H G Zimmer

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi Theodor Wilhelm Engelmann
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 29:518-20. 2006
  2. ncbi The heart-lung machine was invented twice--the first time by Max von Frey
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 26:443-5. 2003
  3. ncbi Profiles in cardiology. Hugo Kronecker and the dependence of heart function on blood supply
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 26:489-90. 2003
  4. ncbi Heinrich Ewald Hering and the carotid sinus reflex
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 27:485-6. 2004
  5. ncbi Sydney Ringer, serendipity, and hard work
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:55-6. 2005
  6. ncbi Albert von Bezold and nervous control of the heart
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:158-9. 2005
  7. ncbi Johann Nepomuk Czermak and his isolated frog heart
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:257-8. 2005
  8. ncbi Alexander von Humboldt
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:353-5. 2005
  9. ncbi Friedrich Hermann Stannius
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Germany
    Clin Cardiol 28:443-4. 2005
  10. ncbi Alfred Wilhelm Volkmann
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:546-7. 2005

Collaborators

Detail Information

Publications51

  1. ncbi Theodor Wilhelm Engelmann
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 29:518-20. 2006
  2. ncbi The heart-lung machine was invented twice--the first time by Max von Frey
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 26:443-5. 2003
  3. ncbi Profiles in cardiology. Hugo Kronecker and the dependence of heart function on blood supply
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 26:489-90. 2003
  4. ncbi Heinrich Ewald Hering and the carotid sinus reflex
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 27:485-6. 2004
  5. ncbi Sydney Ringer, serendipity, and hard work
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:55-6. 2005
  6. ncbi Albert von Bezold and nervous control of the heart
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:158-9. 2005
  7. ncbi Johann Nepomuk Czermak and his isolated frog heart
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:257-8. 2005
  8. ncbi Alexander von Humboldt
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:353-5. 2005
  9. ncbi Friedrich Hermann Stannius
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Germany
    Clin Cardiol 28:443-4. 2005
  10. ncbi Alfred Wilhelm Volkmann
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 28:546-7. 2005
  11. ncbi Ivan Petrovitch Pavlov
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 29:45-6. 2006
  12. ncbi Otto Loewi and the chemical transmission of vagus stimulation in the heart
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 29:135-6. 2006
  13. ncbi Johannes Müller
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Germany
    Clin Cardiol 29:327-8. 2006
  14. ncbi Otto Frank and the fascination of high-tech cardiac physiology
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 27:665-6. 2004
  15. ncbi The contributions of Carl Ludwig to cardiology
    H G Zimmer
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Can J Cardiol 15:323-9. 1999
    ..Thus, Ludwig and his scholars made major substantial contributions to cardiovascular knowledge that can be considered to constitute the basis of modern cardiology...
  16. ncbi Modifications of the isolated frog heart preparation in Carl Ludwig's Leipzig Physiological Institute: relevance for cardiovascular research
    H G Zimmer
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Can J Cardiol 16:61-9. 2000
    ..Furthermore, the isolated perfused frog heart was the starting point for the development of the isolated mammalian heart in the retrogradely perfused, nonworking mode in the heart-lung modification and in the working heart preparation...
  17. ncbi Perfusion of isolated organs and the first heart-lung machine
    H G Zimmer
    Department of Physiology, Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Can J Cardiol 17:963-9. 2001
    ....
  18. ncbi Technology and application of ultraminiature catheter pressure transducers
    H G Zimmer
    Carl Ludwig Institute of Physiology, University of Leipzig, Germany
    Can J Cardiol 14:1259-66. 1998
    ..Future applications of ultraminiature catheter pressure transducers may be directed to catheterization of the pulmonary artery in rats and to the in vivo and in vitro assessment of heart function of transgenic mice...
  19. ncbi August Krogh
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Clin Cardiol 29:231-3. 2006
  20. ncbi Tissue inhibitor of matrix metalloproteinase-1 in norepinephrine-induced remodeling of the mouse heart
    Henning Meier
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Cell Physiol Biochem 20:825-36. 2007
    ..The present study analyzed the contribution of changes in functional and molecular parameters to early cardiac remodeling in mice hearts. The role that TIMPs might play in this process was specially acknowledged...
  21. ncbi Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats
    Alexander Deten
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103, Leipzig, Germany
    Cardiovasc Res 55:329-40. 2002
    ..The proinflammatory cytokines interleukin (IL)-1beta and IL-6 are supposed to be involved in various cardiovascular diseases including reperfusion injury and cardiac hypertrophy...
