Katharina Zimmermann

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi The influence of simultaneous ratings on cortical BOLD effects during painful and non-painful stimulation
    Andrea L A Schoedel
    Department of Physiology and Pathophysiology, University of Erlangen Nuernberg, Universitaetsstrasse 17, D 91054 Erlangen, Germany
    Pain 135:131-41. 2008
  2. pmc Central projection of pain arising from delayed onset muscle soreness (DOMS) in human subjects
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Germany
    PLoS ONE 7:e47230. 2012
  3. ncbi ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater
    K Zimmermann
    Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Universitatsstrasse 17, Germany
    Pain 97:259-65. 2002
  4. ncbi S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater
    K Zimmermann
    Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Universitatsstrasse 17, D 91054 Erlangen, Germany
    Pain 103:313-20. 2003
  5. ncbi The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice
    K Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, D 91054 Erlangen, Germany
    Neuroscience 135:1277-84. 2005
  6. ncbi Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Faculty of Medicine, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Nature 447:855-8. 2007
  7. ncbi Phenotyping sensory nerve endings in vitro in the mouse
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University of Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Nat Protoc 4:174-96. 2009
  8. doi Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro
    Michael St Pierre
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Exp Brain Res 196:31-44. 2009
  9. doi The tetrodotoxin-resistant Na+ channel Na (v)1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors
    Katrin Kistner
    Department of Physiology and Pathophysiology, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Pflugers Arch 459:751-63. 2010
  10. doi Amplified cold transduction in native nociceptors by M-channel inhibition
    Irina Vetter
    Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, Queensland, Australia, Department of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, 91054 Erlangen, Germany, Department of Cellular Neurophysiology, Institute of Physiology, Academy of Sciences of the Czech Republic, CZ 14220 Prague, Czech Republic, Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain, Department of Anesthesiology and Intensive Care, Medical School Hannover, 30625 Hannover, Germany, and Department of Gynecology and Obstetrics, Friedrich Alexander Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Neurosci 33:16627-41. 2013

Collaborators

Detail Information

Publications16

  1. ncbi The influence of simultaneous ratings on cortical BOLD effects during painful and non-painful stimulation
    Andrea L A Schoedel
    Department of Physiology and Pathophysiology, University of Erlangen Nuernberg, Universitaetsstrasse 17, D 91054 Erlangen, Germany
    Pain 135:131-41. 2008
    ....
  2. pmc Central projection of pain arising from delayed onset muscle soreness (DOMS) in human subjects
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Germany
    PLoS ONE 7:e47230. 2012
    ..In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not...
  3. ncbi ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater
    K Zimmermann
    Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Universitatsstrasse 17, Germany
    Pain 97:259-65. 2002
    ..The UTP effect and the antagonist profile is indicative for the P2Y(2) receptor subtype...
  4. ncbi S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater
    K Zimmermann
    Institute of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Universitatsstrasse 17, D 91054 Erlangen, Germany
    Pain 103:313-20. 2003
    ..Thus, inhibition of meningeal neuropeptide secretion is not a common action principle of the drugs that could be essential for their antimigraine effects...
  5. ncbi The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice
    K Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, D 91054 Erlangen, Germany
    Neuroscience 135:1277-84. 2005
    ..e. neurogenic inflammation...
  6. ncbi Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Faculty of Medicine, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Nature 447:855-8. 2007
    ..Our data present strong evidence for a specialized role of Na(v)1.8 in nociceptors as the critical molecule for the perception of cold pain and pain in the cold...
  7. ncbi Phenotyping sensory nerve endings in vitro in the mouse
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University of Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Nat Protoc 4:174-96. 2009
    ..In addition, stimulation techniques, protocols to achieve single-fiber recordings, issues of data acquisition and action potential discrimination are discussed in detail...
  8. doi Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro
    Michael St Pierre
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Exp Brain Res 196:31-44. 2009
    ....
  9. doi The tetrodotoxin-resistant Na+ channel Na (v)1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors
    Katrin Kistner
    Department of Physiology and Pathophysiology, Friedrich Alexander University, Erlangen Nuremberg, Germany
    Pflugers Arch 459:751-63. 2010
    ..In conclusion, our data demonstrate that the expression of Na(v)1.8 in sensory neurons can confine the antinociceptive efficacy of lidocaine and other Na+ channel blockers employed for pain treatment...
  10. doi Amplified cold transduction in native nociceptors by M-channel inhibition
    Irina Vetter
    Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, Queensland, Australia, Department of Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, 91054 Erlangen, Germany, Department of Cellular Neurophysiology, Institute of Physiology, Academy of Sciences of the Czech Republic, CZ 14220 Prague, Czech Republic, Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain, Department of Anesthesiology and Intensive Care, Medical School Hannover, 30625 Hannover, Germany, and Department of Gynecology and Obstetrics, Friedrich Alexander Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Neurosci 33:16627-41. 2013
    ..2/3 channels. The apparent functional synergism arising from TRPM8 activation and M-current block can improve the effectiveness of topical coolants and cooling lotions, and may also enhance TRPM8-mediated analgesia...
  11. pmc Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies
    Mirjam J Eberhardt
    Institute of Physiology and Pathophysiology Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 287:28291-306. 2012
    ..In conclusion, MG is proposed to be a candidate metabolite that causes neuropathic pain in metabolic disorders and thus is a promising target for medicinal chemistry...
  12. ncbi Morphological characterization of rat Mas-related G-protein-coupled receptor C and functional analysis of agonists
    U A Hager
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, D 91054 Erlangen, Germany
    Neuroscience 151:242-54. 2008
    ..Thus, BAM22 sensitizes the capsaicin- and heat-induced CGRP release in an apparently MrgC-unrelated way. The sensitization to heat appears unusually resistant against pharmacological interventions and does not involve TRPV1...
  13. doi Analgesic treatment of ciguatoxin-induced cold allodynia
    Katharina Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, D 91054 Erlangen, Germany
    Pain 154:1999-2006. 2013
    ..These findings highlight the need for suitable animal models to guide the empiric choice of analgesics, and suggest that lamotrigine and flupirtine could be potentially useful for the treatment of ciguatera...
  14. pmc TREK-1, a K+ channel involved in polymodal pain perception
    Abdelkrim Alloui
    Laboratoire de Pharmacologie Médicale EA 3848 INSERM Faculté de Médecine CHU, Clermont Ferrand, France
    EMBO J 25:2368-76. 2006
    ..TREK-1 appears as an important ion channel for polymodal pain perception and as an attractive target for the development of new analgesics...
  15. ncbi Improved superfusion technique for rapid cooling or heating of cultured cells under patch-clamp conditions
    Ivan Dittert
    Department of Cellular Neurophysiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    J Neurosci Methods 151:178-85. 2006
    ..Examples are given of using the device in patch-clamp studies on heterologously expressed TRPV1, TRPM8, and on cultured rat sensory neurons...
  16. pmc Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene
    Jeffrey S Mogil
    Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
    Proc Natl Acad Sci U S A 102:12938-43. 2005
    ..Linkage mapping supports the contention that the genetic variant determining variable heat pain sensitivity across mouse strains affects the expression of the Calca gene that codes for CGRPalpha...