Christof von Eiff

Summary

Country: Germany

Publications

  1. ncbi request reprint The small colony variant (SCV) concept -- the role of staphylococcal SCVs in persistent infections
    Christof von Eiff
    Institut fur Medizinische Mikrobiologie, Universitatsklinikum Munster, Munster, Germany
    Injury 37:S26-33. 2006
  2. pmc Anti-inflammatory effects of ciprofloxacin in S. aureus Newman induced nasal inflammation in vitro
    F Sachse
    Department of Otorhinolaryngology Head and Neck Surgery, University of Muenster, Germany
    J Inflamm (Lond) 5:11. 2008
  3. ncbi request reprint Effect of trimethoprim-sulfamethoxazole prophylaxis in AIDS patients on the formation of the small colony variant phenotype of Staphylococcus aureus
    Christof von Eiff
    Institute of Medical Microbiology, University of Munster, Hospital and Clinics, Munster, Germany
    Diagn Microbiol Infect Dis 48:191-4. 2004
  4. ncbi request reprint Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus
    Christof von Eiff
    Institute of Medical Microbiology, University of Munster, Hospital and Clinics, 48149 Munster, Germany
    Diagn Microbiol Infect Dis 49:157-62. 2004
  5. ncbi request reprint Infections associated with medical devices: pathogenesis, management and prophylaxis
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Domagkstrasse 10, 48149 Munster, Germany
    Drugs 65:179-214. 2005
  6. pmc Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Germany
    Antimicrob Agents Chemother 49:4372-4. 2005
  7. ncbi request reprint Modern strategies in the prevention of implant-associated infections
    C von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Int J Artif Organs 28:1146-56. 2005
  8. pmc Phenotype microarray profiling of Staphylococcus aureus menD and hemB mutants with the small-colony-variant phenotype
    Christof von Eiff
    Institute of Medical Microbiology, University Hospital of Munster, Domagkstrasse 10, 48149 Munster, Germany
    J Bacteriol 188:687-93. 2006
  9. ncbi request reprint Distribution of capsular and surface polysaccharide serotypes of Staphylococcus aureus
    Christof von Eiff
    Institute of Medical Microbiology, University Hospital of Munster, 48149 Munster, Germany
    Diagn Microbiol Infect Dis 58:297-302. 2007
  10. ncbi request reprint Small-colony variants (SCVs) of staphylococci: a role in foreign body-associated infections
    C von Eiff
    Institute of Medical Microbiology, University Hospital of Munster, Munster, Germany
    Int J Artif Organs 30:778-85. 2007

Detail Information

Publications78

  1. ncbi request reprint The small colony variant (SCV) concept -- the role of staphylococcal SCVs in persistent infections
    Christof von Eiff
    Institut fur Medizinische Mikrobiologie, Universitatsklinikum Munster, Munster, Germany
    Injury 37:S26-33. 2006
    ..Therefore, when an infection persists for weeks or months or fails to respond to antimicrobial therapy, clinicians as well as laboratory personnel should consider further efforts to search for this staphylococcal subpopulation...
  2. pmc Anti-inflammatory effects of ciprofloxacin in S. aureus Newman induced nasal inflammation in vitro
    F Sachse
    Department of Otorhinolaryngology Head and Neck Surgery, University of Muenster, Germany
    J Inflamm (Lond) 5:11. 2008
    ..Similar effects have been reported for fluoroquinolones on various cell types. Since these effects have poorly been characterized in CRS, we examined anti-inflammatory effects of ciprofloxacin on human nasal epithelial cells (HNECs)...
  3. ncbi request reprint Effect of trimethoprim-sulfamethoxazole prophylaxis in AIDS patients on the formation of the small colony variant phenotype of Staphylococcus aureus
    Christof von Eiff
    Institute of Medical Microbiology, University of Munster, Hospital and Clinics, Munster, Germany
    Diagn Microbiol Infect Dis 48:191-4. 2004
    ..Thirty-seven patients (29.6%) harbored S. aureus in their anterior nares, three of these patients (8.1%) had S. aureus SCVs. Interestingly, TMP-SMZ does not appear to select for S. aureus SCVs in nasal swabs of these patients...