  22. ncbi Who discovered the Frank-Starling mechanism?
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, D-04103 Leipzig, Germany
    News Physiol Sci 17:181-4. 2002
    ..A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch...
  23. ncbi Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase
    Monika Leicht
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Germany
    Mol Cell Biochem 243:65-72. 2003
    ..These results suggest that NE induces proliferation of rat cardiac fibroblasts in part by increasing the expression of IL-6 through regulation of MAPK...
  24. ncbi Contrast enhanced echocardiographic follow-up of cardiac remodeling and function after myocardial infarction in rats
    Steffen Rabald
    Department of Surgery, University of Leipzig, Leipzig, Germany
    Ultrasound Med Biol 33:1561-71. 2007
    ..In conclusion, contrast enhanced echocardiography in rats is feasible and an economical method to study time-dependent LV remodeling and deterioration of contractile function after MI...
  25. ncbi Cardiac remodeling after long term norepinephrine treatment in rats
    W Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103, Leipzig, Germany
    Cardiovasc Res 52:265-73. 2001
    ..In this study we have tested the hypothesis that degradation of collagen by matrix metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after long term norepinephrine (NE) treatment...
  26. ncbi Serum depletion induces cell loss of rat cardiac fibroblasts and increased expression of extracellular matrix proteins in surviving cells
    M Leicht
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstrasse 27, D 04103, Leipzig, Germany
    Cardiovasc Res 52:429-37. 2001
    ..Furthermore, we measured the role of the cAMP-dependent pathway in these processes...
  27. ncbi Norepinephrine-induced interleukin-6 increase in rat hearts: differential signal transduction in myocytes and non-myocytes
    W Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Pflugers Arch 446:437-46. 2003
    ..In contrast, the IL6R protein and the downstream regulator STAT3 were increased only in MCs after 24 h of NE infusion. The mRNA of C/EBP-delta, which is regulated by STAT3, was elevated only in myocytes...
  28. ncbi Heart function and cytokine expression is similar in mice and rats after myocardial infarction but differences occur in TNFalpha expression
    Alexander Deten
    Carl Ludwig Institute of Physiology, Leipzig University, Liebigstr 27, 04103 Leipzig, Germany
    Pflugers Arch 445:289-96. 2002
    ....
  29. ncbi Time course of hypoxia-induced lung injury in rats
    Beate Rassler
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Respir Physiol Neurobiol 159:45-54. 2007
    ..The time course of hypoxia-induced pulmonary injury resembled that previously observed after continuous norepinephrine infusion in rats...
  30. ncbi Heart function and molecular biological parameters are comparable in young adult and aged rats after chronic myocardial infarction
    Alexander Deten
    Carl Ludwig Institute of Physiology, Leipzig University, Liebigstr 27, D 04103 Leipzig, Germany
    Cardiovasc Res 66:364-73. 2005
    ..To test the hypothesis that IL-1beta and IL-6 play a pivotal role after myocardial infarction (MI) particularly in aged rats...
  31. ncbi Differential cytokine expression in myocytes and non-myocytes after myocardial infarction in rats
    Alexander Deten
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 242:47-55. 2003
    ....
  32. ncbi Hematopoietic stem cells do not repair the infarcted mouse heart
    Alexander Deten
    Carl Ludwig Institute of Physiology, Leipzig University, Liebigstr 27, D 04103 Leipzig, Germany
    Cardiovasc Res 65:52-63. 2005
    ..This concept has recently been challenged by studies in which bone-marrow (BM)-derived cells do not acquire a cardiac phenotype after direct injection into ischemic myocardium...
  33. ncbi Cord blood cell therapy alters LV remodeling and cytokine expression but does not improve heart function after myocardial infarction in rats
    Steffen Rabald
    Department of Surgery, Leipzig University, Leipzig, Germany
    Cell Physiol Biochem 21:395-408. 2008
    ..In this study the ability of unrestricted somatic stem cells (USSC) and mononuclear cord blood cells (MN-CBC) was tested to improve heart function and left ventricular (LV) remodeling after myocardial infarction (MI)...
  34. ncbi Norepinephrine-induced expression of cytokines in isolated biventricular working rat hearts
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 245:69-76. 2003
    ..NE induced an additional time-dependent increase of IL-6 mRNA after 1 h of infusion. Thus, NE has a direct effect on the cardiac IL-6 expression, which occurred earlier in the in vitro preparation than in the rat heart in vivo...
  35. ncbi The expression of mRNA of cytokines and of extracellular matrix proteins in triiodothyronine-treated rat hearts
    Barbara Ziegelhöffer-Mihalovicová
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 247:61-8. 2003
    ..The moderate increase in mRNA for ECMP and MMP may be attributed more to the increasing mass of the ventricles with the accompanying remodelling of the ECM than to increased fibrosis...
  36. ncbi Significance of matrix metalloproteinases in norepinephrine-induced remodelling of rat hearts
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    Cardiovasc Res 57:379-87. 2003
