U Vogel

Summary

Country: Germany

Publications

  1. pmc Spatiotemporal analysis of invasive meningococcal disease, Germany
    Johannes Elias
    University of Wurzburg, Wurzburg, Germany
    Emerg Infect Dis 12:1689-95. 2006
  2. pmc Opc expression, LPS immunotype switch and pilin conversion contribute to serum resistance of unencapsulated meningococci
    Kerstin Hubert
    University of Wurzburg, Institute for Hygiene and Microbiology, Wurzburg, Germany
    PLoS ONE 7:e45132. 2012
  3. pmc Persistence of antibodies in laboratory staff immunized with quadrivalent meningococcal polysaccharide vaccine
    Johannes Elias
    Institute for Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, 97080, Wuerzburg, Germany
    J Occup Med Toxicol 8:4. 2013
  4. pmc Prevalence dependent calibration of a predictive model for nasal carriage of methicillin-resistant Staphylococcus aureus
    Johannes Elias
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, Wurzburg, 97080, Germany
    BMC Infect Dis 13:111. 2013
  5. doi request reprint The use of vaccine antigen characterization, for example by MATS, to guide the introduction of meningococcus B vaccines
    Ulrich Vogel
    Institute for Hygiene and Microbiology, National Reference Laboratory for Meningococci, University of Wurzburg, Germany
    Vaccine 30:B73-7. 2012
  6. pmc Ion torrent personal genome machine sequencing for genomic typing of Neisseria meningitidis for rapid determination of multiple layers of typing information
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Clin Microbiol 50:1889-94. 2012
  7. doi request reprint European efforts to harmonize typing of meningococci
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, Building E2, 97080 Wurzburg, Germany
    Int J Med Microbiol 301:659-62. 2011
  8. pmc EpiScanGIS: an online geographic surveillance system for meningococcal disease
    Markus Reinhardt
    Computer Science II, University of Wurzburg, Germany
    Int J Health Geogr 7:33. 2008
  9. doi request reprint Molecular epidemiology of meningococci: application of DNA sequence typing
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of Wurzburg, Germany
    Int J Med Microbiol 300:415-20. 2010
  10. doi request reprint Meticillin-resistant Staphylococcus aureus (MRSA) contamination of ambulance cars after short term transport of MRSA-colonised patients is restricted to the stretcher
    S J Eibicht
    University of Wurzburg, Institute for Hygiene and Microbiology, Wurzburg, Germany
    J Hosp Infect 78:221-5. 2011

Detail Information

Publications67

  1. pmc Spatiotemporal analysis of invasive meningococcal disease, Germany
    Johannes Elias
    University of Wurzburg, Wurzburg, Germany
    Emerg Infect Dis 12:1689-95. 2006
    ..2%. The study exemplifies how the combination of molecular finetyping and spatiotemporal analysis can be used to assess an infectious disease in a large European country...
  2. pmc Opc expression, LPS immunotype switch and pilin conversion contribute to serum resistance of unencapsulated meningococci
    Kerstin Hubert
    University of Wurzburg, Institute for Hygiene and Microbiology, Wurzburg, Germany
    PLoS ONE 7:e45132. 2012
    ..The study highlights the ability of meningococci to adapt to environmental stress by phase variation and intrachromosomal recombination affecting subcapsular antigens...
  3. pmc Persistence of antibodies in laboratory staff immunized with quadrivalent meningococcal polysaccharide vaccine
    Johannes Elias
    Institute for Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, 97080, Wuerzburg, Germany
    J Occup Med Toxicol 8:4. 2013
    ..While, until recently, immunization with quadrivalent polysaccharide vaccine represented one cornerstone of protection, data on long-term persistence of antibodies in adults remain scarce...
  4. pmc Prevalence dependent calibration of a predictive model for nasal carriage of methicillin-resistant Staphylococcus aureus
    Johannes Elias
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, Wurzburg, 97080, Germany
    BMC Infect Dis 13:111. 2013
    ..In contrast, accurate estimation of carriage probability, which may inform decisions regarding treatment and infection control, is rarely assessed. Furthermore, no published models adjust for MRSA prevalence...
  5. doi request reprint The use of vaccine antigen characterization, for example by MATS, to guide the introduction of meningococcus B vaccines
    Ulrich Vogel
    Institute for Hygiene and Microbiology, National Reference Laboratory for Meningococci, University of Wurzburg, Germany
    Vaccine 30:B73-7. 2012
    ..The paper discusses the pre- and post-licensure application of MATS, the role of reference laboratories, concepts of sustained provision of the assay, external quality assessment, and laboratory twinning...
  6. pmc Ion torrent personal genome machine sequencing for genomic typing of Neisseria meningitidis for rapid determination of multiple layers of typing information
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Clin Microbiol 50:1889-94. 2012
    ..This will reduce workloads and rapidly provide information for laboratory surveillance, outbreak investigation, assessment of vaccine preventability, and antibiotic resistance gene monitoring...
  7. doi request reprint European efforts to harmonize typing of meningococci
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, Building E2, 97080 Wurzburg, Germany
    Int J Med Microbiol 301:659-62. 2011
    ..Although not yet feasible for routine application on hundreds of strains, novel database structures have been developed to accommodate deep sequencing data...
  8. pmc EpiScanGIS: an online geographic surveillance system for meningococcal disease
    Markus Reinhardt
    Computer Science II, University of Wurzburg, Germany
    Int J Health Geogr 7:33. 2008
    ..The integration of pathogen fine typing data in dynamic systems and visualization of spatio-temporal clusters are a technical challenge for system development...
  9. doi request reprint Molecular epidemiology of meningococci: application of DNA sequence typing
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of Wurzburg, Germany
    Int J Med Microbiol 300:415-20. 2010
    ..In Europe, a consensus for molecular typing has been achieved...
  10. doi request reprint Meticillin-resistant Staphylococcus aureus (MRSA) contamination of ambulance cars after short term transport of MRSA-colonised patients is restricted to the stretcher
    S J Eibicht
    University of Wurzburg, Institute for Hygiene and Microbiology, Wurzburg, Germany
    J Hosp Infect 78:221-5. 2011
    ..aureus was detected in 12 cars, predominantly at handles and headrests. This finding highlights the importance of disinfection of surfaces in the vicinity of patients irrespective of the MRSA status...
  11. ncbi request reprint Functional characterization of an isogenic meningococcal alpha-2,3-sialyltransferase mutant: the role of lipooligosaccharide sialylation for serum resistance in serogroup B meningococci
    U Vogel
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Germany
    Med Microbiol Immunol 186:159-66. 1997
    ....
  12. ncbi request reprint Genetic lineages and their traits in Neisseria meningitidis
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int J Med Microbiol 294:75-82. 2004
    ..The oatC and oatWY genes proved to be the first genes identified to be responsible for O-acetylation of polysialic acid...
  13. pmc Bacteremia in an immunocompromised patient caused by a commensal Neisseria meningitidis strain harboring the capsule null locus (cnl)
    Ulrich Vogel
    National Reference Laboratory for Meningococci, Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    J Clin Microbiol 42:2898-901. 2004
    ..The sequence type 845 strain was extensively typed and, furthermore, shown to be sensitive to serum bactericidal activity...
  14. pmc Complement factor C3 deposition and serum resistance in isogenic capsule and lipooligosaccharide sialic acid mutants of serogroup B Neisseria meningitidis
    U Vogel
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Germany
    Infect Immun 65:4022-9. 1997
    ....
  15. ncbi request reprint The evolution of human pathogens: examples and clinical implications
    U Vogel
    Institut für Hygiene und Mikrobiologie, University of Wurzburg, Germany
    Int J Med Microbiol 290:511-8. 2000
    ..Furthermore, examples of the tremendous velocity of bacterial evolution under changing environmental conditions will be discussed...
  16. ncbi request reprint Molecular epidemiology of Neisseria meningitidis
    Ulrich Vogel
    Institute for Hygiene and Microbiology, University of W rzburg, Germany
    Front Biosci 8:e14-22. 2003
    ....
  17. pmc Vaccine development against Neisseria meningitidis
    Ulrich Vogel
    University of Wurzburg, Institute for Hygiene and Microbiology, Reference Laboratory for Meningococci, Germany
    Microb Biotechnol 4:20-31. 2011
    ..Research currently addresses the analysis of life vaccines, meningococcus B polysaccharide modifications and mimotopes, as well as the use of N. lactamica outer membrane vesicles...
  18. pmc Role of lipopolysaccharide sialylation in serum resistance of serogroup B and C meningococcal disease isolates
    U Vogel
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, 97080 Wurzburg, Germany
    Infect Immun 67:954-7. 1999
    ..Lipopolysaccharide sialylation was found to be of minor importance for the resistance of serogroup B and C meningococcal disease isolates to complement attack...
