Paola Zigrino

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Human scalp dermal papilla and fibrous sheath cells have a different expression profile of matrix metalloproteinases in vitro when compared to scalp dermal fibroblasts
    Hiram de Almeida
    Department of Dermatology and Venerology, Faculty of Medicine, University of Cologne, Koln, Germany
    Arch Dermatol Res 297:121-6. 2005
  2. doi request reprint Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization
    Paola Zigrino
    Department of Dermatology and Venerology, University of Cologne, Germany
    Eur J Cell Biol 91:748-56. 2012
  3. pmc The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts
    Paola Zigrino
    Department of Dermatology and Center for Molecular Medicine, University of Cologne, 50937 Cologne, Germany
    J Biol Chem 286:6801-7. 2011
  4. ncbi request reprint Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration
    Paola Zigrino
    Department of Dermatology and Center for Molecular Medicine, Kerpener Strasse 62, University of Cologne, 50937 Cologne, Germany
    J Biol Chem 282:30785-93. 2007
  5. ncbi request reprint Adam-9 expression and regulation in human skin melanoma and melanoma cell lines
    Paola Zigrino
    Department of Dermatology, University of Cologne, Cologne, Germany
    Int J Cancer 116:853-9. 2005
  6. doi request reprint Accelerated wound repair in ADAM-9 knockout animals
    Cornelia Mauch
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 130:2120-30. 2010
  7. doi request reprint Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo
    Anna N Abety
    Department of Dermatology, University Hospital of Cologne, Cologne, Germany
    J Invest Dermatol 132:2451-8. 2012
  8. ncbi request reprint Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells
    Anke Klose
    Department of Dermatology, University of Cologne, Germany
    Anal Biochem 353:57-62. 2006
  9. doi request reprint Stromal expression of MMP-13 is required for melanoma invasion and metastasis
    Paola Zigrino
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 129:2686-93. 2009
  10. ncbi request reprint Melanoma cell-derived vascular endothelial growth factor induces endothelial tubulogenesis within fibrin gels by a metalloproteinase-mediated mechanism
    Stefanie Löffek
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Joseph Stelzmann Street 9, D 50931 Cologne, Germany
    Eur J Cell Biol 85:1167-77. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Human scalp dermal papilla and fibrous sheath cells have a different expression profile of matrix metalloproteinases in vitro when compared to scalp dermal fibroblasts
    Hiram de Almeida
    Department of Dermatology and Venerology, Faculty of Medicine, University of Cologne, Koln, Germany
    Arch Dermatol Res 297:121-6. 2005
    ....
  2. doi request reprint Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization
    Paola Zigrino
    Department of Dermatology and Venerology, University of Cologne, Germany
    Eur J Cell Biol 91:748-56. 2012
    ..Taken together, these data indicate that MMP-14 expression in keratinocytes is dispensable for skin homeostasis and repair, but plays a crucial role in the epidermal-dermal crosstalk leading to modulation of vessel density...
  3. pmc The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts
    Paola Zigrino
    Department of Dermatology and Center for Molecular Medicine, University of Cologne, 50937 Cologne, Germany
    J Biol Chem 286:6801-7. 2011
    ....
  4. ncbi request reprint Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration
    Paola Zigrino
    Department of Dermatology and Center for Molecular Medicine, Kerpener Strasse 62, University of Cologne, 50937 Cologne, Germany
    J Biol Chem 282:30785-93. 2007
    ..In summary, our results indicate that the ADAM-9 adhesive domain plays a role in regulating the motility of cells by interaction with beta1 integrins and modulates MMP synthesis...
  5. ncbi request reprint Adam-9 expression and regulation in human skin melanoma and melanoma cell lines
    Paola Zigrino
    Department of Dermatology, University of Cologne, Cologne, Germany
    Int J Cancer 116:853-9. 2005
    ..In summary, our data suggest a novel role of fibrillar collagen and of soluble factors for the regulation of ADAM-9 expression in vitro...
  6. doi request reprint Accelerated wound repair in ADAM-9 knockout animals
    Cornelia Mauch
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 130:2120-30. 2010
    ..These results show the previously unreported role of ADAM-9 in wound repair by regulating keratinocyte migration through modulation of collagen XVII shedding...
