P Zill

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression
    Peter Zill
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 7:e40479. 2012
  2. ncbi request reprint Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    J Psychiatr Res 41:168-73. 2007
  3. ncbi request reprint SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 32:1687-94. 2007
  4. doi request reprint Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 187:220-3. 2011
  5. doi request reprint Postmortem proteomic analysis in human amygdala of drug addicts: possible impact of tubulin on drug-abusing behavior
    P Zill
    Department of Psychiatry, Division of Psychiatric Genetics and Neurochemistry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 261:121-31. 2011
  6. doi request reprint Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain
    P Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Neuroscience 159:1274-82. 2009
  7. ncbi request reprint Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 284:113-5. 2000
  8. ncbi request reprint SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Munich D 80336, Germany
    Mol Psychiatry 9:1030-6. 2004
  9. doi request reprint No association of alcohol dependence with HOMER 1 and 2 genetic variants
    U W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle Wittenberg, Halle Saale, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:1102-9. 2010
  10. ncbi request reprint Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients
    P Zill
    Psychiatric Hospital, Ludwig Maximilians University, Munich Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:24-8. 2001

Collaborators

Detail Information

Publications71

  1. pmc DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression
    Peter Zill
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 7:e40479. 2012
    ....
  2. ncbi request reprint Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    J Psychiatr Res 41:168-73. 2007
    ....
  3. ncbi request reprint SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 32:1687-94. 2007
    ..Further analysis are needed to confirm these results...
  4. doi request reprint Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 187:220-3. 2011
    ..Our results do not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. Further association studies are needed to confirm our findings...
  5. doi request reprint Postmortem proteomic analysis in human amygdala of drug addicts: possible impact of tubulin on drug-abusing behavior
    P Zill
    Department of Psychiatry, Division of Psychiatric Genetics and Neurochemistry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 261:121-31. 2011
    ..Although further studies have to confirm our results, this might be a possible pathway that may increase our understanding of drug addiction...
  6. doi request reprint Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain
    P Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Neuroscience 159:1274-82. 2009
    ..These observations may open up new research strategies not only for several psychiatric disorders, but also for the relationship between psychiatric and somatic diseases...
  7. ncbi request reprint Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 284:113-5. 2000
    ..This finding indicates that the serotonin transporter does not appear to be a major susceptibility factor in the pathophysiology of Alzheimer's disease and other psychogeriatric disorders...
  8. ncbi request reprint SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Munich D 80336, Germany
    Mol Psychiatry 9:1030-6. 2004
    ..These results may open up new research strategies for the analysis of the observed disturbances in the serotonergic system in patients suffering from several other psychiatric disorders...
  9. doi request reprint No association of alcohol dependence with HOMER 1 and 2 genetic variants
    U W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle Wittenberg, Halle Saale, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:1102-9. 2010
    ..In conclusion, our results suggest that single SNPs, respectively, haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of AD...
  10. ncbi request reprint Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients
    P Zill
    Psychiatric Hospital, Ludwig Maximilians University, Munich Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:24-8. 2001
    ..However, if we combine our results with three previous published positive reports there seems to be an association between the -491A/T polymorphism and AD, though its size is less than found in the original publication...
  11. ncbi request reprint Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  12. doi request reprint Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression
    T Frodl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany
    Mol Psychiatry 13:1093-101. 2008
    ..Patients with depression show reduced GM volumes, particularly when they are homozygous for the L(A)-allele, suggesting that these patients are more vulnerable for morphological changes during depressive episodes...
  13. doi request reprint Impact of gene-gender effects of adrenergic polymorphisms on hypothalamic-pituitary-adrenal axis activity in depressed patients
    S Haefner
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Neuropsychobiology 58:154-62. 2008
    ..We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression...
  14. ncbi request reprint Alcoholism-related phenotypes and genetic variants of the CB1 receptor
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universität Muenchen, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 253:275-80. 2003
    ..The aim of this study is to test the potential influence of a bi-allelic cannabinoid receptor gene (CNR1) polymorphism (G1359A) on severe alcohol withdrawal syndromes...
  15. ncbi request reprint Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Arch Gen Psychiatry 61:177-83. 2004
    ..Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics...
  16. ncbi request reprint Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Pharmacogenomics J 6:34-41. 2006
    ..Although this result is suggestive for a significant role of this polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals, further investigation and confirmation are warranted...
