Robert Zeiser

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc The Nlrp3 inflammasome regulates acute graft-versus-host disease
    Dragana Jankovic
    Department of Dermatology, University Hospital, CH 8091 Zurich, Switzerland
    J Exp Med 210:1899-910. 2013
  2. doi request reprint Trametinib
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106, Freiburg, Germany
    Recent Results Cancer Res 201:241-8. 2014
  3. pmc A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model
    Carina A Bäuerlein
    Department of Medicine II, Würzburg University Clinics, Zinklesweg 10, Wurzburg, D 97078, Germany
    BMC Med 11:134. 2013
  4. ncbi request reprint Immunotherapy for malignant melanoma
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Curr Stem Cell Res Ther 7:217-28. 2012
  5. pmc Regulation of different inflammatory diseases by impacting the mevalonate pathway
    Robert Zeiser
    Department of Haematology and Oncology, Albert Ludwigs University Freiburg, Freiburg, Germany
    Immunology 127:18-25. 2009
  6. ncbi request reprint Danger signals activating innate immunity in graft-versus-host disease
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106 Freiburg, Germany
    J Mol Med (Berl) 89:833-45. 2011
  7. doi request reprint A potential role for P2X7R in allergic airway inflammation in mice and humans
    Tobias Müller
    Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany
    Am J Respir Cell Mol Biol 44:456-64. 2011
  8. pmc Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue
    Christoph Dürr
    Department of Haematology and Oncology, Freiburg University Medical Centre, Albert Ludwigs University, Freiburg, Germany
    Immunology 137:80-8. 2012
  9. doi request reprint Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation
    Rodolfo Paula Vieira
    University Hospital Freiburg, Department of Pneumology, Freiburg, Germany
    Am J Respir Crit Care Med 184:215-23. 2011
  10. pmc Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity
    Felix C Weber
    Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Exp Med 207:2609-19. 2010