  7. doi request reprint Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo
    Anna N Abety
    Department of Dermatology, University Hospital of Cologne, Cologne, Germany
    J Invest Dermatol 132:2451-8. 2012
    ..Taken together, stromal expression of ADAM-9 during melanoma development modulates the expression of TIMP-1 and sTNFR1, which in turn affect tumor cell proliferation and apoptosis...
  8. ncbi request reprint Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells
    Anke Klose
    Department of Dermatology, University of Cologne, Germany
    Anal Biochem 353:57-62. 2006
    ....
  9. doi request reprint Stromal expression of MMP-13 is required for melanoma invasion and metastasis
    Paola Zigrino
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 129:2686-93. 2009
    ..These data suggest an important role of MMP-13 in tumor growth and an unexpected role in organ-specific metastasis of melanoma cells...
  10. ncbi request reprint Melanoma cell-derived vascular endothelial growth factor induces endothelial tubulogenesis within fibrin gels by a metalloproteinase-mediated mechanism
    Stefanie Löffek
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Joseph Stelzmann Street 9, D 50931 Cologne, Germany
    Eur J Cell Biol 85:1167-77. 2006
    ..In conclusion, these results show that VEGF released by melanoma cells is an important mediator of neo-vascularisation and that this process depends on the presence of metalloproteinases...
  11. ncbi request reprint High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1alpha and basic fibroblast growth factor-mediated mechanisms
    Stefanie Löffek
    Department of Dermatology, Center of Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 124:638-43. 2005
    ..Taken together, our results indicate an essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1...
  12. doi request reprint Role of ADAM-15 in wound healing and melanoma development
    Alexander Schönefuß
    Department of Dermatology and Venerology, University of Cologne, Cologne, Germany
    Exp Dermatol 21:437-42. 2012
    ..In conclusion, our study indicated that ADAM-15 is dispensable for cutaneous wound healing and B16F1 melanoma growth, but significantly contributes to metastasis formation...
  13. ncbi request reprint Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B
    Anke Klose
    Department of Dermatology, Center for Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    Int J Cancer 118:2735-43. 2006
    ..These results strongly implicate a pivotal role of cell-matrix interactions for the regulation of cathepsin B localization and activity in melanoma cells...
  14. doi request reprint Monocyte/macrophage MMP-14 modulates cell infiltration and T-cell attraction in contact dermatitis but not in murine wound healing
    Anke Klose
    Department of Dermatology, University of Cologne, Cologne, Germany
    Am J Pathol 182:755-64. 2013
    ..In vitro, the migratory capacity of isolated KO macrophages was significantly impaired on fibronectin, a substrate of MMP-14. These data point to a role of MMP-14 during transendothelial migration of monocytes and T-cell attraction...
  15. ncbi request reprint Invasion of melanoma cells into dermal connective tissue in vitro: evidence for an important role of cysteine proteases
    Ralf Dennhöfer
    Department of Dermatology, University of Cologne, Cologne, Germany
    Int J Cancer 106:316-23. 2003
    ..Cysteine protease inhibitors (E-64 and leupeptin) significantly reduced invasion of melanoma cells into these composites. These results indicate an important role of cysteine proteases for tumor invasion...
  16. doi request reprint NLRP10 enhances Shigella-induced pro-inflammatory responses
    Katja Lautz
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Cell Microbiol 14:1568-83. 2012
    ..Taken together, our data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1-Nodosome...
  17. pmc Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2
    Daliborka Lazic
    Institute of Virology, University of Cologne, Cologne, Germany
    J Virol 86:7943-52. 2012
    ..These results identified syntenin-2 as the first PDZ domain protein controlled by HPV8 and HPV16 at the mRNA level...
  18. ncbi request reprint The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling
    Paola Zigrino
    Department of Dermatology, University of Cologne, Cologne 50924, Germany
    J Biol Chem 277:40528-35. 2002
    ....
  19. ncbi request reprint Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice
    Baki Akgul
    Institute of Virology, University of Cologne, Germany
    Exp Dermatol 15:35-42. 2006
    ..Taken together, these results implicate a role for MMPs in the development of HPV8-induced cutaneous tumors...