  17. ncbi request reprint No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
    Addict Biol 9:73-9. 2004
    ..The possible implications of these findings are discussed...
  18. doi request reprint Citalopram neuropharmacological challenge in alcohol-dependent patients and controls: pharmacogenetic, endocrine and psychobehavioral results
    W M Wong
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 41:72-8. 2008
    ..Furthermore we wanted to know whether functional polymorphisms (5-HTTLPR and 5HT2C Ser23Cys), have any influence on this responsivity...
  19. ncbi request reprint Combined action of the ACE D- and the G-protein beta3 T-allele in major depression: a possible link to cardiovascular disease?
    B Bondy
    Psychiatric Department of University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Mol Psychiatry 7:1120-6. 2002
    ..Nevertheless our study reports for the first time that the same allelic combination of two genes that have been shown to increase the risk for myocardial infarction (Naber et al, 2000) increase the vulnerability for depressive disorder...
  20. ncbi request reprint Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 36:429-35. 2002
    ..These findings are in line with a number of more recent studies questioning the association between novelty-seeking and DRD4 dopamine receptor gene polymorphism. Possible implications of these findings are discussed...
  21. ncbi request reprint Association of anger-related traits with SNPs in the TPH gene
    D Rujescu
    Molecular Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 7:1023-9. 2002
    ..These findings support the hypothesis that the A218C and the A779C SNP in the TPH gene may be associated with anger-related traits in German samples...
  22. doi request reprint 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder
    T Zetzsche
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Genes Brain Behav 7:306-13. 2008
    ..Future research is recommended to clarify possible interactions between this functional polymorphism and symptoms, course and treatment responses in this disorder...
  23. ncbi request reprint D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individuals
    U W Preuss
    Pediatric Hospital of Ludwig Maximilians University, Munich, Germany
    Alcohol Alcohol 42:258-66. 2007
    ....
  24. ncbi request reprint Genetics of suicide
    B Bondy
    Section Psychiatric Genetics and Neurochemistry, Psychiatric Clinic, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 11:336-51. 2006
    ..This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system...
  25. ncbi request reprint Psychopharmacogenetics--a challenge for pharmacotherapy in psychiatry
    B Bondy
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7 80336, Munich, Germany
    World J Biol Psychiatry 2:178-83. 2001
    ..Although some controversy exists among the results, many studies are supportive of the hypothesis that psychopharmacogenetics will be helpful in predicting an individual patient's drug response while minimising the rate of side effects...
  26. ncbi request reprint Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression
    C Minov
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 303:119-22. 2001
    ..However, subtypes might be identified at least on a basis of differential treatment response...
  27. ncbi request reprint No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
    Alcohol Alcohol 37:174-8. 2002
    ..The negative results in this study question the role of these polymorphisms in the pathogenesis of alcohol withdrawal-induced seizures and delirium tremens...
  28. ncbi request reprint Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals
    G Koller
    Substitutionsambulanz, Pestalozzistrasse 2, 80469 München, Germany
    Addict Biol 10:269-73. 2005
    ..Our data do not support the hypothesis of A-6526G, G-5806T or A-779C polymorphisms to be associated with suicide attempts in alcohol-dependent individuals...
  29. ncbi request reprint GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 42:184-91. 2008
    ..These findings support and extend the three previous studies implicating a GABA-A receptor subunit as contributing to the genetic risk for alcohol dependence. Possible implications of these findings are discussed...
  30. ncbi request reprint Association of 5-HT1B receptor gene and antisocial behavior in alcoholism
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Neural Transm 111:101-9. 2004
    ..Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed...
  31. doi request reprint No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms
    Gabriele Koller
    Psychiatrische Klinik, Nussbaumstrasse 7, 80336 Munich, Germany
    Addict Biol 14:506-8. 2009
    ..048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis...
  32. ncbi request reprint Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Psychoneuroendocrinology 31:1019-25. 2006
    ....
  33. doi request reprint SNAP-25 gene polymorphisms and weight gain in schizophrenic patients
    Richard Musil
    Psychiatric Clinic of University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 42:963-70. 2008
    ..In conclusion our study can at least partly replicate the previous findings concerning the impact of SNAP-25 gene polymorphisms on weight gain during antipsychotic treatment...
