Research Topics
Genomes and Genes | A G ZieglerSummaryAffiliation: University of Munich Country: Germany Publications
Research Grants
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Detail Information
Publications
Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty--TEENDIAB: study designAnette Gabriele Ziegler
Forschergruppe Diabetes, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
Pediatr Diabetes 13:419-24. 2012..The findings of this study will increase the understanding of pathogenetic mechanisms behind the increasing diabetes incidence in youth and the impact of obesity on diabetes development in this age period...
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB StudyA G Ziegler
Diabetes Research Institute and 3rd Medical Department, Krankenhaus München Schwabing, Germany
Diabetes 48:460-8. 1999..Autoimmunity associated with childhood diabetes is an early event and a dynamic process. Presence of IAAs is a consistent feature of this autoimmunity, and IAA detection can identify children at risk...
Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young childrenAnette G Ziegler
Institute of Diabetes Research, Helmholtz Center Munich, Neuherberg, Germany
J Autoimmun 37:3-7. 2011..01). The findings suggest that recent increasing incidence of type 1 diabetes in young children could be due to weakening of mechanisms that normally regulate autoimmune destruction of islet beta cells...- Prediction and pathogenesis in type 1 diabetesAnette G Ziegler
Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat Munchen, Kolner Platz 1, 80804 München, Germany
Immunity 32:468-78. 2010.... - Early infant feeding and risk of developing type 1 diabetes-associated autoantibodiesAnette G Ziegler
Diabetes Research Institute and Hospital München Schwabing, Munich, Germany
JAMA 290:1721-8. 2003..Dietary factors modifying type 1 diabetes mellitus (DM) risk have been proposed, but little is known if they trigger the islet autoimmunity that precedes clinical disease... - Immune responses to glutamic acid decarboxylase and insulin in patients with gestational diabetesM Füchtenbusch
Diabetes Research Institute, 3rd Medical Department, Academic Hospital München Schwabing, Munich, Germany
Clin Exp Immunol 135:318-21. 2004..004). Antibody responses in women with gestational diabetes appear to be dampened and restricted, but without change in subclass usage... - Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA(1c)E Bonifacio
Diabetes Research Institute, Kolner Platz 1, D 80804, Munich, Germany
Diabetologia 51:1245-52. 2008..We asked whether children of mothers with type 1 diabetes also have a decreased risk of developing islet autoantibodies, and which factors associated with maternal diabetes contribute to a reduced islet autoantibody risk in offspring... - IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunityM Walter
Diabetes Research Institute, Munich Schwabing Hospital, Kolner Platz 1, 80804 Munich, Germany
Diabetologia 46:712-20. 2003..The aim of this study was to determine whether combining IDDM1/HLA and IDDM2/ insulin( INS) 5' variable number of tandem repeat locus (VNTR) genotypes improves T1D risk assessment... - Age-related islet autoantibody incidence in offspring of patients with type 1 diabetesA G Ziegler
Institute of Diabetes Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
Diabetologia 55:1937-43. 2012..Seroconversion to islet autoantibodies precedes type 1 diabetes. This study aimed to identify periods of high seroconversion incidence, which could be targeted for mechanistic and therapeutic studies... - Fetal growth is increased by maternal type 1 diabetes and HLA DR4-related gene interactionsM Hummel
Institute of Diabetes Research and Academic Hospital Schwabing, Kolner Platz 1, 80804, Munchen, Germany
Diabetologia 50:850-8. 2007..The aim of this study was to determine whether HLA DR4 was associated with increased birthweight in a maternal diabetes environment and whether effects persisted during early childhood... - Exposure to environmental factors in drinking water: risk of islet autoimmunity and type 1 diabetes--the BABYDIAB studyC Winkler
Diabetes Research Institute and Academic Hospital Schwabing, Munich, Germany
Horm Metab Res 40:566-71. 2008..The association is marginal and requires validation in other prospective cohorts... - Development of autoimmunity to transglutaminase C in children of patients with type 1 diabetes: relationship to islet autoantibodies and infant feedingS Hummel
Diabetes Research Institute, Munich, Germany
Diabetologia 50:390-4. 2007..We investigated the development of transglutaminase antibodies and analysed potential risk factors for coeliac disease autoimmunity in first-degree relatives of patients with type 1 diabetes... - Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relativesP Achenbach
Diabetes Research Institute, Munich, Germany
Diabetologia 51:488-92. 2008.... - Reduced IL-4 associated antibody responses to vaccine in early pre-diabetesS Schmid
Diabetes Research Institute and 3rd Medical Department, München Schwabing Hospital, Germany
Diabetologia 45:677-85. 2002..The aim of this study was to determine whether beta-cell autoimmunity is associated with immune response bias to exogenous antigens... - Early infant diet in children at high risk for type 1 diabetesM Pflüger