  19. ncbi request reprint Many carried meningococci lack the genes required for capsule synthesis and transport
    Heike Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Microbiology 148:1813-9. 2002
    ....
  20. doi request reprint Nosocomial outbreak of VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa associated with retrograde urography
    J Elias
    Institute for Hygiene and Microbiology, University of Wuerzburg, Wuerzburg, Germany
    Clin Microbiol Infect 16:1494-500. 2010
    ..Department-specific infection control measures, including reinforced hygiene procedures during retrograde urography, quickly terminated the outbreak...
  21. pmc Differential distribution of novel restriction-modification systems in clonal lineages of Neisseria meningitidis
    H Claus
    Institut für Hygiene und Mikrobiologie, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 182:1296-303. 2000
    ....
  22. ncbi request reprint Genetic mechanisms for loss of encapsulation in polysialyltransferase-gene-positive meningococci isolated from healthy carriers
    Martin V R Weber
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int J Med Microbiol 296:475-84. 2006
    ..These observations are consistent with the postulate that particular meningococcal clonal complexes are associated with possession of a capsule and that this association is important for transmission success...
  23. ncbi request reprint Carbohydrate composition of meningococcal lipopolysaccharide modulates the interaction of Neisseria meningitidis with human dendritic cells
    Oliver Kurzai
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    Cell Microbiol 7:1319-34. 2005
    ..The use of truncated LPS isoforms in vaccine preparations can therefore not only result in attenuation but also in more efficient targeting of DC...
  24. ncbi request reprint Genetic analysis of meningococci carried by children and young adults
    Heike Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Infect Dis 191:1263-71. 2005
    ..The relationship between meningococcal genotype and capsular polysaccharide, the principal virulence factor and vaccine component, was investigated in carried meningococci isolated from 8000 children and young adults in Bavaria, Germany...
  25. ncbi request reprint Mechanisms of neisserial serum resistance
    U Vogel
    Institut für Hygiene und Mikrobiologie, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Mol Microbiol 32:1133-9. 1999
    ..We review current concepts of neisserial serum resistance with emphasis on porins and polysaccharides exposed on the neisserial surface and their interaction with components of normal human serum...
  26. pmc Genetic isolation of meningococci of the electrophoretic type 37 complex
    H Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Bacteriol 183:2570-5. 2001
    ....
  27. ncbi request reprint Living in a changing environment: insights into host adaptation in Neisseria meningitidis from comparative genomics
    Christoph Schoen
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Str 2, Bau E1, D 97080 Wurzburg, Germany
    Int J Med Microbiol 297:601-13. 2007
    ..meningitidis an accidental pathogen. The overall properties of the meningococcal genome are characterized by genomic variability and instability, resulting in increased functional flexibility within this species...
  28. ncbi request reprint Amino acid 310 determines the donor substrate specificity of serogroup W-135 and Y capsule polymerases of Neisseria meningitidis
    Heike Claus
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Mol Microbiol 71:960-71. 2009
    ..In silico analysis revealed a similar amino acid-based association in other members of the same glycosyltransferase family irrespective of the bacterial species...
  29. pmc Vaccine preventability of meningococcal clone, Greater Aachen Region, Germany
    Johannes Elias
    University of Wuerzburg, Wuerzburg, Germany
    Emerg Infect Dis 16:465-72. 2010
    ..Because this globally distributed epidemic strain spreads slowly, vaccination efforts could possibly eliminate meningococcal disease in this area...
  30. pmc Panton-Valentine leukocidin-positive Staphylococcus aureus infections in returning travelers
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Germany
    Am J Trop Med Hyg 83:748-50. 2010
    ..Spa typing of the strains revealed a broad spectrum of variants, but some were clonally related. Methicillin-resistant Staphylococcus aureus (MRSA) was found in three cases...
  31. doi request reprint O-acetyltransferase gene neuO is segregated according to phylogenetic background and contributes to environmental desiccation resistance in Escherichia coli K1
    Ines L Mordhorst
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    Environ Microbiol 11:3154-65. 2009
    ..In contrast, NeuO expression led to a reduced biofilm formation in biofilm positive E. coli K1 isolates. These findings suggest a delicate ecological balance of neuO'on'/'off' switching...