  4. ncbi request reprint Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus
    Christof von Eiff
    Institute of Medical Microbiology, University of Munster, Hospital and Clinics, 48149 Munster, Germany
    Diagn Microbiol Infect Dis 49:157-62. 2004
    ..The co-possession of different virulence factors and their probable synergy should receive more attention in order to better understand their role in pathogenicity...
  5. ncbi request reprint Infections associated with medical devices: pathogenesis, management and prophylaxis
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Domagkstrasse 10, 48149 Munster, Germany
    Drugs 65:179-214. 2005
    ..Finally, further studies are needed to translate the knowledge on the mechanisms of biofilm formation into applicable therapeutic and preventive strategies...
  6. pmc Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Germany
    Antimicrob Agents Chemother 49:4372-4. 2005
    ..This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid...
  7. ncbi request reprint Modern strategies in the prevention of implant-associated infections
    C von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Int J Artif Organs 28:1146-56. 2005
    ..However, future studies are warranted to translate the knowledge on the pathogenesis of device-associated infections into applicable prevention strategies...
  8. pmc Phenotype microarray profiling of Staphylococcus aureus menD and hemB mutants with the small-colony-variant phenotype
    Christof von Eiff
    Institute of Medical Microbiology, University Hospital of Munster, Domagkstrasse 10, 48149 Munster, Germany
    J Bacteriol 188:687-93. 2006
    ..Key results of the PM analysis were confirmed in independent growth studies and by using Etest strips for susceptibility testing. PM technology is a new and efficient technology for assessing cellular phenotypes in S. aureus...
  9. ncbi request reprint Distribution of capsular and surface polysaccharide serotypes of Staphylococcus aureus
    Christof von Eiff
    Institute of Medical Microbiology, University Hospital of Munster, 48149 Munster, Germany
    Diagn Microbiol Infect Dis 58:297-302. 2007
    ....
  10. ncbi request reprint Small-colony variants (SCVs) of staphylococci: a role in foreign body-associated infections
    C von Eiff
    Institute of Medical Microbiology, University Hospital of Munster, Munster, Germany
    Int J Artif Organs 30:778-85. 2007
    ....
  11. doi request reprint Staphylococcus aureus small colony variants: a challenge to microbiologists and clinicians
    Christof von Eiff
    Institute of Medical Microbiology, University of Munster, Domagkstr 10, 48149 Munster, Germany
    Int J Antimicrob Agents 31:507-10. 2008
    ....
  12. pmc Microbiological evaluation of a new growth-based approach for rapid detection of methicillin-resistant Staphylococcus aureus
    Christof von Eiff
    Institute of Medical Microbiology, University Hospital of Munster, Domagkstr 10, 48149 Munster, Germany
    J Antimicrob Chemother 61:1277-80. 2008
    ..To evaluate the reliability of this new assay to successfully detect MRSA strains of different origin and clonality, well-characterized S. aureus strains were tested in this study...
  13. pmc In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from anterior nares and blood
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Muenster, Germany
    Antimicrob Agents Chemother 47:3613-5. 2003
    ..Minimum bactericidal concentrations of 0.16 microg/ml and zones of inhibition ranging between 15 and 21 mm in diameter demonstrate that lysostaphin was highly active against all isolates tested...
  14. ncbi request reprint Pathogenesis of infections due to coagulase-negative staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Lancet Infect Dis 2:677-85. 2002
    ....
  15. ncbi request reprint Comparative in vitro activity of faropenem against staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Munster, Domagkstrasse 10, 48149 Munster, Germany
    J Antimicrob Chemother 50:277-80. 2002
    ..In addition, faropenem was active against many methicillin-resistant strains of S. aureus and coagulase-negative staphylococci...
  16. ncbi request reprint Intracellular persistence of Staphylococcus aureus small-colony variants within keratinocytes: a cause for antibiotic treatment failure in a patient with darier's disease
    C von Eiff
    Institute of Medical Microbiology, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Clin Infect Dis 32:1643-7. 2001
    ..The presence of intracellular S. aureus SCVs may protect against host defenses and antibiotic therapy and thus may have contributed to this patient's very prolonged skin infection...