Forschergruppe Diabetes der Technischen Universität München, Munich, Germany
Horm Metab Res 42:143-8. 2010..04). Our findings indicate that WHO infant feeding recommendations were poorly followed by families with a family history of T1D. Action to improve levels of infant feeding behaviour is essential, especially among young mothers with T1D... - Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes?C Winkler
Institut für Diabetesforschung der Forschergruppe Diabetes e V, Helmholtz Center Munich, Neuherberg, Germany
Diabetologia 52:2072-8. 2009..The aim of the present study was to determine whether insulin demand is increased in children with islet autoantibodies... - Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes riskP Achenbach
Diabetes Research Institute of Forschergruppe Diabetes e V, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
Diabetologia 52:1881-8. 2009..Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk... - A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetesC Winkler
Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universitat, Munchen, Germany
Genes Immun 13:549-55. 2012..Genotyping at multiple susceptibility loci in children from affected families can identify neonates with sufficient genetic risk of type 1 diabetes to be considered for early intervention... - Prevalence, characteristics and diabetes risk associated with transient maternally acquired islet antibodies and persistent islet antibodies in offspring of parents with type 1 diabetesH E Naserke
Institute of Diabetes Research, Academic Hospital Schwabing, , D-80804 Munich, Germany
J Clin Endocrinol Metab 86:4826-33. 2001..These strategies are helpful in discriminating high and low risk antibodies before age 1 yr and should be important for prognosis and reducing unnecessary parent anxiety... - Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relativesP Achenbach
Diabetes Research Institute, Koelner Platz 1, Munich, Germany
Diabetologia 49:2969-76. 2006..Detection of changes through follow-up measurement will improve diabetes risk stratification, particularly in young individuals... - Breastfeeding habits in families with Type 1 diabetesS Hummel
Diabetes Research Institute and Academic Hospital Schwabing, Munich, Germany
Diabet Med 24:671-6. 2007..The aim of this study was to assess the effect of maternal Type 1 diabetes on breastfeeding habits... - Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunizationPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
Curr Diab Rep 8:87-93. 2008.... - Lupus-like panniculitis in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)M Füchtenbusch
Department of Endocrinology, Diabetology and Gastroenterology, Academic Hospital München Schwabing, Munich, Germany
Exp Clin Endocrinol Diabetes 111:288-93. 2003..Here, autoimmune panniculitis appears to be an associated feature of the APECED syndrome. Our findings support the use of immunosuppressive therapy for autoimmune disease components of the APECED syndrome... - Neonatal Bacille Calmette-Guerin vaccination and type 1 diabetesMarceline Huppmann
, , , Germany
Diabetes Care 28:1204-6. 2005 - Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetesPeter Achenbach
, , 80804 Munich, Germany
J Clin Invest 114:589-97. 2004.... - [Prospective observational studies of the development of type 1 diabetes during childhood and puberty]F Meier-Stiegen
Forschergruppe Diabetes, Klinikum rechts der Isar der Technischen Universitat Munchen, Munchen
Dtsch Med Wochenschr 136:271-5. 2011..Aim of this article is to provide an overview of the most relevant observational studies... - Psychological impact of childhood islet autoantibody testing in families participating in the BABYDIAB studyM Hummel
Diabetes Research Institute and 3rd Medical Department, Academic Hospital München Schwabing, Munich, Germany
Diabet Med 21:324-8. 2004..To determine anxiety in parents of children undergoing testing for islet autoantibodies... - Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulinKerstin Koczwara
Diabetes Research Institute, Munich, Germany
Clin Immunol 124:77-82. 2007..The findings suggest that some IAA can result from immunization against molecules other than human insulin at mucosal sites... - Delayed exposure to wheat and barley proteins reduces diabetes incidence in non-obese diabetic miceSandra Schmid
Diabetes Research Institute, , Munich, Germany
Clin Immunol 111:108-18. 2004..These data support a link between dietary wheat and barley proteins and the development of autoimmune diabetes... - Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristicsPeter Achenbach
Diabetes Research Institute and 3rd Medical Department, , Munich, Germany
Diabetes 53:384-92. 2004..Using models based on these antibody characteristics, autoantibody-positive relatives can be classified into groups with risks of diabetes ranging from 7 to 89% within 5 years... - The effect of gestation and fetal mismatching on the development of autoimmune diabetes in non-obese diabetic miceK Adler
Diabetes Research Institute, Forschergruppe Diabetes e V, Munich, Germany
