition of LTP...
  22. ncbi request reprint Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    J Neurosci Res 83:525-31. 2006
    ..J. Neurosci. 16:2434-2440), we suggest that the memory and cognitive decline in the context of aging may be accompanied by rather subtle anatomical changes, such as numbers and morphology of dendritic spines...
  23. ncbi request reprint Mapping of angiotensin AT1 receptors in the rat limbic system
    O von Bohlen und Halbach
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Regul Pept 78:51-6. 1998
    ....
  24. ncbi request reprint Neurotrophin receptor heterozygosity causes deficits in catecholaminergic innervation of amygdala and hippocampus in aged mice
    O von Bohlen und Halbach
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
    J Neural Transm 113:1829-36. 2006
    ..Our observations suggest that signaling through trkB and trkC neurotrophin receptors is important for the maintenance of the catecholaminergic innervation of two limbic key regions, the hippocampus and amygdala...
  25. ncbi request reprint Antidepressant-mediated reversal of abnormal behavior and neurodegeneration in mice following olfactory bulbectomy
    J Jarosik
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Exp Neurol 204:20-8. 2007
    ..This may also be relevant in the context of studies using genetically altered mice...
  26. ncbi request reprint MPTP treatment impairs tyrosine hydroxylase immunopositive fibers not only in the striatum, but also in the amygdala
    Oliver Von Bohlen Und Halbach
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences, IZN, University of Heidelberg, Heidelberg, Germany
    Neurodegener Dis 2:44-8. 2005
    ..These results may provide the morphological basis for behavioral studies analyzing altered emotional responses in animal models of PD...
  27. ncbi request reprint Opposite effects of angiotensin II and IV in the lateral nucleus of the amygdala
    O von Bohlen und Halbach
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Brain Res Bull 47:311-5. 1998
    ....
  28. ncbi request reprint Various effects of angiotensin II on amygdaloid neuronal activity in normotensive control and hypertensive transgenic [TGR(mREN-2)27] rats
    D Albrecht
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    FASEB J 14:925-31. 2000
    ....
  29. doi request reprint Fibroblast growth factor-2 deficiency affects hippocampal spine morphology, but not hippocampal catecholaminergic or cholinergic innervation
    Sabrina Zechel
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany
    Dev Dyn 238:343-50. 2009
    ..Thus, FGF-2 may also affect learning and memory by altering spine morphology...
  30. ncbi request reprint The isolated mammalian brain: an in vivo preparation suitable for pathway tracing
    O von Bohlen und Halbach
    Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Eur J Neurosci 11:1096-100. 1999
    ..The viability of this isolated brain preparation was validated by successful recording of extracellular field potentials 1 day later...
  31. doi request reprint Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice
    Björn Maul
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    J Mol Med (Berl) 86:563-71. 2008
    ..These findings suggest a crucial role of AT2 in normal brain function and that dysfunction of the receptor has impact on brain development and ultrastructural morphology with distinct consequences on learning and memory...
  32. ncbi request reprint Amygdala-kindling induces alterations in neuronal density and in density of degenerated fibers
    Oliver Von Bohlen Und Halbach
    Johannes Muller Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Hippocampus 14:311-8. 2004
    ..These morphological changes might be responsible for the emotional and behavioral disturbances that can accompany epilepsy...
  33. ncbi request reprint Distribution of angiotensin II binding sites in the mouse thalamus: receptor-binding study with fluorescent coupled peptides and their conversion to a light stable product
    O von Bohlen und Halbach
    Institute of Physiology Charité, Humboldt University, Berlin, Germany
    Neuropeptides 33:464-7. 1999
    ....
  34. ncbi request reprint Immunohistological markers for staging neurogenesis in adult hippocampus
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 329:409-20. 2007
    ....
  35. ncbi request reprint The CNS renin-angiotensin system
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 326:599-616. 2006
    ....
  36. ncbi request reprint Diaminobenzidine induces fluorescence in nervous tissue and provides intrinsic counterstaining of sections prepared for peroxidase histochemistry
    O von Bohlen und Halbach
    Institute of Physiology, Faculty of Medicine, Charite, Homboldt University, Berlin, Germany
    Biotech Histochem 74:236-43. 1999
    ..DAB induced fluorescence provides a simple and useful demonstration of background anatomy in sections that also contain specifically localized deposits of peroxidase activity...
  37. ncbi request reprint Modeling neurodegenerative diseases in vivo review
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
    Neurodegener Dis 2:313-20. 2005
    ..In this review, the main characteristics of experimental models of PD induced by the neurotoxic compound MPTP are reviewed...
  38. ncbi request reprint Muscarinic control of graded persistent activity in lateral amygdala neurons
    Alexei V Egorov
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 24:3183-94. 2006
    ..The internal ability of LA neurons to generate graded persistent activity could be essential for amygdala-mediated memory operations...
  39. ncbi request reprint Neurotrophic support of midbrain dopaminergic neurons
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences, Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307 D 69120 Heidelberg, Germany
    Adv Exp Med Biol 651:73-80. 2009
    ..TGF-betas are reviewed in a separate chapter (Roussa et al, this volume)...
  40. ncbi request reprint Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2
    Irina Kiprianova
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
    Exp Neurol 189:252-60. 2004
    ..Together, our data provide the first evidence that endogenous FGF-2 is important in coping with ischemic brain damage suggesting fgf2 as one crucial target gene for new therapeutic strategies in brain ischemia...