  32. doi request reprint A dual role of extracellular DNA during biofilm formation of Neisseria meningitidis
    Martin Lappann
    University of Wurzburg, Institute for Hygiene and Microbiology, Germany
    Mol Microbiol 75:1355-71. 2010
    ..On the contrary, spreaders (ST-11 and ST-8 cc) are unable to use eDNA for biofilm formation and might compensate for poor colonization properties by high transmission rates...
  33. pmc Microbiological evaluation of the new VITEK 2 Neisseria-Haemophilus identification card
    Giuseppe Valenza
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2 E1, 97080, Wurzburg, Germany
    J Clin Microbiol 45:3493-7. 2007
    ..Moreover, further reduction of the detection time would be desirable...
  34. pmc Deletion of the meningococcal fetA gene used for antigen sequence typing of invasive and commensal isolates from Germany: frequencies and mechanisms
    Heike Claus
    University of Wurzburg, Institute for Hygiene and Microbiology, National Reference Centre for Meningococci, Wurzburg, Germany
    J Clin Microbiol 45:2960-4. 2007
    ..ST-35 cc strains and the recently published ST-192 strains from Burkina Faso may benefit from loss of fetA, but their infrequent occurrence among invasive isolates currently does not affect fetA antigen ST...
  35. ncbi request reprint Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci
    Heike Claus
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Mol Microbiol 51:227-39. 2004
    ..Our report is the first description of sequences of sialic acid O-acetyltransferase genes that have not been cloned from either other bacterial or mammalian organisms...
  36. pmc IS1301 fingerprint analysis of Neisseria meningitidis strains belonging to the ET-15 clone
    Johannes Elias
    Institute for Hygiene and Microbiology, University of Wurzburg, 97080 Wurzburg, Germany
    J Clin Microbiol 45:159-67. 2007
    ..A previously described insertion in nadA was present in more than two-thirds of the strains analyzed, suggesting that NadA is probably an unreliable vaccine candidate for the prevention of ET-15 disease...
  37. pmc Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis
    Christoph Schoen
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:3473-8. 2008
    ..meningitidis has emerged as an unencapsulated human commensal from a common ancestor with Neisseria gonorrhoeae and Neisseria lactamica and consecutively acquired the genes responsible for capsule synthesis via horizontal gene transfer...
  38. pmc Molecular epidemiology of hospital-acquired vancomycin-resistant enterococci
    Marianne Abele-Horn
    Institute for Hygiene and Microbiology, University of Wurzburg, Germany
    J Clin Microbiol 44:4009-13. 2006
    ..The combination of MLST and MLVA may be an alternative to PFGE in hospital epidemiology, providing the benefits of high accuracy, reproducibility, and portability...
  39. doi request reprint [Infections with pneumococci, menigococci, H. influenzae and diphtheria in Germany: the RKI Reference Network for Invasive Bacterial Infections (IBI) at the 5th Würzburg Workshop on Epidemiology, Prevention and Therapy for Invasive Meningococcal Diseases
    T T Lam
    Nationales Referenzzentrum für Meningokokken und Konsiliarlabor für H influenzae, Institut für Hygiene und Mikrobiologie, Universitat Wurzburg
    Gesundheitswesen 74:747-53. 2012
    ..pneumoniae infections. The epidemiological data were complemented by clinical aspects concerning the vaccination of immunocompromised children...
  40. ncbi request reprint The genus Neisseria: population structure, genome plasticity, and evolution of pathogenicity
    U Vogel
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Curr Top Microbiol Immunol 264:23-45. 2002
  41. ncbi request reprint Identification of a hotspot for transformation of Neisseria meningitidis by shuttle mutagenesis using signature-tagged transposons
    H Claus
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Germany
    Mol Gen Genet 259:363-71. 1998
    ....
  42. pmc Identification of the hypervirulent lineages of Neisseria meningitidis, the ST-8 and ST-11 complexes, by using monoclonal antibodies specific to NmeDI
    Heike Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    J Clin Microbiol 41:3873-6. 2003
    ..The gene encoding the putative restriction-modification system NmeDI is specific to these lineages. We report here a monoclonal antibody directed against the NmeDI endonuclease as a tool for their rapid and spe-cific identification...
  43. ncbi request reprint Evaluation of custom-made DNA microarrays for multilocus sequence typing of Neisseria meningitidis
    Halina Swiderek
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Int J Med Microbiol 295:39-45. 2005
    ..We assume that the high density of polymorphic sites and the extensive GC-content variations at N. meningitidis MLST loci hinder the successful implementation of MLST microarrays based on polymorphism-directed oligonucleotide design...