  17. ncbi request reprint Small colony variants of Staphylococci: a link to persistent infections
    C von Eiff
    Institut fur Medizinische Mikrobiologie, Westfalische Wilhelms Universitat, Munster, Germany
    Berl Munch Tierarztl Wochenschr 113:321-5. 2000
    ..This review discusses what is known of the biology of SCVs and describes the recovery and significance of Staphylococcus SCVs in clinical specimen...
  18. ncbi request reprint Comparative in vitro activity of ABT-773 and two macrolides against staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Munster, Germany
    J Antimicrob Chemother 49:189-92. 2002
    ..Apart from strains with constitutive expression of MLS(B) resistance, all staphylococcal strains tested were inhibited by < or = 0.063 mg/L of ABT-773, irrespective of the resistance phenotype for methicillin...
  19. ncbi request reprint Coagulase-negative staphylococci. Pathogens have major role in nosocomial infections
    C von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Domagkstrasse 10, 48149 Munster, Germany
    Postgrad Med 110:63-4, 69-70, 73-6. 2001
    ....
  20. ncbi request reprint Bloodstream infections caused by small-colony variants of coagulase-negative staphylococci following pacemaker implantation
    C von Eiff
    Institute of Medical Microbiology, University of Munster, Germany
    Clin Infect Dis 29:932-4. 1999
    ..aureus SCV infections) and strongly suggest that SCVs of coagulase-negative staphylococci must be actively sought, because they grow very slowly and can be easily missed...
  21. ncbi request reprint New aspects in the molecular basis of polymer-associated infections due to staphylococci
    C von Eiff
    Institute of Medical Microbiology, Westfalische Wilhelms Universitat, Munster, Germany
    Eur J Clin Microbiol Infect Dis 18:843-6. 1999
    ..The biofilm present on infected devices plays an important role in the pathogenicity of the infecting organism by protecting the embedded staphylococci and reducing the efficacy of host defenses and antimicrobial killing...
  22. ncbi request reprint Comparative in-vitro activities of moxifloxacin, trovafloxacin, quinupristin/dalfopristin and linezolid against staphylococci
    C von Eiff
    Institute of Medical Microbiology, Westfalische Wilhelms Universitat Munster, Germany
    J Antimicrob Chemother 43:569-73. 1999
    ..A number of isolates with elevated quinolone MICs were observed...
  23. ncbi request reprint Bactericidal effect of extracorporeal shock waves on Staphylococcus aureus
    C von Eiff
    Institute of Medical Microbiology, Westfalische Wilhelms Universitat Munster, Germany
    J Med Microbiol 49:709-12. 2000
    ..The bactericidal effect of extracorporeal shock waves might provide the basis for the development of novel therapeutic strategies for bacterial infections...
  24. doi request reprint Small colony variants of Staphylococcus aureus reveal distinct protein profiles
    Andre Kriegeskorte
    Institute of Medical Microbiology, University Hospital of Munster, Germany
    Proteomics 11:2476-90. 2011
    ..In conclusion, physiological changes between normal and SCV S. aureus phenotypes are more complex than reflected by defined electron transport chain-interrupting mutants and their complemented counterparts...
  25. pmc Augmented expression of polysaccharide intercellular adhesin in a defined Staphylococcus epidermidis mutant with the small-colony-variant phenotype
    Nahed Al Laham
    Institute of Medical Microbiology, University Hospital of Munster, Domagkstr 10, 48149 Munster, Germany
    J Bacteriol 189:4494-501. 2007
    ..In conclusion, interrupting a hemin biosynthetic gene in S. epidermidis resulted in an SCV phenotype. Markedly larger cell clusters and the ability of the hemB mutant to form a biofilm are related to the augmented expression of PIA...
  26. pmc Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period
    Frieder Schaumburg
    Institute of Medical Microbiology, University Hospital Munster, Munster, Germany
    J Clin Microbiol 50:3186-92. 2012
    ..The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment...