  34. ncbi request reprint Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  35. doi request reprint Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 32:430-4. 2008
    ..The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism...
  36. doi request reprint Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1003-7. 2008
    ....
  37. doi request reprint Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals
    Gabi Koller
    Department of addiction research Clinic of Psychiatry LMU Munich Nussbaumstrasse 7 80336 Munich Germany
    Psychiatr Genet 18:59-63. 2008
    ..Higher serotonin levels among carriers of the S allele might exhibit increased liability of serotonin-mediated, psychopathology-like anxiety and depression and may impair social skills reflected by harm avoidance...
  38. doi request reprint Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics
    Ilja Spellmann
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:335-44. 2008
    ....
  39. ncbi request reprint Genetic variants in the angiotensin I-converting-enzyme (ACE) and angiotensin II receptor (AT1) gene and clinical outcome in depression
    Brigitta Bondy
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1094-9. 2005
    ..Our data might further suggest that patients with a haplotype combining the CC and DD/ID genotypes respond better to treatment than those with either single allele. These results should however be replicated in future research...
  40. ncbi request reprint The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:82-7. 2004
    ....
  41. ncbi request reprint Pharmacogenetics and psychopharmacology
    Brigitta Bondy
    Psychiatric Hospital of University Munich, Neurochemistry Department, Nussbaumstrasse 7, D 80336 Munich, Germany
    Curr Opin Pharmacol 4:72-8. 2004
    ..The inclusion of functional genomics, which investigates the complex gene and/or protein expression in response to a given drug, could help lead to the development of novel and safer drugs...
  42. ncbi request reprint No Influence of a functional polymorphism within the serotonin transporter gene on partial sleep deprivation in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 4:111-4. 2003
    ..Thus, the previously reported influence of the serotonin transporter gene on PSD outcome in bipolar depression could not be confirmed in unipolar depressed patients...
  43. ncbi request reprint Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 120:85-9. 2003
    ..05). However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response...
  44. ncbi request reprint Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatr Genet 13:65-9. 2003
    ..The alpha-subunit of the G(olf) gene maps to a region on chromosome 18p that has been implicated in several linkage studies as a potential site of a bipolar disorder susceptibility loci...
  45. ncbi request reprint Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 339:223-6. 2003
    ..This should result in earlier and more intense additional therapeutic interventions in this group of patients...
  46. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 328:299-303. 2002
    ..The HPA axis stimulating properties of higher ACE and consecutively higher AT-II and/or lower substance P concentrations may be crucial factors for the HPA system hyperactivity during major depressive episodes...
  47. ncbi request reprint Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Neuropsychopharmacology 26:489-93. 2002
    ..Our results suggest that the investigated polymorphisms are not major susceptibility factors in the etiology of major depression...
  48. ncbi request reprint Analysis of polymorphisms in the olfactory G-protein Golf in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Psychiatr Genet 12:17-22. 2002
    ..The results of this study agree with the reported parent-of-origin effects on chromosome 18, but do not support the hypothesis that the Golf gene is a major susceptibility factor for major depression...
  49. ncbi request reprint The angiotensin I converting enzyme insertion/deletion polymorphism influences therapeutic outcome in major depressed women, but not in men
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neurosci Lett 363:38-42. 2004
    ..Our investigation gives the first hint that the speed of onset of antidepressant therapies may be dependent on both variants of the ACE genes and the gender of the patients...
  50. ncbi request reprint Regional mRNA expression of a second tryptophan hydroxylase isoform in postmortem tissue samples of two human brains
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Eur Neuropsychopharmacol 14:282-4. 2004
    ..Our finding may open up new research strategies for the analysis of the repeatedly observed disturbances in the serotonergic system in patients suffering from several psychiatric disorders...
  51. ncbi request reprint Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet 114:530-2. 2002
    ....
  52. ncbi request reprint Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 56:581-6. 2004
    ..In a previous postmortem study of our own group, we could demonstrate that TPH2 is also expressed in the human brain but not in peripheral tissues...
  53. ncbi request reprint The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
    ..Further analysis are needed to confirm these results...
  54. doi request reprint Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients
    Ilja Spellmann
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Nußbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 45:234-41. 2011
    ..Thus, these data might further help in detecting differential therapy response in individuals with schizophrenia...
  55. ncbi request reprint Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients
    P Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
    Neurosci Lett 294:69-72. 2000
    ....
  56. doi request reprint The serotonin transporter promoter polymorphism (5-HTTLPR) affects the relation between antidepressant serum concentrations and effectiveness in major depression
    N Dreimüller
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    Pharmacopsychiatry 45:108-13. 2012
    ..Results, however, are inconsistent. The aim of this study was to investigate whether remission or response to SSRIs is influenced by an interaction of 5-HTTLPR and SSRI serum concentrations...
  57. ncbi request reprint Comparative proteomic analysis with postmortem prefrontal cortex tissues of suicide victims versus controls
    Katja Schlicht
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 41:493-501. 2007
    ..Proteomics is a powerful method to investigate modifications in protein expression...
  58. ncbi request reprint Investigating disease susceptibility and the negative correlation of schizophrenia and rheumatoid arthritis focusing on MIF and CD14 gene polymorphisms
    Larissa de la Fontaine
    Klinik fur Psychiatrie und Psychotherapie, Nussbaumstr 7, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    Psychiatry Res 144:39-47. 2006
    ....
  59. ncbi request reprint Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder
    Nicole Praschak-Rieder
    Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 12:129-34. 2002
    ..The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone...
  60. ncbi request reprint A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study
    Nicole Praschak-Rieder
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Psychiatr Res 39:561-7. 2005
    ....
  61. ncbi request reprint Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension
    Nikola Jeck
    Department of Pediatrics, University of Marburg, Germany
    Hypertension 43:1175-81. 2004
    ..In conclusion, the mutation ClC-Kb(T481S) of the renal epithelial Cl- channel ClC-Kb strongly activates ClC-Kb chloride channel function in vitro and may predispose to the development of essential hypertension in vivo...
  62. ncbi request reprint Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: association studies in German and Slavic population
    Jasminka Stefulj
    Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Bijenicka 54, Zagreb, Croatia
    Am J Med Genet B Neuropsychiatr Genet 127:48-50. 2004
    ..Results provide evidence that the investigated 5HT-1B receptor gene variants are not implicated in the susceptibility to suicide...
  63. ncbi request reprint [Suicide attempt, psychopathology and genetics]
    Sandor Fekete
    Pécsi Tudományegyetem Altalános Orvosi Kar, Pszichiatriai es Pszichoterapias Klinika
    Psychiatr Hung 20:18-24. 2005
    ..Thus genes coding for proteins of the serotonergic pathways are leading candidates for investigating possible associations...
  64. ncbi request reprint Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons
    Kathrin Scheuch
    Laboratory of Molecular Psychiatry, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, Berlin, Germany
    Biol Psychiatry 62:1288-94. 2007
    ..Although dysfunction of 5-HT neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human TPH2 promoter has not been characterized in vitro...
  65. ncbi request reprint Interleukin-6-174 G/C promoter gene polymorphism C allele reduces Alzheimer's disease risk
    Frank Faltraco
    J Am Geriatr Soc 51:578-9. 2003
  66. ncbi request reprint Enhanced serotonin transporter function during depression in seasonal affective disorder
    Matthaus Willeit
    Department of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1503-13. 2008
    ..5-HTTLPR was not associated with any of the 5-HTT parameters. In sum, we conclude that the 5-HTT is in a hyperfunctional state during depression in SAD and normalizes after light therapy and in natural summer remission...
  67. ncbi request reprint Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele
    Johanna Krause
    Outpatient Clinic for Psychiatry and Psychotherapy, Ottobrunn, Germany
    World J Biol Psychiatry 7:152-7. 2006
    ..Discrepancies may be explained by differences in patient's age, ethnical differences, different imaging techniques or the limited number of patients included in both studies...
  68. ncbi request reprint 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations
    Jasminka Stefulj
    Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia
    Eur Arch Psychiatry Clin Neurosci 254:224-7. 2004
    ..Results did not provide supporting evidence for the potential involvement of the investigated variants of 5HT-2C receptor in the susceptibility to suicide...
  69. ncbi request reprint C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder
    Matthaus Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Biol Psychiatry 54:682-6. 2003
    ....
  70. ncbi request reprint Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    ..The s allele was associated with lower Self-Directedness scores in SAD patients, whereas there were no significant differences in TCI dimensions between patients and controls in carriers of the long allele...
  71. ncbi request reprint Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...