Collaborators

Detail Information

Publications27

  1. pmc The Nlrp3 inflammasome regulates acute graft-versus-host disease
    Dragana Jankovic
    Department of Dermatology, University Hospital, CH 8091 Zurich, Switzerland
    J Exp Med 210:1899-910. 2013
    ..Thus, the identification of a crucial role for the Nlrp3 inflammasome sheds new light on the pathogenesis of GvHD and opens a potential new avenue for the targeted therapy of this severe complication. ..
  2. doi request reprint Trametinib
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106, Freiburg, Germany
    Recent Results Cancer Res 201:241-8. 2014
    ..Future clinical trial in different solid tumor entities will define the therapeutic role of this targeted therapy approach, possibly as a combination with other targeted therapies such as BRAF inhibitors. ..
  3. pmc A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model
    Carina A Bäuerlein
    Department of Medicine II, Würzburg University Clinics, Zinklesweg 10, Wurzburg, D 97078, Germany
    BMC Med 11:134. 2013
    ..Here we address whether insights into the timing of the aGVHD initiation and effector phases could allow for the detection of migrating alloreactive T cells before clinical aGVHD onset to permit for efficient therapeutic intervention...
  4. ncbi request reprint Immunotherapy for malignant melanoma
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Curr Stem Cell Res Ther 7:217-28. 2012
    ..This review summarizes different immunotherapeutical approaches against melanoma that have been applied in the past and focuses on CTLA-4 blockade with respect to its mechanism, clinical effectiveness and immunological side effects...
  5. pmc Regulation of different inflammatory diseases by impacting the mevalonate pathway
    Robert Zeiser
    Department of Haematology and Oncology, Albert Ludwigs University Freiburg, Freiburg, Germany
    Immunology 127:18-25. 2009
    ..This review discusses possible modes of action of statins in modulating immunity towards autoantigens and alloantigens...
  6. ncbi request reprint Danger signals activating innate immunity in graft-versus-host disease
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106 Freiburg, Germany
    J Mol Med (Berl) 89:833-45. 2011
    ..This review covers both the impact of endogenous and exogenous danger signals activating innate immunity in GvHD...
  7. doi request reprint A potential role for P2X7R in allergic airway inflammation in mice and humans
    Tobias Müller
    Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany
    Am J Respir Cell Mol Biol 44:456-64. 2011
    ..Our data suggest that targeting P2X₇R on hematopoietic cells (e.g., DCs or eosinophils) might be a new therapeutic option for the treatment of asthma...
  8. pmc Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue
    Christoph Dürr
    Department of Haematology and Oncology, Freiburg University Medical Centre, Albert Ludwigs University, Freiburg, Germany
    Immunology 137:80-8. 2012
    ..In conclusion, we demonstrate that GvHD-related inflammation reduced Treg-cell numbers at the tumour sites, which may in turn help to explain the observation that patients with GvHD have a lower risk of tumour relapse...
  9. doi request reprint Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation
    Rodolfo Paula Vieira
    University Hospital Freiburg, Department of Pneumology, Freiburg, Germany
    Am J Respir Crit Care Med 184:215-23. 2011
    ....
  10. pmc Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity
    Felix C Weber
    Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Exp Med 207:2609-19. 2010
    ..The lack of P2X(7) triggering prevents IL-1β release, which is an essential step in the sensitization process. Interference with P2X(7) signaling may be a promising strategy for the prevention of allergic contact dermatitis...
  11. doi request reprint Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R
    Konrad Wilhelm
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Nat Med 16:1434-8. 2010
    ..These data have major implications for transplantation medicine, as pharmacological interference with danger signals that act via P2X(7)R could lead to the development of tolerance without the need for intensive immunosuppression...
  12. pmc Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells
    Anne Kathrin Hechinger
    Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Haematologica 98:31-40. 2013
    ....
  13. doi request reprint Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100
    Franziska Leonhardt
    Department of Hematology and Oncology, FreiburgUniversity Medical Center, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Blood 121:3307-18. 2013
    ..We identify negative regulation of GvHD-related neovascularization by miR-100, which indicates common pathomechanistic features of GvHD and ischemia...
  14. doi request reprint CXCL12 mediates immunosuppression in the lymphoma microenvironment after allogeneic transplantation of hematopoietic cells
    Christoph Dürr
    Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106 Freiburg, Germany
    Cancer Res 70:10170-81. 2010
    ..Blocking CXCR4 enhanced antitumor effects and prolonged survival of tumor-bearing mice by reducing local Treg accumulation, indicating that CXCR4 is a potential target to interfere with tumor escape after alloHCT...
  15. ncbi request reprint Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema
    Sanja Cicko
    Department of Pulmonary Medicine, University Hospital, Freiburg, Germany
    J Immunol 185:688-97. 2010
    ..We demonstrate, for the first time, that endogenous ATP contributes to smoke-induced lung inflammation and then development of emphysema via activation of the purinergic receptor subtypes, such as P2Y(2)R...
  16. ncbi request reprint Stem cell plasticity: the debate begins to clarify
    Alexandros Spyridonidis
    Freiburg University Medical Center, Department of Hematology Oncology, Hugstetter Strasse 55, Freiburg, Germany
    Stem Cell Rev 1:37-43. 2005
    ..This review discusses the current status of the "plasticity" debate and presents existing data on detection methodology, underlying mechanisms, physiological implications, and clinical significance...
  17. doi request reprint Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response
    Annette Dorn
    Department of Pathology, University Medical Centre Freiburg, Freiburg, Germany
    Cell Immunol 276:187-95. 2012
    ..In addition, in a hypersensitivity model rap1-deficient mice demonstrated reduced contact dermatitis compared to wildtype mice, demonstrating the impact of rap1-deficiency on the inflammatory response in vivo...
  18. pmc Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation
    Wilfried Reichardt
    Department of Diagnostic Radiology and Medical Physics, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
    J Immunol 181:4770-9. 2008
    ..This study is the first to delineate the impact of RAPA on DC migration and tolerogenic function after aHCT. Modification of the DC phenotype by mTOR inhibition may have therapeutic potential in an attempt to reduce GvHD following aHCT...
  19. doi request reprint P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema
    Monica Lucattelli
    Department of Pulmonary Medicine, University of Freiburg, Germany
    Am J Respir Cell Mol Biol 44:423-9. 2011
    ..Inhibition of this receptor may be a new therapeutic target for the treatment of chronic obstructive pulmonary disease...
  20. ncbi request reprint Capillary electrophoresis for chimerism monitoring by PCR amplification of microsatellite markers after allogeneic hematopoietic cell transplantation
    Alexandros Spyridonidis
    Department of Hematology and Oncology, Albert Ludwigs University Medical Center, Freiburg, Germany
    Clin Transplant 19:350-6. 2005
    ..In the light of increasing numbers of non-myeloablative aHCT as a treatment modality sensitive, rapid, and accurate chimerism monitoring techniques acquire novel relevance...
  21. ncbi request reprint Fatal varicella zoster virus encephalitis in two patients following allogeneic hematopoietic stem cell transplantation
    Björn Hackanson
    Department of Hematology Oncology, Freiburg University Medical Center, Freiburg, Germany
    Clin Transplant 19:566-70. 2005
    ..Varicella zoster virus (VZV) reactivation in this setting most commonly manifests as dermatomal herpes zoster but in some cases life-threatening VZV encephalitis occurs...
  22. ncbi request reprint Vaccination of advanced prostate cancer patients with PSCA and PSA peptide-loaded dendritic cells induces DTH responses that correlate with superior overall survival
    Anna K Thomas-Kaskel
    Department of Hematology Oncology, Freiburg University Medical Center, D 79106 Freiburg, Germany
    Int J Cancer 119:2428-34. 2006
    ..Testing of DC-based vaccination is warranted for patients at earlier stages of prostate cancer...
  23. pmc Ectonucleotidases in solid organ and allogeneic hematopoietic cell transplantation
    Petya Chernogorova
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, 79106 Freiburg, Germany
    J Biomed Biotechnol 2012:208204. 2012
    ....
  24. ncbi request reprint Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer
    Sabine Jägle
    Institute of Molecular Medicine and Cell Research, Faculty of Biology, Institute of Pathology, University Medical Center, Department of Hematology and Oncology, University Medical Center, Freiburg Institute for Advanced Studies, and BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University Freiburg, D 79117 Freiburg, Germany
    Proc Natl Acad Sci U S A 111:4886-91. 2014
    ..In summary, our results uncover enhancer decommissioning as a mechanism for transcriptional silencing of the EPHB3 tumor suppressor and argue for an antitumorigenic function of Notch signaling in advanced colorectal cancer. ..
  25. ncbi request reprint Immunopathogenesis of acute graft-versus-host disease: implications for novel preventive and therapeutic strategies
    Robert Zeiser
    Department of Hematology and Oncology, Albert Ludwigs University Medical Center Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Ann Hematol 83:551-65. 2004
    ....
  26. pmc Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapy
    Robert Zeiser
    Division of Hematology and Oncology, Department of Medicine, Albert Ludwig University Freiburg, Freiburg, Germany
    Cell Cycle 7:458-62. 2008
    ..In this report we focus on the relevance of these pathways as well as the impact of immunosuppressive drugs that may affect or enhance Treg function by targeting IL-2R signalling...
  27. doi request reprint The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia
    Konrad Aumann
    Institute of Pathology, University Medical Center, 79106 Freiburg, Germany
    Hum Pathol 42:719-26. 2011
    ....