  27. pmc Population structure of Staphylococcus aureus from remote African Babongo Pygmies
    Frieder Schaumburg
    Institute of Medical Microbiology, University of Munster, Munster, Germany
    PLoS Negl Trop Dis 5:e1150. 2011
    ..The objective of our study was to investigate the S. aureus carriage among a remote indigenous African population and to determine the molecular characteristics of the isolates, particularly those that were PVL-positive...
  28. pmc Does nasal cocolonization by methicillin-resistant coagulase-negative staphylococci and methicillin-susceptible Staphylococcus aureus strains occur frequently enough to represent a risk of false-positive methicillin-resistant S. aureus determinations by m
    Karsten Becker
    University of Munster, Institute of Medical Microbiology, D 48149 Munster
    J Clin Microbiol 44:229-31. 2006
    ..aureus-specific gene in parallel and applied directly to clinical specimens would be associated with an unacceptable positive predictive value of about 40%...
  29. ncbi request reprint Systematic survey on the prevalence of genes coding for staphylococcal enterotoxins SElM, SElO, and SElN
    Karsten Becker
    Institute of Hygiene, University Hospital of Munster, Munster, Germany
    Mol Nutr Food Res 48:488-95. 2004
    ..aureus isolates harbor subsets of pyrogenic toxin superantigens. The potential contribution of seo and sem to the pathogenic potential of S. aureus has to be further evaluated...
  30. pmc Prevalence of genes encoding pyrogenic toxin superantigens and exfoliative toxins among strains of Staphylococcus aureus isolated from blood and nasal specimens
    Karsten Becker
    Institute of Medical Microbiology Institute for Hygiene, University Hospital of Munster, 48149 Munster, Germany
    J Clin Microbiol 41:1434-9. 2003
    ..aureus. Moreover, mainly due to the fixed combinations of seg plus sei, as well as sed plus sej, the possession of multiple PTSAg genes (62.9%) is more frequent than assumed so far...
  31. pmc Sequencing and staphylococci identification
    Alexander Mellmann
    University Hospital Munster, Munster, Germany
    Emerg Infect Dis 12:333-6. 2006
    ..This database correctly identified 55 clinical staphylococcal isolates; all were correctly identified at the species level. At the subspecies level, rpoB misidentified only 2 isolates...
  32. ncbi request reprint Staphylococcal chromosomal cassette mec type I, spa type, and expression of Pls are determinants of reduced cellular invasiveness of methicillin-resistant Staphylococcus aureus isolates
    Cornelia Werbick
    Institute of Medical Microbiology, University Hospital of Munster, Germany
    J Infect Dis 195:1678-85. 2007
    ..In contrast, the spa type-deduced multilocus sequence typing clonal complex (MLST-CC) was not able to predict the invasiveness of MRSA strains equally well. The underlying mechanism remains to be elucidated...
  33. pmc Fourier-transform infrared spectroscopic analysis is a powerful tool for studying the dynamic changes in Staphylococcus aureus small-colony variants
    Karsten Becker
    Institute of Medical Microbiology, University Hospital of Munster, D 48149 Munster, Germany
    J Clin Microbiol 44:3274-8. 2006
    ..Thus, FTIR spectroscopy allowed a rapid and reproducible tool for the examination of different subpopulations of S. aureus on solid and in broth media for diagnostic and research purposes...
  34. pmc Evaluation of two chromogenic agar media for recovery and identification of Staphylococcus aureus small-colony variants
    Frank Kipp
    Institute of Medical Microbiology, University Hospital of Munster, Domagkstrasse 10, 48149 Munster, Germany
    J Clin Microbiol 43:1956-9. 2005
    ..In conclusion, the most accurate and rapid method to detect both the species S. aureus and the SCV phenotype is to inoculate specimens onto both Columbia blood agar and SAID...
  35. pmc eap Gene as novel target for specific identification of Staphylococcus aureus
    Muzaffar Hussain
    Institute of Medical Microbiology, University of Munster, 48149 Munster, Germany
    J Clin Microbiol 46:470-6. 2008
    ..Thus, the unique occurrence of Eap in S. aureus offers a promising tool particularly suitable for molecular diagnostics of this pathogen...
  36. ncbi request reprint A quantitative real-time immuno-PCR approach for detection of staphylococcal enterotoxins
    Andreas Fischer
    Institute of Medical Microbiology, University Hospital of Munster, 48149, Munster, Germany
    J Mol Med (Berl) 85:461-9. 2007
    ....
  37. pmc Shiga toxin-mediated hemolytic uremic syndrome: time to change the diagnostic paradigm?
    Martina Bielaszewska
    Institute of Hygiene and the National Consulting Laboratory on Hemolytic Uremic Syndrome, University of Munster, Munster, Germany
    PLoS ONE 2:e1024. 2007
    ..However, the frequency of stx-negative/eae-positive E. coli in stools of HUS patients and the clinical significance of such strains are unknown...
  38. doi request reprint Identification of differentially expressed small non-protein-coding RNAs in Staphylococcus aureus displaying both the normal and the small-colony variant phenotype
    Luay F Abu-Qatouseh
    University Hospital of Munster, Institute of Medical Microbiology, Domagkstr 10, 48149, Munster, Germany
    J Mol Med (Berl) 88:565-75. 2010
    ..aureus phenotype-specific expression of four novel npcRNAs was documented. Thus, the presence of differentially expressed npcRNAs in S. aureus may help to understand the phenotypic variation and its associated pathogenicity...
  39. pmc Development and evaluation of a quality-controlled ribosomal sequence database for 16S ribosomal DNA-based identification of Staphylococcus species
    Karsten Becker
    Institute of Medical Microbiology, University of Munster, D 48149 Munster, Germany
    J Clin Microbiol 42:4988-95. 2004
    ..In contrast to phenotypic methods and the NCBI database, the novel high-quality RIDOM sequence database provides excellent identification of staphylococci, including rarely isolated species and phenotypic variants...
  40. ncbi request reprint Thermonuclease gene as a target for specific identification of Staphylococcus intermedius isolates: use of a PCR-DNA enzyme immunoassay
    Karsten Becker
    Institute of Medical Microbiology, University of Münster Hospital, 48149 Munster, Germany
    Diagn Microbiol Infect Dis 51:237-44. 2005
    ..5%). Except for the limitations with isolates of hoofed animals, the S. intermediusnuc PCR assay has potential for rapid identification of S. intermedius and differentiation from other coagulase-positive staphylococci including S. aureus...
  41. pmc In vitro activity against Staphylococcus aureus of a novel antimicrobial agent, PRF-119, a recombinant chimeric bacteriophage endolysin
    Evgeny A Idelevich
    University Hospital of Munster, Institute of Medical Microbiology, D 48149 Munster, Germany
    Antimicrob Agents Chemother 55:4416-9. 2011
    ..391 μg/ml (range, 0.024 to 1.563 μg/ml). All 192 clinical isolates of coagulase-negative staphylococci exhibited MIC values of >50 μg/ml. In conclusion, PRF-119 exhibited very good activity specifically against S. aureus...
  42. doi request reprint Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence
    Lorena Tuchscherr
    Institutes of Medical Microbiology, Center of Clinical Research, University Hospital of Munster, Munster, Germany
    J Infect Dis 202:1031-40. 2010
    ..Thus far, persistent and antibiotic-refractory infections have been largely associated with a subpopulation of S. aureus, the small-colony variants (SCVs)...
  43. ncbi request reprint Understanding the physiology and adaptation of staphylococci: a post-genomic approach
    Karsten Becker
    Universitat Munster, Institut für Medizinsche Mikrobiologie, Munster, Germany
    Int J Med Microbiol 297:483-501. 2007
    ..aureus and coagulase-negative staphylococci...
  44. pmc Evaluation of different methods to detect methicillin resistance in small-colony variants of Staphylococcus aureus
    Frank Kipp
    Institute of Medical Microbiology, University Hospital of Munster, 48149 Munster, Germany
    J Clin Microbiol 42:1277-9. 2004
    ..Only detection of the mecA gene by PCR and the MRSA-Screen latex agglutination test using a higher colony number were shown to be reliable methods to rapidly detect methicillin resistance in these variants...
