Andreas Zirlik

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice
    Ingo Hilgendorf
    Department of Cardiology, University Hospital Freiburg, Freiburg, Germany
    Arterioscler Thromb Vasc Biol 31:1991-9. 2011
  2. pmc Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice
    Florian Willecke
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e19405. 2011
  3. pmc CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 7:e33026. 2012
  4. ncbi request reprint Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes
    Andreas Zirlik
    Dept of Cardiology and Angiology, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Thromb Haemost 101:1060-9. 2009
  5. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007
  6. doi request reprint TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circ Res 107:757-66. 2010
  7. doi request reprint CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease
    Anna Missiou
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    Thromb Haemost 103:788-96. 2010
  8. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
  9. pmc Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans
    Peter Stachon
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e11589. 2010
  10. pmc Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circulation 121:2033-44. 2010

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice
    Ingo Hilgendorf
    Department of Cardiology, University Hospital Freiburg, Freiburg, Germany
    Arterioscler Thromb Vasc Biol 31:1991-9. 2011
    ..We therefore hypothesized that inhibition of SYK attenuates the inflammatory process underlying atherosclerosis and reduces plaque development...
  2. pmc Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice
    Florian Willecke
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e19405. 2011
    ..However, direct proof of its involvement in lesion formation is lacking. Therefore, the present study aimed to characterize the role of the CB(2) receptor in Murine atherogenesis...
  3. pmc CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 7:e33026. 2012
    ..Here, we tested the hypothesis that CD40L deficiency modulates adipose tissue inflammation in vivo...
  4. ncbi request reprint Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes
    Andreas Zirlik
    Dept of Cardiology and Angiology, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Thromb Haemost 101:1060-9. 2009
    ..Our data support the view that PPARalpha activation down-regulates PAI-expression in adipose cells that may contribute in part to the reduction in cardiovascular mortality seen with fibrates in clinical trials...
  5. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007
    ..Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population...
  6. doi request reprint TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circ Res 107:757-66. 2010
    ..We recently reported overexpression of TRAF5 in murine and human atheromata and that TRAF5 promotes inflammatory functions of cultured endothelial cells and macrophages...
  7. doi request reprint CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease
    Anna Missiou
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    Thromb Haemost 103:788-96. 2010
    ..Our data reveal potent metabolic functions of CD40L aside from its known pivotal pro-inflammatory role within plaques. Our data suggest that CD40L may mediate risk at the interface of metabolic and atherothrombotic disease...
  8. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  9. pmc Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans
    Peter Stachon
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e11589. 2010
    ..This study investigated the role of TRAF6-deficiency in mice developing atherosclerosis, a chronic inflammatory disease...
  10. pmc Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circulation 121:2033-44. 2010
    ..Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for this group of cytokines...
  11. ncbi request reprint TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
    ..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis...
  12. pmc Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Germany
    Circ Res 109:1269-79. 2011
    ..We recently reported that CD40L mediates atherogenesis independently of CD40 and proposed Mac-1 as an alternate receptor...
  13. pmc Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium
    Ingo Hilgendorf
    From the Center for Systems Biology I H, L M S G, C W, B G C, Y I, M N, R W, F K S and Department of Cardiology T C T, M S C, Massachusetts General Hospital, Boston Department of Gastroenterology, Hepatology, and Infectious Diseases, University of Duesseldorf, Duesseldorf, Germany T A W H Department of Medicine R L and Cardiovascular Division, Department of Medicine P L, Brigham and Women s Hospital, Boston, MA Department of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany A Z Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA C C H and Department of Systems Biology, Harvard Medical School, Boston, MA R W
    Circ Res 114:1611-22. 2014
    ....
  14. pmc Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation?
    Katrin Fink
    Department of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany
    PLoS ONE 8:e53103. 2013
    ..In the present study, we aimed to provide proof of concept for a direct binding of EPCR to the β2-integrin Mac-1 on monocytic cells under static and physiological flow conditions...
  15. ncbi request reprint Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones
    Andreas Zirlik
    Brigham and Women s Hospital, Harvard Medical School, Cardiovascular Medicine, Department of Medicine, Boston, Massachusetts 02115, USA
    Thromb Haemost 91:674-82. 2004
    ..Accordingly, patients with insulin resistance may benefit from treatment with thiazolidinediones with respect to diminution of PAI-1 expression in adipose tissue and consequent potential reduction of cardiovascular risk...