  41. pmc Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
    Neural Dev 3:28. 2008
    ..Bone morphogenetic proteins (BMPs) emanating from the dorsal aorta are important signals for the induction of a sympathoadrenal catecholaminergic cell fate...
  42. ncbi request reprint Distribution of the iron-regulating protein hepcidin in the murine central nervous system
    S Zechel
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, Heidelberg, Germany
    J Neurosci Res 84:790-800. 2006
    ..Cellular mechanisms and functions of hepcidin in the CNS remain to be elucidated...
  43. ncbi request reprint Identification of angiotensin IV binding sites in the mouse brain by a fluorescent binding study
    O von Bohlen und Halbach
    Johannes Muller Institute of Physiology, Faculty of Medicine Charite, Humboldt University, Berlin, Germany
    Neuroendocrinology 72:218-23. 2000
    ....
  44. doi request reprint Spontaneous bursting activity in the developing entorhinal cortex
    Maxim G Sheroziya
    Department of Neuroanatomy, University of Heidelberg, Interdisciplinary Center for Neurosciences, D 69120 Heidelberg, Germany
    J Neurosci 29:12131-44. 2009
    ..We conclude that prolonged intrinsic bursting activity is a characteristic feature of developing medial EC layer III neurons that might be involved in neuronal and network maturation...
  45. doi request reprint Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death
    K Lakshmi Narayanan
    Interdisciplinary Centerfor Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Neurosci Lett 446:117-22. 2008
    ..Thus, TRPC1 may represent a promising target for pharmacological interventions to prevent or reduce glutamate-induced neuronal damage...
  46. ncbi request reprint Reciprocal connections of the hippocampal area CA1, the lateral nucleus of the amygdala and cortical areas in a combined horizontal slice preparation
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences, Institute of Anatomy, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Neurosci Res 44:91-100. 2002
    ....
  47. ncbi request reprint Distribution of TRPC4 in developing and adult murine brain
    Sabrina Zechel
    Interdisciplinary Center for Neurosciences IZN, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120, Heidelberg, Germany
    Cell Tissue Res 328:651-6. 2007
    ..Analysis of the adult hippocampal formation has revealed TRPC4 immunoreactivity in hippocampal areas CA1 to CA3 and in the dentate gyrus. Functions consistent with this spatially restricted pattern of expression remain to be revealed...
  48. doi request reprint Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine
    Rosanna Parlato
    Department of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    J Neurochem 115:563-73. 2010
    ..We conclude by a specific genetic approach that the withdrawal-associated hyperexcitability of noradrenergic neurons depends on CREB/CREM activity in these neurons, but does not mediate several behavioral signs of morphine withdrawal...
  49. pmc Ambiguous-cue interpretation is biased under stress- and depression-like states in rats
    Thomas Enkel
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 35:1008-15. 2010
    ..The behavioral paradigm described constitutes a useful tool to study the neuronal basis of decision making under ambiguous conditions and may promote innovative pharmaco- and psychotherapy for depression...
  50. pmc ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3
    Srinivasa Subramaniam
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, Im Neuenheimer Feld 307, 2 OG, D 69120 Heidelberg, Germany
    J Cell Biol 165:357-69. 2004
    ..Antioxidants that reduced ERK activation and PM damage showed no effect on caspase-3 activation or DNA damage. These data identify ERK as an important executor of neuronal damage involving a caspase-3-independent mechanism...
  51. doi request reprint Propagation of specific network patterns through the mouse hippocampus
    Martin Both
    Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Hippocampus 18:899-908. 2008
    ..Our data show that the specificity of neuronal assemblies is maintained with cell-to-cell precision while SPW-R propagate along the hippocampal loop...
  52. doi request reprint Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex
    Gabor C Petzold
    Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Stroke 39:1292-9. 2008
    ..We investigated whether a similar extracellular composition renders the brain more susceptible to CSDs...
  53. ncbi request reprint Distribution of TRPC1 and TRPC5 in medial temporal lobe structures of mice
    Oliver Von Bohlen Und Halbach
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 322:201-6. 2005
    ..The expression of TRPC1 and TRPC5 channels in mammalian temporal lobe structures suggests their involvement in neuronal plasticity, learning and memory...
  54. pmc TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration
    Diego L Medina
    European Molecular Biology Laboratory, Monterotondo, Italy
    EMBO J 23:3803-14. 2004
    ..These results provide genetic evidence that TrkB regulates important functions throughout the formation of the cerebral cortex via recruitment of the Shc/FRS2 adaptors and PLCgamma...
  55. ncbi request reprint Nitric oxide modulates low-Mg2+-induced epileptiform activity in rat hippocampal-entorhinal cortex slices
    Sebastian Schuchmann
    Johannes Müller Institut für Physiologie, Universitatsklinikum, Charité Humboldt Universität Berlin, Germany
    Neurobiol Dis 11:96-105. 2002
    ..Further NO imaging studies may help to elucidate the role of NO in detail and may bring to light new means for epilepsy therapy...
  56. ncbi request reprint Two distinct events, section compression and loss of particles ("lost caps"), contribute to z-axis distortion and bias in optical disector counting
    Larisa M Baryshnikova
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Microsc Res Tech 69:738-56. 2006
    ..Indirect approaches to assess section quality, such as resectioning in a perpendicular plane, yield additional artifacts, and should be replaced by a direct quantitative measurement of z-axis distribution of particles...