  45. doi request reprint Reduction of periprosthetic infection with silver-coated megaprostheses in patients with bone sarcoma
    Jendrik Hardes
    Department of Orthopedics and Tumor Orthopedics, Munster University Hospital, Munster, Germany
    J Surg Oncol 101:389-95. 2010
    ..In individual cases, secondary amputation is unavoidable in the effort to cure infection...
  46. pmc Reporter metabolite analysis of transcriptional profiles of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant displaying the small-colony-variant phenotype
    Jochen Seggewiss
    Institute of Medical Microbiology, University Hospital of Munster, Domagkstrasse 10, 48149 Munster, Germany
    J Bacteriol 188:7765-77. 2006
    ..In conclusion, the identified differences may be responsible for the SCV phenotype and its association with chronic and persistent infections...
  47. pmc Systematic survey of nonspecific agglutination by Candida spp. in latex assays
    Karsten Becker
    Institute of Medical Microbiology, University of Munster, D 48149 Munster, Germany
    J Clin Microbiol 45:1315-8. 2007
    ..In fact, 40 (26.7%) of these isolates revealed nonspecific results, significantly associated with the time allowed for agglutination...
  48. pmc Small colony variants of Staphylococcus aureus and pacemaker-related infection
    Harald Seifert
    Institute of Medical Microbiology, Immunology and Hygiene, University of Koln, Goldenfelstrasse 19 21, 50935 Köln, Germany
    Emerg Infect Dis 9:1316-8. 2003
  49. doi request reprint The influence of the alloy of megaprostheses on infection rate
    Georg Gosheger
    Department of Orthopaedics, University Hospital of Munster, Munster, Germany
    J Arthroplasty 23:916-20. 2008
    ..05)...
  50. doi request reprint Immunomodulation of nasal epithelial cells by Staphylococcus aureus-derived serine proteases
    Claudia Rudack
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Munster, Munster, Germany
    J Immunol 183:7592-601. 2009
    ..S. aureus serine proteases were identified to modulate chemokine synthesis and activate NF-kappaB in nasal epithelial cells, and may therefore be relevant for the pathophysiology of chronic rhinosinusitis...
  51. pmc Kocuria rhizophila adds to the emerging spectrum of micrococcal species involved in human infections
    Karsten Becker
    University Hospital of Munster, Institute of Medical Microbiology, Domagkstr 10, 48149 Munster, Germany
    J Clin Microbiol 46:3537-9. 2008
    ..K. rhizophila expands the emerging number of "micrococci" considered to be etiologically relevant...
  52. pmc agr-dependent bacterial interference has no impact on long-term colonization of Staphylococcus aureus during persistent airway infection of cystic fibrosis patients
    Barbara C Kahl
    Institute of Medical of Microbiology Institute for Hygiene, University of Muenster, Muenster 48149, Germany
    J Clin Microbiol 41:5199-201. 2003
    ..The success of CF clones in terms of cocolonization and/or infection with S. aureus, prevalence of clones, or persistence appeared to be independent of agr group specificity...
  53. doi request reprint Risk variants in the S100B gene predict elevated S100B serum concentrations in healthy individuals
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:291-7. 2010
    ....
  54. ncbi request reprint Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin
    Christian Maaser
    Department of Medicine B, University of Muenster, Muenster, Germany
    J Immunol 172:5056-62. 2004
    ..These results suggest that endothelially expressed TLR5 might play a previously unrecognized role in the innate immune response toward bacterial Ags...
  55. ncbi request reprint Kytococcus schroeteri sp. nov., a novel Gram-positive actinobacterium isolated from a human clinical source
    Karsten Becker
    Institute of Medical Microbiology, University of Munster, Hospital and Clinics, Germany
    Int J Syst Evol Microbiol 52:1609-14. 2002
    ..nov. is proposed. The type strain is strain Muenster 2000T (= DSM 13884T = CCM 4918T)...