Clin Exp Immunol 168:274-8. 2012..Gestation per se appears to have no aggravating or ameliorating effects on pre-existent autoimmune beta cell destruction, but pregnancy from MHC partially mismatched males delays diabetes onset in female NOD mice... - No evidence for an association of coxsackie virus infections during pregnancy and early childhood with development of islet autoantibodies in offspring of mothers or fathers with type 1 diabetesM Füchtenbusch
Diabetes Research Institute, 3rd Medical Department, Academic Hospital München Schwabing, Munich, Germany
J Autoimmun 17:333-40. 2001..These data make it unlikely that CV infections during pregnancy or in early childhood play a major role in the induction of islet autoimmunity in offspring of mothers or fathers with T1D or of mothers with gestational diabetes... - No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetesMarkus Walter
Diabetes Research Institute, Forschergruppe Diabetes e V, Munich, Germany
Diabetes Care 32:2036-40. 2009.... - Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parentsMichael Hummel
Diabetes Research Institute and Academic Hospital Schwabing, Munich, Germany
Ann Intern Med 140:882-6. 2004..02). LIMITATIONS: The findings are limited to childhood diabetes in affected families. CONCLUSIONS: Childhood autoimmune diabetes is associated with autoimmunity that starts before 2 years of age... - Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetesMaren Pflueger
Forschergruppe Diabetes eV at Helmholtz Center Munich, Neuherberg, Germany
Diabetes 60:2740-7. 2011..To support this notion, we examined whether serum metabolite profiles differ between children with respect to islet autoantibody status and the age of islet autoantibody development... - Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET studySandra Hummel
Institute for Diabetes Research, Helmholtz Zentrum Munchen, Munich, Germany
Diabetes Care 34:1301-5. 2011..To determine whether delaying the introduction of gluten in infants with a genetic risk of islet autoimmunity is feasible, safe, and may reduce the risk of type 1 diabetes-associated islet autoimmunity... - Predictors of postpartum diabetes in women with gestational diabetes mellitusKristian Löbner
Diabetes Research Institute and 3rd Medical Department, Krankenhaus München Schwabing, Munich, Germany
Diabetes 55:792-7. 2006..Prospective diabetes assessment is indicated and intervention should be considered in women with gestational diabetes who are autoantibody positive, require insulin treatment during pregnancy, or are obese... - The effect of maternal T1DM on the fatty acid composition of erythrocyte phosphatidylcholine and phosphatidylethanolamine in infants during early lifeChristiane Winkler
Institut fur Diabetesforschung, Kolner Platz 1, 80804 Munich, Germany
Eur J Nutr 47:145-52. 2008..We asked, therefore, whether EPA and DHA FA nutritional status in offspring of mothers with T1DM could contribute to their reduced T1DM risk... - Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunityIvana Durinovic-Bello
Diabetes Research Institute of the Academic Hospital München Schwabing, Koelner Platz 1, 80804 Munich, Germany
J Autoimmun 18:55-66. 2002..In individuals with humoral markers of islet cell autoimmunity and in patients with T1D, spread response to distinct ProInsulin regions was observed... - Natural history of type 1 diabetesPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
Diabetes 54:S25-31. 2005..Characteristics that describe the magnitude of the autoimmunity can stage progression to type 1 diabetes in islet autoantibody-positive subjects regardless of genetic background or age... - IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetesEzio Bonifacio
Immunology of Diabetes Unit, Istituto Scientifico San Raffaele, Milan, Italy
Diabetes Care 27:2695-700. 2004..5% by 5 years of age. CONCLUSIONS: Risk of childhood diabetes in affected families can be stratified using a combination of genetic and family history markers very early in life... - Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigensMassimo Bearzatto
Department of Medicine 1 and Medicine Laboratory, Istituto Scientifico San Raffaele, Milan, Italy
J Immunol 168:4202-8. 2002..This is a unique demonstration of HLA-associated B cell responses to epitopes within a single autoantigen in humans and is consistent with modification of Ag processing by specific Ab-influencing peptide presentation by HLA molecules... - Predicting type 1 diabetesPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
Curr Diab Rep 5:98-103. 2005..Further stratification of diabetes risk in autoantibody-positive subjects can be made on the basis of autoantibody characteristics that correspond to the magnitude of the autoantibody response... - Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR projectHanna Viskari
JDRF Center for Prevention of Type 1 Diabetes, Finland
J Med Virol 72:610-7. 2004.... - Diabetes-related antibodies in euglycemic subjectsPeter Achenbach
Diabetes Research Institute and 3rd Medical Department Academic, , Koelner Platz 1, 80804 Munich, Germany
Best Pract Res Clin Endocrinol Metab 19:101-17. 2005....
Research Grants
- Type 1 Diabetes triggers: diet modification in neonatesANETTE ZIEGLER; Fiscal Year: 2007..If successful this consortium will identify environmental factors which can be manipulated in order to reduce T1DM incidence. ..