  20. pmc Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
    Claus Werner Franzke
    Department of Dermatology, University of Munster, D 48149 Munster, Germany
    EMBO J 21:5026-35. 2002
    ..Functionally, release of the ectodomain of collagen XVII from the cell surface was associated with altered keratinocyte motility in vitro...
  21. ncbi request reprint Expression of membrane type 1 matrix metalloproteinase in papillomavirus-positive cells: role of the human papillomavirus (HPV) 16 and HPV8 E7 gene products
    Sigrun Smola-Hess
    Institute of Virology, University of Cologne, Fürst Pückler Strasse 56, 50935 Cologne, Germany
    J Gen Virol 86:1291-6. 2005
    ..As a consequence, MMP-2 was activated. MT-1 MMP expression might play a role in the HPV life cycle by promoting proliferation of host cells and might contribute to their invasive phenotype during malignant progression...
  22. pmc Eradication of melanomas by targeted elimination of a minor subset of tumor cells
    Patrick Schmidt
    Department I of Internal Medicine, and Center for Molecular Medicine Cologne, University of Cologne, D 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 108:2474-9. 2011
    ..Our data challenge the biological therapy and current drug development paradigms in the treatment of cancer...
  23. doi request reprint Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas
    Baki Akgul
    Institute of Virology, University of Cologne, Fürst Pückler Strasse 56, 50935 Cologne, Germany
    J Gen Virol 92:395-401. 2011
    ..These data indicate that lipocalin-2 expression correlates with HPV positivity of cutaneous SCCs...
  24. ncbi request reprint Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation
    Iris Helfrich
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:782-91. 2007
    ..Indeed, inhibition of aPKC function showed that endogenous aPKC is crucial for in vitro barrier function and this required the presence of both the Par3 and Par6 binding sites...
  25. doi request reprint The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack
    Jens Michael Seeger
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany
    Cancer Res 70:1825-34. 2010
    ..Our data indicate that proteasome inhibition increases the sensitivity of tumor cells toward cytolytic T-cell attack by NOXA-mediated enhancement of mitochondrial SMAC release...
  26. doi request reprint Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA
    Kerstin Brinkmann
    Centre for Molecular Medicine Cologne and Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, 50935 Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, 50674 Cologne, Germany
    Cell Rep 3:881-91. 2013
    ..elegans cells. Our data identify the UCH-L1/NOXA interaction as a therapeutic target for overcoming cancer chemoresistance...
  27. pmc A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses
    Andreas Neerincx
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    J Biol Chem 285:26223-32. 2010
    ..C)-mediated type I interferon pathway-dependent responses in THP-1 cells and human primary dermal fibroblasts. Taken together, this defines a function for NLRC5 in anti-viral innate immune responses...
  28. ncbi request reprint [Tumor-stroma interactions: their role in the control of tumor cell invasion and metastasis]
    Stefanie Löffek
    Klinik und Poliklinik für Dermatologie und Venerologie des Klinikums der Universität zu Köln
    J Dtsch Dermatol Ges 4:496-502; quiz 503. 2006
  29. ncbi request reprint Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS
    Hong Lu
    Institut fur Physiologische Chemie, Abteilung für Zellbiochemie, Bonner Forum Biomedizin and LIMES, Rheinische Friedrich Wilhelms Universitat, Nussallee 11, Bonn, Germany
    J Invest Dermatol 127:2781-9. 2007
    ..Microarray and TaqMan real-time PCR showed a downregulation of matrix metalloproteinase 13 and IL-1beta, indicating an effect of doxycycline on transcription. Our data offer a novel small molecule-based therapy approach for EBS...
  30. ncbi request reprint Delayed wound healing and epidermal hyperproliferation in mice lacking JunB in the skin
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 126:902-11. 2006
    ....
  31. ncbi request reprint Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin
    Paul Gallagher
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908 0734, USA
    Arch Biochem Biophys 441:1-15. 2005
    ....
  32. ncbi request reprint Gene expression profiling reveals cross-talk between melanoma and fibroblasts: implications for host-tumor interactions in metastasis
    Paul G Gallagher
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908 0734, USA
    Cancer Res 65:4134-46. 2005
    ....
  33. pmc Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor
    Svetlana N Popova
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen, Norway
    Mol Cell Biol 27:4306-16. 2007
    ..Our data show a unique role for alpha11beta1 integrin during tooth eruption...