  56. ncbi request reprint Silver-coated megaendoprostheses in a rabbit model--an analysis of the infection rate and toxicological side effects
    Georg Gosheger
    Department of Orthopedics, University of Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    Biomaterials 25:5547-56. 2004
    ....
  57. doi request reprint Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia
    Anya Pedersen
    University Medical Faculty, Department of Psychiatry, 48149 Munster, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1789-92. 2008
    ..The findings support the hypothesis that astrocyte activation might contribute to the development of cognitive dysfunction in schizophrenia...
  58. ncbi request reprint Physiology and antibiotic susceptibility of Staphylococcus aureus small colony variants
    Nicole Baumert
    Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, D 53105 Bonn, Germany
    Microb Drug Resist 8:253-60. 2002
    ..When growing in CDM, the susceptibility of SCVs varied according to the magnitude of deltapsi...
  59. doi request reprint Kytococcus schroeteri: a probably underdiagnosed pathogen involved in prosthetic valve endocarditis
    Christian Aepinus
    Department of Medical Microbiology, Hygiene and Virology, University of Rostock, Rostock, Germany
    Wien Klin Wochenschr 120:46-9. 2008
    ..Since the first description of K. schroeteri in 2002, four cases of endocarditis have been published, suggesting antecedent and continuing underdiagnosis...
  60. pmc Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype
    Brian T Tsuji
    School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 331 Cooke Hall, Buffalo, NY 14260, USA
    Antimicrob Agents Chemother 52:1533-7. 2008
    ..Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model...
  61. ncbi request reprint Virulence of a hemB mutant displaying the phenotype of a Staphylococcus aureus small colony variant in a murine model of septic arthritis
    Ing Marie Jonsson
    Department of Rheumatology, University of Goteborg, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    Microb Pathog 34:73-9. 2003
    ..aureus are more virulent on a per organism basis than its isogenic parental strain in the model of septic arthritis. This can at least in part be explained by the ability of SCV to produce high amounts of destructive proteases...
  62. ncbi request reprint Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney
    Donna M Bates
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Infect Dis 187:1654-61. 2003
    ..These data show that SCVs are able to colonize multiple tissues in vivo and that the menD mutation provides the organism with a survival advantage during antimicrobial therapy, compared with its parent strain, in selected target tissues...
  63. ncbi request reprint Intranasal mupirocin to prevent postoperative infections
    Christof von Eiff
    N Engl J Med 347:1207-8; author reply 1207-8. 2002
  64. pmc Physiological characterization of a heme-deficient mutant of Staphylococcus aureus by a proteomic approach
    Christian Kohler
    Institut fur Mikrobiologie, Universitat Greifswald, 17487 Greifswald, Germany
    J Bacteriol 185:6928-37. 2003
    ..Furthermore, the amounts of most of the extracellular virulence factors were significantly reduced by a mutation in hemB, which is consistent with previous reports...
  65. pmc Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypes
    Pierre Vaudaux
    Division of Infectious Diseases, University Hospital, CH 1211 Geneva 14, Switzerland
    Infect Immun 70:5428-37. 2002
    ..Both agr-positive and agr-lacking hemB mutants were also more efficiently internalized by human embryonic kidney cells than were their isogenic controls, presumably because of increased surface display of their fibronectin adhesins...
  66. ncbi request reprint Staphylococcus aureus infection caused by a Panton Valentine leukocidin-producing strain
    Christian Aepinus
    Pediatr Infect Dis J 24:284-5. 2005
  67. ncbi request reprint Effectiveness of hydroxyapatite-vancomycin bone cement in the treatment of Staphylococcus aureus induced chronic osteomyelitis
    Uwe Joosten
    Department of Trauma and Orthopaedic Surgery, Munarienhospital Osnabrück, Johannisfreiheit 2 4, 49074 Osnabrück Germany
    Biomaterials 26:5251-8. 2005
    ..No local or systemic side effects due to HAC or vancomycin were seen. HAC is an effective carrier material for antibiotic compounds even in refractory infections due to MRSA or S. aureus SCVs...