  44. doi request reprint Streptococcus merionis sp. nov., isolated from Mongolian jirds (Meriones unguiculatus)
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int J Syst Evol Microbiol 59:766-70. 2009
    ..nov. is proposed. The type strain is WUE3771(T) (=DSM 19192(T)=CCUG 54871(T))...
  45. ncbi request reprint Meningococcal biofilm formation: structure, development and phenotypes in a standardized continuous flow system
    Martin Lappann
    University of Wurzburg, Institute for Hygiene and Microbiology, Germany
    Mol Microbiol 62:1292-309. 2006
    ..PilX alleles differed in their propensity to support autoaggregation of cells in suspension, but not in their ability to support microcolony formation within biofilms in the continuous flow system...
  46. ncbi request reprint Microarray analyses of meningococcal genome composition and gene regulation: a review of the recent literature
    Heike Claus
    Institute for Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    FEMS Microbiol Rev 31:43-51. 2007
    ..However, harmonization of protocols and tools, as well as central databases are needed to foster the comparability of studies and the integration of knowledge...
  47. doi request reprint Biofilm formation by the human pathogen Neisseria meningitidis
    Martin Lappann
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, Building E1, Wurzburg, Germany
    Med Microbiol Immunol 199:173-83. 2010
    ..The theory of sub-dividing the meningococcal population in settler and spreader lineages is discussed, which provides a mechanistic framework for the assumed balance of colonization efficacy and transmission frequency...
  48. pmc Evidence for indirect nosocomial transmission of Neisseria meningitidis resulting in two cases of invasive meningococcal disease
    Johannes Elias
    National Reference Centre for Meningococci, Institute for Hygiene and Microbiology, University of Wurzburg, Germany
    J Clin Microbiol 44:4276-8. 2006
    ..The most likely epidemiological link was simultaneous hospitalization, resulting in indirect nosocomial transmission...
  49. ncbi request reprint Analysis of the periodontal microbiota in childhood-type hypophosphatasia
    Giuseppe Valenza
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2 E1, D 97080 Wurzburg, Germany
    Int J Med Microbiol 296:493-500. 2006
    ....
  50. doi request reprint Microbial changes in periodontitis successfully treated by mechanical plaque removal and systemic amoxicillin and metronidazole
    Giuseppe Valenza
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2 E1, 97080 Wurzburg, Germany
    Int J Med Microbiol 299:427-38. 2009
    ..In summary, despite a favorable clinical outcome, a transient effect on only few bacterial species was observed...
  51. ncbi request reprint Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens
    Gerhard Hutter
    Institute for Hygiene, University of Wurzburg, Germany
    Microbiology 149:67-75. 2003
    ....
  52. ncbi request reprint O-Acetylation status of the capsular polysaccharides of serogroup Y and W135 meningococci isolated in the UK
    Emma Longworth
    PHLS Meningococcal Reference Unit, Manchester Public Health Laborotory, Withington Hospital, Manchester M20 2LR, UK
    FEMS Immunol Med Microbiol 32:119-23. 2002
    ..Although the biological relevance of O-acetylation status is unknown for these serogroups, an understanding of O-acetylation status of the respective polysaccharides may provide useful insights into the optimal vaccine formulation...
  53. pmc Target gene sequencing to characterize the penicillin G susceptibility of Neisseria meningitidis
    Muhamed Kheir Taha
    Neisseria Unit, Institut Pasteur, 28 rue du Dr Roux, Paris, France
    Antimicrob Agents Chemother 51:2784-92. 2007
    ..These data argue for the use of penA sequencing to identify isolates with reduced susceptibility to penicillin G and as a tool to improve typing of meningococcal isolates, as well as to analyze DNA exchange among Neisseria species...
  54. ncbi request reprint Standardized nonculture techniques recommended for European reference laboratories
    Andrew J Fox
    Institute for Hygiene and Mikrobiologie, National Reference Centre for Meningococci, Wurzburg, Germany
    FEMS Microbiol Rev 31:84-8. 2007
    ..These approaches can be implemented either by individual reference laboratories or through collaboration and referral between centres...
  55. pmc Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases
    Friedrich Freiberger
    Abteilung Zelluläre Chemie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Mol Microbiol 65:1258-75. 2007
    ....
  56. pmc The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
    Guillermo Madico
    Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:501-10. 2006
    ..These data provide further support for inclusion of this molecule in a meningococcal vaccine. To reflect the critical function of this molecule, we suggest calling it fH-binding protein...
  57. ncbi request reprint Biochemical characterization of the polysialic acid-specific O-acetyltransferase NeuO of Escherichia coli K1
    Anne K Bergfeld
    Department of Cellular Chemistry, Medical School Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    J Biol Chem 282:22217-27. 2007
    ....
  58. ncbi request reprint Three cases of invasive meningococcal disease caused by a capsule null locus strain circulating among healthy carriers in Burkina Faso
    Helen Findlow
    Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, M13 9WZ, UK
    J Infect Dis 195:1071-7. 2007
    ..The presence of cnl meningococci that can escape serum killing and cause invasive disease is of concern for future vaccination strategies and should promote rigorous surveillance of cnl meningococcal disease...
  59. ncbi request reprint Workshop on vaccine pressure and Neisseria meningitidis, Annecy, France, 9-11 March 2005
    Jean Michel Alonso
    Institut Pasteur, Paris, France
    Vaccine 25:4125-9. 2007
    ..The workshop concluded that there is no current evidence to suggest that serogroup C conjugate vaccine pressure has resulted in meningococcal serogroup switching or replacement...
  60. pmc Interlaboratory comparison of PCR-based identification and genogrouping of Neisseria meningitidis
    Muhamed Kheir Taha
    Neisseria Unit and the French National Reference Center for Meningococci, Institut Pasteur, Paris, France
    J Clin Microbiol 43:144-9. 2005
    ..Genogroup B gave the best correlation between participants, as all laboratories routinely perform this PCR. The results for genogroups A and W135 were less similar between the eight participating laboratories that performed these PCRs...
  61. pmc Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: detection by oligonucleotide microarray and real-time PCR analysis
    Holger G Hass
    Department of Oncology, Hematology and Palliative Care, Marien Hospital, Boeheim Street 37, Stuttgart 70199, Germany
    World J Gastroenterol 14:2501-10. 2008
    ..To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling...
  62. pmc Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management
    Dag Harmsen
    Institute for Hygiene, University of Munster, Munster, Germany
    J Clin Microbiol 41:5442-8. 2003
    ..spa typing was valuable for tracking of epidemic isolates. The data show that disproval of epidemiologically suggested transmissions of MRSA is one of the main objectives of spa typing in departments with a high incidence of MRSA...
  63. ncbi request reprint DNA sequence-based tandem repeat analysis of the clfB gene is less discriminatory than spa typing for methicillin-resistant Staphylococcus aureus
    Dag Harmsen
    Institute for Hygiene, University of Munster, Munster, Germany
    Int J Med Microbiol 294:525-8. 2005
    ..Using epidemic MRSA isolates from two German university hospitals, we show that the clfB repeat region does not offer any additional discriminatory power...
  64. ncbi request reprint Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1-specific phages
    Katharina Stummeyer
    Abteilung Zelluläre Chemie, Zentrum Biochemie, Medizinische Hochschule Hannover, Carl Neuberg Street 1, 30625 Hannover, Germany
    Mol Microbiol 60:1123-35. 2006
    ..Thereby, the present study contributes not only to an improved understanding of phage evolution and host-range extension but may also facilitate the on purpose design of therapeutic phages based on well-characterized template phages...
  65. ncbi request reprint Factor H binding and function in sialylated pathogenic neisseriae is influenced by gonococcal, but not meningococcal, porin
    Guillermo Madico
    Evans Biomedical Research Center, Boston University Medical Center, Boston, MA 02118, USA
    J Immunol 178:4489-97. 2007
    ..Our data highlight the different mechanisms used by these two related species to evade complement...
  66. pmc Defining targets for complement components C4b and C3b on the pathogenic neisseriae
    Lisa A Lewis
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 370I, 364 Plantation Street, Worcester, MA 01605, USA
    Infect Immun 76:339-50. 2008
    ..The binding of C3b and C4b to Opa provides a rationale for the recovery of predominantly "transparent" (Opa-negative) neisserial isolates from persons with invasive disease, where the bacteria encounter high levels of complement...
  67. ncbi request reprint Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity
    Sanjay Ram
    Section of Infectious Diseases, Evans Biomedical Research Center, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 278:50853-62. 2003
    ....