  16. ncbi request reprint Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells
    Kikuo Isoda
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:611-7. 2006
    ..Therefore, this study examined the potential action of metformin as an inhibitor of pro-inflammatory responses in human vascular smooth muscle cells (SMCs), macrophages (Mphis), and endothelial cells (ECs)...
  17. ncbi request reprint Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells
    Udo Bavendiek
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass02115, USA
    Arterioscler Thromb Vasc Biol 25:1244-9. 2005
    ....
  18. pmc In vivo detection of activated platelets allows characterizing rupture of atherosclerotic plaques with molecular magnetic resonance imaging in mice
    Dominik Von Elverfeldt
    Department of Radiology Medical Physics, University Hospital, Freiburg, Germany
    PLoS ONE 7:e45008. 2012
    ..In this study, we aim to specifically image activated platelets in murine atherothrombosis by in vivo mMRI, using a dedicated animal model of plaque rupture...
  19. pmc Urine proteome analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows the discovery of new candidate biomarkers in mouse and human atherosclerosis
    Constantin von zur Muhlen
    Department of Cardiology and Angiology, University of Freiburg, Freiburg, 79104 Germany
    Mol Cell Proteomics 11:M111.013847. 2012
    ..Furthermore, this approach represents a novel discovery tool for the identification of proteins relevant in murine and human atherosclerosis and thus also defines potential novel therapeutic targets...
  20. ncbi request reprint Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice
    Dennis Wolf
    From the Atherogenesis Research Group, University Heart Center D W, F J, N A M, E N B, N H, B D, A ö R, C C, L N, B R, A W, L S, A P, A L, S P H, P S, I H, F W, C v z M, C B, A Z and Institute for Medical Microbiology and Hygiene, Department of Immunology P A, University of Freiburg, Freiburg, Germany Atherothrombosis and Vascular Biology F J, J R, Y C C, C C, N B, K P and Cellular and Molecular Metabolism M A F, Baker IDI Heart and Diabetes Institute, Melbourne
    Circulation 129:2414-25. 2014
    ..Here, we tested the hypothesis that CD40 directly modulates traits of the metabolic syndrome in diet-induced obesity in mice...
  21. pmc BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1
    Thomas Helbing
    Department for Cardiology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 30:554-60. 2010
    ..We set out to investigate the effect of statins on BMP endothelial cell precursor-derived regulator (BMPER), a novel member of the BMP pathway...
  22. doi request reprint CCL18 -- potential biomarker of fibroinflammatory activity in chronic periaortitis
    Florian Kollert
    Department of Rheumatology and Clinical Immunology, University Medical Centre Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Rheumatol 39:1407-12. 2012
    ..We investigated whether CCL18 levels are increased in patients with chronic periaortitis and are associated with clinical, laboratory, and imaging findings...
  23. pmc Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity
    Ingo Hilgendorf
    Center for Systems Biology, Massachusetts General Hospital, Boston I H, I T, L M S G, C S R, G F W, Y I, C W, H Y L, M N, R W, F K S Department of Internal Medicine VI, Infectious Diseases, Immunology Rheumatology, Pneumology, University Hospital of Innsbruck, Innsbruck, Austria I T Toronto General Research Institute, University Health Network, Toronto, ON, Canada C S R, N D Department of Medicine, University of California, San Diego, La Jolla A G, J L W Department of Gastroenterology, Hepatology and Infectious Diseases, University of Duesseldorf, Duesseldorf, Germany T A W H Department of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany C W, A Z Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, USA
    Circulation 129:1677-87. 2014
    ..Innate response activator (IRA) B cells are a recently described population of granulocyte macrophage colony-stimulating factor-secreting cells of hitherto unknown function in atherosclerosis...
  24. pmc Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody
    Timo Heidt
    Department of Cardiology and Angiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e18446. 2011
    ....
  25. ncbi request reprint Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arterioscler Thromb Vasc Biol 25:2192-6. 2005
    ..The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis...