Bastian Zimmer

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. ncbi Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Toxicol Sci 121:357-67. 2011
  2. ncbi GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells
    Philipp B Kuegler
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Glia 60:218-28. 2012
  3. ncbi Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome
    Nina V Balmer
    Doerenkamp Zbinden Chair for in vitro Toxicology and Biomedicine, University of Konstanz, D 78457 Konstanz, Germany
    Hum Mol Genet 21:4104-14. 2012
  4. ncbi Compound selection for in vitro modeling of developmental neurotoxicity
    Suzanne Kadereit
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Front Biosci 17:2442-60. 2012
  5. ncbi Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment
    Matthias K Weng
    Doerenkamp Zbinden Department of In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e36708. 2012
  6. ncbi Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    Environ Health Perspect 120:1116-22. 2012
  7. ncbi Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing
    Philipp B Kuegler
    University of Konstanz, Germany
    ALTEX 27:17-42. 2010

Collaborators

Detail Information

Publications7

  1. ncbi Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D 78457 Konstanz, Germany
    Toxicol Sci 121:357-67. 2011
    ..Thus, transcriptional profiling in differentiating mESC identified a subpopulation of neurons affected by MeHg, and a pharmacological intervention was identified that specifically protected these cells...
  2. ncbi GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells
    Philipp B Kuegler
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Glia 60:218-28. 2012
    ..In summary, we described here the generation and functional characterization of microglia-free murine astrocytes, displaying phenotypic heterogeneity as is commonly observed in brain astrocytes...
  3. ncbi Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome
    Nina V Balmer
    Doerenkamp Zbinden Chair for in vitro Toxicology and Biomedicine, University of Konstanz, D 78457 Konstanz, Germany
    Hum Mol Genet 21:4104-14. 2012
    ..The changes in these activating and silencing histone marks provide a more general mechanistic rational for the regulation of developmentally important genes at non-cytotoxic drug concentrations...
  4. ncbi Compound selection for in vitro modeling of developmental neurotoxicity
    Suzanne Kadereit
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany
    Front Biosci 17:2442-60. 2012
    ..A compilation of compound lists corresponding to the above-discussed principles supplement this review...
  5. ncbi Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment
    Matthias K Weng
    Doerenkamp Zbinden Department of In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e36708. 2012
    ..Our findings suggest a hitherto unexpected extent of regulation, and a cell type-dependent specificity of epigenetic modifiers in neurodifferentiation...
  6. ncbi Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells
    Bastian Zimmer
    Doerenkamp Zbinden Chair of in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany
    Environ Health Perspect 120:1116-22. 2012
    ..Objective: We developed a robust and widely applicable human-relevant NC function assay that would allow for sensitive screening of environmental toxicants and defining toxicity pathways...
  7. ncbi Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing
    Philipp B Kuegler
    University of Konstanz, Germany
    ALTEX 27:17-42. 2010
    ..0), that may later include human induced pluripotent stem cells, and that are not designed for 1:1 replacement of animal experiments, but are rather intended to improve human risk assessment by using independent scientific principles...