  68. pmc Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model
    Christopher Faber
    Department of Orthopaedic Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Antimicrob Agents Chemother 49:2438-44. 2005
    ..Therefore, the results of this study warrant further preclinical investigations into the possibilities of using hLF1-11 for the treatment of osteomyelitis...
  69. pmc Staphylococcus lugdunensis pacemaker-related infection
    Harald Seifert
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Emerg Infect Dis 11:1283-6. 2005
    ....
  70. pmc Biotyping of enterotoxigenic Staphylococcus aureus by enterotoxin gene cluster (egc) polymorphism and spa typing analyses
    Giuseppe Blaiotta
    Dipartimento di Scienza degli Alimenti, Universita degli Studi di Napoli Federico II, Via Universita, 10080055 Portici Naples, Italy
    Appl Environ Microbiol 72:6117-23. 2006
    ..Hence, the polyphasic approach used in this study can be reliably and advantageously applied for typing egc-positive S. aureus strains...
  71. pmc sigmaB activity in a Staphylococcus aureus hemB mutant
    Maria M Senn
    Department of Medical Microbiology, University of Zurich, Gloriastrasse 32, 8006 Zurich, Switzerland
    J Bacteriol 187:7397-406. 2005
    ..This study provides the first extended synopsis of the transcriptional patterns of different regulators over the entire growth cycle in the widely used Newman strain...
  72. ncbi request reprint Characteristics of Staphylococcus aureus, isolated from airways of cystic fibrosis patients, and their small colony variants
    Beata Sadowska
    Department of Infectious Biology, Institute of Microbiology and Immunology, University of Lodz, Poland
    FEMS Immunol Med Microbiol 32:191-7. 2002
    ..SCVs are adapted to intracellular survival and persistence in the host under certain circumstances. The ability to form a variant subpopulation affords S. aureus additional survival options...
  73. pmc Virulence of Staphylococcus aureus small colony variants in the Caenorhabditis elegans infection model
    Costi D Sifri
    University of Virginia Health System, Division of Infectious Diseases and International Health, P O Box 801361, Charlottesville, VA 22908, USA
    Infect Immun 74:1091-6. 2006
    ..aureus. In this study, we show that clinical SCVs as well as hemB- and menD-deficient mutants of S. aureus are greatly reduced in virulence in the C. elegans infection model...
  74. ncbi request reprint Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B
    Orjan Samuelsen
    Department of Medical Microbiology, University Hospital of North Norway, Tromsø, Norway
    J Antimicrob Chemother 56:1126-9. 2005
    ..To assess if deficiency in transmembrane potential, a common characteristic of SCVs that are haemin- or menadione-auxotrophs, affects the uptake of the peptide into the bacterial cytoplasm...
  75. pmc Prosthetic valve endocarditis due to Kytococcus schroeteri
    Karsten Becker
    Emerg Infect Dis 9:1493-5. 2003
  76. ncbi request reprint Antibacterial effects of extracorporeal shock waves
    Ludger Gerdesmeyer
    Klinik und Poliklinik für Orthopädie und Sportorthopädie der Technischen Universität München, Munchen, Germany
    Ultrasound Med Biol 31:115-9. 2005
    ..ESWT proved to exert significant antibacterial effect in an energy-dependent manner. Certain types of difficult-to-treat infections could offer new applications for ESWT...
  77. ncbi request reprint Live cell imaging of phagosome maturation in Staphylococcus aureus infected human endothelial cells: small colony variants are able to survive in lysosomes
    Andreas Schröder
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat Munchen, 80336 Munchen, Germany
    Med Microbiol Immunol 195:185-94. 2006
    ..Thus, on one hand we document effective bactericidal activity of human endothelial cell lysosomes towards staphylococci, and on the other hand we provide evidence that certain SCVs are capable to withstand this activity...
  78. ncbi request reprint Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections
    Richard A Proctor
    University of Wisconsin Medical School, 436 SMI, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Rev Microbiol 4:295-305. 2006
    ..This Review covers the phenotypic, genetic and clinical picture associated with small colony variants, with an emphasis on staphylococci, for which the greatest amount of information is available...