    ....
  37. ncbi Pulmonary edema and pleural effusion in norepinephrine-stimulated rats--hemodynamic or inflammatory effect?
    Beate Rassler
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 250:55-63. 2003
    ..Hence, we conclude that they are secondary factors which may contribute to maintain the fluid shifts over a longer period of time...
  38. ncbi Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats
    Alexander Deten
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 251:127-37. 2003
    ..Replacement by scar tissue, however, was not affected as indicated by normal collagen expression...
  39. ncbi Norepinephrine-induced cardiac hypertrophy and fibrosis are not due to mast cell degranulation
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 252:229-37. 2003
    ..Since cromolyn did not reduce the NE-effects in rat hearts in vivo we conclude that mast cell degranulation seems not to be involved in them...
  40. ncbi Norepinephrine-induced acute heart failure in transgenic mice overexpressing erythropoietin
    Alexander Deten
    Carl Ludwig Institute of Physiology, Leipzig University, Liebigstrasse 27, D 04103 Leipzig, Germany
    Cardiovasc Res 61:105-14. 2004
    ..It was the aim of this study to characterize the mechanisms underlying the reduced cardiac performance...
  41. ncbi Cardiac remodeling in erythropoietin-transgenic mice
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Germany
    Cell Physiol Biochem 14:277-84. 2004
    ..This is accompanied by cardiac dysfunction and premature death. The aim of this study was to examine whether this cardiac dysfunction was accompanied by hypertrophy of the heart with remodeling of the extracellular matrix (ECM)...
  42. ncbi Norepinephrine-induced changes in cardiac transforming growth factor-beta isoform expression pattern of female and male rats
    Wilfried Briest
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstr 27, D 04103 Leipzig, Germany
    Hypertension 44:410-8. 2004
    ..The increase in TGF-beta isoforms correlated with that of the mRNA expression of collagens, MMP-2 and TIMP-2...
  43. ncbi Profiles in Cardiology. Ilya Fadeyevich Tsion, alias Elias Cyon, alias Elie de Cyon
    Heinz-Gerd Zimmer
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany. zimmer @medizin.uni-leipzig.de
    Clin Cardiol 27:584-5. 2004
  44. ncbi Transient pleural effusion in norepinephrine-stimulated rats
    B Rassler
    Carl Ludwig Institute of Physiology, University of Leipzig, Germany
    Basic Res Cardiol 96:471-7. 2001
    ..LV hypertrophy which developed after 24 h of NE stimulation is considered to compensate for the hemodynamic disturbance due to the NE-induced elevation in TPR. This is reflected in the disappearance of pleural effusion...
  45. ncbi Catheterization of pulmonary artery in rats with an ultraminiature catheter pressure transducer
    Alexander Deten
    Carl Ludwig Institute of Physiology, University of Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    Am J Physiol Heart Circ Physiol 285:H2212-7. 2003
    ..8 +/- 0.1 mmHg) and diastolic (28.6 +/- 0.4 mmHg) pressures and an elevation in pulmonary vascular resistance from a control value of 0.093 +/- 0.003 to 0.103 +/- 0.004 mmHg.kg.min.ml(-1)...
  46. ncbi Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats
    A Deten
    Carl Ludwig Institute of Physiology, University of Leipzig, Germany
    J Mol Cell Cardiol 33:1191-207. 2001
    ..Thus, the scar formation is an ongoing dynamic process in which TGF-beta(3)seems to play an active role in the complex ventricular remodeling...
  47. ncbi Subchronic alpha- and beta-adrenergic regulation of cardiac gap junction protein expression
    A Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Leipzig, Germany
    FASEB J 20:365-7. 2006
    ..Adrenergic stimulation of cardiomyocytes can enhance Cx43 expression thereby increasing cellular coupling, indicating a possible role for catecholamines in the regulation of cardiac gap junction expression in cardiac disease...
  48. ncbi Mechanism of cell death of rat cardiac fibroblasts induced by serum depletion
    Monika Leicht
    Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany
    Mol Cell Biochem 251:119-26. 2003
    ..The mRNA levels of both Bax and Bcl-2 were increased after 30 min. These results indicate the appearance of necrosis during serum starvation in cardiac fibroblasts. However, some processes typical of apoptosis were also detected...
  49. ncbi Significance of the 5-phosphoribosyl-1-pyrophosphate pool for cardiac purine and pyrimidine nucleotide synthesis: studies with ribose, adenine, inosine, and orotic acid in rats
    H G Zimmer
    Carl Ludwig Institute of Physiology, University of Leipzig, Germany
    Cardiovasc Drugs Ther 12:179-87. 1998
    ..This would exploit the full potential of a therapeutic approach that corrects a natural metabolic deficiency of the heart that is the low capacity of the oxidative pentose phosphate pathway in which PRPP is generated...
  50. ncbi The inotropic response of the isolated, perfused, working rat heart to norepinephrine is attenuated by inhibition of nitric oxide
    Silvio Geier
    , , Germany
    Basic Res Cardiol 97:145-52. 2002
    ..Application of DEA/NO reversed the attenuated inotropic response, but relaxation remained partially impaired. Thus, the presence of NO seems to be necessary for the inotropic effect of NE to become manifest...