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Genomes and Genes | Andreas ZirlikSummaryAffiliation: University Hospital Country: Germany Publications
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Publications
The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient miceIngo Hilgendorf
Department of Cardiology, University Hospital Freiburg, Freiburg, Germany
Arterioscler Thromb Vasc Biol 31:1991-9. 2011..We therefore hypothesized that inhibition of SYK attenuates the inflammatory process underlying atherosclerosis and reduces plaque development...
Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytesAndreas Zirlik
Dept of Cardiology and Angiology, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
Thromb Haemost 101:1060-9. 2009..Our data support the view that PPARalpha activation down-regulates PAI-expression in adipose cells that may contribute in part to the reduction in cardiovascular mortality seen with fibrates in clinical trials...- Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart StudyAndreas Zirlik
Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 27:2043-9. 2007..Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population... - TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formationAnna Missiou
Department of Cardiology, University of Freiburg, Germany
Circ Res 107:757-66. 2010..We recently reported overexpression of TRAF5 in murine and human atheromata and that TRAF5 promotes inflammatory functions of cultured endothelial cells and macrophages... - CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular diseaseAnna Missiou
Department of Cardiology, University of Freiburg, Freiburg, Germany
Thromb Haemost 103:788-96. 2010..Our data reveal potent metabolic functions of CD40L aside from its known pivotal pro-inflammatory role within plaques. Our data suggest that CD40L may mediate risk at the interface of metabolic and atherothrombotic disease... 
Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humansPeter Stachon
Department of Cardiology, University of Freiburg, Freiburg, Germany
PLoS ONE 5:e11589. 2010..This study investigated the role of TRAF6-deficiency in mice developing atherosclerosis, a chronic inflammatory disease...- CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodiesDennis Wolf
Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Freiburg, Germany
PLoS ONE 7:e33026. 2012..Here, we tested the hypothesis that CD40L deficiency modulates adipose tissue inflammation in vivo... - CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1Andreas Zirlik
Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 115:1571-80. 2007..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis... - Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wallAnna Missiou
Department of Cardiology, University of Freiburg, Germany
Circulation 121:2033-44. 2010..Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for this group of cytokines... - Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in miceDennis Wolf
Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Germany
Circ Res 109:1269-79. 2011..We recently reported that CD40L mediates atherogenesis independently of CD40 and proposed Mac-1 as an alternate receptor... - TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cellsAndreas Zirlik
Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 27:1101-7. 2007..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis... - Cannabinoid receptor 2 signaling does not modulate atherogenesis in miceFlorian Willecke
Department of Cardiology, University of Freiburg, Freiburg, Germany
PLoS ONE 6:e19405. 2011..However, direct proof of its involvement in lesion formation is lacking. Therefore, the present study aimed to characterize the role of the CB(2) receptor in Murine atherogenesis... - Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinedionesAndreas Zirlik
Brigham and Women s Hospital, Harvard Medical School, Cardiovascular Medicine, Department of Medicine, Boston, Massachusetts 02115, USA
Thromb Haemost 91:674-82. 2004..Accordingly, patients with insulin resistance may benefit from treatment with thiazolidinediones with respect to diminution of PAI-1 expression in adipose tissue and consequent potential reduction of cardiovascular risk... - BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1Thomas Helbing
Department for Cardiology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
Arterioscler Thromb Vasc Biol 30:554-60. 2010..We set out to investigate the effect of statins on BMP endothelial cell precursor-derived regulator (BMPER), a novel member of the BMP pathway... - Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cellsKikuo Isoda
Donald W. Reynolds Cardiovascular Clinical Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 26:611-7. 2006..The novel anti-inflammatory actions of metformin may explain in part the apparent clinical reduction by metformin of cardiovascular events not fully attributable to its hypoglycemic action... - Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cellsUdo Bavendiek
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass02115, USA
Arterioscler Thromb Vasc Biol 25:1244-9. 2005.... - CCL18 -- potential biomarker of fibroinflammatory activity in chronic periaortitisFlorian Kollert
Department of Rheumatology and Clinical Immunology, University Medical Centre Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
J Rheumatol 39:1407-12. 2012..We investigated whether CCL18 levels are increased in patients with chronic periaortitis and are associated with clinical, laboratory, and imaging findings... - Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibodyTimo Heidt
Department of Cardiology and Angiology, University of Freiburg, Freiburg, Germany
PLoS ONE 6:e18446. 2011.... - Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart StudyJames A de Lemos
Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
Arterioscler Thromb Vasc Biol 25:2192-6. 2005..The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis...