Andreas Zirlik

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice
    Ingo Hilgendorf
    Department of Cardiology, University Hospital Freiburg, Freiburg, Germany
    Arterioscler Thromb Vasc Biol 31:1991-9. 2011
  2. ncbi request reprint Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes
    Andreas Zirlik
    Dept of Cardiology and Angiology, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Thromb Haemost 101:1060-9. 2009
  3. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007
  4. doi request reprint TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circ Res 107:757-66. 2010
  5. doi request reprint CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease
    Anna Missiou
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    Thromb Haemost 103:788-96. 2010
  6. pmc Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans
    Peter Stachon
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e11589. 2010
  7. pmc CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 7:e33026. 2012
  8. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
  9. pmc Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circulation 121:2033-44. 2010
  10. pmc Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Germany
    Circ Res 109:1269-79. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice
    Ingo Hilgendorf
    Department of Cardiology, University Hospital Freiburg, Freiburg, Germany
    Arterioscler Thromb Vasc Biol 31:1991-9. 2011
    ..We therefore hypothesized that inhibition of SYK attenuates the inflammatory process underlying atherosclerosis and reduces plaque development...
  2. ncbi request reprint Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes
    Andreas Zirlik
    Dept of Cardiology and Angiology, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Thromb Haemost 101:1060-9. 2009
    ..Our data support the view that PPARalpha activation down-regulates PAI-expression in adipose cells that may contribute in part to the reduction in cardiovascular mortality seen with fibrates in clinical trials...
  3. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007
    ..Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population...
  4. doi request reprint TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circ Res 107:757-66. 2010
    ..We recently reported overexpression of TRAF5 in murine and human atheromata and that TRAF5 promotes inflammatory functions of cultured endothelial cells and macrophages...
  5. doi request reprint CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease
    Anna Missiou
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    Thromb Haemost 103:788-96. 2010
    ..Our data reveal potent metabolic functions of CD40L aside from its known pivotal pro-inflammatory role within plaques. Our data suggest that CD40L may mediate risk at the interface of metabolic and atherothrombotic disease...
  6. pmc Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans
    Peter Stachon
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e11589. 2010
    ..This study investigated the role of TRAF6-deficiency in mice developing atherosclerosis, a chronic inflammatory disease...
  7. pmc CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 7:e33026. 2012
    ..Here, we tested the hypothesis that CD40L deficiency modulates adipose tissue inflammation in vivo...
  8. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  9. pmc Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circulation 121:2033-44. 2010
    ..Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for this group of cytokines...
  10. pmc Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Germany
    Circ Res 109:1269-79. 2011
    ..We recently reported that CD40L mediates atherogenesis independently of CD40 and proposed Mac-1 as an alternate receptor...
  11. ncbi request reprint TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
    ..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis...
  12. pmc Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice
    Florian Willecke
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e19405. 2011
    ..However, direct proof of its involvement in lesion formation is lacking. Therefore, the present study aimed to characterize the role of the CB(2) receptor in Murine atherogenesis...
  13. ncbi request reprint Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones
    Andreas Zirlik
    Brigham and Women s Hospital, Harvard Medical School, Cardiovascular Medicine, Department of Medicine, Boston, Massachusetts 02115, USA
    Thromb Haemost 91:674-82. 2004
    ..Accordingly, patients with insulin resistance may benefit from treatment with thiazolidinediones with respect to diminution of PAI-1 expression in adipose tissue and consequent potential reduction of cardiovascular risk...
  14. ncbi request reprint Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells
    Kikuo Isoda
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:611-7. 2006
    ..Therefore, this study examined the potential action of metformin as an inhibitor of pro-inflammatory responses in human vascular smooth muscle cells (SMCs), macrophages (Mphis), and endothelial cells (ECs)...
  15. pmc BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1
    Thomas Helbing
    Department for Cardiology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Arterioscler Thromb Vasc Biol 30:554-60. 2010
    ..We set out to investigate the effect of statins on BMP endothelial cell precursor-derived regulator (BMPER), a novel member of the BMP pathway...
  16. ncbi request reprint Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells
    Udo Bavendiek
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass02115, USA
    Arterioscler Thromb Vasc Biol 25:1244-9. 2005
    ....
  17. doi request reprint CCL18 -- potential biomarker of fibroinflammatory activity in chronic periaortitis
    Florian Kollert
    Department of Rheumatology and Clinical Immunology, University Medical Centre Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Rheumatol 39:1407-12. 2012
    ..We investigated whether CCL18 levels are increased in patients with chronic periaortitis and are associated with clinical, laboratory, and imaging findings...
  18. pmc Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody
    Timo Heidt
    Department of Cardiology and Angiology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e18446. 2011
    ....
  19. ncbi request reprint Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arterioscler Thromb Vasc Biol 25:2192-6. 2005
    ..The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis...